20112023

Research output per year

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Research Output

  • 33 Journal article
  • 4 Conference abstract for conference
  • 3 Conference abstract in journal
  • 2 Poster
2019

A tumorsphere model of glioblastoma multiforme with intratumoral heterogeneity for quantitative analysis of cellular migration and drug response

Gudbergsson, J. M., Kostrikov, S., Johnsen, K. B., Fliedner, F. P., Stolberg, C. B., Humle, N., Hansen, A. E., Kristensen, B. W., Christiansen, G., Kjær, A., Andresen, T. L. & Duroux, M., 2019, In : Experimental Cell Research. 379, 1, p. 73-82

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

Characterization of the tumor microenvironment of key suppressive myeloid populations in 11 commonly used preclinical syngeneic cancer models

Ringgaard, L., Christensen, E., Kristensen, L. K., Stavnsbjerg, C., Kjær, A., Hansen, A. E. & Andresen, T. L., 2019, In : Cancer Research. 79, 13, 1528.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Flexible 64Cu-nanoparticle-based cell labeling system allows for in vivo tracking of adoptively transferred T-cells by PET/CT

Halldórsdóttir, H. R., Ringgaard, L., Bak, M., Jæhger, D., Christensen, E., Melander, F., Hübbe, M. L., Eliasen, R., Fliedner, F. P., Kjaer, A., Hansen, A. E., Henriksen, J. & Andresen, T. L., 2019. 2 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Immunogel - an intratumoral multi-drug sustained release technology that polarizes the tumor microenvironment towards a proinflammatory and immunosupportive state

Engel, T., Jørgensen, J. S., Ringgaard, L., Melander, F., Jensen, S., Bruun, L. M., Stavnsbjerg, C., Jensen, A. T., Thuroczy, J., Balogh, L., Fliedner, F., Bak, M., Kjær, A., Henriksen, J., Hansen, A. & Andresen, T. L., 2019, In : Journal for ImmunoTherapy of Cancer. 7, Suppl. 1, P519.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Potent anti-tumor effect of systemically administered nanoparticles containing a TLR7 agonist in combination with radiotherapy

Stavnsbjerg, C., Christensen, E., Münter, R. D., Kjær, A., Panina, S., Bak, M., Henriksen, J. R., Jensen, S., Hansen, A. & Andresen, T., 2019, In : Journal for ImmunoTherapy of Cancer. 7, Suppl 1:283, p. 9-10

Research output: Contribution to journalConference abstract in journalResearchpeer-review

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

EArly Genetics Lifecourse Epidemiology (EAGLE) consortium , Early Growth Genetics (EGG) consortium, McCarthy, M. I. & Hansen, A. E., 2019, In : European Journal of Epidemiology. 34, 3, p. 279-300

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
5 Downloads (Pure)

Tumor associated antigen uptake tracking following immunoradiotherapy

Christensen, E., Ringgaard, L., Brus, A., Kjær, A., Hansen, A. E. & Andresen, T. L., 2019, In : Cancer Research. 79, 13, 1505.

Research output: Contribution to journalJournal articleResearchpeer-review

2018

Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts

Christensen, E., Henriksen, J. R., Jørgensen, J. T., Amitay, Y., Schmeeda, H., Gabizon, A. A., Kjær, A., Andresen, T. L. & Hansen, A. E., 2018, In : International Journal of Nanomedicine. 13, p. 7647-7656

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
233 Downloads (Pure)

Injectable iodine-125 labeled tissue marker for radioactive localization of non-palpable breast lesions

Schaarup-Jensen, H., Jensen, A. I., Hansen, A. E., El Ali, H. H., Hammershøj, P., Jølck, R. I., Kjær, A., Andresen, T. L. & Clausen, M. H., 2018, In : Acta Biomaterialia. 65, p. 197-202

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
52 Downloads (Pure)

Liposome accumulation in irradiated tumors display important tumor and dose dependent differences

Hansen, A. E., Fliedner, F. P., Henriksen, J. R., Jørgensen, J. T., Clemmensen, A. E., Børresen, B., Elema, D. R., Kjær, A. & Andresen, T. L., 2018, In : Nanomedicine: Nanotechnology, Biology and Medicine. 14, p. 27–34

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
263 Downloads (Pure)

Remote loading of liposomes with a 124I-radioiodinated compound and their in vivo evaluation by PET/CT in a murine tumor model

Engudar, G., Schaarup-Jensen, H., Fliedner, F. P., Hansen, A. E., Kempen, P., Jølck, R. I., Kjær, A., Andresen, T. L., Clausen, M. H., Jensen, A. T. I. & Henriksen, J. R., 2018, In : Theranostics. 8, 21, p. 5828-5841 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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438 Downloads (Pure)

Remote-loading of liposomes with manganese-52 and in vivo evaluation of the stabilities of 52Mn-DOTA and 64Cu-DOTA using radiolabelled liposomes and PET imaging

Jensen, A. I., Severin, G. W., Hansen, A. E., Fliedner, F. P., Eliasen, R., Parhamifar, L., Kjær, A., Andresen, T. L. & Henriksen, J. R., 2018, In : Journal of Controlled Release. 269, p. 100-109

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
216 Downloads (Pure)

Synthesis and Evaluation of Hydrogen Peroxide Sensitive Prodrugs of Methotrexate and Aminopterin for the Treatment of Rheumatoid Arthritis

Peiró Cadahía, J., Bondebjerg, J., Hansen, C. A., Previtali, V., Hansen, A. E., Andresen, T. L. & Clausen, M. H., 2018, In : Journal of Medicinal Chemistry. 61, 8, p. 3503-3515 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
169 Downloads (Pure)

Theranostic Imaging May Vaccinate against the Therapeutic Benefit of Long Circulating PEGylated Liposomes and Change Cargo Pharmacokinetics

Børresen, B., Henriksen, J. R., Clergeaud, G., Jørgensen, J. S., Melander, F., Elema, D. R., Szebeni, J., Engelholm, S. A., Kristensen, A. T., Kjær, A., Andresen, T. L. & Hansen, A. E., 2018, In : ACS Nano. 12, 11, p. 11386-11398

Research output: Contribution to journalJournal articleResearchpeer-review

2017

Revisiting the use of sPLA2-sensitive liposomes in cancer therapy

Pourhassan, H., Clergeaud Veiga, G., Hansen, A. E., Østrem, R. G., Fliedner, F. P., Melander, F., Nielsen, O. L., O'Sullivan, C. K., Kjær, A. & Andresen, T. L., 2017, In : Journal of Controlled Release. 261, p. 163-173 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Secretory phospholipase A2 responsive liposomes exhibit a potent anti-neoplastic effect in vitro, but induce unforeseen severe toxicity in vivo

Østrem, R. G., Parhamifar, L., Pourhassan, H., Clergeaud Veiga, G., Nielsen, O. L., Kjær, A., Hansen, A. E. & Andresen, T. L., 2017, In : Journal of Controlled Release. 262, p. 212-221 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
158 Downloads (Pure)
2016

64Cu-ATSM Reflects pO2 Levels in Human Head and Neck Cancer Xenografts but Not in Colorectal Cancer Xenografts: Comparison with 64CuCl2

Li, F., Jørgensen, J. T., Forman, J., Hansen, A. E. & Kjær, A., 2016, In : Journal of Nuclear Medicine. 57, 3, p. 437-443 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

A Mouse Positron Emission Tomography Study of the Biodistribution of Gold Nanoparticles with Different Surface Coatings Using Embedded Copper-64

Frellsen, A. F., Hansen, A. E., Jølck, R. I., Kempen, P., Severin, G. W., Rasmussen, P. H., Kjær, A., Jensen, A. T. I. & Andresen, T. L., 2016, In : A C S Nano. 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Evaluating liposomal nanoparticles for controlled release of chemotherapeutics in vitro and in vivo

Østrem, R. G., Nielsen, O. L., Hansen, A. E. & Andresen, T. L., 2016. 3 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
File
165 Downloads (Pure)

Matrix metalloprotease-sensitive doxorubicin-loaded liposomes for enhanced anticancer activity.

Clergeaud Veiga, G., Fliedner, F. P., Hansen, A. E., Melander, F., Kjær, A. & Andresen, T. L., 2016.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
File
196 Downloads (Pure)

The use of matrigel has no influence on tumor development or PET imaging in FaDu human head and neck cancer xenografts

Fliedner, F. P., Hansen, A. E., Jorgensen, J. T. & Kjær, A., 2016, In : B M C Medical Imaging. 16, 1, p. 5 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
200 Downloads (Pure)
2015

Automated synthesis and PET evaluation of both enantiomers of [18F]FMISO

Revunov, E. V., Jørgensen, J. T., Jensen, A. T. I., Hansen, A. E., Severin, G., Kjær, A. & Zhuravlev, F., 2015, In : Nuclear Medicine and Biology. 42, p. 413–419

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
278 Downloads (Pure)

Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis

Hansen, A. E., Kristensen, A. T., Law, I., Jørgensen, J. T. & Engelholm, S. A., 2015, In : Veterinary and Comparative Oncology. 9, 1, p. 16-37

Research output: Contribution to journalJournal articleResearchpeer-review

Injectable Colloidal Gold for Use in Intrafractional 2D Image-Guided Radiation Therapy

Jølck, R. I., Rydhog, J. S., Christensen, A. N., Hansen, A. E., Bruun, L. M., Schaarup-Jensen, H., von Wenck, A. S., Borresen, B., Kristensen, A. T., Clausen, M. H., Kjær, A., Conradsen, K., Larsen, R., af Rosenschold, P. M. & Andresen, T. L., 2015, In : Advanced Healthcare Materials. 4, 6, p. 856-863 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
366 Downloads (Pure)

Micro Regional Heterogeneity of 64Cu-ATSM and 18F-FDG Uptake in Canine Soft Tissue Sarcomas: Relation to Cell Proliferation, Hypoxia and Glycolysis

Zornhagen, K. W., Hansen, A. E., Oxboel, J., Clemmensen, A. E., El Ali, H. H., Kristensen, A. T., Kjær, A. & Chen, C-T. (ed.), 2015, In : P L o S One. 10, 10, e0141379.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
187 Downloads (Pure)

Positron Emission Tomography Based Elucidation of the Enhanced Permeability and Retention Effect in Dogs with Cancer Using Copper-64 Liposomes

Hansen, A. E., Petersen, A. L., Henriksen, J. R., Børresen, B., Rasmussen, P., Elema, D. R., Rosenschöld, P. M. A., Kristensen, A. T., Kjær, A. & Andresen, T. L., 2015, In : A C S Nano. 9, 7, p. 6985–6995 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
380 Downloads (Pure)

Remote Loading of 64Cu2+ into Liposomes without the Use of Ion Transport Enhancers

Henriksen, J. R., Petersen, A. L., Hansen, A. E., Frankær, C. G., Harris, P., Elema, D. R., Kristensen, A. T., Kjær, A. & Andresen, T. L., 2015, In : A C S Applied Materials and Interfaces. 7, 41, p. 22796-22806 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
341 Downloads (Pure)

Selection of suitable reference genes for normalization of genes of interest in canine soft tissue sarcomas using quantitative real-time polymerase chain reaction

Zornhagen, K. W., Kristensen, A. T., Hansen, A. E., Oxboel, J. & Kjær, A., 2015, In : Veterinary and Comparative Oncology. 13, 4, p. 485-493 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Simultaneous hyperpolarized 13C-pyruvate MRI and 18F-FDG-PET in cancer (hyperPET): feasibility of a new imaging concept using a clinical PET/MRI scanner

Gutte, H., Hansen, A. E., Henriksen, S. T., Johannesen, H. H., Ardenkjær-Larsen, J. H., Vignaud, A., Hansen, A. E., Børresen, B., Klausen, T. L., Wittekind, A-M. N., Gillings, N., Kristensen, A. T., Clemmensen, A., Højgaard, L. & Kjær, A., 2015, In : American Journal of Nuclear Medicine and Molecular Imaging. 5, 1, p. 38-45

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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244 Downloads (Pure)

The impact of weakly bound 89Zr on preclinical studies: Non-specific accumulation in solid tumors and aspergillus infection

Severin, G., Jørgensen, J. T., Wiehr, S., Rolle, A-M., Hansen, A. E., Maurer, A., Hasenberg, M., Pichler, B., Kjær, A. & Jensen, A. T. I., 2015, In : Nuclear Medicine and Biology. 42, 4, p. 360–368 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
368 Downloads (Pure)

Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring

Zornhagen, K., Clausen, M., Hansen, A. E., Law, I., McEvoy, F., Engelholm, S., Kjær, A. & Kristensen, A., 2015, In : Diagnostics. 5, 3, p. 372-382 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
219 Downloads (Pure)
2014

Dose painting based on tumor uptake of Cu-ATSM and FDG: a comparative study

Clausen, M. M., Hansen, A. E., Lundemann, M., Hollensen, C., Pommer, T., af Rosenschold, P. M., Kristensen, A. T., Kjær, A., McEvoy, F. J. & Engelholm, S. A., 2014, In : Radiation Oncology. 9, 228, 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
162 Downloads (Pure)

Hunde med spontan cancer indgår i translationel forskning

Translated title of the contribution: Canine Cancer Patients are included in translational reseachBørresen, B., Clausen, M. M., Hansen, A. E., Zornhagen, K. W., Kristensen, A. T., Engelholm, S. A. & Kjær, A., 2014, In : Ugeskrift for Laeger. 176, 14, p. 1304-1307 V01130041.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
63 Downloads (Pure)

Injectable Colloidal Gold in a Sucrose Acetate Isobutyrate Gelating Matrix with Potential Use in Radiation Therapy

Jølck, R. I., Binderup, T., Hansen, A. E., Scherman, J. B., af Rosenschold, P. M., Kjær, A. & Andresen, T. L., 2014, In : Advanced Healthcare Materials. 3, 10, p. 1680-1687

Research output: Contribution to journalJournal articleResearchpeer-review

Sucrose acetate isobutyrate based nanogels as liquid fiducial tissue markers with potential use in image guided radiotherapy

Bruun, L. M., Schaarup-Jensen, H., Jølck, R. I., Hansen, A. E., Christiansen, A. N., Clausen, M. H., Kjær, A., Scherman, P. J. B. & Andresen, T. L., 2014. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

File
113 Downloads (Pure)

Sucrose acetate isobutyrate based nanogels as liquid fiducial tissue markers with potential use in image guided radiotherapy

Bruun, L. M., Schaarup-Jensen, H., Jølck, R. I., Hansen, A. E., Christiansen, A. N., Clausen, M. H., Kjær, A., Scherman, P. J. B. & Andresen, T. L., 2014. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

File
102 Downloads (Pure)

Sucrose acetate isobutyrate-based nanogels as liquid fiducial tissue markers with potential use in image guided radiotherapy

Bruun, L. M., Schaarup-Jensen, H., Jølck, R. I., Hansen, A. E., Christiansen, A. N., Scherman, P. J. B., Clausen, M. H., Kjær, A. & Andresen, T. L., 2014. 1 p.

Research output: Contribution to conferencePosterResearch

File
252 Downloads (Pure)
2013

Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors: a feasibility study

Clausen, M. M., Hansen, A. E., af Rosenschold, P. M., Kjær, A., Kristensen, A. T., McEvoy, F. J. & Engelholm, S. A., 2013, In : Radiation Oncology. 8, 1, 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
149 Downloads (Pure)
2012

64Cu-ATSM and 18FDG PET uptake and 64Cu-ATSM autoradiography in spontaneous canine tumors: Comparison with pimonidazole hypoxia immunohistochemistry

Hansen, A. E., Kristensen, A. T., Jørgensen, J. T., McEvoy, F. J., Busk, M., van der Kogel, A. J., Bussink, J., Engelholm, S. A. & Kjær, A., 2012, In : Radiation Oncology. 7, 89, 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
40 Downloads (Pure)

Liposome imaging agents in personalized medicine

Petersen, A. L., Hansen, A. E., Gabizon, A. & Andresen, T. L., 2012, In : Advanced Drug Delivery Reviews. 64, p. 1417-1435

Research output: Contribution to journalJournal articleResearchpeer-review

Multimodality functional imaging of spontaneous canine tumors using 64CU-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT

Hansen, A. E., Kristensen, A. T., Law, I., McEvoy, F. J., Kjær, A. & Engelholm, S. A., 2012, In : Radiotherapy and Oncology. 102, 3, p. 424-428 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2011

FDG PET/CT imaging in canine cancer patients

Hansen, A. E., McEvoy, F., Engelholm, S. A., Law, I. & Kristensen, A. T., 2011, In : Veterinary Radiology & Ultrasound. 52, 2, p. 201-206 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review