• Søltofts Plads, Bygning 221

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2020

A comparative genomics study of 23 Aspergillus species from section Flavi

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kildgaard, S., Petersen, T. I., Kuo, A., Sato, A., Lyhne, E. K., Kogle, M. E., Wiebenga, A., Kun, R. S., Lubbers, R. J. M., Mäkelä, M. R., Barry, K., Chovatia, M., Clum, A., Daum, C., Haridas, S. & 17 others, He, G., LaButti, K., Lipzen, A., Mondo, S., Pangilinan, J., Riley, R., Salamov, A., Simmons, B. A., Magnuson, J. K., Henrissat, B., Mortensen, U. H., Larsen, T. O., de Vries, R. P., Grigoriev, I. V., Machida, M., Baker, S. E. & Andersen, M. R., 2020, In : Nature Communications. 11, 1, 12 p., 1106.

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Acrophiarin (antibiotic S31794/F-1) from Penicillium arenicola shares biosynthetic features with both Aspergillus- and Leotiomycete-type echinocandins

Lan, N., Perlatti, B., Kvitek, D. J., Wiemann, P., Harvey, C. J. B., Frisvad, J. C., An, Z. & Bills, G. F., 2020, (Accepted/In press) In : Environmental Microbiology.

Research output: Contribution to journalJournal articleResearchpeer-review

Acurin A, a novel hybrid compound, biosynthesized by individually translated PKS- and NRPS-encoding genes in Aspergillus aculeatus

Wolff, P. B., Nielsen, M. L., Slot, J. C., Andersen, L. N., Petersen, L. M., Isbrandt, T., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2020, In : Fungal Genetics and Biology. 139, 10 p., 103378.

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Anthelmintic and metabolomic analyses of chicory (Cichorium intybus) identify an industrial by-product with potent in vitro antinematodal activity

Pena-Espinoza, M. A., Valente, A. H., Bornancin, L., Simonsen, H. T., Thamsborg, S. M., Williams, A. R. & López-Muñoz, R., 2020, In : Veterinary Parasitology. 280, 11 p., 109088.

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Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens

Malik, A., Ardalani, H., Anam, S., McNair, L. M., Kromphardt, K. J. K., Frandsen, R. J. N., Franzyk, H., Staerk, D. & Kongstad, K. T., 2020, In : Fitoterapia. 142, 8 p., 104522.

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Body fluid from the parasitic worm Ascaris suum inhibits broad-acting pro-inflammatory programs in dendritic cells

Arora, P., Moll, J. M., Andersen, D., Workman, C. T., Williams, A. R., Kristiansen, K. & Brix, S., 2020, In : Immunology. 159, 3, p. 322-334 13 p.

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Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties

Papargyri, N., Pontoppidan, M., Andersen, M. R., Koch, T. & Hagedorn, P. H., 6 Mar 2020, In : Molecular Therapy - Nucleic Acids. 19, p. 706-717

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Exploiting new biorefinery models using non-conventional yeasts and their implications for sustainability

Yamakawa, C. K., Kastell, L., Mahler, M. R., Martinez, J. L. & Mussatto, S. I., 2020, In : Bioresource Technology. 309, 9 p., 123374.

Research output: Contribution to journalJournal articleResearchpeer-review

Fluctuations in glucose availability prevent global proteome changes and physiological transition during prolonged chemostat cultivations of S. cerevisiae

Wright, N. R., Wulff, T., Palmqvist, E. A., Jørgensen, T. R., Workman, C. T., Sonnenschein, N., Rønnest, N. P. & Herrgård, M. J., 2020, (Accepted/In press) In : Biotechnology and Bioengineering.

Research output: Contribution to journalJournal articleResearchpeer-review

Fungal communities in rice cultivated in different Brazilian agroclimatic zones: From field to market

Katsurayama, A. M., Martins, L. M., Iamanaka, B. T., Fungaro, M. H. P., Silva, J. J., Pitt, J. I., Frisvad, J. C. & Taniwaki, M. H., 2020, In : Food Microbiology. 87, 8 p., 103378.

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Genome-Wide CRISPRi-Based Identification of Targets for Decoupling Growth from Production

Li, S., Jendresen, C. B., Landberg, J. M., Pedersen, L. E., Sonnenschein, N., Ingemann Jensen, S. & Nielsen, A. T., 2020, (Accepted/In press) In : ACS Synthetic Biology.

Research output: Contribution to journalJournal articleResearchpeer-review

Identification of SclB, a Zn(II)2Cys6 transcription factor involved in sclerotium formation in Aspergillus niger

Jørgensen, T. R., Burggraaf, A-M., Arentshorst, M., Schutze, T., Lamers, G., Niu, J., Kwon, M. J., Park, J., Frisvad, J. C., Nielsen, K. F., Meyer, V., van den Hondel, C. A. M. J. J., Dyer, P. S. & Ram, A. F. J., 2020, In : Fungal Genetics and Biology. 139, 14 p., 103377.

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Origin of cooperativity in the activation of dimeric transcription factors

Welch, M., Brasen, J. C., Workman, C. & Sams, T., 2020, In : Physical Review Research. 2, 1, 8 p., 013151.

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Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

Williams, K., Ingerslev, L. R., Bork-Jensen, J., Wohlwend, M., Hansen, A. N., Small, L., Ribel-Madsen, R., Astrup, A., Pedersen, O., Auwerx, J., Workman, C. T., Grarup, N., Hansen, T. & Barrès, R., 2020, In : Nature Communications. 11, 1, 16 p., 2695.

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Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent

Knudsen, C., Bavishi, K., Viborg, K. M., Drew, D. P., Simonsen, H. T., Motawia, M. S., Møller, B. L. & Laursen, T., 2020, In : Phytochemistry. 170, 9 p., 112214.

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The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance

Mattos, E. C., Silva, L. P., Valero, C., de Castro, P. A., Dos Reis, T. F., Ribeiro, L. F. C., Marten, M. R., Silva-Rocha, R., Westmann, C., da Silva, C. H. T. D. P., Taft, C. A., Al-Furaiji, N., Bromley, M., Mortensen, U. H., Benz, J. P., Brown, N. A. & Goldman, G. H., 2020, In : mBio. 11, 1, 23 p., e02962-19.

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The draft genome of mandrill (Mandrillus sphinx): An Old World monkey

Yin, Y., Yang, T., Liu, H., Huang, Z., Zhang, Y., Song, Y., Wang, W., Guang, X., Sahu, S. K. & Kristiansen, K., 2020, In : Scientific Reports. 10, 1, 8 p., 2431.

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2019

Anti-protozoal activity of extracts from chicory (Cichorium intybus) against Cryptosporidium parvum in cell culture

Woolsey, I. D., Valente, A. H., Williams, A. R., Thamsborg, S. M., Simonsen, H. T. & Enemark, H. L., 2019, In : Scientific Reports. 9, 1, 9 p., 20414.

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Assessing specialized metabolite diversity in the cosmopolitan plant genus Euphorbia l.

Ernst, M., Nothias, L. F., van der Hooft, J. J. J., Silva, R. R., Saslis-Lagoudakis, C. H., Grace, O. M., Martinez-Swatson, K., Hassemer, G., Funez, L. A., Simonsen, H. T., Medema, M. H., Staerk, D., Nilsson, N., Lovato, P., Dorrestein, P. C. & Rønsted, N., 2019, In : Frontiers in Plant Science. 10, 15 p., 846.

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Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

Andersen, T. B., Rasmussen, S. A., Christensen, S. B. & Simonsen, H. T., 2019, In : Phytochemistry. 157, p. 168-174

Research output: Contribution to journalJournal articleResearchpeer-review

Comparative Transcriptome Analysis Shows Conserved Metabolic Regulation during Production of Secondary Metabolites in Filamentous Fungi

Nielsen, J., Prigent, S., Grijseels, S., Workman, M., Ji, B. & Nielsen, J., 2019, In : mSystems. 4, 2, 14 p., 00012-19.

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Comprehensive profiling of the fission yeast transcription start site activity during stress and media response

Thodberg, M., Thieffry, A., Bornholdt, J., Boyd, M., Holmberg, C., Azad, A., Workman, C. T., Chen, Y., Ekwall, K., Nielsen, O. & Sandelin, A., 2019, In : Nucleic acids research. 47, 4, p. 1671-1691 21 p., gky1227.

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Cpf1 enables fast and efficient genome editing in Aspergilli

Garcia Vanegas, K., Jarczynska, Z. D., Strucko, T. & Mortensen, U. H., 2019, In : Fungal Biology and Biotechnology. 6, 6, 10 p.

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Cyp51A mutations, Extrolite Profiles and Antifungal Susceptibility in Clinical and Environmental Isolates of the Aspergillus viridinutans Species Complex

Talbot, J. J., Frisvad, J. C., Meis, J. F., Hagen, F., Verweij, P. E., Hibbs, D. E., Lai, F., Samson, R. A., Kidd, S. E., Barrs, V. R. & Houbraken, J., 2019, In : Antimicrobial Agents and Chemotherapy. 63, 11, 13 p., e00632-19.

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Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001.

Devi, S., Kiesewalter, H. T., Kovács, R., Frisvad, J. C., Weber, T., Larsen, T. O., Kovács, Á. T. & Ding, L., 2019, In : Synthetic and Systems Biotechnology. 4, 3, p. 142-149 8 p.

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Exploring evolutionary theories of plant defence investment using field populations of the deadly carrot

Martinez-Swatson, K. A., Kjøller, R., Cozzi, F., Simonsen, H. T., Rønsted, N. & Barnes, C. J., 2019, In : Annals of Botany. 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Fungal and chemical diversity in hay and wrapped haylage for equine feed

Andersen, B., Phippen, C., Frisvad, J. C., Emery, S. & Eustace, R. A., 2019, In : Mycotoxin Research. 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Fungal diversity notes 1036–1150: taxonomic and phylogenetic contributions on genera and species of fungal taxa

Hyde, K. D., Tennakoon, D. S., Jeewon, R., Bhat, D. J., Maharachchikumbura, S. S. N., Rossi, W., Leonardi, M., Lee, H. B., Mun, H. Y., Houbraken, J., Nguyen, T. T. T., Jeon, S. J., Frisvad, J. C., Wanasinghe, D. N., Lücking, R., Aptroot, A., Cáceres, M. E. S., Karunarathna, S. C., Hongsanan, S., Phookamsak, R. & 101 others, de Silva, N. I., Thambugala, K. M., Jayawardena, R. S., Senanayake, I. C., Boonmee, S., Chen, J., Luo, Z. L., Phukhamsakda, C., Pereira, O. L., Abreu, V. P., Rosado, A. W. C., Bart, B., Randrianjohany, E., Hofstetter, V., Gibertoni, T. B., Soares, A. M. D. S., Plautz, H. L., Sotão, H. M. P., Xavier, W. K. S., Bezerra, J. D. P., de Oliveira, T. G. L., de Souza-Motta, C. M., Magalhães, O. M. C., Bundhun, D., Harishchandra, D., Manawasinghe, I. S., Dong, W., Zhang, S. N., Bao, D. F., Samarakoon, M. C., Pem, D., Karunarathna, A., Lin, C. G., Yang, J., Perera, R. H., Kumar, V., Huang, S. K., Dayarathne, M. C., Ekanayaka, A. H., Jayasiri, S. C., Xiao, Y., Konta, S., Niskanen, T., Liimatainen, K., Dai, Y. C., Ji, X. H., Tian, X. M., Mešić, A., Singh, S. K., Phutthacharoen, K., Cai, L., Sorvongxay, T., Thiyagaraja, V., Norphanphoun, C., Chaiwan, N., Lu, Y. Z., Jiang, H. B., Zhang, J. F., Abeywickrama, P. D., Aluthmuhandiram, J. V. S., Brahmanage, R. S., Zeng, M., Chethana, T., Wei, D., Réblová, M., Fournier, J., Nekvindová, J., do Nascimento Barbosa, R., dos Santos, J. E. F., de Oliveira, N. T., Li, G. J., Ertz, D., Shang, Q. J., Phillips, A. J. L., Kuo, C. H., Camporesi, E., Bulgakov, T. S., Lumyong, S., Jones, E. B. G., Chomnunti, P., Gentekaki, E., Bungartz, F., Zeng, X. Y., Fryar, S., Tkalčec, Z., Liang, J., Li, G., Wen, T. C., Singh, P. N., Gafforov, Y., Promputtha, I., Yasanthika, E., Goonasekara, I. D., Zhao, R. L., Zhao, Q., Kirk, P. M., Liu, J. K., Yan, J. Y., Mortimer, P. E., Xu, J. & Doilom, M., 2019, In : Fungal Diversity. 96, 1, p. 1-242

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic engineering approaches to improve post-translational modification of biopharmaceuticals in different production platforms

Amann, T., Schmieder, V., Kildegaard, H. F., Borth, N. & Andersen, M. R., 2019, In : Biotechnology and Bioengineering. 116, 10, p. 2778-2796

Research output: Contribution to journalJournal articleResearchpeer-review

Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles

Amann, T., Hansen, A. H., Kol, S., Hansen, H. G., Arnsdorf, J., Nallapareddy, S., Voldborg, B., Min Lee, G., Andersen, M. R. & Kildegaard, H. F., 2019, In : Metabolic Engineering. 52, p. 143-152 10 p.

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In planta and in silico characterization of five sesquiterpene synthases from Vitis vinifera (cv. Shiraz) berries

Dueholm, B., Drew, D. P., Sweetman, C. & Simonsen, H. T., 2019, In : Planta. 249, 1, p. 59-70 12 p.

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Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens

Ikram, N. K. K., Kashkooli, A. B., Peramuna, A. V., Krol, A. R. V. D., Bouwmeester, H. & Simonsen, H. T., 2019, In : Molecules. 24, 21, 13 p., 3822.

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Investigating the Influence of Glycerol on the Utilization of Glucose in Yarrowia lipolytica Using RNA-Seq-Based Transcriptomics

Lubuta, P. J. K., Workman, M., Kerkhoven, E. J. & Workman, C. T., 2019, In : G3: Genes, Genomes, Genetics (Bethesda). 9, 12, p. 4059-4071 48 p., g3.400469.2019.

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Metabolic and regulatory insights from the experimental Horizontal Gene Transfer of the aurofusarin and bikaverin gene clusters to Aspergillus nidulans

de Reus, E., Nielsen, M. R. & Frandsen, R. J. N., 2019, In : Molecular Microbiology. 112, 6, p. 1684-1700 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Microbiological quality of mink feed raw materials and feed production area

Lyhs, U., Frandsen, H. L., Andersen, B., Nonnemann, B., Hjulsager, C. K., Pedersen, K. & Chriél, M., 2019, In : Acta Veterinaria Scandinavica. 61, 1, 10 p., 56.

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Model-Assisted Fine-Tuning of Central Carbon Metabolism in Yeast through dCas9-Based Regulation

Ferreira, R., Skrekas, C., Hedin, A., Sánchez, B. J., Siewers, V., Nielsen, J. & David, F., 2019, In : ACS Synthetic Biology. 8, p. 2457-2463

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Protease activity profiling of snake venoms using high-throughput peptide screening

Kalogeropoulos, K., Treschow, A. F., Auf Dem Keller, U., Escalante, T., Rucavado, A., Gutiérrez, J. M., Laustsen, A. H. & Workman, C. T., 2019, In : Toxins. 11, 3, 23 p., 170.

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Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion

Ley, D., Pereira, S., Pedersen, L. E., Arnsdorf, J., Hefzi, H., Davy, A. M., Kwang Ha, T., Wulff, T., Kildegaard, H. F. & Andersen, M. R., 2019, In : Metabolic Engineering. 56, p. 120-129 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Resistance gene-directed genome mining of 50 Aspergillus species

Kjærbølling, I., Vesth, T. & Andersen, M. R., 2019, In : mSystems. 4, 4, 13 p., e00085-19.

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Systematic Evaluation of Site-Specific Recombinant Gene Expression for Programmable Mammalian Cell Engineering

Pristovšek, N., Nallapareddy, S., Grav, L. M., Hefzi, H., Lewis, N. E., Rugbjerg, P., Hansen, H. G., Lee, G. M., Andersen, M. R. & Kildegaard, H. F., 2019, In : ACS Synthetic Biology. 8, 4, p. 758-774 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

Kato, H., Sebe, M., Nagaki, M., Eguchi, K., Kagiyama, I., Hitora, Y., Frisvad, J. C., Williams, R. M. & Tsukamoto, S., 2019, In : Journal of Natural Products. 82, 5, p. 1377-1381 5 p.

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The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans

La Rosa, S. L., Leth, M. L., Michalak, L., Hansen, M. E., Pudlo, N. A., Glowacki, R., Pereira, G., Workman, C. T., Arntzen, M., Pope, P. B., Martens, E. C., Hachem, M. A. & Westereng, B., 2019, In : Nature Communications. 10, 1, 14 p., 905.

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Time-resolved ATP measurements during vesicle respiration

Lin, J., Weixler, D., Daboss, S., Seibold, G. M., Andronescu, C., Schuhmann, W. & Kranz, C., 2019, In : Talanta. 205, 7 p., 120083.

Research output: Contribution to journalJournal articleResearchpeer-review

2018

A community-driven reconstruction of the Aspergillus niger metabolic network

Brandl, J., Aguilar-Pontes, M. V., Schäpe, P., Nørregaard, A., Arvas, M., Ram, A. F. J., Meyer, V., Tsang, A., de Vries, R. P. & Andersen, M. R., 2018, In : Fungal Biology and Biotechnology. 5, 16 p., 16.

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A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

Frisvad, J. C., 2018, In : World Mycotoxin Journal. 11, 1, p. 73-100

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An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-specific Transcriptomic Signatures

Singh, A., Kildegaard, H. F. & Andersen, M. R., 2018, In : Biotechnology Journal. 13, 10, 11 p., 1800070.

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