Section for Protein Science and Biotherapeutics

  • Søltofts Plads, Bygning 221

    DK-2800 Kgs. Lyngby

    Denmark

Research Output

2020

[99mTc]-labelled interleukin-8 as a diagnostic tool compared to [18F]FDG and CT in an experimental porcine osteomyelitis model

Afzelius, P., Heegaard, P. M. H., Jensen, S. B., Alstrup, A. K. O., Schønheyder, H. C., Eek, A., Boerman, O. & Nielsen, O. L., 2020, In : American Journal of Nuclear Medicine and Molecular Imaging. 10, 1, p. 32-46 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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11 Downloads (Pure)

A Fragment of Collagen Type VI alpha-3 chain is Elevated in Serum from Patients with Gastrointestinal Disorders

Nielsen, S. H., Mortensen, J. H., Willumsen, N., Rasmussen, D. G. K., Mogensen, D. J., Di Sabatino, A., Mazza, G., Jørgensen, L. N., Giuffrida, P., Pinzani, M., Klinge, L., Kjeldsen, J., Leeming, D. J., Karsdal, M. A. & Genovese, F., 2020, In : Scientific Reports. 10, 1, 8 p., 5910.

Research output: Contribution to journalJournal articleResearchpeer-review

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An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity

Krause, K. E., Jenkins, T. P., Skaarup, C., Engmark, M., Casewell, N. R., Ainsworth, S., Lomonte, B., Fernández, J., Gutiérrez, J. M., Lund, O. & Laustsen, A. H., 2020, In : PLOS Neglected Tropical Diseases . 14, 6, 20 p., e0008366.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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17 Downloads (Pure)

An in vitro methodology for discovering broadly-neutralizing monoclonal antibodies

Ahmadi, S., Pucca, M. B., Jürgensen, J. A., Janke, R., Ledsgaard, L., Schoof, E. M., Sørensen, C. V., Çalışkan, F. & Laustsen, A. H., 2020, In : Scientific Reports. 10, 1, 7 p., 10765.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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15 Downloads (Pure)

Assessment of fecal DNA extraction protocols for metagenomic studies

Yang, F., Sun, J., Luo, H., Ren, H., Zhou, H., Lin, Y., Han, M., Chen, B., Liao, H., Brix, S., Li, J., Yang, H., Kristiansen, K. & Zhong, H., 2020, In : GigaScience. 9, 7, 12 p., giaa071.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Body fluid from the parasitic worm Ascaris suum inhibits broad-acting pro-inflammatory programs in dendritic cells

Arora, P., Moll, J. M., Andersen, D., Workman, C. T., Williams, A. R., Kristiansen, K. & Brix, S., 2020, In : Immunology. 159, 3, p. 322-334 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways

Pichler, M. J., Yamada, C., Shuoker, B., Alvarez-Silva, C., Gotoh, A., Leth, M. L., Schoof, E., Katoh, T., Sakanaka, M., Katayama, T., Jin, C., Karlsson, N. G., Arumugam, M., Fushinobu, S. & Abou Hachem, M., 2020, In : Nature Communications. 11, 1, 15 p., 3285.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Causes and Consequences of Snake Venom Variation

Casewell, N. R., Jackson, T. N. W., Laustsen, A. H. & Sunagar, K., 2020, In : Trends in Pharmacological Sciences. 41, 8, p. 570-581 12 p.

Research output: Contribution to journalReviewResearchpeer-review

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Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis

Chevallier, V., Schoof, E. M., Malphettes, L., Andersen, M. R. & Workman, C. T., 2020, (Accepted/In press) In : Biotechnology and Bioengineering.

Research output: Contribution to journalJournal articleResearchpeer-review

Cheaters shape the evolution of phenotypic heterogeneity in Bacillus subtilis biofilms

Martin, M., Dragoš, A., Otto, S. B., Schäfer, D., Brix, S., Maróti, G. & Kovács, Á. T., 2020, (Accepted/In press) In : ISME Journal. 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

CHRONIC SKIN ULCERS - A STUDY OF THE GLOBAL TISSUE PROTEOME AND PROTEASE CLEAVAGE PRODUCTS

Bundgaard, L., Aagren, M. S., Holstein, P., Sabino, F. & auf dem Keller, U., 2020, In : Wound Repair and Regeneration. 28, 2, p. A18-A19 2 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Combinatorial degradomics: Precision tools to unveil proteolytic processes in biological systems

Savickas, S., Kastl, P. & auf dem Keller, U., 2020, In : B B A - Proteins and Proteomics. 1868, 6, 8 p., 140392.

Research output: Contribution to journalJournal articleResearchpeer-review

Development of a high-throughput real-time PCR system for detection of enzootic pathogens in pigs

Goecke, N. B., Hjulsager, C. K., Krog, J. S., Skovgaard, K. & Larsen, L. E., 2020, In : Journal of Veterinary Diagnostic Investigation. 32, 1, p. 51-64

Research output: Contribution to journalJournal articleResearchpeer-review

Distinct immune phenotypes in infants developing asthma during childhood

Thysen, A. H., Waage, J., Larsen, J. M., Rasmussen, M. A., Stokholm, J., Chawes, B., Fink, N. R., Pedersen, T. M., Wolsk, H., Thorsteinsdottir, S., Litman, T., Renz, H., Bønnelykke, K., Bisgaard, H. & Brix, S., 2020, In : Science Translational Medicine. 12, 529, 12 p., eaaw0258.

Research output: Contribution to journalJournal articleResearchpeer-review

Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms?

Sørensen, C. V., Knudsen, C., auf dem Keller, U., Kalogeropoulos, K., Gutiérrez-Jiménez, C., Pucca, M. B., Arantes, E. C., Bordon, K. C. F. & Laustsen, A. H., 2020, In : Toxins. 12, 4, 6 p., 240.

Research output: Contribution to journalJournal articleCommunication

Open Access
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Early life bacterial airway colonization, local immune mediator response and risk of otitis media

Christensen, E. D., Thorsen, J., Stokholm, J., Pedersen, T. M., Brix, S., Krogfelt, K. A., Schjørring, S., Chawes, B., Bønnelykke, K., Bisgaard, H. & Rasmussen, M. A., 2020, (Accepted/In press) In : Journal of Medical Microbiology. 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Editorial: Novel Immunotherapies Against Envenomings by Snakes and Other Venomous Animals

Laustsen, A. H., Ainsworth, S., Lomonte, B., Kini, R. M. & Chavez-Olortegui, C., 2020, In : Frontiers in Immunology. 11, 2 p., 1004.

Research output: Contribution to journalEditorialResearchpeer-review

Open Access
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ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control

Yip, M. C. J., Savickas, S., Gygi, S. P. & Shao, S., 2020, In : Cell Reports. 30, 7, p. 2106-2114.e5 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

Holm Nielsen, S., Jonasson, L., Kalogeropoulos, K., Karsdal, M. A., Reese-Petersen, A. L., auf dem Keller, U., Genovese, F., Nilsson, J. & Goncalves, I., 2020, In : Journal of Internal Medicine. 287, 5, p. 493-513 21 p.

Research output: Contribution to journalReviewResearchpeer-review

Fermentable Dietary Fiber Promotes Helminth Infection and Exacerbates Host Inflammatory Responses

Myhill, L. J., Stolzenbach, S., Mejer, H., Jakobsen, S. R., Hansen, T. V. A., Andersen, D., Brix, S., Hansen, L. H., Krych, L., Nielsen, D. S., Nejsum, P., Thamsborg, S. M. & Williams, A. R., 2020, In : Journal of Immunology. 204, 11, p. 3042-3055 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Identification of cross-reactive human single-chain variable fragments against phospholipases A2 from Lachesis muta and Bothrops spp venoms

Campos, L. B., Pucca, M. B., Silva, L. C., Pessenda, G., Filardi, B. A., Cerni, F. A., Oliveira, I. S., Laustsen, A. H., Arantes, E. C. & Barbosa, J. E., 2020, In : Toxicon. 184, p. 116-121

Research output: Contribution to journalJournal articleResearchpeer-review

Matrix Metalloproteinases: How Much Can They Do?

Ågren, M. S. & auf dem Keller, U., 2020, In : International Journal of Molecular Sciences . 21, 8, 9 p., 2678.

Research output: Contribution to journalEditorialResearchpeer-review

Open Access
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Metagenome-wide association of gut microbiome features for schizophrenia

Zhu, F., Ju, Y., Wang, W., Wang, Q., Guo, R., Ma, Q., Sun, Q., Fan, Y., Xie, Y., Yang, Z., Jie, Z., Zhao, B., Xiao, L., Yang, L., Zhang, T., Feng, J., Guo, L., He, X., Chen, Y., Chen, C. & 10 others, Gao, C., Xu, X., Yang, H., Wang, J., Dang, Y., Madsen, L., Brix, S., Kristiansen, K., Jia, H. & Ma, X., 2020, In : Nature Communications. 11, 1, 10 p., 1612.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Optimising the sampling procedure for forensic investigation of bruises on pigs

Barington, K., Skovgaard, K., Henriksen, N. L. & Jensen, H. E., 2020, (Accepted/In press) In : Veterinary Record. 105625.

Research output: Contribution to journalJournal articleResearchpeer-review

Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

Hjelmsø, M. H., Shah, S. A., Thorsen, J., Rasmussen, M., Vestergaard, G., Mortensen, M. S., Brejnrod, A., Brix, S., Chawes, B., Bønnelykke, K., Sørensen, S. J., Stokholm, J. & Bisgaard, H., 2020, In : Nature Communications. 11, 1, 10 p., 426.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Scorpion Venom: Detriments and Benefits

Ahmadi, S., Knerr, J. M., Argemi, L., Bordon, K. C. F., Pucca, M. B., Cerni, F. A., Arantes, E. C., Çalışkan, F. & Laustsen, A. H., 2020, In : Biomedicines. 8, 5, 34 p., 118.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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Season of Birth Impacts the Neonatal Nasopharyngeal Microbiota

Schoos, A-M. M., Kragh, M., Ahrens, P., Kuhn, K. G., Rasmussen, M. A., Chawes, B. L., Jensen, J. S., Brix, S., Bisgaard, H. & Stokholm, J., 2020, In : Children. 7, 5, 15 p., 45.

Research output: Contribution to journalJournal articleResearchpeer-review

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SERINE PROTEASE HTRA1-A REGULATOR OF STRESS RESPONSE AND CELL SURVIVAL IN WOUND FIBROBLASTS?

Sabino, F., Madzharova, E. & auf dem Keller, U., 2020, In : Wound Repair and Regeneration. 28, 2, p. A21-A21 1 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Tendon response to matrix unloading is determined by the patho-physiological niche

Wunderli, S. L., Blache, U., Beretta Piccoli, A., Niederöst, B., Holenstein, C. N., Passini, F. S., Silván, U., Bundgaard, L., auf dem Keller, U. & Snedeker, J. G., 2020, In : Matrix Biology. 89, p. 11-26 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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The host response to bacterial bone infection involves a local upregulation of several acute phase proteins

Lüthje, F. L., Blirup-Plum, S. A., Møller, N. S., Heegaard, P. M. H., Jensen, H. E., Kirketerp-Møller, K., Gottlieb, H., Skovgaard, K. & Jensen, L. K., 2020, In : Immunobiology. 225, 3, 10 p., 151914.

Research output: Contribution to journalJournal articleResearchpeer-review

The inflammatory response to bone infection A review based on animal models and human patients

Lüthje, F. L., Jensen, L. K., Elvang Jensen, H. & Skovgaard, K., 2020, In : APMIS. 128, 4, p. 275-286 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Unity Makes Strength: Exploring Intraspecies and Interspecies Toxin Synergism between Phospholipases A2 and Cytotoxins

Pucca, M. B., Ahmadi, S., Cerni, F. A., Ledsgaard, L., Sørensen, C. V., McGeoghan, F. T. S., Stewart, T., Schoof, E., Lomonte, B., auf dem Keller, U., Arantes, E. C., Çalışkan, F. & Laustsen, A. H., 2020, In : Frontiers in Pharmacology. 11, 10 p., 611.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2019

A biomarker of collagen type I degradation is associated with cardiovascular events and mortality in patients with atherosclerosis

Nielsen, S. H., Tengryd, C., Edsfeldt, A., Brix, S., Genovese, F., Bengtsson, E., Karsdal, M., Leeming, D. J., Nilsson, J. & Goncalves, I., 2019, In : Journal of Internal Medicine. 285, 1, p. 118-123 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

A human touch to snakebite antivenoms

Laustsen, A. H., 2019, In : Toxicon. 158, Suppl. 1, p. S16-S16 1 p., 52.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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AU Content in the MicroRNA Sequence Influences its Stability After Heat Treatment

López, A. G., Brogaard, L., Heegaard, P. M. H., Cirera, S. & Skovgaard, K., 2019, In : MicroRNA. 8, 3, p. 216-222 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Bee Updated: Current Knowledge on Bee Venom and Bee Envenoming Therapy

Pucca, M. B., Cerni, F. A., Oliveira, I. S., Jenkins, T. P., Argemí, L., Sørensen, C. V., Ahmadi, S., Barbosa, J. E. & Laustsen, A. H., 2019, In : Frontiers in Immunology. 10, 15 p., 2090.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs

Obelitz-Ryom, K., Bering, S. B., Overgaard, S. H., Eskildsen, S. F., Ringgaard, S., Olesen, J. L., Skovgaard, K., Pankratova, S., Wang, B., Brunse, A., Heckmann, A. B., Rydal, M. P., Sangild, P. T. & Thymann, T., 2019, In : Nutrients. 11, 6, 20 p., 1335.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Bronchoalveolar lavage fluid cytokine, cytology and IgE allergen in horses with equine asthma

Hansen, S., Otten, N. D., Birch, K., Skovgaard, K., Hopster-Iversen, C. & Fjeldborg, J., 2019, In : Veterinary Immunology and Immunopathology. 220, 6 p., 109976.

Research output: Contribution to journalJournal articleResearchpeer-review

Cocktails of human monoclonal IgG antibodies capable of neutralizing dendrotoxin-mediated neurotoxicity of black mamba venom in vivo

Laustsen, A. H., Karatt-Vellatt, A., Masters, E. W., Arias, A. S., Pus, U., Knudsen, C., Oscoz, S., Slavny, P., Griffiths, D. T., Luther, A. M., Leah, R. A., Lindholm, M., Lomonte, B., Mar a Guti rrez, J. & McCafferty, J., 2019, In : Toxicon. 159, Supp. 1, p. S5-S6

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Collagen turnover profiles in chronic kidney disease

Rasmussen, D. G. K., Boesby, L., Nielsen, S. H., Tepel, M., Birot, S., Karsdal, M. A., Kamper, A. L. & Genovese, F., 2019, In : Scientific Reports. 9, 1, 11 p., 16062.

Research output: Contribution to journalJournal articleResearchpeer-review

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Connecting comorbidities with brain-gut-microbiome-stress axis biology in autism spectrum disorder

Yap, C., Wray, N., Brix, S. & Gratten, J., 2019, In : EUROPEAN NEUROPSYCHOPHARMACOLOGY. 29, p. S227-S228 2 p., T16.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Deregulated Immune Response in Early Life and The Development of Asthma

Wang, N., 2019, Technical University of Denmark. 110 p.

Research output: Book/ReportPh.D. thesisResearch

Open Access
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Design of scfab-based chimeric antibodies against Bothrops asper pi-metalloproteinase

Friis, R. U. W., Dam, S. H., Haack, A. M., Hallgren, M. B., Esteban, A. M., Andersen, M. R., Kilstrup, M. & Laustsen, A. H., 2019, In : Toxicon. 158, p. S41-S41

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Discovery and evaluation of monoclonal antibodies for stratification of venoms from brazilian Bothrops, Crotalus, and Lachesis species

Knudsen, C., Dam, S. H., Friis, R. U. W., Haack, A. M., Andersen, J. K. & Laustsen, A. H., 2019, In : Toxicon. 177, p. S38-S38 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Discovery of cross-reactive and recyclable human monoclonal antibodies for new recombinant antivenoms

Ledsgaard, L., Ahmadi, S., Pucca, M. B., Cerni, F. A., Jürgensen, J. A., Knudsen, C., Pus, U., Sørensen, C. V., Føns, S., Janke, R., Knerr, J., Bertelsen, A. B., Dehli, R. I., Esteban, A. M., Karatt-Vellatt, A., McCafferty, J., Lomonte, B., Arantes, E. C. & Laustsen, A. H., 2019, In : Toxicon. 177, p. S38-S38 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Discovery of human antibodies against forest cobra toxins

Jensen, L. L., Øhlenschlæger, M., Karatt-­Vellatt, A., Andersen, M. R., Harrison, R., Casewell, N., McCafferty, J. & Laustsen, A. H., 2019, In : Toxicon. 158, Suppl. 1, p. S51-S52 2 p., 170.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics

Zhong, H., Ren, H., Lu, Y., Fang, C., Hou, G., Yang, Z., Chen, B., Yang, F., Zhao, Y., Shi, Z., Zhou, B., Wu, J., Zou, H., Zi, J., Chen, J., Bao, X., Hu, Y., Gao, Y., Zhang, J., Xu, X. & 10 others, Hou, Y., Yang, H., Wang, J., Liu, S., Jia, H., Madsen, L., Brix, S., Kristiansen, K., Liu, F. & Li, J., 2019, In : EBioMedicine. 47, p. 373-383 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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Engineering and design considerations for next-generation snakebite antivenoms

Knudsen, C., Ledsgaard, L., Dehli, R. I., Ahmadi, S., Sørensen, C. V. & Laustsen, A. H., 2019, In : Toxicon. 167, p. 67-75 9 p.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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Exploring extracellular matrix degradomes by TMT-TAILS N-terminomics

Madzharova, E., Sabino, F. & auf dem Keller, U., 2019, Collagen. Sagi, I. & Afratis, N. A. (eds.). Humana Press, p. 115-126 12 p. (Methods in Molecular Biology, Vol. 1944).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Factors affecting the intensity of the inflammatory response in experimental porcine bruises

Barington, K., Skovgaard, K., Henriksen, N. L., Johansen, A. S. B. & Jensen, H. E., 2019, In : Journal of Comparative Pathology. 166, p. 117-117 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review