Profile

CURRICULUM VITAE

Associate Professor Dr. Martin Dufva,

Personel Data           

Martin Dufva, Swedish citizen born Nov-11 1967, married 1994 and has three children, Granvænget 3, DK3100 Hornbæk tel +45 3012 8416, Working address work: Department of micro and Nanotechnology, Technical University of Denmark, DK2800 Kgs Lyngby. Tel +45 25 63 24, e-mail: [email protected]

Educations 

1994            Bachelor of Science in Biology at Göteborg University

1998             Master of Science in molecular biology at Göteborg University.

2001            Ph D (Med. Dr.) in Clinical chemistry and transfusion medicine, Göteborg University

Positions

1987-1990: Atlas Resors computer department.

1991-2001: Computer consultant for SIXU föreningsservice AB.

1995-2001: PhD students at clinical chemistry and transfusion medicine, Göteborg University

2001-2005: Assistant Prof, Department of Micro and Nano Technology, Danish Technical University (DTU)

2005-        :Associate Prof, Department of Micro and Nano Technology, (DTU)

2002-2006:Paternity leave for 25 whole weeks and 25 on part time during the period

Selected Management skills:

• Since 2005- leader of my research group at DTU Nanotech consisting of 3-8 people.
• Medarbejder udvikling samtaler (MUS) with employees.
• Principle leader of 8 PhD projects and nine master projects.

Supervisor for 26 PhD student project.20 Master students, 10 Bachelor projects

Research focus areas:

DNA and protein microarray technology: Function of biomolecules on surfaces, immobilisation of DNA and proteins to surfaces, genotyping, antibody assays, detection technologies and clinical performance of my invention gradient processing of DNA microarrays.

Cell culture on chip: design of large combinatory assay system for high throughput cell analysis, biocompatibility issues of perfusion and programming of cells by multiple fluidic streams

Microfluidics:design fluidics networks to solve limitation in molecular and cell based assays. Often I utilize arrays of fluidics streams in combination with biochemical arrays. I seek solution that can be utilized by end users and develop fluidics components to that end including good optimal quality of chips for time laps microscopy and interconnection and pumping for simplicity and robustness.

High throughput screening of biological: This is a novel acvitivity employing microfluidics droplet technology. Curretly the screening deals with antibody,  phage diplay and bacterial promoter libraries. 

Other information

Management skills:

• Coordinator of FP7 project Nadine (Since 2013).
• Managing the Fluidic Array System Technologies (FAST) group at DTU Nanotech consisting of about 8 people (since 2005).
• Manager for Danish research Concil project FTP 09-070568 (2010-2013)
• Scientific board member and activity platform responsible in the EU FP7 project EXCELL
• Co-coordinator of EU-FP7 project “Nanobio4Trans”.
• Member of the management group of the Labchip section (2005-2007) and BIOMICS section at DTU Nanotech (2007-1012).
• Member of executive board and research leader of ProCell (NABIIT project)
• Managing of biological agents (plasmid, cell lines, viruses, fungi, etc) according to Swedish  legislations at Göteborg University
• Managing laboratory safety of the molecular and cell culture laboratories at MIC-DTU
• Responsible for the work place descriptions (“APV”) in my group at DTU Nanotech
• Organizer of BIOMICS section team days (Mölle, Sweden May 2007 and Nyborg Strand, Denmark August 2008) and FAST group team days (Fredensborg 2005, 2006
• Organizer of the yearly Science day for DTU Nanotech (2009)

Personal development courses

• Leading research projects - six day course organized by DTU - 2009.
• 2013 DTU Teaching Seminar: Teaching and learning environment (1/2 day)
• 2012 DTU Teaching Seminar: Scholarship of Teaching & Learning” Good Teaching Practice in Engineering Education (1/2 day).

• 2003-2006. Danish Research Council appointed contact person for a Ph D. student (Anpan Han Neuchâtel, Switzerland). The work includes evaluating the progress of the Ph D project, which provides the basis for further founding from the Council.
• Reviewer for: European Research council, ERC (2013, 2015, 2016),  EU-Marie Curie (2016), Engineering and Physical Research Council (2009, UK), FP7 reviewer (2009), Swiss National Science foundation (2008), Cancer Research foundation UK (2005), The Agency for Science, Technology and Research’s (A*STAR) Biomedical Research Council (BMRC) in Singapore (2005). 
• 2008 External examiner of the PhD thesis  “Development of a real time array platform for nucleic acid detection using microfluidics ad microheaters” by Layne D Williams. Electrical and Computer Engineering Department, University of Utah, USA. 
• 2010. External examiner of Anders Carlsson PhD thesis “Molecular serum Portraits – a step towards personalized medicine”. Lund University, Sweden.
• 2012. External examiner of Marcel Reichen PhD project “Multiplexed microfabricated cell culture device for stem cell process development.”, University Collage London, Great Britain.
• 2015 External examiner of Anna Säll, Recombinant Antibodies - Tools for building proteomic platforms Lund University, Sweden
• 2016. Opponent of PhD thesis.Prem Kumar, Droplet microfluidics for single cell and nucleic acid analysis Royal Technical University, Stockholm. 

Research areas

Research profile

The major research line is to create in vivo like condition in vitro  and to monitor, in real time, intracellular events like the regulation of key genes. Currently, the technology is used  for stem cell research. The problems investigated are to control and increase the efficiency of stem cell differentiation (mostly adult stem cells like nerve stem cells and adipocyte stem cells) and migration to sites of injury (mesenchymal stem cells). The aim of the research is to find tools based to gain new biological knowledge. The approach is integrating many fields of technology, including micro and nanotechnology, automation, surface chemistry and molecular biology. A lesser part of the research interests is microarray technology and its applications in cell function, genetics, proteomics and implementation in point of care devices. In this research line, the interests are in mechanistic insight of biomolecule/surface interactions, assay development strategies and surface chemistries.