20012020

Research output per year

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Research Output

2020

Anthelmintic and metabolomic analyses of chicory (Cichorium intybus) identify an industrial by-product with potent in vitro antinematodal activity

Pena-Espinoza, M. A., Valente, A. H., Bornancin, L., Simonsen, H. T., Thamsborg, S. M., Williams, A. R. & López-Muñoz, R., 2020, In : Veterinary Parasitology. 280, 11 p., 109088.

Research output: Contribution to journalJournal articleResearchpeer-review

Biosynthesis and Industrial Production of Androsteroids

Batth, R., Nicolle, C., Cuciurean, I. S. & Simonsen, H. T., 2020, In : Plants. 9, 9, 11 p., 1144.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
8 Downloads (Pure)

Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent

Knudsen, C., Bavishi, K., Viborg, K. M., Drew, D. P., Simonsen, H. T., Motawia, M. S., Møller, B. L. & Laursen, T., 2020, In : Phytochemistry. 170, 9 p., 112214.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
124 Downloads (Pure)

Thapsigargins and induced chemical defence in Thapsia garganica

Martinez-Swatson, K., Quiñonero-López, C., Ernst, M., Rønsted, N., Barnes, C. J. & Simonsen, H. T., 2020, In : Chemoecology. 30, p. 255-267 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2019

Anti-protozoal activity of extracts from chicory (Cichorium intybus) against Cryptosporidium parvum in cell culture

Woolsey, I. D., Valente, A. H., Williams, A. R., Thamsborg, S. M., Simonsen, H. T. & Enemark, H. L., 2019, In : Scientific Reports. 9, 1, 9 p., 20414.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
55 Downloads (Pure)

Assessing specialized metabolite diversity in the cosmopolitan plant genus Euphorbia l.

Ernst, M., Nothias, L. F., van der Hooft, J. J. J., Silva, R. R., Saslis-Lagoudakis, C. H., Grace, O. M., Martinez-Swatson, K., Hassemer, G., Funez, L. A., Simonsen, H. T., Medema, M. H., Staerk, D., Nilsson, N., Lovato, P., Dorrestein, P. C. & Rønsted, N., 2019, In : Frontiers in Plant Science. 10, 15 p., 846.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
104 Downloads (Pure)

Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

Andersen, T. B., Rasmussen, S. A., Christensen, S. B. & Simonsen, H. T., 2019, In : Phytochemistry. 157, p. 168-174

Research output: Contribution to journalJournal articleResearchpeer-review

Exploring evolutionary theories of plant defence investment using field populations of the deadly carrot

Martinez-Swatson, K. A., Kjøller, R., Cozzi, F., Simonsen, H. T., Rønsted, N. & Barnes, C. J., 2019, In : Annals of Botany. 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

In planta and in silico characterization of five sesquiterpene synthases from Vitis vinifera (cv. Shiraz) berries

Dueholm, B., Drew, D. P., Sweetman, C. & Simonsen, H. T., 2019, In : Planta. 249, 1, p. 59-70 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
80 Downloads (Pure)

Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens

Ikram, N. K. K., Kashkooli, A. B., Peramuna, A. V., Krol, A. R. V. D., Bouwmeester, H. & Simonsen, H. T., 2019, In : Molecules. 24, 21, 13 p., 3822.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
78 Downloads (Pure)

Parasites and plants - bioactive compounds with anti-parasitic effect from Cichorium intybus

Valente, A. H., de Roode, B. M., Williams, A. R., Simonsen, H. T. & Thamsborg, S. M., 2019, In : Planta Medica. 85, 18, 1 p., 1420.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Production of terpenes and terpenoids

Simonsen, H. T. & Peramuna, A. V., 28 Mar 2019, IPC No. A01H 11/ 00 A N, Patent No. WO2019057258, 21 Sep 2018, Priority date 22 Sep 2017, Priority No. EP20170192650

Research output: Patent

Open Access
File
126 Downloads (Pure)

Valuable Fatty Acids in Bryophytes-Production, Biosynthesis, Analysis and Applications

Lu, Y., Eiriksson, F. F., Thorsteinsdóttir, M. & Simonsen, H. T., 2019, In : Nature Plants. 8, 11, 18 p., 524.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
File
57 Downloads (Pure)
2018

Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review

Pena-Espinoza, M., Valente, A. H., Thamsborg, S. M., Simonsen, H. T., Boas, U., Enemark, H. L., Lopez-Munoz, R. & Williams, A. R., 2018, In : Parasites & Vectors. 11, 14 p., 475.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
240 Downloads (Pure)

Effects of gamma irradiation and comparison of different extraction methods on sesquiterpene lactone yields from the medicinal plant Thapsia garganica L. (Apiaceae)

Mohamed Ibrahim, A. M., Martinez-Swatson, K. A., Benkaci-Ali, F., Cozzi, F., Zoulikha, F. & Simonsen, H. T., 2018, In : Journal of Applied Research on Medicinal and Aromatic Plants. 8, p. 26-32

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
94 Downloads (Pure)

Evaluation of synthetic promoters in Physcomitrella patens

Peramuna, A., Bae, H., Rasmussen, E. K., Dueholm, B., Waibel, T., Critchley, J. H., Brzezek, K., Roberts, M. & Simonsen, H. T., 2018, In : BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 500, 2, p. 418-422

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
131 Downloads (Pure)

Physcomitrella patens, a versatile synthetic biology chassis

Reski, R., Bae, H. & Simonsen, H. T., 2018, In : Plant Cell Reports. 37, 10, p. 1409-1417

Research output: Contribution to journalJournal articleResearchpeer-review

Use of a temporary immersion bioreactor system for the sustainable production of thapsigargin in shoot cultures of Thapsia garganica

López, C. Q., Corral, P., Lorrain-Lorrette, B., Martinez-Swatson, K., Michoux, F. & Simonsen, H. T., 2018, In : Plant Methods. 14, 1, 17 p., 79.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
206 Downloads (Pure)
2017

Anthelmintic effects of forage chicory (Cichorium intybus) against free-living and parasitic stages of Cooperia oncophora

Pena-Espinoza, M. A., Williams, A. R., Thamsborg, S. M., Simonsen, H. T. & Enemark, H. L., 2017, In : Veterinary Parasitology. 243, p. 204-207

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
240 Downloads (Pure)

A Review of Biotechnological Artemisinin Production in Plants

Ikram, N. K. B. K. & Simonsen, H. T., 2017, In : Frontiers in Plant Science. 8, 10 p., 1966.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
429 Downloads (Pure)

Fragrant plants used as air fresheners in private households

Simonsen, H. T., 2017, Book of Abstracts, Sustain 2017. Technical University of Denmark, 1 p. G-3

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
66 Downloads (Pure)

Localization and in-vivo characterization of thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis

Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, K., Andersen-Ranberg, J., Nyberg, N., Christensen, S. B. & Simonsen, H. T., 1 May 2017, In : Plant Physiology. 174, 1, p. 56-72 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
319 Downloads (Pure)

Stable production of the antimalarial drug artemisinin in the moss Physcomitrella patens

Binti Khairul Ikram, N. K., Kashkooli, A. B., Peramuna, A. V., van der Krol, A. R., Bouwmeester, H. & Simonsen, H. T., 2017, In : Frontiers in Bioengineering and Biotechnology. 5, 47, 20 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
350 Downloads (Pure)
2016

Anthelmintic activity of chicory (Cichorium intybus): in vitro effects on swine nematodes and relationship to sesquiterpene lactone composition

Williams, A., Pena-Espinoza, M. A., Boas, U., Simonsen, H. T., Enemark, H. & Thamsborg, S. M., 2016, In : Parasitology (Cambridge). 143, 6, p. 770-777

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

Bryophytes - an emerging source for herbal remedies and chemical production

Sabovljevic, M. S., Sabovljević, A. D., Ikram, N. K. K., Peramuna, A. V., Bae, H. & Simonsen, H. T., 2016, In : Plant Genetic Resources. 14, 4, p. 314-327 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

Domesticating deadly carrots: Predicting the biosynthetic pathway of thapsigargins for the treatment of solid tumors

Martinez, K., Simonsen, H. T., Rønsted, N., Bundgaard Andersen, T., Barnes, C., Boughton, B. & Cozzi, F., 2016, In : Planta Medica. 81, S 01, 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Evolutionary prediction of medicinal properties in the genus Euphorbia L.

Ernst, M., Saslis Lagoudakis, H., Grace, O. M., Nilsson, N., Simonsen, H. T., Horn, J. W. & Rønsted, N., 2016, In : Scientific Reports. 6, 30531 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
273 Downloads (Pure)

Evolution of NADPH-cytochrome P450 oxidoreductases (POR) in Apiales - POR 1 is missing

Andersen, T. B., Hansen, N. B., Laursen, T., Weitzel, C. & Simonsen, H. T., 2016, In : Molecular Phylogenetics and Evolution. 98, p. 21-28 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Increasing Oil Bodies in Physcomitrella patens by Overexpressing Oil Body- Associated Proteins

Bae, H., Peramuna, A. V. & Simonsen, H. T., 2016.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access

Insight into Biochemical Characterization of Plant Sesquiterpene Synthases

Manczak, T. & Simonsen, H. T., 2016, In : Analytical Chemistry Insights. 11, S1, 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
256 Downloads (Pure)

In vivo assembly of DNA-fragments in the moss, Physcomitrella patens

King, B. C., Vavitsas, K., Ikram, N. K. B. K., Schroder, J., Scharff, L. B., Hamberger, B., Jensen, P. E. & Simonsen, H. T., 2016, In : Scientific Reports. 6, 7 p., 25030.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
241 Downloads (Pure)

Meet the Moss - User Testing Our First Fragrance

Simonsen, H. T., 2016

Research output: Non-textual formSound/Visual production (digital)Research

Molecular phylogenetics as a predictive tool in plant-based drug discovery in the genus Euphorbia L.

Ernst, M., Saslis-Lagoudakis, C. H., Grace, O. M., Nilsson, N., Simonsen, H. T., Horn, J. W., Stærk, D. & Rønsted, N., 2016, In : Planta Medica. 82, S 01, 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Role of the Colletotrichum acutatum sesquiterpene synthase CaTPS in the biosynthesis of sesquiterpenoids

Amby, D. B., Manczak, T., Petersen, M. A., Sundelin, T., Weitzel, C., Grajewski, M., Simonsen, H. T. & Jensen, B., 2016, In : Microbiology. 162, p. 1773–1783

Research output: Contribution to journalJournal articleResearchpeer-review

The decision to germinate is regulated by divergent molecular networks in spores and seeds

Vesty, E. F., Saidi, Y., Moody, L. A., Holloway, D., Whitbread, A., Needs, S., Choudhary, A., Burns, B., Mcleod, D., Bradshaw, S. J., Bae, H., King, B. C., Bassel, G. W., Simonsen, H. T. & Coates, J. C., 2016, In : New Phytologist. 211, 3, p. 952-966 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
244 Downloads (Pure)

Two key polymorphisms in a newly discovered allele of the Vitis vinifera TPS24 gene are responsible for the production of the rotundone precursor α-guaiene

Drew, D. P., Andersen, T. B., Sweetman, C., Møller, B. L., Ford, C. & Simonsen, H. T., 2016, In : Journal of Experimental Botany. 67, 3, p. 799-808 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
93 Downloads (Pure)
2015

Additional diterpenes from Physcomitrella patens synthesized by copalyl diphosphate/kaurene synthase (PpCPS/KS)

Zhan, X., Bach, S. S., Hansen, N. L., Lunde, C. & Simonsen, H. T., 2015, In : Plant Physiology and Biochemistry. 96, p. 110-114 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cytochrome P450-enzymes involved in the biosynthesis of mono- and sesquiterpenes

Weitzel, C. & Simonsen, H. T., 2015, In : Phytochemistry Reviews. 14, 1, p. 7-24 18 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Evolution of substrate recognition sites (SRSs) in cytochromes P450 from Apiaceae exemplified by the CYP71AJ subfamily

Dueholm, B., Krieger, C., Drew, D., Olry, A., Kamo, T., Taboureau, O., Weitzel, C., Bourgaud, F., Hehn, A. & Simonsen, H. T., 2015, In : B M C Evolutionary Biology. 15, 122, 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
285 Downloads (Pure)

Global medicinal uses of Euphorbia L. (Euphorbiaceae)

Ernst, M., Grace, O. M., Saslis-Lagoudakis, C. H., Nilsson, N., Simonsen, H. T. & Rønsted, N., 2015, In : Journal of Ethnopharmacology. 176, p. 90-101 12 p.

Research output: Contribution to journalReviewResearchpeer-review

Optimization of Biochemical Screening Methods for Volatile and Unstable Sesquiterpenoids Using HS-SPME-GC-MS

Andersen, T., Cozzi, F. & Simonsen, H. T., 2015, In : Chromatography. 2, 2, p. 277-292 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
63 Downloads (Pure)

Sclareol production in the moss Physcomitrella patens and observations on growth and terpenoid biosynthesis

Pan, X-W., Han, L., Zhang, Y-H., Chen, D-F. & Simonsen, H. T., 2015, In : Plant Biotechnology Reports. 9, 3, p. 149-159 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Sesquiterpene lactone containing extracts from two cultivars of forage chicory (Cichorium intybus) show distinctive chemical profiles and in vitro activity against Ostertagia ostertagi

Pena-Espinoza, M. A., Boas, U., Williams, A., Thamsborg, S. M., Simonsen, H. T. & Enemark, H., 2015, In : International Journal for Parasitology: Drugs and Drug Resistance. 5, 3, p. 191-200

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
397 Downloads (Pure)

Stable heterologous expression of biologically active terpenoids in green plant cells

Ikram, N. K. B. K., Zhan, X., Pan, X-W., King, B. C. & Simonsen, H. T., 2015, In : Frontiers in Plant Science. 6, 10 p., 129.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
File
121 Downloads (Pure)

Thapsigargin-From Thapsia L. to Mipsagargin

Andersen, T. B., Lopez, C. Q., Manczak, T., Martinez, K. & Simonsen, H. T., 2015, In : Molecules. 20, 4, p. 6113-6127 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
141 Downloads (Pure)
2014

Heterologous Stable Expression of Terpenoid Biosynthetic Genes Using the Moss Physcomitrella patens: Plant Isoprenoids: Methods and Protocols

Bach, S. S., King, B. C., Zhan, X., Simonsen, H. T. & Hamberger, B., 2014, Plant Isoprenoids: Methods and Protocols. Rodríguez-Concepción, M. (ed.). Springer, Vol. 1153. p. 257-271 15 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

High-Throughput Testing of Terpenoid Biosynthesis Candidate Genes Using Transient Expression in Nicotiana benthamiana: Plant Isoprenoids: Methods and Protocols

Bach, S. S., Bassard, J. É., Andersen-Ranberg, J., Møldrup, M. E., Simonsen, H. T. & Hamberger, B., 2014, Plant Isoprenoids: Methods and Protocols. Rodríguez-Concepción, M. (ed.). Springer, Vol. 1153. p. 245-255 11 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Metabolic engineering of the moss Physcomitrella patens to produce the sesquiterpenoids patchoulol and α/β-santalene

Zhan, X., Zhang, Y-H., Chen, D-F. & Simonsen, H. T., 2014, In : Frontiers in Plant Science. 5, 10 p., 636.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
98 Downloads (Pure)

Resurrecting deadly carrots: towards a revision of Thapsia (Apiaceae) based on phylogenetic analysis of nrITS sequences and chemical profiles

Weitzel, C., Ronsted, N., Spalik, K. & Simonsen, H. T., 2014, In : Botanical Journal of the Linnean Society. 174, 4, p. 620-636 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2013

Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis

Simonsen, H. T., Weitzel, C. & Christensen, S. B., 2013, Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. Ramawat, K. G. & Mérillon, J-M. (eds.). Springer, Vol. XI. p. 3069-3098 30 p. (Journal of Natural Products).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review