• Kemitorvet, 220, 408F

    2800 Kgs. Lyngby

    Denmark

20032022
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Research Output 2003 2020

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Journal article
2020
6 Downloads (Pure)

A single-host fermentation process for the production of flavor lactones from non-hydroxylated fatty acids

Marella, E. R., Dahlin, J., Dam, M. I., ter Horst, J., Christensen, H. B., Sudarsan, S., Wang, G., Holkenbrink, C. & Borodina, I., 2020, (Accepted/In press) In : Metabolic Engineering.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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4 Downloads (Pure)
Open Access
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2019
137 Downloads (Pure)

CRISPR/Cas9-RNAi system for combinatorial metabolic engineering of Saccharomyces cerevisiae

Kildegaard, K. R., Ribeiro Ramos Tramontin, L., Chekina, K., Li, M., Goedecke, T. J., Kristensen, M. & Borodina, I., 2019, In : Yeast. 36, 5, p. 237-247

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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52 Downloads (Pure)
Open Access
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27 Downloads (Pure)

Engineering Oleaginous Yeast as the Host for Fermentative Succinic Acid Production From Glucose

Babaei, M., Kildegaard, K. R., Niaei, A., Hosseini, M., Ebrahimi, S., Sudarsan, S., Angelidaki, I. & Borodina, I., 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 14 p., 361.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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48 Downloads (Pure)
Open Access
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6 Downloads (Pure)

Enhancement of astaxanthin biosynthesis in oleaginous yeast Yarrowia lipolytica via microalgal pathway

Tramontin, L. R. R., Kildegaard, K. R., Sudarsan, S. & Borodina, I., 2019, In : Microorganisms. 7, 10, 17 p., 472.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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12 Downloads (Pure)

Identification and characterisation of two high-affinity glucose transporters from the spoilage yeast Brettanomyces bruxellensis

Tiukova, I. A., Møller-Hansen, I., Belew, Z. M., Darbani, B., Boles, E., Nour-Eldin, H. H., Linder, T., Nielsen, J. & Borodina, I., 2019, In : FEMS Microbiology Letters. 366, 17, fnz222.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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5 Downloads (Pure)

Metabolic engineering and transcriptomic analysis of Saccharomyces cerevisiae producing p-coumaric acid from xylose

Manuel Borja Zamfir, G., Rodriguez Prado, E. A., Campbell, K., Borodina, I., Chen, Y. & Nielsen, J., 2019, In : Microbial Cell Factories. 18, 1, 14 p., 191.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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14 Downloads (Pure)

Multi-omics analysis of fatty alcohol production in engineered yeasts saccharomyces cerevisiae and yarrowia lipolytica

Dahlin, J., Holkenbrink, C., Marella, E. R., Wang, G., Liebal, U., Lieven, C., Weber, D., McCloskey, D., Ebert, B. E., Herrgård, M. J., Blank, L. M. & Borodina, I., 2019, In : Frontiers in Genetics. 10, 747.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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31 Downloads (Pure)

The transcriptome and flux profiling of Crabtree-negative hydroxy acid producing strains of Saccharomyces cerevisiae reveals changes in the central carbon metabolism

Jessop-Fabre, M. M., Dahlin, J., Biron, M. B., Stovicek, V., Ebert, B. E., Blank, L. M., Budin, I., Keasling, J. D. & Borodina, I., 2019, In : Biotechnology Journal. 14, 9, 11 p., e1900013.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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251 Downloads (Pure)

Understanding metabolite transport gives an upper hand in strain development

Borodina, I., 2019, In : Microbial Biotechnology. 12, 1, p. 69-70

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2018

Advances in synthetic biology of oleaginous yeast Yarrowia lipolytica for producing non-native chemicals

Darvishi, F., Ariana, M., Marella, E. R. & Borodina, I., 2018, In : Applied Microbiology and Biotechnology. 102, 14, p. 5925-5938

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
330 Downloads (Pure)

EasyCloneYALI: CRISPR/Cas9-based synthetic toolbox for engineering of the yeast Yarrowia lipolytica

Holkenbrink, C., Dam, M. I., Kildegaard, K. R., Beder, J., Dahlin, J., Belda, D. D. & Borodina, I., 2018, In : Biotechnology Journal. 13, 9, 23 p., 1700543.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
219 Downloads (Pure)

Energetic evolution of cellular Transportomes

Darbani, B., Kell, D. B. & Borodina, I., 2018, In : B M C Genomics. 19, 11 p., 418.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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184 Downloads (Pure)

Glucose-dependent promoters for dynamic regulation of metabolic pathways

Maury, J., Kannan, S., Jensen, N. B., Öberg, F. K., Kildegaard, K. R., Forster, J., Nielsen, J., Workman, C. T. & Borodina, I., 2018, In : Frontiers in Bioengineering and Biotechnology. 6, 63.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2017
255 Downloads (Pure)

Comparison of the metabolic response to over-production of p-coumaric acid in two yeast strains

Rodriguez, A., Chen, Y., Khoomrung, S., Özdemir, E., Borodina, I. & Nielsen, J., 2017, In : Metabolic Engineering. 44, p. 265-272

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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1971 Downloads (Pure)

CRISPR/Cas system for yeast genome engineering: advances and applications

Stovicek, V., Holkenbrink, C. & Borodina, I., 2017, In : F E M S Yeast Research. 17, 5, 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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322 Downloads (Pure)

Engineering microbial fatty acid metabolism for biofuels and biochemicals

Marella, E. R., Holkenbrink, C., Siewers, V. & Borodina, I., 2017, In : Current Opinion in Biotechnology. 50, p. 39-46

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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482 Downloads (Pure)

Engineering of Yarrowia lipolytica for production of astaxanthin

Kildegaard, K. R., Adiego Pérez, B., Doménech Belda, D., Khangura, J. K., Holkenbrink, C. & Borodina, I., 2017, In : Synthetic and Systems Biotechnology. 2, 4, p. 287-294

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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353 Downloads (Pure)

Metabolic engineering of yeast for fermentative production of flavonoids

Rodriguez Prado, E. A., Strucko, T., Stahlhut, S. G., Kristensen, M., Svenssen, D. K., Förster, J., Nielsen, J. & Borodina, I., 2017, In : Bioresource Technology. 245, Part B, p. 1645-1654

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2016
737 Downloads (Pure)

EasyClone-MarkerFree: A vector toolkit for marker-less integration of genes into Saccharomyces cerevisiae via CRISPR-Cas9

Fabre, M. M. J., Jakociunas, T., Stovicek, V., Dai, Z., Jensen, M. K., Keasling, J. & Borodina, I., 2016, In : Biotechnology Journal. 11, 8, p. 1110-1117 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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348 Downloads (Pure)

EasyCloneMulti: A Set of Vectors for Simultaneous and Multiple Genomic Integrations in Saccharomyces cerevisiae

Maury, J., Germann, S. M., Jacobsen, S. A., Jensen, N. B., Kildegaard, K. R., Herrgard, M., Schneider, K., Koza, A., Förster, J., Nielsen, J. & Borodina, I., 2016, In : P L o S One. 11, 3, 22 p., e0150394.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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418 Downloads (Pure)

Engineering and systems level analysis of Saccharomyces cerevisiae for production of 3 hydroxypropionic acid via malonyl CoA reductase dependent pathway

Kildegaard, K. R., Jensen, N. B., Schneider, K., Czarnotta, E., Özdemir, E., Klein, T., Maury, J., E. Eber, B., Christensen, H. B., Chen, Y., Kim, I-K., Herrgard, M., Blank, L. M., Förster, J., Nielsen, J. & Borodina, I., 2016, In : Microbial Cell Factories. 15, 53, 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Engineering prokaryotic transcriptional activators as metabolite biosensors in yeast

Skjødt, M. L., Snoek, T., Kildegaard, K. R., Arsovska, D., Eichenberger, M., Goedecke, T. J., Rajkumar, A. S., Zhang, J., Kristensen, M., Lehka, B., Siedler, S., Borodina, I., Jensen, M. K. & Keasling, J., 2016, In : Nature Chemical Biology. 12, 11, p. 951-958 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

229 Downloads (Pure)

Engineering yeast for high-level production of stilbenoid antioxidants

Li, M., Schneider, K., Kristensen, M., Borodina, I. & Nielsen, J., 2016, In : Scientific Reports. 6, 8 p., 36827.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
856 Downloads (Pure)

Glucose-based microbial production of the hormone melatonin in yeast Saccharomyces cerevisiae

Germann, S. M., Jacobsen, S. A., Schneider, K., Harrison, S. J., Jensen, N. B., Chen, X., Stahlhut, S. G., Borodina, I., Luo, H., Zhu, J., Maury, J. & Förster, J., 2016, In : Biotechnology Journal. 11, 5, p. 717-724 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2015

Application of synthetic biology for production of chemicals in yeast Saccharomyces cerevisiae

Borodina, I. & Li, M., 2015, In : F E M S Yeast Research. 15, 1, 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

CasEMBLR: Cas9-Facilitated Multiloci Genomic Integration of in Vivo Assembled DNA Parts in Saccharomyces cerevisiae

Jakociunas, T., Rajkumar, A. S., Zhang, J., Arsovska, D., Rodriguez Prado, E. A., Jendresen, C. B., Skjødt, M. L., Nielsen, A. T., Borodina, I., Jensen, M. K. & Keasling, J., 2015, In : A C S Synthetic Biology. 4, 11, p. 1226-1234 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

427 Downloads (Pure)

CrEdit: CRISPR mediated multi-loci gene integration in Saccharomyces cerevisiae

Ronda, C., Maury, J., Jakociunas, T., Jacobsen, S. A. B., Germann, S. M., Harrison, S. J., Borodina, I., Keasling, J. D., Jensen, M. K. & Nielsen, A. T., 2015, In : Microbial Cell Factories. 14, 97, 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
527 Downloads (Pure)

CRISPR–Cas system enables fast and simple genome editing of industrial Saccharomyces cerevisiae strains

Stovicek, V., Borodina, I. & Förster, J., 2015, In : Metabolic Engineering Communications. 2, p. 13-22 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
456 Downloads (Pure)

De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

Li, M., Kildegaard, K. R., Chen, Y., Rodriguez Prado, E. A., Borodina, I. & Nielsen, J., 2015, In : Metabolic Engineering. 32, p. 1-11

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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296 Downloads (Pure)

EasyClone 2.0: expanded toolkit of integrative vectors for stable gene expression in industrial Saccharomyces cerevisiae strains

Stovicek, V., Borja Zamfir, G. M., Förster, J. & Borodina, I., Oct 2015, In : Journal of Industrial Microbiology and Biotechnology. 42, 11, p. 1519-1531 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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468 Downloads (Pure)

Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via β-alanine

Borodina, I., Kildegaard, K. R., Jensen, N. B., Blicher, T. H., Maury, J., Sherstyk, S., Schneider, K., Lamosa, P., Herrgard, M., Rosenstand, I., Öberg, F., Förster, J. & Nielsen, J., 2015, In : Metabolic Engineering. 27, p. 57-64

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
492 Downloads (Pure)

Establishment of a yeast platform strain for production of p-coumaric acid through metabolic engineering of aromatic amino acid biosynthesis

Rodriguez Prado, E. A., Kildegaard, K. R., Li, M., Borodina, I. & Nielsen, J., 2015, In : Metabolic Engineering. 31, p. 181-188 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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500 Downloads (Pure)

Highly Active and Specific Tyrosine Ammonia-Lyases from Diverse Origins Enable Enhanced Production of Aromatic Compounds in Bacteria and Saccharomyces cerevisiae

Jendresen, C. B., Stahlhut, S. G., Li, M., Gaspar, P., Siedler, S., Förster, J., Maury, J., Borodina, I. & Nielsen, A. T., 2015, In : Applied and Environmental Microbiology. 81, 13, p. 4458-4476 19 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
513 Downloads (Pure)

Production of 3-hydroxypropionic acid from glucose and xylose by metabolically engineered Saccharomyces cerevisiae

Kildegaard, K. R., Wang, Z., Chen, Y., Nielsen, J. & Borodina, I., 2015, In : Metabolic Engineering Communications. 2, p. 132-136 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2014
1 Downloads (Pure)

Advances in metabolic engineering of yeast Saccharomyces cerevisiae for production of chemicals

Borodina, I. & Nielsen, J., 2014, In : Biotechnology Journal. 9, 5, p. 609-620 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

1256 Downloads (Pure)

EasyClone: method for iterative chromosomal integration of multiple genes in Saccharomyces cerevisiae

Jensen, N. B., Strucko, T., Kildegaard, K. R., David, F., Maury, J., Mortensen, U. H., Förster, J., Nielsen, J. & Borodina, I., 2014, In : F E M S Yeast Research. 14, 2, p. 238–248

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
289 Downloads (Pure)

Evolution reveals a glutathione-dependent mechanism of 3-hydroxypropionic acid tolerance

Kildegaard, K. R., Hallström, B. M., Blicher, T. H., Sonnenschein, N., Jensen, N. B., Sherstyk, S., Harrison, S. J., Maury, J., Herrgard, M., Juncker, A., Förster, J., Nielsen, J. & Borodina, I., 2014, In : Metabolic Engineering. 26, p. 57-66 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2011
236 Downloads (Pure)

Expression of Enzymatically Inactive Wasp Venom Phospholipase A1 in Pichia pastoris

Borodina, I., Jensen, B. M., Wagner, T., Abou Hachem, M., Søndergaard, I. & Poulsen, L. K., 2011, In : P L o S One. 6, 6, p. e21267

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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High-yield production of hydrophobins RodA and RodB from Aspergillus fumigatus in Pichia pastoris

Pedersen, M. H., Borodina, I., Moresco, J. L., Svendsen, W. E., Frisvad, J. C. & Søndergaard, I., 2011, In : Applied Microbiology and Biotechnology. 90, 6, p. 1923-1932

Research output: Contribution to journalJournal articleResearchpeer-review

520 Downloads (Pure)

Increased isobutanol production in Saccharomyces cerevisiae by overexpression of genes in valine metabolism

Chen, X., Nielsen, K. F., Borodina, I., Kielland-Brandt, M. & Karhumaa, K., 2011, In : Biotechnology for Biofuels. 4, 1, p. 21

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2010
404 Downloads (Pure)

Display of wasp venom allergens on the cell surface of Saccharomyces cerevisiae

Borodina, I., Jensen, B. M., Søndergaard, I. & Poulsen, L. K., 2010, In : Microbial Cell Factories. 9, 74, 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2008

Antibiotic Overproduction in Steptomyces coelicolor A3(2) Mediated by Phosphofructokinase Deletion

Borodina, I., Siebring, J., Zhang, J., Smith, C. P., van Keulen, G., Dijkhuizen, L. & Nielsen, J., 2008, In : Journal of Biological Chemistry. 283, 37, p. 25186-25199

Research output: Contribution to journalJournal articleResearchpeer-review

2005

From genomes to in silico cells via metabolic networks

Borodina, I. & Nielsen, J., 2005, In : Current Opinion in Biotechnology. 16, 3, p. 350-355

Research output: Contribution to journalJournal articleResearchpeer-review

Genome-scale analysis of Streptomyces coelicolor A3 (2) metabolism

Borodina, I., Krabben, P. & Nielsen, J., 2005, In : Genome Research. 15, p. 820-829

Research output: Contribution to journalJournal articleResearchpeer-review

Metabolic network analysis of Streptomyces tenebrarius, Streptomyces with Entner-Doudoroff pathway

Borodina, I., Schöller, C. E. G., Eliasson Lantz, A. & Nielsen, J., 2005, In : Applied Enviromental Microbioogy. 71, p. 2294-2302

Research output: Contribution to journalJournal articleResearchpeer-review