Charlotte Held Gotfredsen

2024

Alligamycin A, an antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

Yang, Z., Qiao, Y., Strøbech, E., Morth, J. P., Walther, G., Jørgensen, T. S., Lum, K. Y., Peschel, G., Rosenbaum, M. A., Previtali, V., Clausen, M. H., Lukassen, M. V., Gotfredsen, C. H., Kurzai, O., Weber, T. & Ding, L., 2024, In: Nature Communications. 15, 12 p., 9259.

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Designing optimal experiments in metabolomics

Sørensen, M. B., Møller, J. K., Strube, M. L. & Gotfredsen, C. H., 2024, In: Metabolomics. 20, 4, 13 p., 69.

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Enzymatic synthesis of mono- and trifluorinated alanine enantiomers expands the scope of fluorine biocatalysis

Nieto-Domínguez, M., Sako, A., Enemark-Rasmussen, K., Gotfredsen, C. H., Rago, D. & Nikel, P. I., 2024, In: Communications Chemistry. 7, 1, 104.

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Genome-Driven Discovery of Hygrocins in Streptomyces rapamycinicus

Mahmoud Mohamed, M. M., Yang, Z., Lum, K. Y., Peschel, G., Rosenbaum, M. A., Weber, T., Coriani, S., Gotfredsen, C. H. & Ding, L., 2024, In: Journal of Natural Products. 87, 5, p. 1321-1329 9 p.

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Maramycin, a Cytotoxic Isoquinolinequinone Terpenoid Produced through Heterologous Expression of a Bifunctional Indole Prenyltransferase/Tryptophan Indole-Lyase in S. albidoflavus

Maleckis, M., Wibowo, M., Williams, S. E., Gotfredsen, C. H., Sigrist, R., Souza, L. D. O., Cowled, M. S., Charusanti, P., Gren, T., Saha, S., Moreira, J. M. A., Weber, T. & Ding, L., 2024, In: ACS chemical biology. 19, 6, p. 1303–1310

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NMR-Onion - a transparent multi-model based 1D NMR deconvolution algorithm

Brinks Sørensen, M., Riis Andersen, M., Siewertsen, M. M., Bro, R., Strube, M. L. & Gotfredsen, C. H., 2024, In: Heliyon. 10, 17, 19 p., e36998.

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Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2

Mohamed, M. M. M., Abboud, M. M., Maleckis, M., Souza, L. D. O., Moreira, J. M. A., Gotfredsen, C. H., Weber, T. & Ding, L., 2024, In: Journal of Natural Products. 87, 4, p. 1075-1083 9 p.

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Serum metabolic signatures for Alzheimer's Disease reveal alterations in amino acid composition: a validation study

Nielsen, J. E., Andreassen, T., Gotfredsen, C. H., Olsen, D. A., Vestergaard, K., Madsen, J. S., Kristensen, S. R. & Pedersen, S., 2024, In: Metabolomics. 20, 1, 11 p., 12.

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2023

Small-molecule modulators of tumor necrosis factor signaling

Chédotal, H., Narayanan, D., Povlsen, K., Gotfredsen, C. H., Brambilla, R., Gajhede, M., Bach, A. & Clausen, M. H., 2023, In: Drug Discovery Today. 28, 6, 9 p., 103575.

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Sulochrins and alkaloids from a fennel endophyte Aspergillus sp. FVL2

Shaaban, M., Abdel-Razek, A. S., Previtali, V., Clausen, M. H., Gotfredsen, C. H., Laatsch, H. & Ding, L., 2023, In: Natural Product Research. 37, 8, p. 1310-1320 11 p.

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2022

Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening

Lee, S.-W., Tran, K. T., Vazquez-Uribe, R., Gotfredsen, C. H., Clausen, M. H., Mendez, B. L., Montoya, G., Bach, A. & Sommer, M. O. A., 2022, In: Journal of Medicinal Chemistry. 65, 4, p. 3266–3305 40 p.

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Identification of the Biosynthetic Gene Cluster for Pyracrimycin A, an Antibiotic Produced by Streptomyces sp.

Nielsen, J. B., Gren, T., Mohite, O. S., Jørgensen, T. S., Klitgaard, A. K., Mourched, A.-S., Blin, K., Oves-Costales, D., Genilloud, O., Larsen, T. O., Tanner, D., Weber, T., Gotfredsen, C. H. & Charusanti, P., 2022, In: ACS chemical biology. 17, 9, p. 2411-2417 7 p.

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Small RNA stabilization via non-covalent binding with a metalloporphyrin nanocage to accomplish synergistic gene and photodynamic therapy

Jin, W., Xin, L., Veiga, G. C., Ray, R. M., Hong Lin, M. K. T., Andresen, T. L., Gotfredsen, C. H., Nielsen, M., Astakhova, K. & Qvortrup, K., 2022, In: Cell Reports Physical Science. 3, 12, 14 p., 101187.

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Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity

Andersen, F. D., Pedersen, K. D., Juhl, D. W., Mygind, T., Chopin, P., B. Svenningsen, E., Poulsen, T. B., Braad Lund, M., Schramm, A., Gotfredsen, C. H. & Tørring, T., 2022, In: Journal of Natural Products. 85, 6, p. 1514-1521 8 p.

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2021

Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics

Nielsen, J. E., Maltesen, R. G., Havelund, J. F., Færgeman, N. J., Gotfredsen, C. H., Vestergård, K., Kristensen, S. R. & Pedersen, S., 2021, In: Metabolism Open. 12, 9 p., 100125.

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Collagenase and Tyrosinase Inhibitory Effect of Isolated Constituents from the Moss Polytrichum formosum

Marques, R. V., Guillaumin, A., Abdelwahab, A. B., Salwinski, A., Gotfredsen, C. H., Bourgaud, F., Enemark-Rasmussen, K., Miguel, S. & Simonsen, H. T., 2021, In: Plants. 10, 7, 13 p., 1271.

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Fragment-based drug discovery for RNA targets

Lundquist, K. P., Panchal, V., Gotfredsen, C. H., Brenk, R. & Clausen, M. H., 2021, In: ChemMedChem. 16, 17, p. 2588-2603 16 p.

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Genetic origin of homopyrones, a rare type of hybrid phenylpropanoid- and polyketide-derived yellow pigments from Aspergillus homomorphus

Futyma, M. E., Guo, Y., Hoeck, C., Hoof, J. B., Gotfredsen, C. H., Mortensen, U. H. & Larsen, T. O., 2021, In: Applied Microbiology and Biotechnology. 105, p. 5113-5121 9 p.

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Mass Spectrometry guided discovery and design of novel Asperphenamate analogues from Penicilium astrolabium reveals an extraordinary NRPS flexibility

Subko, K., Wang, X., Nielsen, F. H., Petersen, T. I., Gotfredsen, C. H., Ramos, C., Mackenzie, T., Vicente, F., Genilloud, O., Frisvad, J. C. & Larsen, T. O., 2021, In: Frontiers in Microbiology. 11, 13 p., 618730.

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Taxonomy Driven Discovery of Polyketides from Aspergillus californicus

Guo, Y., Ding, L., Ghidinelli, S., Gotfredsen, C. H., de la Cruz, M., Mackenzie, T. A., Ramos, M. C., Sánchez, P., Vicente, F., Genilloud, O., Coriani, S., Larsen, R. W., Frisvad, J. C. & Larsen, T. O., 2021, In: Journal of Natural Products. 84, 4, p. 979-985 7 p.

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2020

A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida

Calero, P., Volke, D. C., Lowe, P. T., Gotfredsen, C. H., O'Hagan, D. & Nikel, P. I., 2020, In: Nature Communications. 11, 1, 11 p., 5045.

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Azodyrecins A-C: Azoxides from a Soil-Derived Streptomyces Species

Wibowo, M., Gotfredsen, C. H., Sassetti, E., Melchiorsen, J., Clausen, M. H., Gram, L. & Ding, L., 2020, In: Journal of Natural Products. 83, 12, p. 3519-3525 7 p.

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Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery

Solbak, S. M. Ø., Zang, J., Narayanan, D., Høj, L. J., Bucciarelli, S., Softley, C., Meier, S., Langkilde, A. E., Gotfredsen, C. H., Sattler, M. & Bach, A., 2020, In: Journal of Medicinal Chemistry. 63, 3, p. 1156-1177

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Frontispiece: The 3F Library: Fluorinated Fsp3‐Rich Fragments for Expeditious ¹⁹F NMR Based Screening

Troelsen, N. S., Shanina, E., Gonzalez‐Romero, D., Danková, D., Jensen, I. S. A., Śniady, K. J., Nami, F., Zhang, H., Rademacher, C., Cuenda, A., Gotfredsen, C. H. & Clausen, M. H., 2020, In: Angewandte Chemie International Edition. 59, 6, p. 2204-2204

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Frontispiz: The 3F Library: Fluorinated Fsp³ ‐Rich Fragments for Expeditious ¹⁹F NMR Based Screening

Troelsen, N. S., Shanina, E., Gonzalez‐Romero, D., Danková, D., Jensen, I. S. A., Śniady, K. J., Nami, F., Zhang, H., Rademacher, C., Cuenda, A., Gotfredsen, C. H. & Clausen, M. H., 2020, In: Chemistry - A European Journal. 132, 6, p. 2224-2224

Research output: Contribution to journal › Journal article › Communication

Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast

Jakočiūnas, T., Klitgaard, A. K., Kontou, E. E., Nielsen, J. B., Thomsen, E., Romero Suarez, D., Blin, K., Petzold, C. J., Gin, J. W., Tong, Y., Gotfredsen, C. H., Charusanti, P., Frandsen, R. J. N., Weber, T., Lee, S. Y., Jensen, M. K. & Keasling, J. D., 2020, In: Synthetic and Systems Biotechnology. 5, 1, p. 11-18 8 p.

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The 3F Library: Fluorinated Fsp3-rich Fragments for Expeditious 19F-NMR-based Screening

Troelsen, N. S., Shanina, E., Gonzalez-Romero, D., Dankova, D., Jensen, I. S. A., Sniady, K. J., Nami, F., Zhang, H., Rademacher, C., Cuenda, A., Gotfredsen, C. H. & Clausen, M. H., 2020, In: Angewandte Chemie. 131, 6, p. 2224-2230

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The 3F Library: Fluorinated Fsp3-rich Fragments for Expeditious 19F-NMR-based Screening

Troelsen, N. S., Shanina, E., Gonzalez-Romero, D., Dankova, D., Jensen, I. S. A., Sniady, K. J., Nami, F., Zhang, H., Rademacher, C., Cuenda, A., Gotfredsen, C. H. & Clausen, M. H., 2020, In: Angewandte Chemie International Edition. 59, 6, p. 2204-2210

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2019

Iridoid glucosides in the genus Sutera (Scrophulariaceae) as chemotaxonomic markers in tribe Limoselleae

Gousiadou, C., Kokubun, T., Albach, D. C., Gotfredsen, C. H. & Jensen, S. R., 2019, In: Phytochemistry. 158, p. 149-155 7 p.

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Isolation of Methyl Troposulfenin from Phaeobacter inhibens

Phippen, C. B. W., Jørgensen, C. M., Bentzon-Tilia, M., Gotfredsen, C. H., Larsen, T. O., Gram, L. & Sonnenschein, E. C., 2019, In: Journal of Natural Products. 82, 5, p. 1387-1390 4 p.

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2018

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On the biosynthetic origin of carminic acid

Rasmussen, S. A., Kongstad, K. T., Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F., Gotfredsen, C. H., Stærk, D., Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In: Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

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Synthesis of branched and linear 1,4-linked galactan oligosaccharides

Andersen, M. C. F., Boos, I., Kinnaert, C., Awan, S. I., Pedersen, H. L., Kracun, S. K., Lanz, G., Rydahl, M. G., Kjærulff, L., Håkansson, M., Kimbung, R., Logan, D., Gotfredsen, C. H., Willats, W. G. T. & Clausen, M. H. H., 2018, In: Organic and Biomolecular Chemistry. 16, 7, p. 1157-1162

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Synthesis of Two Tetrasaccharide Pentenyl Glycosides Related to the Pectic Rhamnogalacturonan I Polysaccharide

Zakharova , A. N., Awan, S. I., Nami, F., Gotfredsen, C. H., Madsen, R. & Clausen, M. H., 2018, In: Molecules. 23, 2, 14 p., 327.

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2017

A Dereplication and Bioguided Discovery Approach to Reveal New Compounds from a Marine-Derived Fungus Stilbella fimetaria

Kildgaard, S., Subko, K., Phillips, E., Goidts, V., de la Cruz, M., Díaz, C., Gotfredsen, C. H., Andersen, B., Frisvad, J. C., Nielsen, K. F. & Larsen, T. O., 2017, In: Marine Drugs. 15, 8, 253.

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Iridoid glucosides in the genus Veronica (Plantaginaceae) from New Zealand

Kroll-Møller, P., Pedersen, K. D., Gousiadou, C., Kokubun, T., Albach, D., Taskova, R., Garnock-Jones, P. J., Gotfredsen, C. H. & Jensen, S. R., 2017, In: Phytochemistry. 140, p. 174-180

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S³ HMBC hetero: Spin-State-Selective HMBC for accurate measurement of long-range heteronuclear coupling constants

Hoeck, C., Gotfredsen, C. H. & Sørensen, O. W., 2017, In: Journal of Magnetic Resonance. 275, p. 68-72 5 p.

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Structure–Activity Relationship Study Based on Autoinducing Peptide (AIP) from Dog Pathogen S. schleiferi

Gless, B. H., Peng, P., Pedersen, K. D., Gotfredsen, C. H., Ingmer, H. & Olsen, C. A., 2017, In: Organic Letters. 19, 19, p. 5276-5279

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2016

Black perithecial pigmentation in Fusarium species is due to the accumulation of 5-deoxybostrycoidin-based melanin

Frandsen, R. J. N., Rasmussen, S. A., Knudsen, P. B., Uhlig, S., Petersen, D., Lysøe, E., Gotfredsen, C. H., Giese, H. & Larsen, T. O., 2016, In: Scientific Reports. 6, 13 p., 26206.

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Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent Site

Einarsdottir, E., Liu, H. B., Freysdottir, J., Gotfredsen, C. H. & Omarsdottir, S., 2016, In: Planta Medica. 82, 9-10, p. 903-909 7 p.

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Influence of Niche-Specific Nutrients on Secondary Metabolism in Vibrionaceae

Giubergia, S., Phippen, C., Gotfredsen, C. H., Nielsen, K. F. & Gram, L., 2016, In: Applied and Environmental Microbiology. 82, 13, p. 4035-4044 10 p.

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Iridoids in Hydrangeaceae

Gousiadou, C., Li, H.-Q., Gotfredsen, C. H. & Jensen, S. R., 2016, In: Biochemical Systematics and Ecology. 64, p. 122-130 9 p.

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Novel α-L-Fucosidases from a Soil Metagenome for Production of Fucosylated Human Milk Oligosaccharides

Lezyk, M. J., Jers, C., Kjaerulff, L., Gotfredsen, C. H., Mikkelsen, M. D. & Mikkelsen, J. D., 2016, In: P L o S One. 11, 1, 18 p., e0147438.

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S³ HMBC: Spin-State-Selective HMBC for accurate measurement of homonuclear coupling constants. Application to strychnine yielding thirteen hitherto unreported JHH

Kjaerulff, L., Benie, A. J., Hoeck, C., Gotfredsen, C. H. & Sørensen, O. W., 2016, In: Journal of Magnetic Resonance. 263, p. 101-107 7 p.

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Specific Electrostatic Molecular Recognition in Water

Li, M., Hoeck, C., Schoffelen, S., Gotfredsen, C. H. & Meldal, M., 2016, In: Chemistry - A European Journal. 22, 21, p. 7206-7214 10 p.

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2015

Charlotte Held Gotfredsen

Research output

Search results