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Research Output

2020

A single-host fermentation process for the production of flavor lactones from non-hydroxylated fatty acids

Marella, E. R., Dahlin, J., Dam, M. I., ter Horst, J., Christensen, H. B., Sudarsan, S., Wang, G., Holkenbrink, C. & Borodina, I., 2020, (Accepted/In press) In : Metabolic Engineering.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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80 Downloads (Pure)
Open Access
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97 Downloads (Pure)

Improvement of cis,cis-Muconic Acid Production in Saccharomyces cerevisiae through Biosensor-Aided Genome Engineering

Wang, G., Øzmerih, S., Guerreiro, R., Meireles, A. C., Carolas, A., Milne, N., Jensen, M. K., Ferreira, B. S. & Borodina, I., 2020, In : ACS Synthetic Biology. 9, 3, p. 634-646

Research output: Contribution to journalJournal articleResearchpeer-review

Metabolic engineering of Saccharomyces cerevisiae for the de novo production of psilocybin and related tryptamine derivatives

Milne, N., Thomsen, P., Mølgaard Knudsen, N., Rubaszka, P., Kristensen, M. & Borodina, I., 2020, In : Metabolic Engineering. 60, p. 25-36

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2 Downloads (Pure)

The biology of ergothioneine, an antioxidant nutraceutical

Borodina, I., Kenny, L. C., McCarthy, C. M., Paramasivan, K., Pretorius, E., Roberts, T. J., van der Hoek, S. A. & Kell, D. B., 2020, (Accepted/In press) In : Nutrition Research Reviews. 28 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
27 Downloads (Pure)
2019

CRISPR/Cas9-RNAi system for combinatorial metabolic engineering of Saccharomyces cerevisiae

Kildegaard, K. R., Ribeiro Ramos Tramontin, L., Chekina, K., Li, M., Goedecke, T. J., Kristensen, M. & Borodina, I., 2019, In : Yeast. 36, 5, p. 237-247

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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241 Downloads (Pure)
Open Access
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130 Downloads (Pure)

Engineering Oleaginous Yeast as the Host for Fermentative Succinic Acid Production From Glucose

Babaei, M., Kildegaard, K. R., Niaei, A., Hosseini, M., Ebrahimi, S., Sudarsan, S., Angelidaki, I. & Borodina, I., 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 14 p., 361.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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101 Downloads (Pure)
Open Access
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128 Downloads (Pure)

Enhancement of astaxanthin biosynthesis in oleaginous yeast Yarrowia lipolytica via microalgal pathway

Tramontin, L. R. R., Kildegaard, K. R., Sudarsan, S. & Borodina, I., 2019, In : Microorganisms. 7, 10, 17 p., 472.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
61 Downloads (Pure)

Identification and characterisation of two high-affinity glucose transporters from the spoilage yeast Brettanomyces bruxellensis

Tiukova, I. A., Møller-Hansen, I., Belew, Z. M., Darbani, B., Boles, E., Nour-Eldin, H. H., Linder, T., Nielsen, J. & Borodina, I., 2019, In : FEMS Microbiology Letters. 366, 17, fnz222.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
62 Downloads (Pure)

Metabolic engineering and transcriptomic analysis of Saccharomyces cerevisiae producing p-coumaric acid from xylose

Manuel Borja Zamfir, G., Rodriguez Prado, E. A., Campbell, K., Borodina, I., Chen, Y. & Nielsen, J., 2019, In : Microbial Cell Factories. 18, 1, 14 p., 191.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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44 Downloads (Pure)

Multi-omics analysis of fatty alcohol production in engineered yeasts saccharomyces cerevisiae and yarrowia lipolytica

Dahlin, J., Holkenbrink, C., Marella, E. R., Wang, G., Liebal, U., Lieven, C., Weber, D., McCloskey, D., Ebert, B. E., Herrgård, M. J., Blank, L. M. & Borodina, I., 2019, In : Frontiers in Genetics. 10, 747.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
62 Downloads (Pure)

The transcriptome and flux profiling of Crabtree-negative hydroxy acid producing strains of Saccharomyces cerevisiae reveals changes in the central carbon metabolism

Jessop-Fabre, M. M., Dahlin, J., Biron, M. B., Stovicek, V., Ebert, B. E., Blank, L. M., Budin, I., Keasling, J. D. & Borodina, I., 2019, In : Biotechnology Journal. 14, 9, 11 p., e1900013.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
112 Downloads (Pure)

Understanding metabolite transport gives an upper hand in strain development

Borodina, I., 2019, In : Microbial Biotechnology. 12, 1, p. 69-70

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
310 Downloads (Pure)
2018

Advances in synthetic biology of oleaginous yeast Yarrowia lipolytica for producing non-native chemicals

Darvishi, F., Ariana, M., Marella, E. R. & Borodina, I., 2018, In : Applied Microbiology and Biotechnology. 102, 14, p. 5925-5938

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

EasyCloneYALI: CRISPR/Cas9-based synthetic toolbox for engineering of the yeast Yarrowia lipolytica

Holkenbrink, C., Dam, M. I., Kildegaard, K. R., Beder, J., Dahlin, J., Belda, D. D. & Borodina, I., 2018, In : Biotechnology Journal. 13, 9, 23 p., 1700543.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
472 Downloads (Pure)

Energetic evolution of cellular Transportomes

Darbani, B., Kell, D. B. & Borodina, I., 2018, In : B M C Genomics. 19, 11 p., 418.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
299 Downloads (Pure)

Glucose-dependent promoters for dynamic regulation of metabolic pathways

Maury, J., Kannan, S., Jensen, N. B., Öberg, F. K., Kildegaard, K. R., Forster, J., Nielsen, J., Workman, C. T. & Borodina, I., 2018, In : Frontiers in Bioengineering and Biotechnology. 6, 63.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
260 Downloads (Pure)

Method for production of moth pheromones in yeast

Borodina, I., Holkenbrink, C., Dam, M. I., Löfstedt, C., Ding, B. & Wang, H., 2018, IPC No. C07K14/435; C12N1/16; C12P7/04; C12P7/24; C12P7/64, Patent No. US2018162916 , 14 Jun 2018, Priority date 26 Jun 2015, Priority No. EP20150174099

Research output: Patent

Open Access
File
110 Downloads (Pure)

Methods for producing fatty alcohols and derivatives thereof in yeast

Borodina, I., Holkenbrink, C., Dam, M. I. & Löfstedt, C., 2018, IPC No. C12N9/02; C12P7/04, Patent No. WO2018109163 , 21 Jun 2018, Priority date 16 Dec 2016, Priority No. EP20160204769

Research output: Patent

Open Access
File
105 Downloads (Pure)

Native chinese hamster ovary cell secretion signal peptides for production of recombinant polypeptides

Andersen, M. R., Borodina, I., Do, D. D. & Lund, A. M., 2018, IPC No. C07K14/47; C12N15/85, Patent No. EP3323826 , 23 May 2018, Priority date 21 Nov 2016, Priority No. EP20160199726

Research output: Patent

Open Access
File
366 Downloads (Pure)

Production of desaturated fatty alcohols and desaturated fatty acyl acetates in yeast

Borodina, I., Holkenbrink, C., Dam, M. I., Löfstedt, C., Ding, B. & Wang, H., 2018, IPC No. C12N9/02; C12P7/04, Patent No. WO2018109167 , 21 Jun 2018, Priority date 16 Dec 2016, Priority No. EP20160204783

Research output: Patent

Open Access
File
173 Downloads (Pure)

Yeast cell factories for more sustainable pest control in agriculture/ Engineered Oleaginous Yeast Cell Factories for Fine Chemicals

Borodina, I., 2018, The Danish Microbiological Society Annual Congress 2018 - programme & abstracts. Copenhagen, Denmark: Danish Microbiological Society, p. 13-13

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
505 Downloads (Pure)
2017

BIOREFINE-2G — Result In Brief: Novel biopolymers from biorefinery waste-streams

Stovicek, V., Chen, X., Borodina, I. & Förster, J., 2017, European Commission. 2 p.

Research output: Book/ReportReportCommunication

Open Access
File
85 Downloads (Pure)

Comparison of the metabolic response to over-production of p-coumaric acid in two yeast strains

Rodriguez, A., Chen, Y., Khoomrung, S., Özdemir, E., Borodina, I. & Nielsen, J., 2017, In : Metabolic Engineering. 44, p. 265-272

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
337 Downloads (Pure)

CRISPR/Cas system for yeast genome engineering: advances and applications

Stovicek, V., Holkenbrink, C. & Borodina, I., 2017, In : F E M S Yeast Research. 17, 5, 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2266 Downloads (Pure)

Easyclone-markerfree: A vector toolkit for marker-less integration of genes into saccharomyces cerevisiae via CRISPR-Cas9

Jessop Fabre, M., Jakociunas, T., Stovicek, V., Dai, Z., Jensen, M. K., Keasling, J. & Borodina, I., 2017, Synthetic Biology Conference, SEED 2017: Engineering, Evolution, and Design. American Institute of Chemical Engineers, p. 149-150 2 p.

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Engineering microbial fatty acid metabolism for biofuels and biochemicals

Marella, E. R., Holkenbrink, C., Siewers, V. & Borodina, I., 2017, In : Current Opinion in Biotechnology. 50, p. 39-46

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
478 Downloads (Pure)

Engineering of Yarrowia lipolytica for production of astaxanthin

Kildegaard, K. R., Adiego Pérez, B., Doménech Belda, D., Khangura, J. K., Holkenbrink, C. & Borodina, I., 2017, In : Synthetic and Systems Biotechnology. 2, 4, p. 287-294

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
627 Downloads (Pure)

Metabolic engineering of yeast for fermentative production of flavonoids

Rodriguez Prado, E. A., Strucko, T., Stahlhut, S. G., Kristensen, M., Svenssen, D. K., Förster, J., Nielsen, J. & Borodina, I., 2017, In : Bioresource Technology. 245, Part B, p. 1645-1654

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
480 Downloads (Pure)

Yeast Cell Factories for Production of Fuels and Chemicals

Borodina, I. & Zhao, Z. K., 2017, In : FEMS Yeast Research. 17, 8, 1 p., fox082.

Research output: Contribution to journalEditorialResearchpeer-review

Open Access
File
239 Downloads (Pure)
2016

A toolbox for accelerating strain engineering of oleaginous yeast Yarrowia lipolytica

Holkenbrink, C., Beder, J., Dam, M. I. & Borodina, I., 2016, Online Proceedings. American Institute of Chemical Engineers, 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
147 Downloads (Pure)

EasyClone-MarkerFree: A vector toolkit for marker-less integration of genes into Saccharomyces cerevisiae via CRISPR-Cas9

Fabre, M. M. J., Jakociunas, T., Stovicek, V., Dai, Z., Jensen, M. K., Keasling, J. & Borodina, I., 2016, In : Biotechnology Journal. 11, 8, p. 1110-1117 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
918 Downloads (Pure)

EasyCloneMulti: A Set of Vectors for Simultaneous and Multiple Genomic Integrations in Saccharomyces cerevisiae

Maury, J., Germann, S. M., Jacobsen, S. A., Jensen, N. B., Kildegaard, K. R., Herrgard, M., Schneider, K., Koza, A., Förster, J., Nielsen, J. & Borodina, I., 2016, In : P L o S One. 11, 3, 22 p., e0150394.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
425 Downloads (Pure)

Engineering and systems level analysis of Saccharomyces cerevisiae for production of 3 hydroxypropionic acid via malonyl CoA reductase dependent pathway

Kildegaard, K. R., Jensen, N. B., Schneider, K., Czarnotta, E., Özdemir, E., Klein, T., Maury, J., E. Eber, B., Christensen, H. B., Chen, Y., Kim, I-K., Herrgard, M., Blank, L. M., Förster, J., Nielsen, J. & Borodina, I., 2016, In : Microbial Cell Factories. 15, 53, 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
477 Downloads (Pure)

Engineering prokaryotic transcriptional activators as metabolite biosensors in yeast

Skjødt, M. L., Snoek, T., Kildegaard, K. R., Arsovska, D., Eichenberger, M., Goedecke, T. J., Rajkumar, A. S., Zhang, J., Kristensen, M., Lehka, B., Siedler, S., Borodina, I., Jensen, M. K. & Keasling, J., 2016, In : Nature Chemical Biology. 12, 11, p. 951-958 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Engineering yeast for high-level production of stilbenoid antioxidants

Li, M., Schneider, K., Kristensen, M., Borodina, I. & Nielsen, J., 2016, In : Scientific Reports. 6, 8 p., 36827.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
290 Downloads (Pure)

Glucose-based microbial production of the hormone melatonin in yeast Saccharomyces cerevisiae

Germann, S. M., Jacobsen, S. A., Schneider, K., Harrison, S. J., Jensen, N. B., Chen, X., Stahlhut, S. G., Borodina, I., Luo, H., Zhu, J., Maury, J. & Förster, J., 2016, In : Biotechnology Journal. 11, 5, p. 717-724 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
1004 Downloads (Pure)

Microbial production of the flavonoids garbanzol, resokaempferol and fisetin

Stahlhut, S. G., Siedler, S., Neves, A. R., MAURY, JEROME., Förster, J., Gaspar, P., Borodina, I., Rodriguez Prado, E. A. & Strucko, T., 12 May 2016, IPC No. C07D 311/ 30 A I, Patent No. WO2016071505, 12 May 2016, Priority date 11 Jun 2015, Priority No. EP20150171638

Research output: Patent

Open Access
File
330 Downloads (Pure)

Rational and Evolutionary Engineering of Industrial Saccharomyces Cerevisiae Strains for Production of Chemicals from Xylose-Rich Feedstocks

Stovicek, V., Lis, A. V., Borodina, I. & Förster, J., 2016, Online Proceedings. American Institute of Chemical Engineers, 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
174 Downloads (Pure)

Yeast cell factories for bio-based chemicals

Borodina, I., 2016. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
2015

Application of synthetic biology for production of chemicals in yeast Saccharomyces cerevisiae

Borodina, I. & Li, M., 2015, In : F E M S Yeast Research. 15, 1, 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

CasEMBLR: Cas9-Facilitated Multiloci Genomic Integration of in Vivo Assembled DNA Parts in Saccharomyces cerevisiae

Jakociunas, T., Rajkumar, A. S., Zhang, J., Arsovska, D., Rodriguez Prado, E. A., Jendresen, C. B., Skjødt, M. L., Nielsen, A. T., Borodina, I., Jensen, M. K. & Keasling, J., 2015, In : A C S Synthetic Biology. 4, 11, p. 1226-1234 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

CrEdit: CRISPR mediated multi-loci gene integration in Saccharomyces cerevisiae

Ronda, C., Maury, J., Jakociunas, T., Jacobsen, S. A. B., Germann, S. M., Harrison, S. J., Borodina, I., Keasling, J. D., Jensen, M. K. & Nielsen, A. T., 2015, In : Microbial Cell Factories. 14, 97, 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
536 Downloads (Pure)

CRISPR–Cas system enables fast and simple genome editing of industrial Saccharomyces cerevisiae strains

Stovicek, V., Borodina, I. & Förster, J., 2015, In : Metabolic Engineering Communications. 2, p. 13-22 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
608 Downloads (Pure)

De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

Li, M., Kildegaard, K. R., Chen, Y., Rodriguez Prado, E. A., Borodina, I. & Nielsen, J., 2015, In : Metabolic Engineering. 32, p. 1-11

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
537 Downloads (Pure)

Development of a yeast cell factory for production of aromatic compounds: test case flavonoids production

Rodriguez Prado, E. A., Kildegaard, K. R., Li, M., Borodina, I., Stahlhut, S. G., Förster, J. & Nielsen, J., 2015, In : Yeast. 32, S1, p. S127-S127 1 p., PS3-26.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

EasyClone 2.0: expanded toolkit of integrative vectors for stable gene expression in industrial Saccharomyces cerevisiae strains

Stovicek, V., Borja Zamfir, G. M., Förster, J. & Borodina, I., Oct 2015, In : Journal of Industrial Microbiology and Biotechnology. 42, 11, p. 1519-1531 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
348 Downloads (Pure)

Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via β-alanine

Borodina, I., Kildegaard, K. R., Jensen, N. B., Blicher, T. H., Maury, J., Sherstyk, S., Schneider, K., Lamosa, P., Herrgard, M., Rosenstand, I., Öberg, F., Förster, J. & Nielsen, J., 2015, In : Metabolic Engineering. 27, p. 57-64

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
593 Downloads (Pure)