Research group for Molecular and Reproductive Toxicology

  • Kemitorvet, Bygning 202

    DK-2800 Kgs Lyngby

    Denmark

Research Output

2020

Bisphenols B, E, F, and S and 4‐cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A

Ramskov Tetzlaff, C. N., Svingen, T., Vinggaard, A. M., Rosenmai, A. K. & Taxvig, C., 2020, In : Environmental Toxicology. 35, 5, p. 543-552

Research output: Contribution to journalJournal articleResearchpeer-review

Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat

Johansson, H. K. L., Svingen, T., Boberg, J., Fowler, P. A., Stead, D., Vinggaard, A. M. & Filis, P., 2020, In : Archives of Toxicology. 94, p. 1241–1250

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Developmental biology meets toxicology: contributing reproductive mechanisms to build Adverse Outcome Pathways

Kam Draskau, M., Spiller, C. M., Boberg, J., Bowles, J. & Svingen, T., 2020, In : Molecular Human Reproduction. 26, 2, p. 111–116

Research output: Contribution to journalJournal articleResearchpeer-review

Evaluating thyroid hormone disruption: investigations of long-term neurodevelopmental effects in rats after perinatal exposure to perfluorohexane sulfonate (PFHxS)

Ramhøj, L., Hass, U., Gilbert, M. E., Wood, C., Svingen, T., Usai, D., Vinggaard, A. M., Mandrup, K. & Axelstad Petersen, M., 2020, In : Scientific Reports. 10, 1, 16 p., 2672.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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33 Downloads (Pure)

Genetic and functional insights into CDA-I prevalence and pathogenesis

Olijnik, A. A., Roy, N. B. A., Scott, C., Marsh, J. A., Brown, J., Lauschke, K., Ask, K., Roberts, N., Downes, D. J., Brolih, S., Johnson, E., Xella, B., Proven, M., Hipkiss, R., Ryan, K., Frisk, P., Mäkk, J., Stattin, E. L. M., Sadasivam, N., McIlwaine, L. & 9 others, Hill, Q. A., Renella, R., Hughes, J. R., Gibbons, R. J., Groth, A., McHugh, P. J., Higgs, D. R., Buckle, V. J. & Babbs, C., 2020, (Accepted/In press) In : Journal of Medical Genetics.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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4 Downloads (Pure)

Grouping of endocrine disrupting chemicals for mixture risk assessment - Evidence from a rat study

Christiansen, S., Axelstad, M. A., Scholze, M., Johansson, H. K. L., Hass, U., Mandrup, K. M., Frandsen, H. L., Frederiksen, H., Isling, L. K. & Boberg, J., 2020, In : Environment International. 142, 105870.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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6 Downloads (Pure)

Intrauterine exposure to diethylhexyl phthalate disrupts gap junctions in the fetal rat testis

Di Lorenzo, M., Winge, S. B., Svingen, T., De Falco, M. & Boberg, J., 2020, In : Current Research in Toxicology. 1, p. 5-11

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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23 Downloads (Pure)

Migration studies and toxicity evaluation of cyclic polyesters oligomers from food packaging adhesives

Ubeda, S., Aznar, M., Rosenmai, A. K., Vinggaard, A. M. & Nerín, C., 2020, In : Food Chemistry. 311, 10 p., 125918.

Research output: Contribution to journalJournal articleResearchpeer-review

MIraculiX - Strengthened risk assessment of chemicals

Vinggaard, A. M., Svingen, T., Boberg, J., Taxvig, C., Christiansen, S., Frandsen, H. L., Pedersen, M., Petersen, A., Bredsdorff, L., Nielsen, E. E., Jensen, B. H., Dybdahl, M., Christensen, T., Fagt, S., Plesning, B. M., Letting, H. B., Sztuk, L., El-Baroudy, U., Jørgensen, V., Lykkegaard Korsbech, D. & 12 others, Jessen, M. V., Ørngreen, A-M., Johansson, H. K. L., Schwartz, C. V. L., Löbl, N. M., Silva Melo, D., Kortenkamp, A., Scholze, M., Ermler, S., Chalmel, F., Fowler, P. & Nørby, E., 2020, Kgs. Lyngby: Technical University of Denmark. 42 p.

Research output: Book/ReportReportCommissioned

Open Access
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55 Downloads (Pure)

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

Johansson, H. K. L., Damdimopoulou, P., van Duursen, M. B. M., Boberg, J., Franssen, D., de Cock, M., Jääger, K., Wagner, M., Velthut-Meikas, A., Xie, Y., Connolly, L., Lelandais, P., Mazaud-Guittot, S., Salumets, A., Draskau, M. K., Filis, P., Fowler, P. A., Christiansen, S., Parent, A. S. & Svingen, T., 2020, (Accepted/In press) In : Archives of Toxicology. 21 p.

Research output: Contribution to journalReviewResearchpeer-review

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QSAR modeling of different minimum potency levels for in vitro human CAR activation and inhibition and screening of 80,086 REACH and 54,971 U.S. substances

Chinen, K. K., Klimenko, K., Taxvig, C., Nikolov, N. G. & Wedebye, E. B., 2020, In : Computational Toxicology. 14, 14 p., 100121.

Research output: Contribution to journalJournal articleResearchpeer-review

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Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project

Kortenkamp, A., Axelstad Petersen, M., Baig, A. H., Bergman, Å., Bornehag, C-G., Cenijn, P., Christiansen, S., Demeneix, B., Derakhshan, A., Fini, J-B., Frädrich, C., Hamers, T., Hellwig, L., Köhrle, J., Korevaar, T. I. M., Lindberg, J., Martin, O., Meima, M. E., Mergenthaler, P., Georgiev Nikolov, N. & 12 others, Du Pasquier, D., Peeters, R. P., Platzack, B., Ramhøj, L., Remaud, S., Renko, K., Scholze, M., Stachelscheid, H., Svingen, T., Wagenaars, F., Wedebye, E. B. & Zoeller, R. T., 2020, In : International Journal of Molecular Sciences . 21, 9, 13 p., 3123.

Research output: Contribution to journalJournal articleResearchpeer-review

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20 Downloads (Pure)

Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals-The FREIA Project

Duursen, M. B. M. V., Boberg, J., Christiansen, S., Connolly, L., Damdimopoulou, P., Filis, P., Fowler, P. A., Gadella, B. M., Holte, J., Jääger, K., Johansson, H. K. L., Li, T., Mazaud-Guittot, S., Parent, A-S., Salumets, A., Soto, A. M., Svingen, T., Velthut-Meikas, A., Wedebye, E. B., Xie, Y. & 1 others, Berg, M. V. D., 2020, In : International Journal of Molecular Sciences . 21, 9, 13 p., 3215.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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14 Downloads (Pure)

The impact of dietary habits on contaminant exposures

Petersen, A., Jensen, B. H., Löbl, N. M., Nielsen, E. E., Bredsdorff, L., Fagt, S., Christensen, T. & Boberg, J., 2020, In : Food and Chemical Toxicology. 135, 8 p., 110885.

Research output: Contribution to journalJournal articleResearchpeer-review

2019
417 Downloads (Pure)

A pragmatic approach for human risk assessment of chemical mixtures

Boberg, J., Dybdahl, M., Petersen, A., Hass, U., Svingen, T. & Vinggaard, A. M., 2019, In : Current Opinion in Toxicology. 15, p. 1-7

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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109 Downloads (Pure)

Chemical risk assessment based on in vitro and human biomonitoring data: A case study on thyroid toxicants

Johansson, H. K. L., Boberg, J., Dybdahl, M., Axelstad, M. & Vinggaard, A. M., 2019, In : Current Opinion in Toxicology. 15, p. 8-17

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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83 Downloads (Pure)

Development of a study protocol for thyroid disruptor testing in the mammalian system: Deliverable 16: final feasibility study report

Petersen, M. A., Ramhøj, L., Scholze, M., Martin, O., Köhrle, J. & Kortenkamp, A., 2019, Brussels: European Commission. 49 p.

Research output: Book/ReportReportCommissioned

Open Access

Diminished Serum T4 Concentrations Induced by PTU or Brominated Flame Retardants (DE-71) are Necessary But Not Sufficient for a Congenital Malformation of the Brain

Ramhøj, L., Kortenkamp, A., Scholze, M., Svingen, T., Köhrle, J. & Petersen, M. A., 2019. 2 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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20 Downloads (Pure)

Distinct transcriptional profiles of the female, male and finasteride-induced feminized male anogenital region in rat fetuses

Lindgren Schwartz, C. V., Vinggaard, A. M., Christiansen, S., Darde, T. A., Chalmel, F. & Svingen, T., 2019, In : Toxicological Sciences. 169, 1, p. 303-311

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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93 Downloads (Pure)

DTU Fødevareinstituttet i front for at forebygge sygdomme

Kornholt, H., Svingen, T., Aarestrup, F. M. & Poulsen, M., 2019, In : Miljø og sundhed. 25, 2, p. 13-17

Research output: Contribution to journalJournal articleResearch

Open Access
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120 Downloads (Pure)

Editorial overview: Risk assessment in toxicology

Vinggaard, A. M. & Judson, R. S., 2019, In : Current Opinion in Toxicology. 15, p. iii-vi

Research output: Contribution to journalEditorialResearchpeer-review

Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future

Louro, H., Heinälä, M., Bessems, J., Buekers, J., Vermeire, T., Woutersen, M., van Engelen, J., Borges, T., Rousselle, C., Ougier, E., Alvito, P., Martins, C., Assunção, R., Silva, M. J., Pronk, A., Schaddelee-Scholten, B., Del Carmen Gonzalez, M., de Alba, M., Castaño, A., Viegas, S. & 7 others, Humar-Juric, T., Kononenko, L., Lampen, A., Vinggaard, A. M., Schoeters, G., Kolossa-Gehring, M. & Santonen, T., 2019, In : International Journal of Hygiene and Environmental Health. 222, 5, p. 727-737

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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272 Downloads (Pure)

QSAR modelling of a large imbalanced aryl hydrocarbon activation dataset by rational and random sampling and screening of 80,086 REACH pre-registered and/or registered substances

Klimenko, K. O., Abildgaard Rosenberg, S., Dybdahl, M., Wedebye, E. B. & Nikolov, N. G., 2019, In : PLOS ONE. 14, 3, 21 p., e0213848.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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177 Downloads (Pure)

Quantitative in vitro to in vivo extrapolation (IVIVE) predict adverse male reproductive health disorders caused by pesticides

Taxvig, C., Scholze, M., Kortenkamp, A., Boberg, J., Svingen, T., Lauschke, K., Christiansen, S., Ermler, S., Hermann, S. S., Pedersen, M., Frandsen, H., Kruse Lykkeberg, A. & Vinggard, A. M., 2019, In : Toxicology Letters. 314, SI, p. S38-S38 #1005.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Validation of endogenous reference genes in rat cerebral cortex for RT-qPCR analyses in developmental toxicity studies

Ramhøj, L., Petersen, M. A. & Svingen, T., 2019, In : PeerJ. 7, 13 p., e7181.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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115 Downloads (Pure)

Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution

Burgdorf, T., Piersma, A. H., Landsiedel, R., Clewell, R., Kleinstreuer, N., Oelgeschläger, M., Desprez, B., Kienhuis, A., Bos, P., de Vries, R., de Wit, L., Seidle, T., Scheel, J., Schönfelder, G., van Benthem, J., Vinggaard, A. M., Eskes, C. & Ezendam, J., 2019, In : Toxicology in Vitro. 59, p. 1-11

Research output: Contribution to journalJournal articleResearchpeer-review

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2018

A call for action: Improve reporting of research studies to increase the scientific basis for regulatory decision-making

Ågerstrand, M., Christiansen, S., Hanberg, A., Rudén, C., Andersson, L., Andersen, S., Appelgren, H., Bjørge, C., Clausen, I. H., Eide, D. M., Hartmann, N. B., Husøy, T., Halldórsson, H. P., van der Hagen, M., Ingre-Khans, E., Lillicrap, A. D., Beltoft, V. M., Mörk, A-K., Murtomaa-Hautala, M., Nielsen, E. E. & 8 others, Ólafsdóttir, K., Palomäki, J., Papponen, H., Reiler, E. M., Stockmann-Juvala, H., Suutari, T., Tyle, H. & Beronius, A., 2018, In : Journal of Applied Toxicology. 38, 5, p. 783-785

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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227 Downloads (Pure)
74 Downloads (Pure)

Advisory self-classifications for 54,135 substances based on (Q)SAR predictions from the Danish (Q)SAR database, VEGA QSAR and the OECD QSAR Toolbox

Nikolov, N. G., Tyle, H., Løfstedt, M. & Wedebye, E. B., 2018. 2 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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38 Downloads (Pure)

Anmodning om kommentering på EFSAs kommende risikovurdering for dioxin

Boberg, J. & Cederberg, T. L., 2018, 4 p.. No. 19/1027880, Oct 30, 2018.

Research output: Memorandum/expositionMemorandum

Open Access
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Cellekulturer danner blod-hjerne-barrieren i laboratoriet

Lauschke, K. & Schwartz, C. V. L., 2018, In : BestPractice Neurologi. Juli

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Characterizing novel molecular mechanisms for short AGD – a biomarker of fetal testicular dysfunction

Schwartz, C. V. L., Vinggaard, A. M., Christiansen, S., Chalmel, F. & Svingen, T., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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257 Downloads (Pure)
Open Access
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120 Downloads (Pure)

DNA damage in mouse organs and in human sperm cells by bisphenol A

Sharma, A. K., Boberg, J. & Dybdahl, M., 2018, In : Toxicological and Environmental Chemistry. 100, 4, p. 465-478 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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EDC IMPACT: Reduced sperm counts in rats exposed to human relevant mixtures of endocrine disrupters

Axelstad Petersen, M., Hass, U., Scholze, M., Christiansen, S., Kortenkamp, A. & Boberg, J., 2018, In : Endocrine Connections. 7, 1, p. 139-148 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides

Svingen, T., Ramhøj, L., Egebjerg, K. M., Christiansen, S., Petersen, M. A., Vinggaard, A. M. & Hass, U., 2018, In : Scientific Reports. 8, 10 p., 305.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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529 Downloads (Pure)

Environmental toxicology: Pesticides

Svingen, T., Christiansen, S., Taxvig, C. & Vinggaard, A. M., 2018, Encyclopedia of Reproduction. Skinner, M. (ed.). 2 ed. Academic Press, Vol. 1. p. 624-628 5 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearchpeer-review

Environmental Toxicology: Plastics

Boberg, J., Granby, K., Svingen, T. & Vinggaard, A. M., 2018, Encyclopedia of Reproduction. Skinner, M. (ed.). 2 ed. Academic Press, Vol. 1. p. 619-623 5 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearchpeer-review

Erratum to: The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study

Hecker, M., Hollert, H., Cooper, R., Vinggaard, A. M., Akahori, Y., Murphy, M., Nellemann, C., Higley, E., Newsted, J., Laskey, J., Buckalew, A., Grund, S., Maletz, S., Giesy, J. & Timm, G., 2018, In : Environmental Science and Pollution Research. 25, 15, p. 15265–15267

Research output: Contribution to journalJournal articleCommunication

Exploiting advances in transcriptomics to improve on human-relevant toxicology

Darde, T. A., Chalmel, F. & Svingen, T., 1 Oct 2018, In : Current Opinion in Toxicology. 11-12, p. 43-50

Research output: Contribution to journalReviewResearchpeer-review

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Open Access
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172 Downloads (Pure)

Glyphosate alone does not adversely affect testicular androgen function in mature rats

Johansson, H. K. L., Nielsen, L. N., Vinggaard, A. M., Bahl, M. I. & Svingen, T., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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How many vPvM/PMT substances have been registered under REACH? - vPvM/PMT screening by using the Danish QSAR database

Holmberg, R., Wedebye, E. B., Nikolov, N. G. & Tyle, K., 2018, SETAC Europe 28th Annual Meeting - Abstract book. Brussels, Belgium: Society of Environmental Toxicology and Chemistry, p. 346-346 WE072

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

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