19962020

Research output per year

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Research Output

2020

An autoinducible trp-T7 expression system for production of proteins and biochemicals in Escherichia coli

Landberg, J., Mundhada, H. & Nielsen, A. T., 2020, In : Biotechnology and Bioengineering. 117, 5, p. 1513-1524

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
47 Downloads (Pure)

Genome-Based Comparison of All Species of the Genus Moorella, and Status of the Species Moorella thermoacetica and Moorella thermoautotrophica

Redl, S. M. A., Poehlein, A., Esser, C., Bengelsdorf, F. R., Jensen, T. Ø., Jendresen, C. B., Tindall, B. J., Daniel, R., Dürre, P. & Nielsen, A. T., 2020, In : Frontiers in Microbiology. 10, 3070.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
33 Downloads (Pure)

Genome-Wide CRISPRi-Based Identification of Targets for Decoupling Growth from Production

Li, S., Jendresen, C. B., Landberg, J. M., Pedersen, L. E., Sonnenschein, N., Ingemann Jensen, S. & Nielsen, A. T., 2020, (Accepted/In press) In : ACS Synthetic Biology.

Research output: Contribution to journalJournal articleResearchpeer-review

2019

A metabolic reconstruction of Lactobacillus reuteri JCM 1112 and analysis of its potential as a cell factory

Kristjansdottir, T., Bosma, E. F., Branco Dos Santos, F., Özdemir, E., Herrgård, M. J., França, L., Ferreira, B., Toftgaard Nielsen, A. & Gudmundsson, S., 2019, In : Microbial Cell Factories. 18, 1, 19 p., 186.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
65 Downloads (Pure)

Generation of an E. coli platform strain for improved sucrose utilization using adaptive laboratory evolution

Mohamed, E. T. T., Mundhada, H., Landberg, J. M., Cann, I., Mackie, R. I., Nielsen, A. T., Herrgard, M. J. & Feist, A. M., 2019, In : Microbial Cell Factories. 18, 116.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
150 Downloads (Pure)

Genome editing of lactic acid bacteria: opportunities for food, feed, pharma and biotech

Börner, R. A., Kandasamy, V., Axelsen, A. M., Nielsen, A. T. & Bosma, E. F., 2019, In : F E M S Microbiology Letters. 366, 1, 12 p., fny291.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
486 Downloads (Pure)

Genome-wide systematic identification of methyltransferase recognition and modification patterns

Jensen, T. Ø., Tellgren-Roth, C., Redl, S. M. A., Maury, J., Baallal Jacobsen, S. A., Pedersen, L. E. & Nielsen, A. T., 2019, In : Nature Communications. 10, 1, 3311.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
174 Downloads (Pure)

Industrializing a Bacterial Strain for l -Serine Production through Translation Initiation Optimization

Rennig, M., Mundhada, H., Wordofa, G. G., Gerngross, D., Wulff, T., Worberg, A., Nielsen, A. T. & Nørholm, M. H. H., 2019, In : ACS Synthetic Biology. 8, 10, p. 2347-2358

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
114 Downloads (Pure)

Production of zosteric acid and other sulfated phenolic biochemicals in microbial cell factories

Jendresen, C. B. & Nielsen, A. T., 2019, In : Nature Communications. 10, 4071.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
127 Downloads (Pure)

Simultaneous quantification of multiple bacterial metabolites using surface-enhanced Raman scattering

Morelli, L., Centorbi, F. A., Ilchenko, O., Jendresen, C. B., Demarchi, D., Nielsen, A. T., Zor, K. & Boisen, A., 2019, In : Analyst. 144, 5, p. 1600-1607 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2018

A Capture-SELEX Strategy for Multiplexed Selection of RNA Aptamers Against Small Molecules

Lauridsen, L. H., Doessing, H. B., Long, K. S. & Nielsen, A. T., 2018, Synthetic Metabolic Pathways. Vol. 1671. p. 291-306 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Bacterial cells with improved tolerance to diacids

Lennen, R., Nielsen, A. T., Herrgard, M., Sommer, M. O. A., Feist, A. & Tharwat Tolba Mohamed, E., 2018, IPC No. C12N1/20; C12P7/44; C12P7/46, Patent No. WO2018091525 , 24 May 2018, Priority date 15 Nov 2016, Priority No. US201662422457P

Research output: Patent

Open Access
File
210 Downloads (Pure)

Bacterial Genome Editing Strategy for Control of Transcription and Protein Stability

Lauritsen, I., Martinez, V., Ronda, C., Nielsen, A. T. & Nørholm, M. H. H., 2018, Synthetic Metabolic Pathways. Vol. 1671. p. 27-37 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Genome-wide identification of tolerance mechanisms towards p-coumaric acid in Pseudomonas putida

Calero, P., Jensen, S. I., Bojanovič, K., Lennen, R., Koza, A. & Nielsen, A. T., 2018, In : Biotechnology and Bioengineering. 115, 3, p. 762-774

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
482 Downloads (Pure)

Injection molded lab-on-a-disc platform for screening of genetically modified E. coli using liquid-liquid extraction and surface enhanced Raman scattering

Morelli, L., Serioli, L., Centorbi, F. A., Jendresen, C. B., Matteucci, M., Ilchenko, O., Demarchi, D., Nielsen, A. T., Zor, K. & Boisen, A., 2018, In : Lab on a Chip. 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
168 Downloads (Pure)

Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides

Li, S., Jendresen, C. B., Pedersen, L. E., Landberg, J. M., Falkenberg, K. B., Mundhada, H. & Nielsen, A. T., 2018, IPC No. C12N1/21; C12N15/63; C12N9/88; C12P13/22; C12P21/02; C12P7/42, Patent No. WO2018020012, 1 Feb 2018, Priority date 29 Jul 2016, Priority No. EP20160182046

Research output: Patent

Open Access
File
284 Downloads (Pure)

Multiplex Genome Editing in Escherichia coli

Ingemann Jensen, S. & Nielsen, A. T., 2018, Synthetic Metabolic Pathways. Vol. 1671. p. 119-129 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Towards Improved Biophysical Calculations to Identify Disease-Causing Mutations

Lindorff-Larsen, K., Stein, A., Teilum, K., Nielsen, A. T. & Hartmann-Petersen, R., 2018, In : BIOPHYSICAL JOURNAL. 114, 3, Suppl 1, p. 199a 1005-Plat.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

1 Downloads (Pure)

Bacterial cells with improved tolerance to isobutyric acid

Lennen, R., Nielsen, A. T., Herrgård, M., Sommer, M. O. A., Feist, A. & Mohamed, E. T. T., 16 Nov 2017, IPC No. C12P 7/ 52 A I, Patent No. WO2017194696, 16 Nov 2017, Priority date 9 Jun 2016, Priority No. EP20160173673

Research output: Patent

Bacterial cells with improved tolerance to polyamines

Lennen, R., Nielsen, A. T., Herrgaard, M., Sommer, M. O. A., Feist, A. & Tharwat Tolba Mohamed, E., 15 Jun 2017, IPC No. C12P 13/ 00 A I, Patent No. WO2017097828, 15 Jun 2017, Priority date 9 Feb 2016, Priority No. EP20160154829

Research output: Patent

Open Access
File
127 Downloads (Pure)

Bacterial cells with improved tolerance to polyols

Lennen, R., Nielsen, A. T., Herrgard, M., Sommer, M. O. A., Feist, A. & Tharwat Tolba Mohamed, E., 17 Jun 2017, IPC No. C12P7/18 , Patent No. WO2017211883, 14 Dec 2017, Priority date 27 Jun 2016, Priority No. EP20160176365

Research output: Patent

Open Access
File
365 Downloads (Pure)

CRISPR/Cas9-based genome editing for simultaneous interference with gene expression and protein stability

Martinez, V., Lauritsen, I., Hobel, T., Li, S., Nielsen, A. T. & Nørholm, M., 2017, In : Nucleic Acids Research. 45, 20, 8 p., gkx797.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
244 Downloads (Pure)

Detection of p-coumaric acid from cell supernatant using surface enhanced Raman scattering

Morelli, L., Jendresen, C. B., Zor, K., Rindzevicius, T., Schmidt, M. S., Nielsen, A. T. & Boisen, A., 2017, In : Procedia Technology. 27, p. 190-192 3 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
File
304 Downloads (Pure)

Development and Application of Efficient Forward and Reverse Genetic Tools

Baker, J. P., Saez, J., Ingemann Jensen, S., Wiechmann, A., Bengelsdorf, F., Beck, M., Fernandez-Sanchis, E. M., Müller, V., Nielsen, A. T., Dürre, P., Baldauf, M., Simpson, S. & Minton, N. P., 2017, Proceedings of C1net Conference 3. 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
115 Downloads (Pure)

Exploiting the potential of gas fermentation

Redl, S. M. A., Diender, M., Jensen, T. Ø., Sousa, D. Z. & Nielsen, A. T., 2017, In : Industrial Crops and Products. 106, p. 21-30

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic toolbox for controlled expression of functional proteins in Geobacillus spp.

Pogrebnyakov, I., Jendresen, C. B. & Nielsen, A. T., 2017, In : PLOS ONE. 12, 2, 15 p., e0171313.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
574 Downloads (Pure)

Improved biological processes for the production of aryl sulfates

Jendresen, C. B. & Nielsen, A. T., 31 Aug 2017, IPC No. C12P 5/ 00 A I, Patent No. WO2017144671, 31 Aug 2017, Priority date 24 Feb 2016, Priority No. EP20160157231

Research output: Patent

Open Access
File
135 Downloads (Pure)

Improved process for producing a fermentation product from a lignocellulose-containing material

Jendresen, C. B. & Nielsen, A. T., 31 Aug 2017, IPC No. C12P 11/ 00 A I, Patent No. WO2017144670, 31 Aug 2017, Priority date 24 Feb 2016, Priority No. EP20160157232

Research output: Patent

Open Access
File
371 Downloads (Pure)

Increased production of L-serine in Escherichia coli through Adaptive Laboratory Evolution

Mundhada, H., Seoane, J. M., Schneider, K., Christensen, H. B., Koza, A., Herrgard, M., Feist, A. & Nielsen, A. T., 2017, In : Metabolic Engineering. 39, p. 141–150 24 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
633 Downloads (Pure)
Open Access
File
141 Downloads (Pure)

Lactobacilli and pediococci as versatile cell factories - Evaluation of strain properties and genetic tools

Bosma, E. F., Förster, J. & Nielsen, A. T., 2017, In : Biotechnology Advances. 35, 4, p. 419-442 24 p.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
File
384 Downloads (Pure)

Quantification of a bacterial secondary metabolite by SERS combined with SLM extraction for bioprocess monitoring

Morelli, L., Andreasen, S. Z., Jendresen, C. B., Nielsen, A. T., Emnéus, J., Zor, K. & Boisen, A., 2017, In : Analyst. 142, 23, p. 4553-4559

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
150 Downloads (Pure)

Surface Enhanced Raman Scattering for Quantification of p-Coumaric Acid Produced by Escherichia coli

Morelli, L., Zor, K., Jendresen, C. B., Rindzevicius, T., Schmidt, M. S., Nielsen, A. T. & Boisen, A., 2017, In : Analytical chemistry. 89, p. 3981-3987 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
118 Downloads (Pure)

Thermodynamics and economic feasibility of acetone production from syngas using the thermophilic production host Moorella thermoacetica

Redl, S. M. A., Sukumara, S., Ploeger, T., Wu, L., Jensen, T. Ø., Nielsen, A. T. & Noorman, H., 2017, In : Biotechnology for Biofuels. 10, 150.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
567 Downloads (Pure)

Using A Metabolic Model Of Acetobacterium woodii For Insights Into Its Utility For Biotechnological Purposes

Mesfin, N., Ingemann Jensen, S., Nielsen, A. T., Fell, D. & Poolman, M., 2017, Proceedings of C1net Conference 3. 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
262 Downloads (Pure)
2016

A process for producing a fermentation product from a lignocellulose-containing material.

Jendresen, C. B. & Nielsen, A. T., 25 Feb 2016, IPC No. C12N 9/ 10 A I, Patent No. WO2016026977, 25 Feb 2016, Priority date 22 Aug 2014, Priority No. EP20140182040

Research output: Patent

Open Access
File
136 Downloads (Pure)

A two-cassette reporter system for assessing target gene translation and target gene product inclusion body formation

Nielsen, A. T., Zutz, A. & Lennen, R., 28 Apr 2016, IPC No. C12N 15/ 09 A I, Patent No. WO2016062819, 28 Apr 2016, Priority date 22 Oct 2014, Priority No. EP20140189892

Research output: Patent

Open Access
File
194 Downloads (Pure)

Biological processes for the production of aryl sulfates.

Jendresen, C. B. & Nielsen, A. T., 25 Feb 2016, IPC No. C12N 9/ 10 A I, Patent No. WO2016026976, 25 Feb 2016, Priority date 22 Aug 2014, Priority No. EP20140182032

Research output: Patent

Open Access
File
131 Downloads (Pure)

Consortia based production of biochemicals

Ingemann Jensen, S., Sukumara, S., Özdemir, E., Schneider, K., Li, S., Calero Valdayo, P., Ronda, C. & Nielsen, A. T., 2016, Programme & Abstracts. The Danish Microbiological Society Annual Congress 2016. Danish Microbiological Society, p. 84-85

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
199 Downloads (Pure)

Consortia based production of biochemicals

Ingemann Jensen, S., Sukumara, S., Özdemir, E., Schneider, K., Calero Valdayo, P. M., Li, S., Ronda, C. & Nielsen, A. T., 2016. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access

CRMAGE: CRISPR Optimized MAGE Recombineering

Ronda, C., Pedersen, L. E., Sommer, M. O. A. & Nielsen, A. T., 2016, In : Scientific Reports. 6, 11 p., 19452.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
546 Downloads (Pure)

Developing Lactic Acid Bacteria for the conversion of brown macroalgae into green chemicals and fuels

Bosma, E. F. & Nielsen, A. T., 2016. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access

Engineering of High Yield Production of L-serine in Escherichia coli

Mundhada, H., Schneider, K., Christensen, H. B. & Nielsen, A. T., 2016, In : Biotechnology and Bioengineering. 113, 4, p. 807-816 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Enhanced protein and biochemical production using CRISPRi-based growth switches

Li, S., Jendresen, C. B., Grünberger, A., Ronda, C., Ingemann Jensen, S., Noack, S. & Nielsen, A. T., 2016, In : Metabolic Engineering. 38, p. 274-284 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Genetically modified microorganisms having improved tolerance towards l-serine.

Mundhada, H. & Nielsen, A. T., 4 Aug 2016, IPC No. C12N 15/ 00 A I, Patent No. WO2016120345, 4 Aug 2016, Priority date 27 Jan 2015, Priority No. EP20150152643

Research output: Patent

Open Access
File
150 Downloads (Pure)

Genome-wide Escherichia coli stress response and improved tolerance towards industrially relevant chemicals

Rau, M. H., Calero Valdayo, P., Lennen, R., Long, K. & Nielsen, A. T., 2016, In : Microbial Cell Factories. 15, 18 p., 176.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
513 Downloads (Pure)

Increasing production yield of tyrosine and mevalonate through inhibition of biomass formation

Li, S., Jendresen, C. B. & Nielsen, A. T., 2016, In : Process Biochemistry. 51, 12, p. 1992–2000 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review