20012020

Research output per year

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Journal article
2020

Anthelmintic and metabolomic analyses of chicory (Cichorium intybus) identify an industrial by-product with potent in vitro antinematodal activity

Pena-Espinoza, M. A., Valente, A. H., Bornancin, L., Simonsen, H. T., Thamsborg, S. M., Williams, A. R. & López-Muñoz, R., 2020, In : Veterinary Parasitology. 280, 11 p., 109088.

Research output: Contribution to journalJournal articleResearchpeer-review

Biosynthesis and Industrial Production of Androsteroids

Batth, R., Nicolle, C., Cuciurean, I. S. & Simonsen, H. T., 2020, In : Plants. 9, 9, 11 p., 1144.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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8 Downloads (Pure)

Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent

Knudsen, C., Bavishi, K., Viborg, K. M., Drew, D. P., Simonsen, H. T., Motawia, M. S., Møller, B. L. & Laursen, T., 2020, In : Phytochemistry. 170, 9 p., 112214.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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124 Downloads (Pure)

Thapsigargins and induced chemical defence in Thapsia garganica

Martinez-Swatson, K., Quiñonero-López, C., Ernst, M., Rønsted, N., Barnes, C. J. & Simonsen, H. T., 2020, In : Chemoecology. 30, p. 255-267 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2019

Anti-protozoal activity of extracts from chicory (Cichorium intybus) against Cryptosporidium parvum in cell culture

Woolsey, I. D., Valente, A. H., Williams, A. R., Thamsborg, S. M., Simonsen, H. T. & Enemark, H. L., 2019, In : Scientific Reports. 9, 1, 9 p., 20414.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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55 Downloads (Pure)

Assessing specialized metabolite diversity in the cosmopolitan plant genus Euphorbia l.

Ernst, M., Nothias, L. F., van der Hooft, J. J. J., Silva, R. R., Saslis-Lagoudakis, C. H., Grace, O. M., Martinez-Swatson, K., Hassemer, G., Funez, L. A., Simonsen, H. T., Medema, M. H., Staerk, D., Nilsson, N., Lovato, P., Dorrestein, P. C. & Rønsted, N., 2019, In : Frontiers in Plant Science. 10, 15 p., 846.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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104 Downloads (Pure)

Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

Andersen, T. B., Rasmussen, S. A., Christensen, S. B. & Simonsen, H. T., 2019, In : Phytochemistry. 157, p. 168-174

Research output: Contribution to journalJournal articleResearchpeer-review

Exploring evolutionary theories of plant defence investment using field populations of the deadly carrot

Martinez-Swatson, K. A., Kjøller, R., Cozzi, F., Simonsen, H. T., Rønsted, N. & Barnes, C. J., 2019, In : Annals of Botany. 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

In planta and in silico characterization of five sesquiterpene synthases from Vitis vinifera (cv. Shiraz) berries

Dueholm, B., Drew, D. P., Sweetman, C. & Simonsen, H. T., 2019, In : Planta. 249, 1, p. 59-70 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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80 Downloads (Pure)

Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens

Ikram, N. K. K., Kashkooli, A. B., Peramuna, A. V., Krol, A. R. V. D., Bouwmeester, H. & Simonsen, H. T., 2019, In : Molecules. 24, 21, 13 p., 3822.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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78 Downloads (Pure)
2018

Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review

Pena-Espinoza, M., Valente, A. H., Thamsborg, S. M., Simonsen, H. T., Boas, U., Enemark, H. L., Lopez-Munoz, R. & Williams, A. R., 2018, In : Parasites & Vectors. 11, 14 p., 475.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
240 Downloads (Pure)

Effects of gamma irradiation and comparison of different extraction methods on sesquiterpene lactone yields from the medicinal plant Thapsia garganica L. (Apiaceae)

Mohamed Ibrahim, A. M., Martinez-Swatson, K. A., Benkaci-Ali, F., Cozzi, F., Zoulikha, F. & Simonsen, H. T., 2018, In : Journal of Applied Research on Medicinal and Aromatic Plants. 8, p. 26-32

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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94 Downloads (Pure)

Evaluation of synthetic promoters in Physcomitrella patens

Peramuna, A., Bae, H., Rasmussen, E. K., Dueholm, B., Waibel, T., Critchley, J. H., Brzezek, K., Roberts, M. & Simonsen, H. T., 2018, In : BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 500, 2, p. 418-422

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
131 Downloads (Pure)

Physcomitrella patens, a versatile synthetic biology chassis

Reski, R., Bae, H. & Simonsen, H. T., 2018, In : Plant Cell Reports. 37, 10, p. 1409-1417

Research output: Contribution to journalJournal articleResearchpeer-review

Use of a temporary immersion bioreactor system for the sustainable production of thapsigargin in shoot cultures of Thapsia garganica

López, C. Q., Corral, P., Lorrain-Lorrette, B., Martinez-Swatson, K., Michoux, F. & Simonsen, H. T., 2018, In : Plant Methods. 14, 1, 17 p., 79.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
206 Downloads (Pure)
2017

Anthelmintic effects of forage chicory (Cichorium intybus) against free-living and parasitic stages of Cooperia oncophora

Pena-Espinoza, M. A., Williams, A. R., Thamsborg, S. M., Simonsen, H. T. & Enemark, H. L., 2017, In : Veterinary Parasitology. 243, p. 204-207

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
240 Downloads (Pure)

A Review of Biotechnological Artemisinin Production in Plants

Ikram, N. K. B. K. & Simonsen, H. T., 2017, In : Frontiers in Plant Science. 8, 10 p., 1966.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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429 Downloads (Pure)

Localization and in-vivo characterization of thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis

Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, K., Andersen-Ranberg, J., Nyberg, N., Christensen, S. B. & Simonsen, H. T., 1 May 2017, In : Plant Physiology. 174, 1, p. 56-72 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
319 Downloads (Pure)

Stable production of the antimalarial drug artemisinin in the moss Physcomitrella patens

Binti Khairul Ikram, N. K., Kashkooli, A. B., Peramuna, A. V., van der Krol, A. R., Bouwmeester, H. & Simonsen, H. T., 2017, In : Frontiers in Bioengineering and Biotechnology. 5, 47, 20 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
350 Downloads (Pure)
2016

Anthelmintic activity of chicory (Cichorium intybus): in vitro effects on swine nematodes and relationship to sesquiterpene lactone composition

Williams, A., Pena-Espinoza, M. A., Boas, U., Simonsen, H. T., Enemark, H. & Thamsborg, S. M., 2016, In : Parasitology (Cambridge). 143, 6, p. 770-777

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

Bryophytes - an emerging source for herbal remedies and chemical production

Sabovljevic, M. S., Sabovljević, A. D., Ikram, N. K. K., Peramuna, A. V., Bae, H. & Simonsen, H. T., 2016, In : Plant Genetic Resources. 14, 4, p. 314-327 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

Evolutionary prediction of medicinal properties in the genus Euphorbia L.

Ernst, M., Saslis Lagoudakis, H., Grace, O. M., Nilsson, N., Simonsen, H. T., Horn, J. W. & Rønsted, N., 2016, In : Scientific Reports. 6, 30531 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
273 Downloads (Pure)

Evolution of NADPH-cytochrome P450 oxidoreductases (POR) in Apiales - POR 1 is missing

Andersen, T. B., Hansen, N. B., Laursen, T., Weitzel, C. & Simonsen, H. T., 2016, In : Molecular Phylogenetics and Evolution. 98, p. 21-28 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Insight into Biochemical Characterization of Plant Sesquiterpene Synthases

Manczak, T. & Simonsen, H. T., 2016, In : Analytical Chemistry Insights. 11, S1, 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
256 Downloads (Pure)

In vivo assembly of DNA-fragments in the moss, Physcomitrella patens

King, B. C., Vavitsas, K., Ikram, N. K. B. K., Schroder, J., Scharff, L. B., Hamberger, B., Jensen, P. E. & Simonsen, H. T., 2016, In : Scientific Reports. 6, 7 p., 25030.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
241 Downloads (Pure)

Role of the Colletotrichum acutatum sesquiterpene synthase CaTPS in the biosynthesis of sesquiterpenoids

Amby, D. B., Manczak, T., Petersen, M. A., Sundelin, T., Weitzel, C., Grajewski, M., Simonsen, H. T. & Jensen, B., 2016, In : Microbiology. 162, p. 1773–1783

Research output: Contribution to journalJournal articleResearchpeer-review

The decision to germinate is regulated by divergent molecular networks in spores and seeds

Vesty, E. F., Saidi, Y., Moody, L. A., Holloway, D., Whitbread, A., Needs, S., Choudhary, A., Burns, B., Mcleod, D., Bradshaw, S. J., Bae, H., King, B. C., Bassel, G. W., Simonsen, H. T. & Coates, J. C., 2016, In : New Phytologist. 211, 3, p. 952-966 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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244 Downloads (Pure)

Two key polymorphisms in a newly discovered allele of the Vitis vinifera TPS24 gene are responsible for the production of the rotundone precursor α-guaiene

Drew, D. P., Andersen, T. B., Sweetman, C., Møller, B. L., Ford, C. & Simonsen, H. T., 2016, In : Journal of Experimental Botany. 67, 3, p. 799-808 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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93 Downloads (Pure)
2015

Additional diterpenes from Physcomitrella patens synthesized by copalyl diphosphate/kaurene synthase (PpCPS/KS)

Zhan, X., Bach, S. S., Hansen, N. L., Lunde, C. & Simonsen, H. T., 2015, In : Plant Physiology and Biochemistry. 96, p. 110-114 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cytochrome P450-enzymes involved in the biosynthesis of mono- and sesquiterpenes

Weitzel, C. & Simonsen, H. T., 2015, In : Phytochemistry Reviews. 14, 1, p. 7-24 18 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Evolution of substrate recognition sites (SRSs) in cytochromes P450 from Apiaceae exemplified by the CYP71AJ subfamily

Dueholm, B., Krieger, C., Drew, D., Olry, A., Kamo, T., Taboureau, O., Weitzel, C., Bourgaud, F., Hehn, A. & Simonsen, H. T., 2015, In : B M C Evolutionary Biology. 15, 122, 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
285 Downloads (Pure)

Optimization of Biochemical Screening Methods for Volatile and Unstable Sesquiterpenoids Using HS-SPME-GC-MS

Andersen, T., Cozzi, F. & Simonsen, H. T., 2015, In : Chromatography. 2, 2, p. 277-292 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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63 Downloads (Pure)

Sclareol production in the moss Physcomitrella patens and observations on growth and terpenoid biosynthesis

Pan, X-W., Han, L., Zhang, Y-H., Chen, D-F. & Simonsen, H. T., 2015, In : Plant Biotechnology Reports. 9, 3, p. 149-159 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Sesquiterpene lactone containing extracts from two cultivars of forage chicory (Cichorium intybus) show distinctive chemical profiles and in vitro activity against Ostertagia ostertagi

Pena-Espinoza, M. A., Boas, U., Williams, A., Thamsborg, S. M., Simonsen, H. T. & Enemark, H., 2015, In : International Journal for Parasitology: Drugs and Drug Resistance. 5, 3, p. 191-200

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
397 Downloads (Pure)

Thapsigargin-From Thapsia L. to Mipsagargin

Andersen, T. B., Lopez, C. Q., Manczak, T., Martinez, K. & Simonsen, H. T., 2015, In : Molecules. 20, 4, p. 6113-6127 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
141 Downloads (Pure)
2014

Metabolic engineering of the moss Physcomitrella patens to produce the sesquiterpenoids patchoulol and α/β-santalene

Zhan, X., Zhang, Y-H., Chen, D-F. & Simonsen, H. T., 2014, In : Frontiers in Plant Science. 5, 10 p., 636.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
98 Downloads (Pure)

Resurrecting deadly carrots: towards a revision of Thapsia (Apiaceae) based on phylogenetic analysis of nrITS sequences and chemical profiles

Weitzel, C., Ronsted, N., Spalik, K. & Simonsen, H. T., 2014, In : Botanical Journal of the Linnean Society. 174, 4, p. 620-636 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2013

Tea toxicity and cholinesterase inhibition of Huilliche herbal medicine

Adsersen, A., Guzman, A., Mølgaard, P. & Simonsen, H. T., 2013, In : Journal of Complementary and Integrative Medicine. 10, 1, p. 123-127 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Transcriptome Analysis of Thapsia laciniata Rouy Provides Insights into Terpenoid Biosynthesis and Diversity in Apiaceae

Drew, D. P., Dueholm, B., Weitzel, C., Zhang, Y., Sensen, C. W. & Simonsen, H. T., 2013, In : International Journal of Molecular Sciences (Online). 14, 5, p. 9080-9098 19 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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44 Downloads (Pure)

Four novel geminally dialkylated, non-aromatic acetophenone derivatives from Melicope coodeana

Simonsen, H. T., 2012, In : Phytochemistry Letters. 5, 2, p. 371-375 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Identification and characterization of a kunzeaol synthase from Thapsia garganica: implications for the biosynthesis of the pharmaceutical thapsigargin

Pickel, B., Drew, D. P., Manczak, T., Weitzel, C., Simonsen, H. T. & Ro, D-K., 2012, In : Biochemical Journal. 448, Part 2, p. 261-271 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mapuche HerbalMedicine Inhibits Blood Platelet Aggregation

Falkenberg, S. S., Tarnow, I., Guzman, A. & Simonsen, H. T., 2012, In : Evidence-Based Complementary and Alternative Medicine. p. 647620

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)
2011

Antimicrobial evaluation of Huilliche plant medicine used to treat wounds

Mølgaard, P., Holler, J. G., Asar, B., Liberna, I., Rosenbæk, L. B., Jebjerg, C. P., Jørgensen, L., Lauritzen, J., Guzman, A., Adsersen, A. & Simonsen, H. T., 2011, In : Journal of Ethnopharmacology. 138, 1, p. 219-227

Research output: Contribution to journalJournal articleResearchpeer-review

Effect of Antioxidants and Carbohydrates in Callus Cultures of Taxus brevifolia: Evaluation of Browning, Callus Growth, Total Phenolics and Paclitaxel Production

Khosroushahi, A-Y., Naderi-Manesh, H. & Simonsen, H. T., 2011, In : BioImpacts. 1, 1, p. 37-45 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2009

Chemical Composition and Antibacterial Activity of the Leaf Essential Oil of Baccharis magellanica (Lam.) Pers. and Baccharis elaeoides Remy From Chile

Simonsen, H. T., Riedel, C., Gade, L. B., Jebjerg, C. P., Guzman, A. & Molgaard, P., 2009, In : Journal of Essential Oil Research. 21, 4, p. 377-380 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Guaianolides in apiaceae: Perspectives on pharmacology and biosynthesis

Drew, D. P., Krichau, N., Reichwald, K. & Simonsen, H. T., 2009, In : Phytochemistry Reviews. 8, 3, p. 581-599 19 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Molecular Interactions between Barley and Oat β-Glucans and Phenolic Derivatives

Simonsen, H. T., Nielsen, M. S., Christensen, N. J., Christensen, U., La Cour, T. V., Motawia, M. S., Jespersen, B. P. A., Engelsen, S. B. & Møller, B. L., 2009, In : Journal of Agricultural and Food Chemistry. 57, 5, p. 2056-2064 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Perspectives on Using Physcomitrella Patens as an Alternative Production Platform for Thapsigargin and Other Terpenoid Drug Candidates

Simonsen, H. T., Drew, D. P. & Lunde, C., 2009, In : Perspectives in Medicinal Chemistry. 2009, 3, p. 1-6 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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47 Downloads (Pure)
2008

Sulfur starvation in rice: the effect on photosynthesis, carbohydrate metabolism, and oxidative stress protective pathways

Lunde, C., Zygadlo, A., Simonsen, H. T., Nielsen, P. L., Blennow, A. & Haldrup, A., 2008, In : Physiologia Plantarum. 134, 3, p. 508-521 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review