Research Group for Molecular and Reproductive Toxicology

Projects

Projects per year 2012 2016 2017 2018 2019 2022 2029

• 10 Active
• 38 Finished

Projects per year

Search results

• Active

  MERLON: Merging scientific evidence with regulatory practices and leveraging idenitification of endocrine disruptors using new approach methodologies

  Svingen, T. (PI), Axelstad Petersen, M. Z. (CoI), Holmer, M. L. (CoI), Johansson, H. K. L. (CoI), Rosenmai, A. K. (CoI) & Christiansen, S. (Project Manager)

  01/01/2024 → 31/12/2028

  Project: Research

• Thyroid hormone system disruption: deciphering mechanism of action to improve testing and regulation of endocrine disruptors

  Stub, M. H. (PhD Student), Svingen, T. (Main Supervisor) & Ramhøj, L. (Supervisor)

  01/06/2023 → 31/05/2026

  Project: PhD

• Characterizing the molecular mechanisms underpinninggenital malformations caused bydevelopmental exposure to endocrine disruptors

  Elmelund, E. (PhD Student), Svingen, T. (Main Supervisor) & Draskau, M. K. (Supervisor)

  01/12/2022 → 30/11/2025

  Project: PhD

• PAN: Partnership to develop Adverse Outcome Pathways for endcorine disrupters

  Svingen, T. (PI), Rosenmai, A. K. (Project Participant), Draskau, M. K. (Project Participant), Holmer, M. L. (Project Participant), Christiansen, S. (Project Participant), Johansson, H. K. L. (Project Participant), Damdimopoulou, P. (Collaborative Partner), Panagiotou, E. M. (Project Participant), Beronius, A. (Collaborative Partner), Zilliacus, J. (Project Participant), Beatrix Maria van Duursen, M. (Collaborative Partner), Bouftas, N. (Project Participant) & Elmelund, E. (Project Participant)

  01/12/2022 → 30/11/2025

  Project: Research

• Endocrine disruption across signaling axes:combined effects of endocrine disrupting chemicals withdissimilar modes of action

  Strand, I. S. W. (PhD Student), Svingen, T. (Main Supervisor) & Petersen, M. Z. A. (Supervisor)

  01/08/2022 → 02/04/2026

  Project: PhD

• Endocrine disrupting potentials of chlorinated paraffins: from in vitro screening to in vivo toxicity studies

  Melchiors, M. (PhD Student), Svingen, T. (Main Supervisor) & Rosenmai, A. K. (Supervisor)

  01/07/2022 → 29/09/2025

  Project: PhD

• CeHoS: Danish Center for Endocrine Disruptors

  Svingen, T. (PI), Andersson, A.-M. (PI), Ebsen Morthorst, J. (PI), Juul, A. (PI), Christiansen, S. (Project Participant), Axelstad Petersen, M. Z. (Project Participant), Holmer, M. L. (Project Participant), Johansson, H. K. L. (Project Participant), Ramhøj, L. (Project Participant), Draskau, M. K. (Project Participant), Rosenmai, A. K. (Project Participant), Elmelund, E. (PhD Student) & Davidsen, N. (Project Participant)

  01/06/2022 → 31/12/2025

  Project: Research

• PARC: Partnership for the Assessment of Risks from Chemicals

  Svingen, T. (PI), Wedebye, E. B. (PI), Pires, S. M. (PI), Vinggaard, A. M. (PI), Beltoft, V. M. (Project Manager), Ramhøj, L. (Project Participant), Houmark Stub, M. (PhD Student), Nikolov, N. G. (Project Participant), Nissen, A. C. V. E. (Project Participant) & Axelstad Petersen, M. Z. (Project Participant)

  01/05/2022 → 30/04/2029

  Project: Research

• PARC T5.2.1c: New approach methods to improve human health risk assessment of thyroid hormone system disruption

  Svingen, T. (PI), Ramhøj, L. (Project Participant), Axelstad Petersen, M. Z. (Project Participant) & Houmark Stub, M. (PhD Student)

  01/05/2022 → 30/04/2026

  Project: Research

• MICA: Toxicological mechanisms of action for improving chemical risk assessment

  Svingen, T. (PI), Petersen, M. Z. A. (Project Manager), Rosenmai, A. K. (Project Manager), Ramhøj, L. (Project Manager) & Strand, I. S. W. (PhD Student)

  01/01/2022 → 31/12/2025

  Project: Research

• Finished

  ToAD: Improved tools to assess whether biocides and plant protection products have endocrine disrupting properties

  Svingen, T. (PI), Wedebye, E. B. (Project Participant), Rosenmai, A. K. (Project Participant), Christiansen, S. (Project Participant), Axelstad Petersen, M. Z. (Project Participant), Ramhøj, L. (Project Participant), Draskau, M. K. (Project Participant) & Pejtersen, M. B. M. (PhD Student)

  01/07/2021 → 30/06/2024

  Project: Research

• Thyro-map: Molekylære effekter af lavt skjold-bruskkirtelhormon – en kortlægning på organniveau til udvikling af biomarkø-rer og forbedret behandling

  Ramhøj, L. (PI), Svingen, T. (Project Participant) & Axelstad Petersen, M. Z. (Project Participant)

  01/12/2020 → 31/03/2022

  Project: Research

• RA-AOP: The development of Adverse Outcome Pathways on Inhibition of retinol/alcohol dehydrogenase (RDH/ADH) during foetal development leading to urogenital or cardiovascular malformations

  Svingen, T. (PI), Bowles, J. (Project Participant), Spiller, C. M. (Project Participant), Draskau, M. K. (Project Participant), Christiansen, S. (Project Participant) & Bech, C. L. (Project Participant)

  20/10/2020 → 20/10/2021

  Project: Research

• TEBU-ED: Update to Tebuconazole ED assessment & classification proposal for reproductive toxicity

  Boberg, J. (Project Coordinator), Ramhøj, L. (Project Participant), Johansson, H. K. L. (Project Participant), Axelstad Petersen, M. Z. (Project Participant), Christiansen, S. (Project Participant), Bennekou, S. H. (Project Participant), Draskau, M. K. (Project Participant) & Svingen, T. (PI)

  16/06/2020 → 11/09/2020

  Project: Consultancy

• Optimering af in vivo, ex vivo og in vitro modeller for thyreoideahormonforstyrrelser

  Rosenmai, A. K. (Project Manager), Ramhøj, L. (Project Manager) & Svingen, T. (Project Participant)

  01/10/2019 → 31/12/2021

  Project: Research

• Strategies for the prevention and treatment of peanut allergy

  Sztuk, T. K. S. (PhD Student), Bøgh, K. L. (Main Supervisor) & Larsen, J. M. (Supervisor)

  01/08/2019 → 03/02/2023

  Project: PhD

  • Peanut Allergy 100%
  • Brown Norway Rat 43%
  • Immunotherapy 31%
  • Immunoglobulin E 25%
  • Rat Model 18%

• Improved human risk assessment of polyfluoroalkyl substances

  Davidsen, N. (PhD Student), Rosenmai, A. K. (Supervisor), Svingen, T. (Main Supervisor), Ramhøj, L. (Supervisor), Hendriksen, R. S. (Examiner), Hadrup, N. (Examiner) & Hamers, T. H. M. (Examiner)

  01/03/2019 → 30/04/2022

  Project: PhD

  • Developmental Effect 100%
  • Perfluorooctanesulfonic Acid 100%
  • Cardiac Muscle Cell 100%
  • Thyroid Hormone 100%
  • Thyroid Gland 35%

• Improved human risk assessment of polyfluoroalkyl substances

  Davidsen, N. (PhD Student), Hendriksen, R. S. (Examiner), Hadrup, N. (Examiner), Hamers, T. H. M. (Examiner), Svingen, T. (Main Supervisor), Ramhøj, L. (Supervisor) & Rosenmai, A. K. (Supervisor)

  01/03/2019 → 30/09/2022

  Project: PhD

• FREIA: Female Reproductive toxicity of EDCs: a human evidence-based screening and Identification Approach

  Boberg, J. (PI), Wedebye, E. B. (Project Participant), Christiansen, S. (Project Participant) & Svingen, T. (Project Participant)

  01/01/2019 → 31/12/2023

  Project: Research

• FEMINIX: Improved chemical safety assessment of endocrine disruptors, alone and in mixtures

  Svingen, T. (PI), Boberg, J. (Project Manager), Vinggaard, A. M. (Project Manager), Christiansen, S. (Project Manager), Davidsen, N. (Project Participant), Rosenmai, A. K. (Project Participant), Ramhøj, L. (Project Participant), Axelstad Petersen, M. Z. (Project Participant), Hass, U. (Project Participant), Taxvig, C. (Project Participant) & Löbl, N. M. (Project Participant)

  01/01/2019 → 31/12/2021

  Project: Research

• ATHENA: Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies

  Svingen, T. (PI), Axelstad Petersen, M. Z. (Project Participant), Christiansen, S. (Project Participant), Nikolov, N. G. (Project Participant) & Wedebye, E. B. (Project Participant)

  01/01/2019 → 31/12/2023

  Project: Research

• Farevurdering af tre fosforbaserede klorede flammehæmmere: TCEP, TCPP og TDCP, med fokus på reproduktionstoksicitet og hormonforstyrrende effekter

  Petersen, M. A. (PI) & Taxvig, C. (Project Participant)

  01/10/2018 → 30/04/2019

  Project: Consultancy

• LIFE CONCERT REACH: Concerting experimental data and in silico models for REACH

  Wedebye, E. B. (PI) & Nikolov, N. G. (PI)

  01/09/2018 → 28/02/2022

  Project: Research

  • In Silico Modeling 100%
  • In Silico Tools 100%
  • In Silico 100%
  • Chemical Substances 75%
  • Making Available 50%

• Reproductive effects and mechanisms-of-action of fetal exposure to azole fungicides

  Draskau, M. K. (PhD Student), Toppari, J. I. K. (Examiner), Bennekou, S. H. (Examiner), Svingen, T. (Main Supervisor), Boberg, J. (Supervisor) & Jørgensen, A. (Examiner)

  Samfinansieret - Andet

  01/06/2018 → 07/03/2022

  Project: PhD

  • Endocrine Disruptor 100%
  • Pyrrole 100%
  • Fetus Development 100%
  • Male Reproductive Toxicity 100%
  • Diseases 85%

• Further development of the Danish (Q)SAR Database

  Wedebye, E. B. (Project Manager) & Nikolov, N. G. (Project Participant)

  02/05/2018 → 30/11/2018

  Project: Research

  • Modeller 100%
  • (Q)SAR 100%
  • Further Development 100%
  • Pregnane 100%
  • Endpoints 100%

• CeHoS: Center for Hormonforstyrrende Stoffer (Centre for Endocrine Disruptors)

  Svingen, T. (PI) & Vinggaard, A. M. (PI)

  01/04/2018 → 31/12/2021

  Project: Research

• Effects of chemical exposure on Hedgehog signaling and development

  Svingen, T. (Main Supervisor), Taxvig, C. (Supervisor), Blomberg, A. L. (Project Participant) & Intzilaki, S. E. (Project Participant)

  29/01/2018 → 21/06/2018

  Project: Research

• "Development of a study protocol for thyroid disruptor testing in the mammalian system”

  Petersen, M. Z. A. (PI), Ramhøj, L. (Project Participant) & Christiansen, S. (Project Participant)

  20/12/2017 → 21/07/2019

  Project: Research

  • Mammalian System 100%
  • Thyroid Disruptors 100%
  • European Commission 50%
  • Subcontractors 50%
  • Framework Contracts 50%

• JANUS: Prediction of male reproductive health effects by integrating in vitro data and PBK modelling

  Vinggaard, A. M. (PI), Taxvig, C. (Project Participant), Christiansen, S. (Project Participant), Frandsen, H. L. (Project Participant) & Svingen, T. (Project Participant)

  01/10/2017 → 30/09/2020

  Project: Research

• “A study on supporting the organisation of a workshop on thyroid disruption”

  Petersen, M. A. (PI)

  07/02/2017 → 30/09/2017

  Project: Consultancy

  • Thyroid Disruption 100%
  • European Commission 100%
  • Service Contract 100%
  • London 100%
  • Framework Contracts 50%

• Future risk assessment of chemicals (MIraculiX)

  Vinggaard, A. M. (Project Coordinator), Taxvig, C. (Project Manager), Svingen, T. (Project Manager), Boberg, J. (Project Manager) & Bonomo, S. (Project Participant)

  02/01/2017 → 31/12/2018

  Project: Research

  • Chemical Risk Assessment 100%
  • Future Risk 100%
  • Kinetic Model 100%
  • Physiologically Based Kinetic Model 50%

• MST Hormon: Development and validation of toxicological test methods for assessment of endocrine disrupting effects of chemicals with focus on development of OECD test guidelines

  Petersen, M. Z. A. (PI), Christiansen, S. (Project Participant), Ramhøj, L. (Project Participant) & Boberg, J. (Project Participant)

  01/01/2017 → 31/12/2020

  Project: Research

• Towards improved human reproductive health: gaining new insight into chemically induced effects on male reproduction’

  Vinggaard, A. M. (PI), Svingen, T. (Project Participant) & Bech, C. L. (PhD Student)

  01/01/2017 → 31/12/2019

  Project: Research

  • Induced Effect 100%
  • Male Reproduction 100%
  • Reproductive Health 100%
  • Research Councils 100%
  • Chemically Induced 100%

• HBM4EU: H2020 European Joint Program: Human Biomonitoring for Europe

  Vinggaard, A. M. (PI), Taxvig, C. (Project Participant), Rosenmai, A. K. (Project Participant), Boberg, J. (Project Participant), Johansson, H. K. L. (Project Participant) & Svingen, T. (Project Participant)

  01/01/2017 → 31/12/2021

  Project: Research

  • Europe 100%
  • H2020 100%
  • Human Biomonitoring 100%
  • Joint Programs 100%
  • Europeans 100%

• Optimizing and refining 3D culturing of human stem cells for predictive toxicity

  Lauschke, K. (PhD Student), Pistollato, F. (Examiner), Roursgaard, M. (Examiner), Hansen, E. B. (Examiner), Vinggaard, A. M. (Main Supervisor), Emnéus, J. (Supervisor) & Taxvig, C. (Supervisor)

  Technical University of Denmark

  01/12/2016 → 20/05/2021

  Project: PhD

  • Developmental Toxicity 100%
  • Toxicity in Vitro 100%
  • Epoxiconazole 80%
  • Thalidomide 60%
  • Sodium Valproate 40%

• CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

  Wedebye, E. B. (Project Participant) & Nikolov, N. G. (Project Participant)

  01/12/2016 → 01/02/2019

  Project: Research

  • Androgen Signaling 100%
  • QSAR Model 100%
  • Collaborative Modeling 100%
  • Modeling Project 100%
  • Quantitative Structure-Activity Relationship 100%

• Mechanisms of action involved in chemically-induced effects on male reproductive health

  Bech, C. L. (PhD Student), Mitchell, R. T. (Examiner), Hansen, E. B. (Examiner), Vinggaard, A. M. (Main Supervisor), Svingen, T. (Supervisor) & Kristensen, D. M. (Examiner)

  Forskningsrådsfinansiering

  01/12/2016 → 11/02/2021

  Project: PhD

  • Perineum 100%
  • Estrogen Signaling 15%
  • Enzalutamide 10%
  • Perineal muscles 10%
  • Masculinization Programming Window 5%

• ThyroMix: Development of tool for mixture risk assessment of thyroid hormone disrupting chemicals

  Vinggaard, A. M. (PI), Johansson, H. K. L. (Project Participant), Boberg, J. (Project Participant) & Axelstad Petersen, M. Z. (Project Participant)

  01/10/2016 → 31/01/2018

  Project: Research

  • Mixture Risk Assessment 100%
  • Tool Development 100%
  • Ministry of Environment 100%
  • Denmark 100%
  • Thyroid Hormones 100%

• Research stay with Dr. Mary Gilbert, Perfluorinated Chemicals and Brain Development: Interaction with the Thyroid Axis

  Ramhøj, L. (Project Participant)

  19/07/2016 → 19/07/2017

  Project: Research

  • Perfluorinated Chemicals 100%
  • Chemical Development 100%
  • Thyroid Axis 100%
  • Brain Development 100%
  • Gilbert 100%

• Investigation of endpoints relevant for endocrine disruption in the the OECD Prenatal Developmental Toxicity Study (OECD TG 414).

  Christiansen, S. (PI) & Hass, U. (PI)

  01/01/2016 → 31/12/2018

  Project: Research

  • Prenatal Developmental Toxicity 100%
  • Endocrine-disrupting Substances 100%
  • Male Genitalia 100%
  • Female Genitalia 100%
  • Endocrine Disruption 100%

• MIraculiX: Future risk assessment of chemicals

  Vinggaard, A. M. (Project Coordinator), Boberg, J. (Project Manager), Svingen, T. (Project Manager) & Taxvig, C. (Project Manager)

  01/01/2015 → 31/12/2018

  Project: Research

• Effekter af kemiske stoffer på udviklingen af immunforsvaret (developmental immunotoxicity, DIT)

  Ramhøj, L. (Project Participant), Hass, U. (PI) & Madsen, C. B. (PI)

  01/01/2015 → 31/12/2017

  Project: Research

• Udvikling af en iED liste - En liste over mistænkte hormonforstyrrende stoffer

  Wedebye, E. B. (Project Manager) & Nikolov, N. G. (Project Participant)

  Environmental Protection Agency

  01/10/2014 → 31/12/2014

  Project: Research

  • Endocrine Disrupting Effects 100%
  • Other-knowledge 100%

• CEHOS PFC: Endocrine disrupting effects of PFCs: in vitro profiling and effect in rats exposed during development to a PFC plus/minus background exposure to a mixture of known endocrine disrupters

  Hass, U. (Project Manager), Vinggaard, A. M. (Project Participant), Christiansen, S. (Project Participant), Boberg, J. (Project Participant), Egebjerg, K. M. (Project Participant), Petersen, M. Z. A. (Project Participant) & Taxvig, C. (Project Participant)

  Centre on Endocrine Disrupters

  01/06/2014 → 31/12/2017

  Project: Research

  • Perfluorinated Compounds 100%
  • In Vitro Profiling 100%
  • Plus-Minus 100%
  • In Vitro Effect 100%
  • Endocrine Disrupting Effects 100%

• Development of a QSAR database for identification of hazardous properties of chemicals with inadequate testing data

  Wedebye, E. B. (Project Manager), Nikolov, N. G. (Project Participant), Dybdahl, M. (Project Participant) & Abildgaard Rosenberg, S. (Project Participant)

  Environmental Protection Agency

  01/10/2013 → 30/11/2014

  Project: Research

  • Testing Data 100%
  • Mutagenicity 100%
  • Hazardous Properties 100%
  • Quantitative Structure-Activity Relationship 100%
  • Reporting Formats 50%

• PANDA: Persistent health effects caused by widely used pesticides with antiandrogenic activity

  Vinggaard, A. M. (Project Participant), Taxvig, C. (Project Participant), Pedersen, M. (Project Participant), Kortenkamp, A. (Project Participant), Boberg, J. (Project Participant) & Svingen, T. (Project Participant)

  The Danish Environmental Protection Agency

  01/08/2013 → 31/05/2016

  Project: Research

  • Health Effects 100%
  • Anti-androgenic Activity 100%
  • Pesticides 100%
  • Androgen Receptor 100%
  • In Vitro 100%

• MST Hormon: Development and validation of toxicological test methods for assessment of endocrine disrupting effects of chemicals with focus on development of OECD test guidelines

  Hass, U. (Project Manager), Vinggaard, A. M. (Project Participant), Christiansen, S. (Project Participant), Boberg, J. (Project Participant), Egebjerg, K. M. (Project Participant) & Petersen, M. Z. A. (Project Participant)

  01/01/2013 → 31/12/2016

  Project: Research

  • OECD Test Guidelines 100%
  • Endocrine Disrupting Effects 100%
  • Chemical Effect 100%
  • Method Development 100%
  • Toxicological Testing 100%

• ComPest: Combination effects of pesticides on birth weight and metabolic programming in rat offspring

  Hass, U. (Project Manager), Christiansen, S. (Project Participant), Vinggaard, A. M. (Project Participant), Boberg, J. (Project Participant), Egebjerg, K. M. (Project Participant), Petersen, M. Z. A. (Project Participant), Taxvig, C. (Project Participant) & Scholze, M. (Project Participant)

  The Danish Environmental Protection Agency

  01/08/2012 → 31/12/2015

  Project: Research

  • Metabolic Programming 100%
  • Birth Weight 100%
  • Combination Effect 100%
  • Rat Offspring 100%
  • Pesticides 100%