Folmer Fredslund

Search results

• 2022

  Family 1 Glycosyltransferase UGT706F8 from Zea mays Selectively Catalyzes the Synthesis of Silibinin 7-Ο-β-D-Glucoside

  Bidart, G. N., Putkaradze, N., Fredslund, F., Kjeldsen, C., Ruiz, A. G., Duus, J. Ø., Teze, D. & Welner, D. H., 2022, In: ACS Sustainable Chemistry and Engineering. 10, 16, p. 5078-5083 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glycosyltransferase 100%
  • Silibinin 100%
  • Glycosylation 75%
  • Glucoside 75%
  • Turnover Number 50%

• Oligomerization engineering of the fluorinase enzyme leads to an active trimer that supports synthesis of fluorometabolites in vitro

  Kittila, T-R., Calero Valdayo, P. M., Fredslund, F., Lowe, P. T., Tezé, D., Nieto Domínguez, M. J., O'Hagan, D., Nikel, P. I. & Welner, D. H., 2022, In: Microbial Biotechnology. 15, 5, p. 1622-1632 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Oligomerization 100%
  • Methionine 100%
  • Enzymes 100%
  • Dissociation 50%
  • Enzyme Activity 50%
  52 Downloads (Pure)

• Structure-guided engineering of key amino acids in UGT85B1 controlling substrate and stereo-specificity in aromatic cyanogenic glucoside biosynthesis

  Del Giudice, R., Putkaradze, N., dos Santos, B. M., Hansen, C. C., Crocoll, C., Motawia, M. S., Fredslund, F., Laursen, T. & Welner, D. H., 2022, In: Plant Journal. 111, 6, p. 1539-1549 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Glucoside 100%
  • Glycosyltransferase 83%
  • Uridine Diphosphate 66%
  • UDP 66%
  • Hydroxyl Group 33%
  9 Downloads (Pure)
• 2021

  Discovery of fungal oligosaccharide-oxidising flavo-enzymes with previously unknown substrates, redox-activity profiles and interplay with LPMOs

  Haddad Momeni, M., Fredslund, F., Bissaro, B., Raji, O., Vuong, T. V., Meier, S., Nielsen, T. S., Lombard, V., Guigliarelli, B., Biaso, F., Haon, M., Grisel, S., Henrissat, B. P., Welner, D. H., Master, E. R., Berrin, J-G. & Abou Hachem, M., 2021, In: Nature Communications. 12, 13 p., 2132.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Enzymes 100%
  • Polysaccharides 50%
  • Oligosaccharide 50%
  • Fungi 25%
  • Feedstock 25%
  132 Downloads (Pure)

• Natural product C-glycosyltransferases - a scarcely characterised enzymatic activity with biotechnological potential

  Putkaradze, N., Tezé, D., Fredslund, F. & Welner, D. H., 2021, In: Natural Product Reports. 38, p. 432-443

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Glycosyltransferase 100%
  • Glycosidic Bond 100%
  • Aromatic Structure 50%
  • Carbon Atom 50%
  • Enzyme Activity 50%
  152 Downloads (Pure)

• O-/N-/S-specificity in glycosyltransferase catalysis: From mechanistic understanding to engineering

  Tezé, D., Coines, J., Fredslund, F., Dubey, K. D., Bidart, G. N., Adams, P. D., Dueber, J. E., Svensson, B., Rovira, C. & Welner, D. H., 2021, In: ACS Catalysis. 11, 3, p. 1810-1815

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File

  • Specificity 100%
  • Glycosidic Bond 100%
  • Active Site 49%
  • Acceptor 49%
  • Acceptor Substrate 49%
  64 Downloads (Pure)
• 2020

  The catalytic acid-base in GH109 resides in a conserved GGHGG loop and allows for comparable α-retaining and β-inverting activity in an N-acetylgalactosaminidase from Akkermansia muciniphila

  Teze, D., Shuoker, B., Chaberski, E. K., Kunstmann, S., Fredslund, F., Nielsen, T. S., Stender, E. G. P., Peters, G. H. J., Nordberg Karlsson, E., Welner, D. H. & Abou Hachem, M., 2020, In: A C S Catalysis. 10, p. 3809-3819 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Polysaccharides 100%
  • Enzymes 100%
  • Broad Range 50%
  • Specificity 50%
  • Bioinformatics 50%
  458 Downloads (Pure)
• 2019

  A carbohydrate-binding family 48 module enables feruloyl esterase action on polymeric arabinoxylan

  Holck, J., Fredslund, F., Møller, M. S., Brask, J., Krogh, K. B. R. M., Lange, L., Welner, D. H., Svensson, B., Meyer, A. S. & Wilkens, C., 2019, In: Journal of Biological Chemistry. 294, 46, p. 17339-17353 16 p., jbc.RA119.009523.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Carbohydrates 100%
  • Arabinoxylan 100%
  • Esterase 100%
  • Carbohydrate 100%
  • Feruloyl Esterase 30%
  323 Downloads (Pure)

• Molecular characteristics of plant UDP-arabinopyranose mutases

  Saqib, A., Scheller, H. V., Fredslund, F. & Welner, D. H., 2019, In: Glycobiology. 29, 12, p. 839-846

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Protein 100%
  • Enzymes 60%
  • Cell Wall 60%
  • Arabinose 50%
  • Biosynthesis 50%
  48 Downloads (Pure)

• Structural and functional aspects of mannuronic acid-specific PL6 alginate lyase from the human gut microbe Bacteroides cellulosilyticus

  Stender, E. G. P., Andersen, C. D., Fredslund, F., Holck, J., Solberg, A., Teze, D., Peters, G. H. J., Christensen, B. E., Aachmann, F. L., Welner, D. H. & Svensson, B., 2019, In: Journal of Biological Chemistry. 294, 47, p. 17915-17930 17 p., jbc.RA119.010206.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Alginic Acid 100%
  • Alginate 100%
  • Enzymes 57%
  • Bacteria 28%
  • Bacteroides 28%
  278 Downloads (Pure)
• 2014

  A β1-6/β1-3 galactosidase from B ifidobacterium animalis subsp. lactis Bl-04 gives insight into sub-specificities of β-galactoside catabolism within B ifidobacterium

  Viborg, A. H., Fredslund, F., Katayama, T., Nielsen, S. K., Svensson, B., Kitaoka, M., Leggio, L. L. & Abou Hachem, M., 2014, In: Molecular Microbiology. 94, 5, p. 1024–1040 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Galactoside 100%
  • Glycosidase 50%
  • Glycoside Hydrolase 50%
  • Glycoside 50%
  • Enzymes 33%
• 2013

  A snapshot into the metabolism of isomalto-oligosaccharides in probiotic bacteria

  Abou Hachem, M., Møller, M. S., Andersen, J. M., Fredslund, F., Majumder, A., Nakai, H., Leggio, L. L., Goh, Y-J., Barrangou, R., Klaenhammer, T. R. & Svensson, B., 2013, In: Journal of Applied Glycoscience. 60, 2, p. 95-100

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Oligosaccharide 100%
  • Lactobacillus 50%
  • Glucosidases 40%
  • Probiotics 30%
  • Bifidobacterium 30%

• Recent insight into oligosaccharide uptake and metabolism in probiotic bacteria

  Abou Hachem, M., Andersen, J. M., Barrangou, R., Møller, M. S., Fredslund, F., Majumder, A., Hansen, M. E., Lahtinen, S. J., Jacobsen, S., Lo Leggio, L., Goh, Y. J., Klaenhammer, T. R. & Svensson, B., 2013, In: Biocatalysis and Biotransformation. 31, 4, p. 226-235

  Research output: Contribution to journal › Conference article › Research › peer-review

  • Oligosaccharide 100%
  • Prebiotics 100%
  • Probiotic Bacteria 100%
  • Probiotics 75%
  • Metabolism 50%

• Structural basis for arabinoxylo‐oligosaccharide capture by the probiotic Bifidobacterium animalis subsp. lactis Bl‐04

  Hansen, M. E., Fredslund, F., Vujicic‐Zagar, A., Svensson, B., Slotboom, D. J. & Abou Hachem, M., 2013, In: Molecular Microbiology. 90, 5, p. 1100-1112

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Probiotics 100%
  • Bifidobacterium 100%
  • Oligosaccharide 66%
  • Bifidobacterium animalis 66%
  • Proteins 33%
• 2012

  Enzymology and Structure of the GH13_31 Glucan 1,6-α-Glucosidase That Confers Isomaltooligosaccharide Utilization in the Probiotic Lactobacillus acidophilus NCFM

  Møller, M. S., Fredslund, F., Majumder, A., Nakai, H., Poulsen, J-C. N., Lo Leggio, L., Svensson, B. & Abou Hachem, M., 2012, In: Journal of Bacteriology. 194, 16, p. 4249-4259

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glycosidase 100%
  • Isomaltooligosaccharide 100%
  • Dextran 80%
  • Glucosidase 60%
  • ABC Transporter 40%

• Raffinose family oligosaccharide utilisation by probiotic bacteria: insight into substrate recognition, molecular architecture and diversity of GH36 alpha-galactosidases

  Abou Hachem, M., Fredslund, F., Andersen, J. M., Larsen, R. J., Majumder, A., Hansen, M. E., van Zanten, G. C., Lahtinen, S. J., Barrangou, R., Klaenhammer, T., Jacobsen, S., Coutinho, P. M., Lo Leggio, L. & Svensson, B., 2012, In: Biocatalysis and Biotransformation. 30, 3, p. 316-325

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glycosidase 100%
  • Raffinose 100%
  • Glycoside Hydrolase 100%
  • Glycoside 100%
  • Raffinose Family Oligosaccharide 87%
• 2011

  Crystal Structure of α-Galactosidase from Lactobacillus acidophilus NCFM: Insight into Tetramer Formation and Substrate Binding

  Fredslund, F., Abou Hachem, M., Larsen, R. J., Sørensen, P. G., Coutinho, P. M., Lo Leggio, L. & Svensson, B., 2011, In: Journal of Molecular Biology. 412, 3, p. 466-480

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Probiotics 100%
  • Galactosidases 100%
  • Lactobacillus acidophilus 100%
  • Galactose 100%
  • Monomer 100%
• 2010

  Structure of α-galactosidase from Lactobacillus acidophilus NCFM: insight into tetramer formation and substrate binding

  Fredslund, F., Abou Hachem, M., Larsen, R. J., Sørensen, P. G., lo Leggio, L. & Svensson, B., 2010.

  Research output: Contribution to conference › Conference abstract for conference › Research

• The GH36 α-galactosidases from Lactobacillus acidophilus NCFM is substrate inhibited and reveals the involvement of an active site cysteine in substrate binding

  Abou Hachem, M., Larsen, J. J., Sørensen, P. G., Fredslund, F., Leggio, L. L. & Svensson, B., 2010.

  Research output: Contribution to conference › Conference abstract for conference › Research

• The structure of a GH13_31 α-glucosidase from the probiotic bacterium Lactobacillus acidophilus NCFM

  Svensson, B., Fredslund, F., Møller, M. S., Leggio, L. L. & Abou Hachem, M., 2010.

  Research output: Contribution to conference › Conference abstract for conference › Research
• 2008

  Den ¤rumlige opbygning af proteiner fra immunforsvaret

  Fredslund, F., Stub Laursen, N., Sottrup-Jensen, L. & Rom Andersen, G., 2008, In: Dansk Kemi.

  Research output: Contribution to journal › Journal article › Research

  • Proteins 100%

• Erratum: Structure of and influence of a tick complement inhibitor on human complement component 5

  Fredslund, F., Laursen, N. S., Roversi, P., Jenner, L., Oliveira, C. L. P., Pedersen, J. S., Nunn, M. A., Lea, S. M., Discipio, R., Søttrup-Jensen, L. & Andersen, G. R., 2008, In: Nature Immunology. 9, 8, p. 945

  Research output: Contribution to journal › Journal article › Research › peer-review

• Structure of and influence of a tick complement inhibitor on human complement component 5.

  Fredslund, F., Laursen, N. S., Roversi, P., Jenner, L., Oliveira, C. L. P., Pedersen, J. S., Nunn, M. A., Lea, S. M., Discipio, R., Sottrup-Jensen, L. & Andersen, G. R., 2008, In: Nature Immunology. 9, 7, p. 753-760

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Real Estate Sector 100%
  • Stabilization 100%
  • Inhibitor 50%
  • Cleavage 33%
  • Crystal Structure 16%