• Søltofts Plads, Bygning 221

    DK-2800 Kgs. Lyngby

    Denmark

Research Output

A-, B- and C-type prymnesins are clade specific compounds and chemotaxonomic markers in Prymnesium parvum

Binzer, S. B., Svenssen, D. K., Daugbjerg, N., Alves-de-Souza, C., Pinto, E., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Harmful Algae. 81, p. 10-17

Research output: Contribution to journalJournal articleResearchpeer-review

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235 Downloads (Pure)

A comparative genomics study of 23 Aspergillus species from section Flavi

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kildgaard, S., Petersen, T. I., Kuo, A., Sato, A., Lyhne, E. K., Kogle, M. E., Wiebenga, A., Kun, R. S., Lubbers, R. J. M., Mäkelä, M. R., Barry, K., Chovatia, M., Clum, A., Daum, C., Haridas, S. & 17 others, He, G., LaButti, K., Lipzen, A., Mondo, S., Pangilinan, J., Riley, R., Salamov, A., Simmons, B. A., Magnuson, J. K., Henrissat, B., Mortensen, U. H., Larsen, T. O., de Vries, R. P., Grigoriev, I. V., Machida, M., Baker, S. E. & Andersen, M. R., 2020, In : Nature Communications. 11, 1, 12 p., 1106.

Research output: Contribution to journalJournal articleResearchpeer-review

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Acurin A, a novel hybrid compound, biosynthesized by individually translated PKS- and NRPS-encoding genes in Aspergillus aculeatus

Wolff, P. B., Nielsen, M. L., Slot, J. C., Andersen, L. N., Petersen, L. M., Isbrandt, T., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2020, In : Fungal Genetics and Biology. 139, 10 p., 103378.

Research output: Contribution to journalJournal articleResearchpeer-review

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A Dereplication and Bioguided Discovery Approach to Reveal New Compounds from a Marine-Derived Fungus Stilbella fimetaria

Kildgaard, S., Subko, K., Phillips, E., Goidts, V., de la Cruz, M., Díaz, C., Gotfredsen, C. H., Andersen, B., Frisvad, J. C., Nielsen, K. F. & Larsen, T. O., 2017, In : Marine Drugs. 15, 8, 253.

Research output: Contribution to journalJournal articleResearchpeer-review

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260 Downloads (Pure)

Atrorosins: a new subgroup of Monascus pigments from Talaromyces atroroseus

Isbrandt, T., Tolborg, G., Ødum, A. S. R., Workman, M. & Larsen, T. O., 2019, In : Applied Microbiology and Biotechnology. p. 1-8 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Bioactive Lipids in Dairy Fat

Hellgren, L. & Nordby, P., 2017, Dairy in Human Health and Disease Across the Lifespan. Elsevier, p. 233-237

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Biosynthesis of acurin A and B in Aspergillus aculeatus

Hoof, J. B., Nielsen, M. L., Wolff, P. P., Petersen, L. M., Andersen, L. N., Petersen, T. I., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2017. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

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93 Downloads (Pure)

Biosynthesis of acurin A and B in Aspergillus aculeatus

Nielsen, M. L., Wolff, P. P., Petersen, L. M., Andersen, L. N., Petersen, T. I., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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155 Downloads (Pure)

Biosynthesis of the antimicrobial cyclic lipopeptides nunamycin and nunapeptin by Pseudomonas fluorescens strain In5 is regulated by the LuxR-type transcriptional regulator NunF

Hennessy, R. C., Phippen, C., Nielsen, K. F., Olsson, S. & Stougaard, P., 2017, In : MicrobiologyOpen. 6, 6, 14 p., e00516.

Research output: Contribution to journalJournal articleResearchpeer-review

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248 Downloads (Pure)

Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

Andersen, T. B., Rasmussen, S. A., Christensen, S. B. & Simonsen, H. T., 2019, In : Phytochemistry. 157, p. 168-174

Research output: Contribution to journalJournal articleResearchpeer-review

Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa

Kannangara, R., Siukstaite, L., Borch-Jensen, J., Madsen, B., Kongstad, K. T., Stærk, D., Bennedsen, M., Okkels, F. T., Rasmussen, S. A., Larsen, T. O., Frandsen, R. J. N. & Møller, B. L., 2017, In : Nature Communications. 8, 1, 12 p., 1987 .

Research output: Contribution to journalJournal articleResearchpeer-review

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263 Downloads (Pure)

Chemotaxonomy of the genus Stemphylium

Olsen, K. J. K. & Andersen, B., 2016, In : Planta Medica. 81, S 01, 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Cyclopiamines C and D: Epoxide Spiroindolinone Alkaloids from Penicillium sp. CML 3020

Kildgaard, S., de Medeiros, L. S., Phillips, E., Gotfredsen, C. H., Frisvad, J. C., Nielsen, K. F., Abreu, L. M. & Larsen, T. O., 2018, In : Journal of Natural Products. 81, 4, p. 785-790 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001.

Devi, S., Kiesewalter, H. T., Kovács, R., Frisvad, J. C., Weber, T., Larsen, T. O., Kovács, Á. T. & Ding, L., 2019, In : Synthetic and Systems Biotechnology. 4, 3, p. 142-149 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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108 Downloads (Pure)

Development of a LC-MS/MS method for the quantification of goniodomins A and B and its application to Alexandrium pseudogonyaulax strains and plankton field samples of Danish coastal waters

Krock, B., Tillmann, U., Wen, Y., Hansen, P. J., Larsen, T. O. & Andersen, A. J. C., 2018, In : Toxicon. 155, p. 51-60

Research output: Contribution to journalJournal articleResearchpeer-review

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50 Downloads (Pure)

Development of an indirect quantitation method to assess ichthyotoxic b-type prymnesins from prymnesium parvum

Svenssen, D. K., Binzer, S. B., Medić, N., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Toxins. 11, 5, 251.

Research output: Contribution to journalJournal articleResearchpeer-review

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54 Downloads (Pure)
Open Access
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222 Downloads (Pure)

Disease-free monoculture farming by fungus-growing termites

Otani, S., Challinor, V. L., Kreuzenbeck, N. B., Kildgaard, S., Krath Christensen, S., Larsen, L. L. M., Aanen, D. K., Rasmussen, S. A., Beemelmanns, C. & Poulsen, M., 2019, In : Scientific Reports. 9, 1, 10 p., 8819.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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62 Downloads (Pure)

Elucidating the biosynthetic pathway of the anticancer secondary metabolite calbistrin in Penicillium decumbens

Grijseels, S., Pohl, C., Wasil, Z., Froslev Nielsen, J. C., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2017. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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147 Downloads (Pure)

Exploiting fungal cell factories for pigment production

Tolborg, G., 2018, Kgs. Lyngby: Technical University of Denmark. 193 p.

Research output: Book/ReportPh.D. thesis

Open Access
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182 Downloads (Pure)

Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions

Robertsen, H. L., Musiol-Kroll, E. M., Ding, L., Laiple, K. J., Hofeditz, T., Wohlleben, W., Lee, S. Y., Grond, S. & Weber, T., 2018, In : Scientific Reports. 8, 9 p., 3230.

Research output: Contribution to journalJournal articleResearchpeer-review

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214 Downloads (Pure)

Filling The Gaps In The Kirromycin Biosynthetic Gene Cluster In Streptomyces Collinus Tü 365

Robertsen, H. L., Musiol-Kroll, E. M., Ding, L., Lee, S. Y. & Weber, T., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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62 Downloads (Pure)

Friends and Foes -Comparative Genomics of 23 Aspergillus Flavi Species

Kjærbølling, I., Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Kogle, M. E., Lyhne, E. K., Sato, A., Hainaut, M., Drula, E., Henrissat, B., Kuo, A., Salamov, A., Riley, R., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Friends and foes - comparative genomics of 23 Aspergillus Flavi species

Kjærbølling, I., Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Kogle, M. E., Lyhne, E. K., Kuo, A., Salamov, A., Riley, R., Larsen, T. O., Mortensen, U. H., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 2018. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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134 Downloads (Pure)

Genes Linked to Production of Secondary Metabolites in Talaromyces atroroseus Revealed Using CRISPR-Cas9

Nielsen, M. L., Petersen, T. I., Rasmussen, K. B., Thrane, U., Hoof, J. B., Larsen, T. O. & Mortensen, U. H., 2017, In : P L o S One. 12, 1, 9 p., e0169712.

Research output: Contribution to journalJournal articleResearchpeer-review

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323 Downloads (Pure)

Genetic Characterization of Neosartorin Biosynthesis Provides Insight into Heterodimeric Natural Product Generation

Matsuda, Y., Gotfredsen, C. H. & Larsen, T. O., 2018, In : ORGANIC LETTERS. 20, 22, p. 7194-7200 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Genomics driven discovery and engineering of fungal polycyclic polyketides

Subko, K., Wolff, P. B., Theobald, S., Frisvad, J. C., Gotfredsen, C. H., Andersen, M. R., Mortensen, U. H. & Larsen, T. O., 2018, p. 68.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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540 Downloads (Pure)

Genus level analysis of secondary metabolism reveals the origin of Aspergillus hybrid NRPS-PKS gene clusters

Theobald, S., Vesth, T. C., Rasmussen, J. L. N., Kjærbølling, I., Frisvad, J. C., Nielsen, K. F., Larsen, T. O., Grigoriev, I. V., Salamov, A., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2017. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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75 Downloads (Pure)

Glycerol metabolism of Pichia pastoris (Komagataella spp.) characterised by 13C-based metabolic flux analysis

Tomàs-Gamisans, M., Ødum, A. S. R., Workman, M., Ferrer, P. & Albiol, J., 2019, In : New Biotechnology. 50, p. 52-59 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

HldE Is Important for Virulence Phenotypes in Enterotoxigenic Escherichia coli

Maigaard Hermansen, G. M., Boysen, A., Krogh, T. J., Nawrocki, A., Jelsbak, L. & Møller-Jensen, J., 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 253, 13 p., 253.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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129 Downloads (Pure)

HPLC-HRMS Quantification of the Ichthyotoxin Karmitoxin from Karlodinium armiger

Andersen, A. J. C., Soman De Medeiros, L., Binzer, S. B., Rasmussen, S. A., Hansen, P. J., Nielsen, K. F., Jørgensen, K. & Larsen, T. O., 2017, In : Marine Drugs. 15, 9, 13 p., 278.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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228 Downloads (Pure)

Identification of the decumbenone biosynthetic gene cluster in Penicilliuum decumbens and the importance for production of calbistrin

Grijseels, S., Pohl, C., Nielsen, J. C., Wasil, Z., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2018, In : Fungal Biology and Biotechnology. 5, 17 p., 18.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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189 Downloads (Pure)

Identifying more than 300 Biosynthetic Gene Clusters with Potential Resistance Genes in over 75 Aspergillus species using Resistance Gene-Guided Genome Mining

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Rasmussen, J. L. N., Theobald, S., Grigoriev, I. V., Salamov, A., Larsen, T. O., Mortensen, U. H. & Andersen, M. R., 2017. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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115 Downloads (Pure)

Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri

Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Larsen, T. O., Nielsen, K. F., Hoof, J. B., Brandl, J., Salamov, A., Riley, R., Gladden, J. M., Phatale, P., Nielsen, M. T., Lyhne, E. K., Kogle, M. E., Strasser, K., McDonnell, E., Barry, K., Clum, A., Chen, C. & 19 others, LaButti, K., Haridas, S., Nolan, M., Sandor, L., Kuo, A., Lipzen, A., Hainaut, M., Drula, E., Tsang, A., Magnuson, J. K., Henrissat, B., Wiebenga, A., Simmons, B. A., Mäkelä, M. R., de Vries, R. P., Grigoriev, I. V., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2018, In : Nature Genetics. 50, p. 1688–1695

Research output: Contribution to journalJournal articleResearchpeer-review

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227 Downloads (Pure)

In vivo engineering of polyketide synthases

Olsen, K. J. K., Larsen, T. O. & Frandsen, R. J. N., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

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112 Downloads (Pure)

Isolation of Methyl Troposulfenin from Phaeobacter inhibens

Phippen, C. B. W., Jørgensen, C. M., Bentzon-Tilia, M., Gotfredsen, C. H., Larsen, T. O., Gram, L. & Sonnenschein, E. C., 2019, In : Journal of Natural Products. 82, 5, p. 1387-1390 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Karmitoxin: An amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger

Rasmussen, S. A., Binzer, S. B., Hoeck, C., Meier, S., Soman De Medeiros, L., Andersen, N. G., Place, A. D., Nielsen, K. F., Hansen, P. J. & Larsen, T. O., 2017, In : Journal of Natural Products. 80, 5, p. 1287-1293 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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239 Downloads (Pure)

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kuo, A., Bowyer, P., Matsuda, Y., Mondo, S., Lyhne, E. K., Kogle, M. E., Clum, A., Lipzen, A., Salamov, A., Ngan, C. Y., Daum, C., Chiniquy, J., Barry, K., LaButti, K., Haridas, S. & 7 others, Simmons, B. A., Magnuson, J. K., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 23 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E753-E761

Research output: Contribution to journalJournal articleResearchpeer-review

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Localization and in-vivo characterization of thapsia garganica CYP76AE2 indicates a role in thapsigargin biosynthesis

Andersen, T. B., Martinez-Swatson, K. A., Rasmussen, S. A., Boughton, B. A., Jørgensen, K., Andersen-Ranberg, J., Nyberg, N., Christensen, S. B. & Simonsen, H. T., 1 May 2017, In : Plant Physiology. 174, 1, p. 56-72 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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221 Downloads (Pure)

Metabolic engineering of yeast for fermentative production of flavonoids

Rodriguez Prado, E. A., Strucko, T., Stahlhut, S. G., Kristensen, M., Svenssen, D. K., Förster, J., Nielsen, J. & Borodina, I., 2017, In : Bioresource Technology. 245, Part B, p. 1645-1654

Research output: Contribution to journalJournal articleResearchpeer-review

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353 Downloads (Pure)

Metabolite production by species of Stemphylium

Olsen, K. J. K., Rossman, A. & Andersen, B., 2018, In : Fungal Biology. 122, 2-3, p. 172-181 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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160 Downloads (Pure)

Microbial platform for production of aromatic compounds

Skovbjerg, C. A. E., Olsen, K. J. K., Larsen, T. O. & Frandsen, R. J. N., 2017. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

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Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation

Matsuda, Y., Bai, T., Phippen, C. B. W., Nødvig, C. S., Kjærbølling, I., Vesth, T. C., Andersen, M. R., Mortensen, U. H., Gotfredsen, C. H., Abe, I. & Larsen, T. O., 2018, In : Nature Communications. 9, 1, 10 p., 2587 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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219 Downloads (Pure)

On the biosynthetic origin of carminic acid

Rasmussen, S. A., Kongstad, K. T., Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F., Gotfredsen, C. H., Stærk, D., Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In : Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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328 Downloads (Pure)

Phaeobacter piscinae sp. nov., a species of the Roseobacter group and potential aquaculture probiont

Sonnenschein, E. C., Phippen, C. B. W., Nielsen, K. F., Mateiu, R. V., Melchiorsen, J., Gram, L., Overmann, J. & Freese, H. M., 2017, In : International Journal of Systematic and Evolutionary Microbiology. 67, 10, p. 4559-4564

Research output: Contribution to journalJournal articleResearchpeer-review

Phylogenetic distribution of roseobacticides in the Roseobacter group and their effect on microalgae

Sonnenschein, E. C., Phippen, C. B. W., Bentzon-Tilia, M., Rasmussen, S. A., Nielsen, K. F. & Gram, L., 2018, In : Environmental Microbiology Reports. 10, 3, p. 383-393

Research output: Contribution to journalJournal articleResearchpeer-review

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Physiological characterization of secondary metabolite producing Penicillium cell factories

Grijseels, S., Nielsen, J., Nielsen, J., Larsen, T. O., Frisvad, J. C., Nielsen, K. F., Frandsen, R. J. N. & Workman, M., 2017, In : Fungal Biology and Biotechnology. 4, 8, 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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168 Downloads (Pure)

Prediction of secondary metabolite encoding genes based on chemical structure analysis

Petersen, T. I., Nielsen, M. L., Hoeck, C., Gezgin, Y., Frandsen, R. J. N., Nielsen, K. F. & Larsen, T. O., 2016, In : Planta Medica. 81, S 01, 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Pseudoalteromonas haloplanktis TAC125 produces 4-hydroxybenzoic acid that induces pyroptosis in human A459 lung adenocarcinoma cells

Sannino, F., Sansone, C., Galasso, C., Kildgaard, S., Tedesco, P., Fani, R., Marino, G., de Pascale, D., Ianora, A., Parrilli, E., Larsen, T. O., Romano, G. & Tutino, M. L., 2018, In : Scientific Reports. 8, 1, 10 p., 1190.

Research output: Contribution to journalJournal articleResearchpeer-review

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