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Profile
With a substantial tenure in research spanning many years, my primary area of expertise centers on translational research, bridging the gap between scientific discovery and practical application. My research is primarily oriented toward adoptive cell therapy, with a particular emphasis on T cells and lineage differentiated immune cells.
In addition to advancing scientific knowledge, I am actively involved in technology transfer, facilitating the seamless transition of research findings from the laboratory bench to clinical implementation. Gene editing technology (viral and non-viral) has been a pivotal tool in my work, allowing for innovative approaches in T-cell immunotherapy and precision medicine.
Throughout my career, I have demonstrated a commitment to project development, ensuring that research efforts lead to tangible benefits for patients. My dedication to the bench-to-bedside journey, coupled with a keen focus on gene editing and immunotherapy, underscores my commitment to making a meaningful impact in the field of translational research.
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Collaborations and top research areas from the last five years
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Harnessing arginase 2-specific CD8+ T cells to target immunosuppressive cutaneous T-cell lymphoma
Lisle, T. L., Weis-Banke, S. E., Ahmad, S. M., Holmström, M. O., Luu, T. V., Buus, T. B., Jessen, L. E., Dellgren, C., Barington, T., Met, Ö., Ødum, N. & Andersen, M. H., 2026, In: The British journal of dermatology. 194, 4, p. 689-698Research output: Contribution to journal › Journal article › Research › peer-review
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Safety and feasibility of blood-derived multiple antigen-specific endogenously derived T cells (MASE-T) for metastatic melanoma
Monberg, T. J., Tvingsholm, S. A., Svensson-Frej, M., Vestergaard, C., Ormhøj, M., Kjeldsen, J. W., Borch, T. H., Holmstroem, R. B., Jayashankar, N., Granhøj, J. S., Cordt, A. R., Larsen, S. K., Met, Hadrup, S. R. & Svane, I. M., 2026, In: Immuno-Oncology and Technology. 29, 15 p., 101581.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile7 Downloads (Orbit) -
Case Report: Severe HHV-6-related encephalitis following anti-CD19 CAR-T therapy with no evidence of HHV-6 reactivation in transduced CAR-T cells
Birk, N. M., Kielsen, K., Met, Ö., Haastrup, E. K., Hulen, T. M., Madsen, C., Barington, T., Nielsen, J., Schønning, K., Petersen, S. L. & Ifversen, M., 2025, In: Frontiers in Hematology. 4, 9 p., 1628552.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile12 Downloads (Orbit) -
Overcoming antigen loss in CAR T therapy with Vγ9Vδ2 CAR T-cells
Velasco Santiago, M., Aehnlich, P., Hulen, T. M., Jensen, K. M., Holmen Olofsson, G., Met & thor Straten, P., 2025, In: Immuno-Oncology and Technology. 26, 11 p., 101053.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile20 Downloads (Orbit) -
ProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality
Kurzay, A., Fresnillo Saló, S., Rahbech, A., Seremet, T., Oelvang Madsen, C., Chamberlain, C. A., Bülow Jensen, E., Thy Luu, V., Met, Ö., Peeters, M. J. W. & Straten, P. T., 2025, In: OncoImmunology. 14, 1, 16 p., 2532662.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile12 Downloads (Orbit)
Projects
- 1 Active
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Genetically Engineered Antigen Reactive T cells (GEAR-T) for Next Generation T Cell Therapy
Madsen, C. Ø. (PhD Student), Met, Ö. (Main Supervisor), Hadrup, S. R. (Supervisor) & Svane, I. M. (Supervisor)
01/01/2025 → 31/12/2027
Project: PhD