• Søltofts Plads, Bygning 221

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Journal article
2020

A comparative genomics study of 23 Aspergillus species from section Flavi

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kildgaard, S., Petersen, T. I., Kuo, A., Sato, A., Lyhne, E. K., Kogle, M. E., Wiebenga, A., Kun, R. S., Lubbers, R. J. M., Mäkelä, M. R., Barry, K., Chovatia, M., Clum, A., Daum, C., Haridas, S. & 17 others, He, G., LaButti, K., Lipzen, A., Mondo, S., Pangilinan, J., Riley, R., Salamov, A., Simmons, B. A., Magnuson, J. K., Henrissat, B., Mortensen, U. H., Larsen, T. O., de Vries, R. P., Grigoriev, I. V., Machida, M., Baker, S. E. & Andersen, M. R., 2020, In : Nature Communications. 11, 1, 12 p., 1106.

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Tenuazonic acid from Stemphylium loti inhibits the plant plasma membrane H+-ATPase by a mechanism involving the C-terminal regulatory domain

Bjørk, P. K., Rasmussen, S. A., Gjetting, S. K., Havshøi, N. W., Petersen, T. I., Ipsen, J. Ø., Larsen, T. O. & Fuglsang, A. T., 2020, (Accepted/In press) In : New Phytologist.

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Open Access
2019

A-, B- and C-type prymnesins are clade specific compounds and chemotaxonomic markers in Prymnesium parvum

Binzer, S. B., Svenssen, D. K., Daugbjerg, N., Alves-de-Souza, C., Pinto, E., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Harmful Algae. 81, p. 10-17

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235 Downloads (Pure)

Atrorosins: a new subgroup of Monascus pigments from Talaromyces atroroseus

Isbrandt, T., Tolborg, G., Ødum, A. S. R., Workman, M. & Larsen, T. O., 2019, In : Applied Microbiology and Biotechnology. p. 1-8 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

Andersen, T. B., Rasmussen, S. A., Christensen, S. B. & Simonsen, H. T., 2019, In : Phytochemistry. 157, p. 168-174

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Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001.

Devi, S., Kiesewalter, H. T., Kovács, R., Frisvad, J. C., Weber, T., Larsen, T. O., Kovács, Á. T. & Ding, L., 2019, In : Synthetic and Systems Biotechnology. 4, 3, p. 142-149 8 p.

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Development of an indirect quantitation method to assess ichthyotoxic b-type prymnesins from prymnesium parvum

Svenssen, D. K., Binzer, S. B., Medić, N., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Toxins. 11, 5, 251.

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Disease-free monoculture farming by fungus-growing termites

Otani, S., Challinor, V. L., Kreuzenbeck, N. B., Kildgaard, S., Krath Christensen, S., Larsen, L. L. M., Aanen, D. K., Rasmussen, S. A., Beemelmanns, C. & Poulsen, M., 2019, In : Scientific Reports. 9, 1, 10 p., 8819.

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Glycerol metabolism of Pichia pastoris (Komagataella spp.) characterised by 13C-based metabolic flux analysis

Tomàs-Gamisans, M., Ødum, A. S. R., Workman, M., Ferrer, P. & Albiol, J., 2019, In : New Biotechnology. 50, p. 52-59 8 p.

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Isolation of Methyl Troposulfenin from Phaeobacter inhibens

Phippen, C. B. W., Jørgensen, C. M., Bentzon-Tilia, M., Gotfredsen, C. H., Larsen, T. O., Gram, L. & Sonnenschein, E. C., 2019, In : Journal of Natural Products. 82, 5, p. 1387-1390 4 p.

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Taxonomy of Aspergillus section Flavi and their production of aflatoxins, ochratoxins and other mycotoxins

Frisvad, J. C., Hubka, V., Ezekiel, C. N., Hong, S. B., Nováková, A., Chen, A. J., Arzanlou, M., Larsen, T. O., Sklenář, F., Mahakarnchanakul, W., Samson, R. A. & Houbraken, J., 2019, In : Studies in Mycology. 93, p. 1-63

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Unique processes yielding pure azaphilones in Talaromyces atroroseus

Tolborg, G., Ødum, A. S. R., Isbrandt, T., Larsen, T. O. & Workman, M., 2019, In : Applied Microbiology and Biotechnology. 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B

Copmans, D., Kildgaard, S., Rasmussen, S. A., Ślezak, M., Dirkx, N., Partoens, M., Esguerra, C. V., Crawford, A. D., Larsen, T. O. & De Witte, P. A. M., 2019, In : Marine Drugs. 17, 11, 20 p., 607.

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2018

Cyclopiamines C and D: Epoxide Spiroindolinone Alkaloids from Penicillium sp. CML 3020

Kildgaard, S., de Medeiros, L. S., Phillips, E., Gotfredsen, C. H., Frisvad, J. C., Nielsen, K. F., Abreu, L. M. & Larsen, T. O., 2018, In : Journal of Natural Products. 81, 4, p. 785-790 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Development of a LC-MS/MS method for the quantification of goniodomins A and B and its application to Alexandrium pseudogonyaulax strains and plankton field samples of Danish coastal waters

Krock, B., Tillmann, U., Wen, Y., Hansen, P. J., Larsen, T. O. & Andersen, A. J. C., 2018, In : Toxicon. 155, p. 51-60

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Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions

Robertsen, H. L., Musiol-Kroll, E. M., Ding, L., Laiple, K. J., Hofeditz, T., Wohlleben, W., Lee, S. Y., Grond, S. & Weber, T., 2018, In : Scientific Reports. 8, 9 p., 3230.

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Genetic Characterization of Neosartorin Biosynthesis Provides Insight into Heterodimeric Natural Product Generation

Matsuda, Y., Gotfredsen, C. H. & Larsen, T. O., 2018, In : ORGANIC LETTERS. 20, 22, p. 7194-7200 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

HldE Is Important for Virulence Phenotypes in Enterotoxigenic Escherichia coli

Maigaard Hermansen, G. M., Boysen, A., Krogh, T. J., Nawrocki, A., Jelsbak, L. & Møller-Jensen, J., 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 253, 13 p., 253.

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Identification of the decumbenone biosynthetic gene cluster in Penicilliuum decumbens and the importance for production of calbistrin

Grijseels, S., Pohl, C., Nielsen, J. C., Wasil, Z., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2018, In : Fungal Biology and Biotechnology. 5, 17 p., 18.

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Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri

Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Larsen, T. O., Nielsen, K. F., Hoof, J. B., Brandl, J., Salamov, A., Riley, R., Gladden, J. M., Phatale, P., Nielsen, M. T., Lyhne, E. K., Kogle, M. E., Strasser, K., McDonnell, E., Barry, K., Clum, A., Chen, C. & 19 others, LaButti, K., Haridas, S., Nolan, M., Sandor, L., Kuo, A., Lipzen, A., Hainaut, M., Drula, E., Tsang, A., Magnuson, J. K., Henrissat, B., Wiebenga, A., Simmons, B. A., Mäkelä, M. R., de Vries, R. P., Grigoriev, I. V., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2018, In : Nature Genetics. 50, p. 1688–1695

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227 Downloads (Pure)

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kuo, A., Bowyer, P., Matsuda, Y., Mondo, S., Lyhne, E. K., Kogle, M. E., Clum, A., Lipzen, A., Salamov, A., Ngan, C. Y., Daum, C., Chiniquy, J., Barry, K., LaButti, K., Haridas, S. & 7 others, Simmons, B. A., Magnuson, J. K., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 23 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E753-E761

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Metabolite production by species of Stemphylium

Olsen, K. J. K., Rossman, A. & Andersen, B., 2018, In : Fungal Biology. 122, 2-3, p. 172-181 10 p.

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Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation

Matsuda, Y., Bai, T., Phippen, C. B. W., Nødvig, C. S., Kjærbølling, I., Vesth, T. C., Andersen, M. R., Mortensen, U. H., Gotfredsen, C. H., Abe, I. & Larsen, T. O., 2018, In : Nature Communications. 9, 1, 10 p., 2587 .

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On the biosynthetic origin of carminic acid

Rasmussen, S. A., Kongstad, K. T., Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F., Gotfredsen, C. H., Stærk, D., Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In : Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

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Phylogenetic distribution of roseobacticides in the Roseobacter group and their effect on microalgae

Sonnenschein, E. C., Phippen, C. B. W., Bentzon-Tilia, M., Rasmussen, S. A., Nielsen, K. F. & Gram, L., 2018, In : Environmental Microbiology Reports. 10, 3, p. 383-393

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Pseudoalteromonas haloplanktis TAC125 produces 4-hydroxybenzoic acid that induces pyroptosis in human A459 lung adenocarcinoma cells

Sannino, F., Sansone, C., Galasso, C., Kildgaard, S., Tedesco, P., Fani, R., Marino, G., de Pascale, D., Ianora, A., Parrilli, E., Larsen, T. O., Romano, G. & Tutino, M. L., 2018, In : Scientific Reports. 8, 1, 10 p., 1190.

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Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei

Frisvad, J. C., Møller, L. L. H., Larsen, T. O., Kumar, R. & Arnau, J., 2018, In : Applied Microbiology and Biotechnology. 102, 22, p. 9481-9515

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The FlbA-regulated predicted transcription factor Fum21 of Aspergillus niger is involved in fumonisin production

Aerts, D., Hauer, E. E., Ohm, R. A., Arentshorst, M., Teertstra, W. R., Phippen, C., Ram, A. F. J., Frisvad, J. C. & Wösten, H. A. B., 2018, In : Antonie Van Leeuwenhoek. 111, 3, p. 311-322

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Uncovering secondary metabolite evolution and biosynthesis using gene cluster networks and genetic dereplication

Theobald, S., Vesth, T. C., Rendsvig, J. K., Nielsen, K. F., Riley, R., de Abreu, L. M., Salamov, A., Frisvad, J. C., Larsen, T. O., Andersen, M. R. & Hoof, J. B., 2018, In : Scientific Reports. 8, 12 p., 17957.

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2017

A Dereplication and Bioguided Discovery Approach to Reveal New Compounds from a Marine-Derived Fungus Stilbella fimetaria

Kildgaard, S., Subko, K., Phillips, E., Goidts, V., de la Cruz, M., Díaz, C., Gotfredsen, C. H., Andersen, B., Frisvad, J. C., Nielsen, K. F. & Larsen, T. O., 2017, In : Marine Drugs. 15, 8, 253.

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Biosynthesis of the antimicrobial cyclic lipopeptides nunamycin and nunapeptin by Pseudomonas fluorescens strain In5 is regulated by the LuxR-type transcriptional regulator NunF

Hennessy, R. C., Phippen, C., Nielsen, K. F., Olsson, S. & Stougaard, P., 2017, In : MicrobiologyOpen. 6, 6, 14 p., e00516.

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Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa

Kannangara, R., Siukstaite, L., Borch-Jensen, J., Madsen, B., Kongstad, K. T., Stærk, D., Bennedsen, M., Okkels, F. T., Rasmussen, S. A., Larsen, T. O., Frandsen, R. J. N. & Møller, B. L., 2017, In : Nature Communications. 8, 1, 12 p., 1987 .

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Genes Linked to Production of Secondary Metabolites in Talaromyces atroroseus Revealed Using CRISPR-Cas9

Nielsen, M. L., Petersen, T. I., Rasmussen, K. B., Thrane, U., Hoof, J. B., Larsen, T. O. & Mortensen, U. H., 2017, In : P L o S One. 12, 1, 9 p., e0169712.

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HPLC-HRMS Quantification of the Ichthyotoxin Karmitoxin from Karlodinium armiger

Andersen, A. J. C., Soman De Medeiros, L., Binzer, S. B., Rasmussen, S. A., Hansen, P. J., Nielsen, K. F., Jørgensen, K. & Larsen, T. O., 2017, In : Marine Drugs. 15, 9, 13 p., 278.

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Karmitoxin: An amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger

Rasmussen, S. A., Binzer, S. B., Hoeck, C., Meier, S., Soman De Medeiros, L., Andersen, N. G., Place, A. D., Nielsen, K. F., Hansen, P. J. & Larsen, T. O., 2017, In : Journal of Natural Products. 80, 5, p. 1287-1293 7 p.

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Localization and in-vivo characterization of thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis

Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, K., Andersen-Ranberg, J., Nyberg, N., Christensen, S. B. & Simonsen, H. T., 1 May 2017, In : Plant Physiology. 174, 1, p. 56-72 17 p.

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Metabolic engineering of yeast for fermentative production of flavonoids

Rodriguez Prado, E. A., Strucko, T., Stahlhut, S. G., Kristensen, M., Svenssen, D. K., Förster, J., Nielsen, J. & Borodina, I., 2017, In : Bioresource Technology. 245, Part B, p. 1645-1654

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Phaeobacter piscinae sp. nov., a species of the Roseobacter group and potential aquaculture probiont

Sonnenschein, E. C., Phippen, C. B. W., Nielsen, K. F., Mateiu, R. V., Melchiorsen, J., Gram, L., Overmann, J. & Freese, H. M., 2017, In : International Journal of Systematic and Evolutionary Microbiology. 67, 10, p. 4559-4564

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Physiological characterization of secondary metabolite producing Penicillium cell factories

Grijseels, S., Nielsen, J., Nielsen, J., Larsen, T. O., Frisvad, J. C., Nielsen, K. F., Frandsen, R. J. N. & Workman, M., 2017, In : Fungal Biology and Biotechnology. 4, 8, 12 p.

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