Research group for Molecular and Reproductive Toxicology

  • Kemitorvet, Bygning 202

    DK-2800 Kgs Lyngby

    Denmark

Research Output 2008 2019

2019
252 Downloads (Pure)
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A pragmatic approach for human risk assessment of chemical mixtures

Boberg, J., Dybdahl, M., Petersen, A., Hass, U., Svingen, T. & Vinggaard, A. M., 2019, In : Current Opinion in Toxicology. 15, p. 1-7

Research output: Contribution to journalJournal articleResearchpeer-review

Chemical risk assessment based on in vitro and human biomonitoring data: A case study on thyroid toxicants

Johansson, H. K. L., Boberg, J., Dybdahl, M., Axelstad, M. & Vinggaard, A. M., 2019, In : Current Opinion in Toxicology. 15, p. 8-17

Research output: Contribution to journalJournal articleResearchpeer-review

Distinct transcriptional profiles of the female, male and finasteride-induced feminized male anogenital region in rat fetuses

Lindgren Schwartz, C. V., Vinggaard, A. M., Christiansen, S., Darde, T. A., Chalmel, F. & Svingen, T., 2019, In : Toxicological Sciences. 169, 1, p. 303-311

Research output: Contribution to journalJournal articleResearchpeer-review

13 Downloads (Pure)

DTU Fødevareinstituttet i front for at forebygge sygdomme

Kornholt, H., Svingen, T., Aarestrup, F. M. & Poulsen, M., 2019, In : Miljø og sundhed. 25, 2, p. 13-17

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Editorial overview: Risk assessment in toxicology

Vinggaard, A. M. & Judson, R. S., 2019, (Accepted/In press) In : Current Opinion in Toxicology.

Research output: Contribution to journalEditorialResearchpeer-review

48 Downloads (Pure)

Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future

Louro, H., Heinälä, M., Bessems, J., Buekers, J., Vermeire, T., Woutersen, M., van Engelen, J., Borges, T., Rousselle, C., Ougier, E., Alvito, P., Martins, C., Assunção, R., Silva, M. J., Pronk, A., Schaddelee-Scholten, B., Del Carmen Gonzalez, M., de Alba, M., Castaño, A., Viegas, S. & 7 others, Humar-Juric, T., Kononenko, L., Lampen, A., Vinggaard, A. M., Schoeters, G., Kolossa-Gehring, M. & Santonen, T., 2019, In : International Journal of Hygiene and Environmental Health. 222, 5, p. 727-737

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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93 Downloads (Pure)

QSAR modelling of a large imbalanced aryl hydrocarbon activation dataset by rational and random sampling and screening of 80,086 REACH pre-registered and/or registered substances

Klimenko, K. O., Abildgaard Rosenberg, S., Dybdahl, M., Wedebye, E. B. & Nikolov, N. G., 2019, In : PLOS ONE. 14, 3, 21 p., e0213848.

Research output: Contribution to journalJournal articleResearchpeer-review

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Quantitative in vitro to in vivo extrapolation (IVIVE) predict adverse male reproductive health disorders caused by pesticides

Taxvig, C., Scholze, M., Kortenkamp, A., Boberg, J., Svingen, T., Lauschke, K., Christiansen, S., Ermler, S., Hermann, S. S., Pedersen, M., Frandsen, H., Kruse Lykkeberg, A. & Vinggard, A. M., 2019, In : Toxicology Letters. 314, SI, p. S38-S38 #1005.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

The impact of dietary habits on contaminant exposures

Petersen, A., Jensen, B. H., Löbl, N. M., Nielsen, E. E., Bredsdorff, L., Fagt, S., Christensen, T. & Boberg, J., 2019, (Accepted/In press) In : Food and Chemical Toxicology. 8 p., 110885.

Research output: Contribution to journalJournal articleResearchpeer-review

34 Downloads (Pure)

Validation of endogenous reference genes in rat cerebral cortex for RT-qPCR analyses in developmental toxicity studies

Ramhøj, L., Petersen, M. A. & Svingen, T., 2019, In : PeerJ. 7, 13 p., e7181.

Research output: Contribution to journalJournal articleResearchpeer-review

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Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution

Burgdorf, T., Piersma, A. H., Landsiedel, R., Clewell, R., Kleinstreuer, N., Oelgeschläger, M., Desprez, B., Kienhuis, A., Bos, P., de Vries, R., de Wit, L., Seidle, T., Scheel, J., Schönfelder, G., van Benthem, J., Vinggaard, A. M., Eskes, C. & Ezendam, J., 2019, In : Toxicology in Vitro. 59, p. 1-11

Research output: Contribution to journalJournal articleResearchpeer-review

2018
131 Downloads (Pure)

A call for action: Improve reporting of research studies to increase the scientific basis for regulatory decision-making

Ågerstrand, M., Christiansen, S., Hanberg, A., Rudén, C., Andersson, L., Andersen, S., Appelgren, H., Bjørge, C., Clausen, I. H., Eide, D. M., Hartmann, N. B., Husøy, T., Halldórsson, H. P., van der Hagen, M., Ingre-Khans, E., Lillicrap, A. D., Beltoft, V. M., Mörk, A-K., Murtomaa-Hautala, M., Nielsen, E. E. & 8 others, Ólafsdóttir, K., Palomäki, J., Papponen, H., Reiler, E. M., Stockmann-Juvala, H., Suutari, T., Tyle, H. & Beronius, A., 2018, In : Journal of Applied Toxicology. 38, 5, p. 783-785

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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61 Downloads (Pure)
Open Access
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28 Downloads (Pure)

Advisory self-classifications for 54,135 substances based on (Q)SAR predictions from the Danish (Q)SAR database, VEGA QSAR and the OECD QSAR Toolbox

Nikolov, N. G., Tyle, H., Løfstedt, M. & Wedebye, E. B., 2018. 2 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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Cellekulturer danner blod-hjerne-barrieren i laboratoriet

Lauschke, K. & Schwartz, C. V. L., 2018, In : BestPractice Neurologi. Juli

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Characterizing novel molecular mechanisms for short AGD – a biomarker of fetal testicular dysfunction

Schwartz, C. V. L., Vinggaard, A. M., Christiansen, S., Chalmel, F. & Svingen, T., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

166 Downloads (Pure)
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14 Downloads (Pure)
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16 Downloads (Pure)

DNA damage in mouse organs and in human sperm cells by bisphenol A

Sharma, A. K., Boberg, J. & Dybdahl, M., 2018, In : Toxicological and Environmental Chemistry. 100, 4, p. 465-478 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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169 Downloads (Pure)

EDC IMPACT: Reduced sperm counts in rats exposed to human relevant mixtures of endocrine disrupters

Axelstad Petersen, M., Hass, U., Scholze, M., Christiansen, S., Kortenkamp, A. & Boberg, J., 2018, In : Endocrine Connections. 7, 1, p. 139-148 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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399 Downloads (Pure)

Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides

Svingen, T., Ramhøj, L., Egebjerg, K. M., Christiansen, S., Petersen, M. A., Vinggaard, A. M. & Hass, U., 2018, In : Scientific Reports. 8, 10 p., 305.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Environmental toxicology: Pesticides

Svingen, T., Christiansen, S., Taxvig, C. & Vinggaard, A. M., 2018, Encyclopedia of Reproduction. Skinner, M. (ed.). 2 ed. Academic Press, Vol. 1. p. 624-628 5 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearchpeer-review

Environmental Toxicology: Plastics

Boberg, J., Granby, K., Svingen, T. & Vinggaard, A. M., 2018, Encyclopedia of Reproduction. Skinner, M. (ed.). 2 ed. Academic Press, Vol. 1. p. 619-623 5 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearchpeer-review

Erratum to: The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study

Hecker, M., Hollert, H., Cooper, R., Vinggaard, A. M., Akahori, Y., Murphy, M., Nellemann, C., Higley, E., Newsted, J., Laskey, J., Buckalew, A., Grund, S., Maletz, S., Giesy, J. & Timm, G., 2018, In : Environmental Science and Pollution Research. 25, 15, p. 15265–15267

Research output: Contribution to journalJournal articleCommunication

Exploiting advances in transcriptomics to improve on human-relevant toxicology

Darde, T. A., Chalmel, F. & Svingen, T., 1 Oct 2018, In : Current Opinion in Toxicology. 11-12, p. 43-50

Research output: Contribution to journalReviewResearchpeer-review

35 Downloads (Pure)
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163 Downloads (Pure)

Glyphosate alone does not adversely affect testicular androgen function in mature rats

Johansson, H. K. L., Nielsen, L. N., Vinggaard, A. M., Bahl, M. I. & Svingen, T., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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94 Downloads (Pure)

How many vPvM/PMT substances have been registered under REACH? - vPvM/PMT screening by using the Danish QSAR database

Holmberg, R., Wedebye, E. B., Nikolov, N. G. & Tyle, K., 2018, SETAC Europe 28th Annual Meeting - Abstract book. Brussels, Belgium: Society of Environmental Toxicology and Chemistry, p. 346-346 WE072

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
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52 Downloads (Pure)

Hvorfor drenge bliver til drenge og piger bliver til piger samt hvordan kemikalier kan forstyrre den udvikling

Svingen, T., 2018, In : Miljø og sundhed. 24, 3, p. 31-32

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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3 Downloads (Pure)

Input til høringssvar vedrørende ny opinion for salicylsyre

Hass, U., Petersen, M. A. & Christiansen, S., 2018, 3 p.. No. 18/15413, Nov 08, 2018.

Research output: Contribution to memorandum/expositionMemorandum contribution

Open Access
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Low-dose exposure to Bisphenol A during development has limited effects on male reproduction in midpubertal and aging Fischer 344 rats

Spörndly-Nees, E., Boberg, J., Ekstedt, E., Holm, L., Fakhrzadeh, A., Dunder, L., Kushnir, M. M., Lejonklou, M. H. & Lind, P. M., 2018, In : Reproductive Toxicology. 81, p. 196-206

Research output: Contribution to journalJournal articleResearchpeer-review

43 Downloads (Pure)

Mere tid til forskning på den naturvidenskabelige ph.d.-uddannelse

Rasmussen, P. H. & Svingen, T., 2018, In : Dansk Kemi. 99, 3, p. 4-4

Research output: Contribution to journalJournal articleCommunication

Open Access
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101 Downloads (Pure)

Perfluorohexane Sulfonate (PFHxS) and a Mixture of Endocrine Disrupters Reduce Thyroxine Levels and Cause Anti-Androgenic Effects in Rats

Ramhøj, L., Hass, U., Boberg, J., Scholze, M., Christiansen, S., Nielsen, F. & Axelstad Petersen, M., 2018, In : Toxicological Sciences. 163, 2, p. 579-591

Research output: Contribution to journalJournal articleResearchpeer-review

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Perineal gene expression profiling in rats with chemically induced short anogenital distance

Schwartz, C. V. L., Vinggaard, A. M., Christiansen, S., Chalmel, F. & Svingen, T., 2018. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

115 Downloads (Pure)

PFHxS Causes Developmental Hypothyroxinemia Without Affecting Behavioral Tests in Rat Offspring

Ramhøj, L., Boberg, J., Wood, C., Gilbert, M., Vinggaard, A. M. & Petersen, M. A., 2018. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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Prediction of adverse male reproductive health effects by integrating in vitro data and physiologically-based kinetic modelling

Taxvig, C., Scholze, M., Kortenkamp, A., Boberg, J., Svingen, T., Ermler, S., Hermann, S. S., Lykkeberg, A. K., Pedersen, M., Hass, U., Bonomo, S. & Vinggaard, A. M., 2018, In : Toxicology Letters. 295, Suppl. 1, p. S61-S61 OP02-02.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

25 Downloads (Pure)

QSAR Models for Constitutive Androstane Receptor (CAR) Activation and Inhibition, and Screening of a Large Set of Environmental Chemicals

Chinen, K., Nikolov, N. G. & Wedebye, E. B., 2018. 2 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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22 Downloads (Pure)

Recent developments of the Danish (Q)SAR Database: Updates, statistics and link to the OECD QSAR Toolbox

Nikolov, N. G. & Wedebye, E. B., 2018. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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Reproductive Effects and Mechanisms of Action of Fetal Exposure to Azole Fungicides

Draskau, M. K., Christiansen, S., Boberg, J. & Svingen, T., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Reproductive Effects and Mechanisms of Action of Fetal Exposure to Azole Fungicides

Draskau, M. K., Christiansen, S., Boberg, J. & Svingen, T., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Reproductive effects of fetal exposure to Linuron in rats

Löbl, N. M., Johansson, H. K. L., Christiansen, S., Svingen, T. & Boberg, J., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

The Danish (Q)SAR Database with in silico predictions for 650.000 chemical substances

Nikolov, N. G. & Wedebye, E. B., 2018, Sustain Conference 2018: Creating Technology for a Sustainable Society. C. M. & K. M. (eds.). Lyngby, Denmark: Technical University of Denmark, 1 p. U-7

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
20 Downloads (Pure)

The effect of rational selection of training sets from an imbalanced AhR activation dataset on QSAR models accuracy and applicability domain coverage for a large set of REACH substances

Klimenko, K. O., Abildgaard Rosenberg, S., Dybdahl, M., Wedebye, E. B. & Nikolov, N. G., 2018. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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15 Downloads (Pure)

Tolerable Intakes of PFOS & PFOA

Vinggaard, A. M., 2018, 2 p.. No. 18/0586, Apr 18, 2018.

Research output: Memorandum/expositionMemorandum

Open Access
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Transcriptional profiling of the chemically induced feminized anogenital region in male rats

Schwartz, C. V. L., Vinggaard, A. M., Christiansen, S., Chalmel, F. & Svingen, T., 2018. 2 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Transcriptional profiling of the chemically induced feminized anogenital region in male rats

Schwartz, C. V. L., Vinggaard, A. M., Christiansen, S., Chalmel, F. & Svingen, T., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review