• Søltofts Plads, Bygning 221

    DK-2800 Kgs. Lyngby

    Denmark

Research Output 2016 2019

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Journal article
2019
227 Downloads (Pure)

A-, B- and C-type prymnesins are clade specific compounds and chemotaxonomic markers in Prymnesium parvum

Binzer, S. B., Svenssen, D. K., Daugbjerg, N., Alves-de-Souza, C., Pinto, E., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Harmful Algae. 81, p. 10-17

Research output: Contribution to journalJournal articleResearchpeer-review

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Atrorosins: a new subgroup of Monascus pigments from Talaromyces atroroseus

Isbrandt, T., Tolborg, G., Ødum, A. S. R., Workman, M. & Larsen, T. O., 2019, In : Applied Microbiology and Biotechnology. p. 1-8 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

Andersen, T. B., Rasmussen, S. A., Christensen, S. B. & Simonsen, H. T., 2019, In : Phytochemistry. 157, p. 168-174

Research output: Contribution to journalJournal articleResearchpeer-review

100 Downloads (Pure)

Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001.

Devi, S., Kiesewalter, H. T., Kovács, R., Frisvad, J. C., Weber, T., Larsen, T. O., Kovács, Á. T. & Ding, L., 2019, In : Synthetic and Systems Biotechnology. 4, 3, p. 142-149 8 p.

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50 Downloads (Pure)

Development of an indirect quantitation method to assess ichthyotoxic b-type prymnesins from prymnesium parvum

Svenssen, D. K., Binzer, S. B., Medić, N., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Toxins. 11, 5, 251.

Research output: Contribution to journalJournal articleResearchpeer-review

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57 Downloads (Pure)

Disease-free monoculture farming by fungus-growing termites

Otani, S., Challinor, V. L., Kreuzenbeck, N. B., Kildgaard, S., Krath Christensen, S., Larsen, L. L. M., Aanen, D. K., Rasmussen, S. A., Beemelmanns, C. & Poulsen, M., 2019, In : Scientific Reports. 9, 1, 10 p., 8819.

Research output: Contribution to journalJournal articleResearchpeer-review

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Glycerol metabolism of Pichia pastoris (Komagataella spp.) characterised by 13C-based metabolic flux analysis

Tomàs-Gamisans, M., Ødum, A. S. R., Workman, M., Ferrer, P. & Albiol, J., 2019, In : New Biotechnology. 50, p. 52-59 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Isolation of Methyl Troposulfenin from Phaeobacter inhibens

Phippen, C. B. W., Jørgensen, C. M., Bentzon-Tilia, M., Gotfredsen, C. H., Larsen, T. O., Gram, L. & Sonnenschein, E. C., 2019, In : Journal of Natural Products. 82, 5, p. 1387-1390 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

217 Downloads (Pure)

Taxonomy of Aspergillus section Flavi and their production of aflatoxins, ochratoxins and other mycotoxins

Frisvad, J. C., Hubka, V., Ezekiel, C. N., Hong, S. B., Nováková, A., Chen, A. J., Arzanlou, M., Larsen, T. O., Sklenář, F., Mahakarnchanakul, W., Samson, R. A. & Houbraken, J., 2019, In : Studies in Mycology. 93, p. 1-63

Research output: Contribution to journalJournal articleResearchpeer-review

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Tenuazonic acid from Stemphylium loti inhibits the plant plasma membrane H+-ATPase by a mechanism involving the C-terminal regulatory domain

Bjørk, P. K., Rasmussen, S. A., Gjetting, S. K., Havshøi, N. W., Petersen, T. I., Ipsen, J. Ø., Larsen, T. O. & Fuglsang, A. T., 2019, (Accepted/In press) In : New Phytologist.

Research output: Contribution to journalJournal articleResearchpeer-review

Unique processes yielding pure azaphilones in Talaromyces atroroseus

Tolborg, G., Ødum, A. S. R., Isbrandt, T., Larsen, T. O. & Workman, M., 2019, In : Applied Microbiology and Biotechnology. 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

15 Downloads (Pure)

Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B

Copmans, D., Kildgaard, S., Rasmussen, S. A., Ślezak, M., Dirkx, N., Partoens, M., Esguerra, C. V., Crawford, A. D., Larsen, T. O. & De Witte, P. A. M., 2019, In : Marine Drugs. 17, 11, 20 p., 607.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2018

Cyclopiamines C and D: Epoxide Spiroindolinone Alkaloids from Penicillium sp. CML 3020

Kildgaard, S., de Medeiros, L. S., Phillips, E., Gotfredsen, C. H., Frisvad, J. C., Nielsen, K. F., Abreu, L. M. & Larsen, T. O., 2018, In : Journal of Natural Products. 81, 4, p. 785-790 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

43 Downloads (Pure)

Development of a LC-MS/MS method for the quantification of goniodomins A and B and its application to Alexandrium pseudogonyaulax strains and plankton field samples of Danish coastal waters

Krock, B., Tillmann, U., Wen, Y., Hansen, P. J., Larsen, T. O. & Andersen, A. J. C., 2018, In : Toxicon. 155, p. 51-60

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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207 Downloads (Pure)

Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions

Robertsen, H. L., Musiol-Kroll, E. M., Ding, L., Laiple, K. J., Hofeditz, T., Wohlleben, W., Lee, S. Y., Grond, S. & Weber, T., 2018, In : Scientific Reports. 8, 9 p., 3230.

Research output: Contribution to journalJournal articleResearchpeer-review

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Genetic Characterization of Neosartorin Biosynthesis Provides Insight into Heterodimeric Natural Product Generation

Matsuda, Y., Gotfredsen, C. H. & Larsen, T. O., 2018, In : ORGANIC LETTERS. 20, 22, p. 7194-7200 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

123 Downloads (Pure)

HldE Is Important for Virulence Phenotypes in Enterotoxigenic Escherichia coli

Maigaard Hermansen, G. M., Boysen, A., Krogh, T. J., Nawrocki, A., Jelsbak, L. & Møller-Jensen, J., 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 253, 13 p., 253.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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179 Downloads (Pure)

Identification of the decumbenone biosynthetic gene cluster in Penicilliuum decumbens and the importance for production of calbistrin

Grijseels, S., Pohl, C., Nielsen, J. C., Wasil, Z., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2018, In : Fungal Biology and Biotechnology. 5, 17 p., 18.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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215 Downloads (Pure)

Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri

Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Larsen, T. O., Nielsen, K. F., Hoof, J. B., Brandl, J., Salamov, A., Riley, R., Gladden, J. M., Phatale, P., Nielsen, M. T., Lyhne, E. K., Kogle, M. E., Strasser, K., McDonnell, E., Barry, K., Clum, A., Chen, C. & 19 others, LaButti, K., Haridas, S., Nolan, M., Sandor, L., Kuo, A., Lipzen, A., Hainaut, M., Drula, E., Tsang, A., Magnuson, J. K., Henrissat, B., Wiebenga, A., Simmons, B. A., Mäkelä, M. R., de Vries, R. P., Grigoriev, I. V., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2018, In : Nature Genetics. 50, p. 1688–1695

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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91 Downloads (Pure)

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kuo, A., Bowyer, P., Matsuda, Y., Mondo, S., Lyhne, E. K., Kogle, M. E., Clum, A., Lipzen, A., Salamov, A., Ngan, C. Y., Daum, C., Chiniquy, J., Barry, K., LaButti, K., Haridas, S. & 7 others, Simmons, B. A., Magnuson, J. K., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 23 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E753-E761

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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150 Downloads (Pure)

Metabolite production by species of Stemphylium

Olsen, K. J. K., Rossman, A. & Andersen, B., 2018, In : Fungal Biology. 122, 2-3, p. 172-181 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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212 Downloads (Pure)

Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation

Matsuda, Y., Bai, T., Phippen, C. B. W., Nødvig, C. S., Kjærbølling, I., Vesth, T. C., Andersen, M. R., Mortensen, U. H., Gotfredsen, C. H., Abe, I. & Larsen, T. O., 2018, In : Nature Communications. 9, 1, 10 p., 2587 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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320 Downloads (Pure)

On the biosynthetic origin of carminic acid

Rasmussen, S. A., Kongstad, K. T., Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F., Gotfredsen, C. H., Stærk, D., Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In : Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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Phylogenetic distribution of roseobacticides in the Roseobacter group and their effect on microalgae

Sonnenschein, E. C., Phippen, C. B. W., Bentzon-Tilia, M., Rasmussen, S. A., Nielsen, K. F. & Gram, L., 2018, In : Environmental Microbiology Reports. 10, 3, p. 383-393

Research output: Contribution to journalJournal articleResearchpeer-review

181 Downloads (Pure)

Pseudoalteromonas haloplanktis TAC125 produces 4-hydroxybenzoic acid that induces pyroptosis in human A459 lung adenocarcinoma cells

Sannino, F., Sansone, C., Galasso, C., Kildgaard, S., Tedesco, P., Fani, R., Marino, G., de Pascale, D., Ianora, A., Parrilli, E., Larsen, T. O., Romano, G. & Tutino, M. L., 2018, In : Scientific Reports. 8, 1, 10 p., 1190.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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231 Downloads (Pure)

Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei

Frisvad, J. C., Møller, L. L. H., Larsen, T. O., Kumar, R. & Arnau, J., 2018, In : Applied Microbiology and Biotechnology. 102, 22, p. 9481-9515

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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165 Downloads (Pure)

The FlbA-regulated predicted transcription factor Fum21 of Aspergillus niger is involved in fumonisin production

Aerts, D., Hauer, E. E., Ohm, R. A., Arentshorst, M., Teertstra, W. R., Phippen, C., Ram, A. F. J., Frisvad, J. C. & Wösten, H. A. B., 2018, In : Antonie Van Leeuwenhoek. 111, 3, p. 311-322

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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180 Downloads (Pure)

Uncovering secondary metabolite evolution and biosynthesis using gene cluster networks and genetic dereplication

Theobald, S., Vesth, T. C., Rendsvig, J. K., Nielsen, K. F., Riley, R., de Abreu, L. M., Salamov, A., Frisvad, J. C., Larsen, T. O., Andersen, M. R. & Hoof, J. B., 2018, In : Scientific Reports. 8, 12 p., 17957.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2017
250 Downloads (Pure)

A Dereplication and Bioguided Discovery Approach to Reveal New Compounds from a Marine-Derived Fungus Stilbella fimetaria

Kildgaard, S., Subko, K., Phillips, E., Goidts, V., de la Cruz, M., Díaz, C., Gotfredsen, C. H., Andersen, B., Frisvad, J. C., Nielsen, K. F. & Larsen, T. O., 2017, In : Marine Drugs. 15, 8, 253.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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243 Downloads (Pure)

Biosynthesis of the antimicrobial cyclic lipopeptides nunamycin and nunapeptin by Pseudomonas fluorescens strain In5 is regulated by the LuxR-type transcriptional regulator NunF

Hennessy, R. C., Phippen, C., Nielsen, K. F., Olsson, S. & Stougaard, P., 2017, In : MicrobiologyOpen. 6, 6, 14 p., e00516.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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253 Downloads (Pure)

Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa

Kannangara, R., Siukstaite, L., Borch-Jensen, J., Madsen, B., Kongstad, K. T., Stærk, D., Bennedsen, M., Okkels, F. T., Rasmussen, S. A., Larsen, T. O., Frandsen, R. J. N. & Møller, B. L., 2017, In : Nature Communications. 8, 1, 12 p., 1987 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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311 Downloads (Pure)

Genes Linked to Production of Secondary Metabolites in Talaromyces atroroseus Revealed Using CRISPR-Cas9

Nielsen, M. L., Petersen, T. I., Rasmussen, K. B., Thrane, U., Hoof, J. B., Larsen, T. O. & Mortensen, U. H., 2017, In : P L o S One. 12, 1, 9 p., e0169712.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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220 Downloads (Pure)

HPLC-HRMS Quantification of the Ichthyotoxin Karmitoxin from Karlodinium armiger

Andersen, A. J. C., Soman De Medeiros, L., Binzer, S. B., Rasmussen, S. A., Hansen, P. J., Nielsen, K. F., Jørgensen, K. & Larsen, T. O., 2017, In : Marine Drugs. 15, 9, 13 p., 278.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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233 Downloads (Pure)

Karmitoxin: An amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger

Rasmussen, S. A., Binzer, S. B., Hoeck, C., Meier, S., Soman De Medeiros, L., Andersen, N. G., Place, A. D., Nielsen, K. F., Hansen, P. J. & Larsen, T. O., 2017, In : Journal of Natural Products. 80, 5, p. 1287-1293 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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215 Downloads (Pure)

Localization and in-vivo characterization of thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis

Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, K., Andersen-Ranberg, J., Nyberg, N., Christensen, S. B. & Simonsen, H. T., 1 May 2017, In : Plant Physiology. 174, 1, p. 56-72 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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340 Downloads (Pure)

Metabolic engineering of yeast for fermentative production of flavonoids

Rodriguez Prado, E. A., Strucko, T., Stahlhut, S. G., Kristensen, M., Svenssen, D. K., Förster, J., Nielsen, J. & Borodina, I., 2017, In : Bioresource Technology. 245, Part B, p. 1645-1654

Research output: Contribution to journalJournal articleResearchpeer-review

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Phaeobacter piscinae sp. nov., a species of the Roseobacter group and potential aquaculture probiont

Sonnenschein, E. C., Phippen, C. B. W., Nielsen, K. F., Mateiu, R. V., Melchiorsen, J., Gram, L., Overmann, J. & Freese, H. M., 2017, In : International Journal of Systematic and Evolutionary Microbiology. 67, 10, p. 4559-4564

Research output: Contribution to journalJournal articleResearchpeer-review

402 Downloads (Pure)

Physiological characterization of secondary metabolite producing Penicillium cell factories

Grijseels, S., Nielsen, J., Nielsen, J., Larsen, T. O., Frisvad, J. C., Nielsen, K. F., Frandsen, R. J. N. & Workman, M., 2017, In : Fungal Biology and Biotechnology. 4, 8, 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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