Research group for Molecular and Reproductive Toxicology

  • Kemitorvet, Bygning 202

    DK-2800 Kgs Lyngby

    Denmark

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2020

Bisphenols B, E, F, and S and 4‐cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A

Ramskov Tetzlaff, C. N., Svingen, T., Vinggaard, A. M., Rosenmai, A. K. & Taxvig, C., 2020, In : Environmental Toxicology. 35, 5, p. 543-552

Research output: Contribution to journalJournal articleResearchpeer-review

Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat

Johansson, H. K. L., Svingen, T., Boberg, J., Fowler, P. A., Stead, D., Vinggaard, A. M. & Filis, P., 2020, (Accepted/In press) In : Archives of Toxicology.

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Developmental biology meets toxicology: contributing reproductive mechanisms to build Adverse Outcome Pathways

Kam Draskau, M., Spiller, C. M., Boberg, J., Bowles, J. & Svingen, T., 2020, In : Molecular Human Reproduction. 26, 2, p. 111–116

Research output: Contribution to journalJournal articleResearchpeer-review

Evaluating thyroid hormone disruption: investigations of long-term neurodevelopmental effects in rats after perinatal exposure to perfluorohexane sulfonate (PFHxS)

Ramhøj, L., Hass, U., Gilbert, M. E., Wood, C., Svingen, T., Usai, D., Vinggaard, A. M., Mandrup, K. & Axelstad Petersen, M., 2020, In : Scientific Reports. 10, 1, 16 p., 2672.

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Intrauterine exposure to diethylhexyl phthalate disrupts gap junctions in the fetal rat testis

Di Lorenzo, M., Winge, S. B., Svingen, T., De Falco, M. & Boberg, J., 2020, In : Current Research in Toxicology. 1, p. 5-11

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Migration studies and toxicity evaluation of cyclic polyesters oligomers from food packaging adhesives

Ubeda, S., Aznar, M., Rosenmai, A. K., Vinggaard, A. M. & Nerín, C., 2020, In : Food Chemistry. 311, 10 p., 125918.

Research output: Contribution to journalJournal articleResearchpeer-review

QSAR modeling of different minimum potency levels for in vitro human CAR activation and inhibition and screening of 80,086 REACH and 54,971 U.S. substances

Chinen, K. K., Klimenko, K., Taxvig, C., Nikolov, N. G. & Wedebye, E. B., 2020, In : Computational Toxicology. 14, 14 p., 100121.

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Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project

Kortenkamp, A., Axelstad Petersen, M., Baig, A. H., Bergman, Å., Bornehag, C-G., Cenijn, P., Christiansen, S., Demeneix, B., Derakhshan, A., Fini, J-B., Frädrich, C., Hamers, T., Hellwig, L., Köhrle, J., Korevaar, T. I. M., Lindberg, J., Martin, O., Meima, M. E., Mergenthaler, P., Georgiev Nikolov, N. & 12 others, Du Pasquier, D., Peeters, R. P., Platzack, B., Ramhøj, L., Remaud, S., Renko, K., Scholze, M., Stachelscheid, H., Svingen, T., Wagenaars, F., Wedebye, E. B. & Zoeller, R. T., 2020, In : International Journal of Molecular Sciences . 21, 9, 13 p., 3123.

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Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals-The FREIA Project

Duursen, M. B. M. V., Boberg, J., Christiansen, S., Connolly, L., Damdimopoulou, P., Filis, P., Fowler, P. A., Gadella, B. M., Holte, J., Jääger, K., Johansson, H. K. L., Li, T., Mazaud-Guittot, S., Parent, A-S., Salumets, A., Soto, A. M., Svingen, T., Velthut-Meikas, A., Wedebye, E. B., Xie, Y. & 1 others, Berg, M. V. D., 2020, In : International Journal of Molecular Sciences . 21, 9, 13 p., 3215.

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The impact of dietary habits on contaminant exposures

Petersen, A., Jensen, B. H., Löbl, N. M., Nielsen, E. E., Bredsdorff, L., Fagt, S., Christensen, T. & Boberg, J., 2020, In : Food and Chemical Toxicology. 135, 8 p., 110885.

Research output: Contribution to journalJournal articleResearchpeer-review

2019

A pragmatic approach for human risk assessment of chemical mixtures

Boberg, J., Dybdahl, M., Petersen, A., Hass, U., Svingen, T. & Vinggaard, A. M., 2019, In : Current Opinion in Toxicology. 15, p. 1-7

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Chemical risk assessment based on in vitro and human biomonitoring data: A case study on thyroid toxicants

Johansson, H. K. L., Boberg, J., Dybdahl, M., Axelstad, M. & Vinggaard, A. M., 2019, In : Current Opinion in Toxicology. 15, p. 8-17

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Distinct transcriptional profiles of the female, male and finasteride-induced feminized male anogenital region in rat fetuses

Lindgren Schwartz, C. V., Vinggaard, A. M., Christiansen, S., Darde, T. A., Chalmel, F. & Svingen, T., 2019, In : Toxicological Sciences. 169, 1, p. 303-311

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DTU Fødevareinstituttet i front for at forebygge sygdomme

Kornholt, H., Svingen, T., Aarestrup, F. M. & Poulsen, M., 2019, In : Miljø og sundhed. 25, 2, p. 13-17

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QSAR modelling of a large imbalanced aryl hydrocarbon activation dataset by rational and random sampling and screening of 80,086 REACH pre-registered and/or registered substances

Klimenko, K. O., Abildgaard Rosenberg, S., Dybdahl, M., Wedebye, E. B. & Nikolov, N. G., 2019, In : PLOS ONE. 14, 3, 21 p., e0213848.

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Validation of endogenous reference genes in rat cerebral cortex for RT-qPCR analyses in developmental toxicity studies

Ramhøj, L., Petersen, M. A. & Svingen, T., 2019, In : PeerJ. 7, 13 p., e7181.

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Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution

Burgdorf, T., Piersma, A. H., Landsiedel, R., Clewell, R., Kleinstreuer, N., Oelgeschläger, M., Desprez, B., Kienhuis, A., Bos, P., de Vries, R., de Wit, L., Seidle, T., Scheel, J., Schönfelder, G., van Benthem, J., Vinggaard, A. M., Eskes, C. & Ezendam, J., 2019, In : Toxicology in Vitro. 59, p. 1-11

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2018

A call for action: Improve reporting of research studies to increase the scientific basis for regulatory decision-making

Ågerstrand, M., Christiansen, S., Hanberg, A., Rudén, C., Andersson, L., Andersen, S., Appelgren, H., Bjørge, C., Clausen, I. H., Eide, D. M., Hartmann, N. B., Husøy, T., Halldórsson, H. P., van der Hagen, M., Ingre-Khans, E., Lillicrap, A. D., Beltoft, V. M., Mörk, A-K., Murtomaa-Hautala, M., Nielsen, E. E. & 8 others, Ólafsdóttir, K., Palomäki, J., Papponen, H., Reiler, E. M., Stockmann-Juvala, H., Suutari, T., Tyle, H. & Beronius, A., 2018, In : Journal of Applied Toxicology. 38, 5, p. 783-785

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Cellekulturer danner blod-hjerne-barrieren i laboratoriet

Lauschke, K. & Schwartz, C. V. L., 2018, In : BestPractice Neurologi. Juli

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

DNA damage in mouse organs and in human sperm cells by bisphenol A

Sharma, A. K., Boberg, J. & Dybdahl, M., 2018, In : Toxicological and Environmental Chemistry. 100, 4, p. 465-478 14 p.

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EDC IMPACT: Reduced sperm counts in rats exposed to human relevant mixtures of endocrine disrupters

Axelstad Petersen, M., Hass, U., Scholze, M., Christiansen, S., Kortenkamp, A. & Boberg, J., 2018, In : Endocrine Connections. 7, 1, p. 139-148 10 p.

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Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides

Svingen, T., Ramhøj, L., Egebjerg, K. M., Christiansen, S., Petersen, M. A., Vinggaard, A. M. & Hass, U., 2018, In : Scientific Reports. 8, 10 p., 305.

Research output: Contribution to journalJournal articleResearchpeer-review

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Erratum to: The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study

Hecker, M., Hollert, H., Cooper, R., Vinggaard, A. M., Akahori, Y., Murphy, M., Nellemann, C., Higley, E., Newsted, J., Laskey, J., Buckalew, A., Grund, S., Maletz, S., Giesy, J. & Timm, G., 2018, In : Environmental Science and Pollution Research. 25, 15, p. 15265–15267

Research output: Contribution to journalJournal articleCommunication

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Hvorfor drenge bliver til drenge og piger bliver til piger samt hvordan kemikalier kan forstyrre den udvikling

Svingen, T., 2018, In : Miljø og sundhed. 24, 3, p. 31-32

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Low-dose exposure to Bisphenol A during development has limited effects on male reproduction in midpubertal and aging Fischer 344 rats

Spörndly-Nees, E., Boberg, J., Ekstedt, E., Holm, L., Fakhrzadeh, A., Dunder, L., Kushnir, M. M., Lejonklou, M. H. & Lind, P. M., 2018, In : Reproductive Toxicology. 81, p. 196-206

Research output: Contribution to journalJournal articleResearchpeer-review

Mere tid til forskning på den naturvidenskabelige ph.d.-uddannelse

Rasmussen, P. H. & Svingen, T., 2018, In : Dansk Kemi. 99, 3, p. 4-4

Research output: Contribution to journalJournal articleCommunication

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Perfluorohexane Sulfonate (PFHxS) and a Mixture of Endocrine Disrupters Reduce Thyroxine Levels and Cause Anti-Androgenic Effects in Rats

Ramhøj, L., Hass, U., Boberg, J., Scholze, M., Christiansen, S., Nielsen, F. & Axelstad Petersen, M., 2018, In : Toxicological Sciences. 163, 2, p. 579-591

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Transcriptomic analysis of mRNA expression and alternative splicing during mouse sex determination

Zhao, L., Wang, C., Lehman, M. L., He, M., An, J., Svingen, T., Spiller, C. M., Ng, E. T., Nelson, C. C. & Koopman, P., 2018, In : Molecular and Cellular Endocrinology. 478, p. 84-96

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Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies

Piersma, A. H., Burgdorf, T., Louekari, K., Desprez, B., Taalman, R., Landsiedel, R., Barroso, J., Rogiers, V., Eskes, C., Oelgeschläger, M., Whelan, M., Braeuning, A., Vinggaard, A. M., Kienhuis, A., van Benthem, J. & Ezendam, J., 1 Aug 2018, In : Toxicology in Vitro. 50, p. 62-74

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2017

Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice

Johansson, H. K. L., Hansen, J. S., Elfving, B., Lund, S. P., Kyjovska, Z. O., Loft, S., Barfod, K. K., Jackson, P., Vogel, U. B. & Hougaard, K. S., 2017, In : Particle and Fibre Toxicology. 14, 1, 13 p., 17.

Research output: Contribution to journalJournal articleResearchpeer-review

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An effect-directed strategy for characterizing emerging chemicals in food contact materials made from paper and board

Rosenmai, A. K., Bengtström, L., Taxvig, C., Trier, X., Petersen, J. H., Svingen, T., Binderup, M-L., van Vugt-Lussenburg, B. M. A., Dybdahl, M., Granby, K. & Vinggaard, A. M., 2017, In : Food and Chemical Toxicology. 106, Part A, p. 250-259

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Combined exposure to low doses of pesticides causes decreased birth weights in rats

Hass, U., Christiansen, S., Petersen, M. A., Scholze, M. & Boberg, J., 2017, In : Reproductive Toxicology. 72, p. 97-105 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Enniatin B and beauvericin are common in Danish cereals and show high hepatotoxicity on a high-content imaging platform

Svingen, T., Hansen, N. L., Taxvig, C., Vinggaard, A. M., Jensen, U. & Rasmussen, P. H., 2017, In : Environmental Toxicology. 32, 5, p. 1658–1664

Research output: Contribution to journalJournal articleResearchpeer-review

Environmental influences on ovarian dysgenesis - developmental windows sensitive to chemical exposures

Johansson, H. K. L., Svingen, T., Fowler, P. A., Vinggaard, A. M. & Boberg, J., 2017, In : Nature Reviews. Endocrinology. 13, p. 400-414

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Open Access

Mellemkødet sladrer om skadelige kemikalier

Vinggaard, A. M., Svingen, T., Schwartz, C. V. L. & Kjær, C. R., 2017, In : Aktuel Naturvidenskab. 3, p. 12-17

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QSAR development and profiling of 72,524 REACH substances for PXR activation and CYP3A4 induction

Abildgaard Rosenberg, S., Xia, M., Huang, R., Nikolov, N. G., Wedebye, E. B. & Dybdahl, M., 2017, In : Computational Toxicology. 1, p. 39-48 10 p.

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QSAR Models for Thyroperoxidase Inhibition and Screening of U.S. and EU Chemical Inventories

Abildgaard Rosenberg, S., D. Watt, E., Judson, R. S., Simmons, S. O., Paul Friedmann, K., Dybdahl, M., Nikolov, N. G. & Wedebye, E. B., 2017, In : Computational Toxicology. 4, p. 11-21

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Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement

Solecki, R., Kortenkamp, A., Bergman, Å., Chahoud, I., Degen, G. H., Dietrich, D., Greim, H., Håkansson, H., Hass, U., Husoy, T., Jacobs, M., Jobling, S., Mantovani, A., Marx-Stoelting, P., Piersma, A., Ritz, V., Slama, R., Stahlmann, R., van den Berg, M., Zoeller, R. T. & 1 others, Boobis, A. R., 2017, In : Archives of Toxicology. 91, 2, p. 1001-1006 6 p.

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The flame retardant DE-71 (a mixture of polybrominated diphenyl ethers) inhibits human differentiated thyroid cell function in vitro

Kronborg, T. M., Hansen, J. F., Rasmussen, Å. K., Vorkamp, K., Nielsen, C. H., Frederiksen, M., Hofman-Bang, J., Hahn, C. H., Ramhøj, L. & Feldt-Rasmussen, U., 2017, In : P L o S One. 12, 6, 18 p., e0179858.

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2016

A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals

Vandenberg, L. N., Agerstrand, M., Beronius, A., Beausoleil, C., Bergman, A., Bero, L. A., Bornehag, C-G., Boyer, C. S., Cooper, G. S., Cotgreave, I., Gee, D., Grandjean, P., Guyton, K. Z., Hass, U., Heindel, J. J., Jobling, S., Kidd, K. A., Kortenkamp, A., Macleod, M. R., Martin, O. V. & 7 others, Norinder, U., Scheringer, M., Thayer, K. A., Toppari, J., Whaley, P., Woodruff, T. J. & Ruden, C., 2016, In : Environmental Health: A Global Access Science Source. 15, 1, 19 p., 74.

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Burden of disease and costs of exposure to endocrine disrupting chemicals in the European Union: an updated analysis

Trasande, L., Zoeller, R. T., Hass, U., Kortenkamp, A., Grandjean, P., Myers, J. P., DiGangi, J., Hunt, P. M., Rudel, R., Sathyanarayana, S., Bellanger, M., Hauser, R., Legler, J., Skakkebaek, N. E. & Heindel, J. J., 2016, In : International Journal of Andrology. 4, 4, p. 565-572 8 p.

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CERAPP: Collaborative estrogen receptor activity prediction project

Mansouri, K., Abdelaziz, A., Rybacka, A., Roncaglioni, A., Tropsha, A., Varnek, A., Zakharov, A., Worth, A., Richard, A. M., Grulke, C. M., Trisciuzzi, D., Fourches, D., Horvath, D., Benfenati, E., Muratov, E., Wedebye, E. B., Grisoni, F., Mangiatordi, G. F., Incisivo, G. M., Hong, H. & 21 others, Ng, H. W., Tetko, I. V., Balabin, I., Kancherla, J., Shen, J., Burton, J., Nicklaus, M., Cassotti, M., Nikolov, N. G., Nicolotti, O., Andersson, P. L., Zang, Q., Politi, R., Beger, R. D., Todeschini, R., Huang, R., Farag, S., Abildgaard Rosenberg, S., Slavov, S., Hu, X. & Judson, R. S., 2016, In : Environmental Health Perspectives. 124, 7, p. 1023-1033 11 p.

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Corrigendum to “Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats” [Reprod. Toxicol. 31 (2) (2011) 200–209]

Boberg, J., Christiansen, S., Petersen, M. A., Kledal, T. S., Vinggaard, A. M., Dalgaard, M., Nellemann, C. & Hass, U., 2016, In : Reproductive Toxicology. 63, p. 183-184 2 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Effects of the Commercial Flame Retardant Mixture DE-71 on Cytokine Production by Human Immune Cells

Mynster Kronborg, T., Frohnert Hansen, J., Nielsen, C. H., Ramhøj, L., Frederiksen, M., Vorkamp, K., Feldt-Rasmussen, U. & Tansey, M. G. (ed.), 2016, In : P L o S One. 11, 4, p. 13 e0154621.

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Fluorinated alkyl substances and technical mixtures used in food paper-packaging exhibit endocrine-related activity in vitro

Rosenmai, A. K., Taxvig, C., Svingen, T., Trier, X., Alice van Vugt-Lussenburg, B. M., Pedersen, M., Lesne, B. & Vinggaard, A. M., 2016, In : Andrology. 4, 4, p. 662-672 11 p.

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Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility

Holm, J. B., Mazaud-Guittot, S., Danneskiold-Samsøe, N. B., Chalmey, C., Jensen, B., Nørregård, M. M., Hansen, C. H., Styrishave, B., Svingen, T., Vinggaard, A. M., Koch, H. M., Bowles, J., Koopman, P., Jåégou, B., Kristiansen, K. & Kristensen, D. M., 2016, In : Toxicological Sciences. 150, 1, p. 178-189 12 p.

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Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects

Hadrup, N., Svingen, T., Egebjerg, K. M., Skov, K., Pedersen, M., Frederiksen, H., Frandsen, H. L. & Vinggaard, A. M., 2016, In : P L o S One. 11, 9, 22 p., e0162027.

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