Publications per year
Publications per year
Kemitorvet, 220, 504F
2800 Kgs. Lyngby
Denmark
Enzyme Engineering and Structural Biology
We develop enzyme biocatalysts for the industrial production of natural products used as e.g. aromas, fragrances, dyes, and pharmaceuticals. The existing industrial pipelines have large environmental footprints due to their use of petroleum-derived, hazardous materials and their generation of toxic waste streams. Therefore, replacing the current chemical synthesis routes with bio-based processes including cell factories and chemo-enzymatic approaches will constitute a significant step towards a greener society.
In nature, many natural products are glycosylated by an enzyme class termed secondary metabolism glycosyltransferases (GTs). Glycosylation alters the physico-chemical properties of the natural product, including solubility, stability and bioavailability. We aim at harnessing this glycosylation activity for industrial purposes by tailoring secondary metabolism GTs for specific pipelines. Thus, we are engaged in a systematic study of secondary metabolism GT structural and functional determinants, to provide the framework for efficient secondary metabolism GT discovery and engineering.
We combine high-throughput enzyme discovery and evolution with structure-based rational engineering to elucidate the structural determinants of key enzymatic properties such as
Our core methods are X-ray crystallography, enzymology, and other classical protein chemistry techniques for biophysical characterization.
Biochemistry, University of Copenhagen
2000 → 2011
Research output: Contribution to journal › Comment/debate › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Comment/debate › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Della Gala, V. & Welner, D. H.
01/03/2022 → 28/02/2025
Project: PhD
de Boer, R. M., Welner, D. H. & Sukumara, S.
01/03/2022 → 28/02/2025
Project: PhD
Cros, A. T. R., Nikel, P. I. & Welner, D. H.
01/06/2019 → 31/08/2022
Project: PhD
Tumas, S., Sommer, M. O. A., Hadrup, S. R., Welner, D. H., Straten, P. T. & Lambin, P.
01/08/2018 → 30/11/2021
Project: PhD
Ditte Hededam Welner (Organizer)
Activity: Attending an event › Participating in or organising a conference
Ditte Hededam Welner (Guest lecturer)
Activity: Talks and presentations › Conference presentations
Ditte Hededam Welner (Reviewer)
Activity: Editorial work and peer review › Peer review of manuscripts › Research
Ditte Hededam Welner (Reviewer)
Activity: Editorial work and peer review › Peer review of manuscripts › Research
Ditte Hededam Welner (Reviewer)
Activity: Editorial work and peer review › Peer review of manuscripts › Research