• Søltofts Plads, Bygning 221

    DK-2800 Kgs. Lyngby

    Denmark

Research Output

2020

A comparative genomics study of 23 Aspergillus species from section Flavi

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kildgaard, S., Petersen, T. I., Kuo, A., Sato, A., Lyhne, E. K., Kogle, M. E., Wiebenga, A., Kun, R. S., Lubbers, R. J. M., Mäkelä, M. R., Barry, K., Chovatia, M., Clum, A., Daum, C., Haridas, S. & 17 others, He, G., LaButti, K., Lipzen, A., Mondo, S., Pangilinan, J., Riley, R., Salamov, A., Simmons, B. A., Magnuson, J. K., Henrissat, B., Mortensen, U. H., Larsen, T. O., de Vries, R. P., Grigoriev, I. V., Machida, M., Baker, S. E. & Andersen, M. R., 2020, In : Nature Communications. 11, 1, 12 p., 1106.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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55 Downloads (Pure)

Acurin A, a novel hybrid compound, biosynthesized by individually translated PKS- and NRPS-encoding genes in Aspergillus aculeatus

Wolff, P. B., Nielsen, M. L., Slot, J. C., Andersen, L. N., Petersen, L. M., Isbrandt, T., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2020, In : Fungal Genetics and Biology. 139, 10 p., 103378.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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75 Downloads (Pure)

Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens

Malik, A., Ardalani, H., Anam, S., McNair, L. M., Kromphardt, K. J. K., Frandsen, R. J. N., Franzyk, H., Staerk, D. & Kongstad, K. T., 2020, In : Fitoterapia. 142, 8 p., 104522.

Research output: Contribution to journalJournal articleResearchpeer-review

Oxygenated Geosmins and Plant-like Eudesmanes from a Bacterial Mangrove Endophyte

Ding, L. & Hertweck, C., 2020, (Accepted/In press) In : Journal of Natural Products. 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Plant‐like Cadinane Sesquiterpenes from an Actinobacterial Mangrove Endophyte

Ding, L., Görls, H. & Hertweck, C., 2020, (Accepted/In press) In : Magnetic Resonance in Chemistry.

Research output: Contribution to journalJournal articleResearchpeer-review

Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides

Guo, Y., Frisvad, J. C. & Larsen, T. O., 2020, In : Metabolites. 10, 6, 13 p., 246.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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7 Downloads (Pure)

Surfactin production is not essential for pellicle and root-associated biofilmdevelopment of Bacillus subtilis

Thérien, M., Kiesewalter, H. T., Auria, E., Charron-Lamoreux, V., Wibowo, M., Maróti, G., Kovács, Á. T. & Beuregard, P. B., 2020, In : Biofilm. 2, 7 p., 100021.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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29 Downloads (Pure)

Tenuazonic acid from Stemphylium loti inhibits the plant plasma membrane H+-ATPase by a mechanism involving the C-terminal regulatory domain

Bjørk, P. K., Rasmussen, S. A., Gjetting, S. K., Havshøi, N. W., Petersen, T. I., Ipsen, J. Ø., Larsen, T. O. & Fuglsang, A. T., 2020, In : New Phytologist. 226, 3, p. 770-784 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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45 Downloads (Pure)
2019

A-, B- and C-type prymnesins are clade specific compounds and chemotaxonomic markers in Prymnesium parvum

Binzer, S. B., Svenssen, D. K., Daugbjerg, N., Alves-de-Souza, C., Pinto, E., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Harmful Algae. 81, p. 10-17

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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292 Downloads (Pure)

Atrorosins: a new subgroup of Monascus pigments from Talaromyces atroroseus

Isbrandt, T., Tolborg, G., Ødum, A. S. R., Workman, M. & Larsen, T. O., 2019, In : Applied Microbiology and Biotechnology. p. 1-8 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

Andersen, T. B., Rasmussen, S. A., Christensen, S. B. & Simonsen, H. T., 2019, In : Phytochemistry. 157, p. 168-174

Research output: Contribution to journalJournal articleResearchpeer-review

Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001.

Devi, S., Kiesewalter, H. T., Kovács, R., Frisvad, J. C., Weber, T., Larsen, T. O., Kovács, Á. T. & Ding, L., 2019, In : Synthetic and Systems Biotechnology. 4, 3, p. 142-149 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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215 Downloads (Pure)

Development of an indirect quantitation method to assess ichthyotoxic b-type prymnesins from prymnesium parvum

Svenssen, D. K., Binzer, S. B., Medić, N., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Toxins. 11, 5, 251.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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102 Downloads (Pure)

Disease-free monoculture farming by fungus-growing termites

Otani, S., Challinor, V. L., Kreuzenbeck, N. B., Kildgaard, S., Krath Christensen, S., Larsen, L. L. M., Aanen, D. K., Rasmussen, S. A., Beemelmanns, C. & Poulsen, M., 2019, In : Scientific Reports. 9, 1, 10 p., 8819.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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117 Downloads (Pure)

Glycerol metabolism of Pichia pastoris (Komagataella spp.) characterised by 13C-based metabolic flux analysis

Tomàs-Gamisans, M., Ødum, A. S. R., Workman, M., Ferrer, P. & Albiol, J., 2019, In : New Biotechnology. 50, p. 52-59 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Isolation of Methyl Troposulfenin from Phaeobacter inhibens

Phippen, C. B. W., Jørgensen, C. M., Bentzon-Tilia, M., Gotfredsen, C. H., Larsen, T. O., Gram, L. & Sonnenschein, E. C., 2019, In : Journal of Natural Products. 82, 5, p. 1387-1390 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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48 Downloads (Pure)
Open Access
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275 Downloads (Pure)

Taxonomy of Aspergillus section Flavi and their production of aflatoxins, ochratoxins and other mycotoxins

Frisvad, J. C., Hubka, V., Ezekiel, C. N., Hong, S. B., Nováková, A., Chen, A. J., Arzanlou, M., Larsen, T. O., Sklenář, F., Mahakarnchanakul, W., Samson, R. A. & Houbraken, J., 2019, In : Studies in Mycology. 93, p. 1-63

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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313 Downloads (Pure)

Unique processes yielding pure azaphilones in Talaromyces atroroseus

Tolborg, G., Ødum, A. S. R., Isbrandt, T., Larsen, T. O. & Workman, M., 2019, In : Applied Microbiology and Biotechnology. 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B

Copmans, D., Kildgaard, S., Rasmussen, S. A., Ślezak, M., Dirkx, N., Partoens, M., Esguerra, C. V., Crawford, A. D., Larsen, T. O. & De Witte, P. A. M., 2019, In : Marine Drugs. 17, 11, 20 p., 607.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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68 Downloads (Pure)
2018

Cyclopiamines C and D: Epoxide Spiroindolinone Alkaloids from Penicillium sp. CML 3020

Kildgaard, S., de Medeiros, L. S., Phillips, E., Gotfredsen, C. H., Frisvad, J. C., Nielsen, K. F., Abreu, L. M. & Larsen, T. O., 2018, In : Journal of Natural Products. 81, 4, p. 785-790 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Development of a LC-MS/MS method for the quantification of goniodomins A and B and its application to Alexandrium pseudogonyaulax strains and plankton field samples of Danish coastal waters

Krock, B., Tillmann, U., Wen, Y., Hansen, P. J., Larsen, T. O. & Andersen, A. J. C., 2018, In : Toxicon. 155, p. 51-60

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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113 Downloads (Pure)

Discovery and Characterization of Fungal Natural Product Biosynthetic Pathways

Isbrandt, T., 2018, Kgs. Lyngby: Technical University of Denmark. 374 p.

Research output: Book/ReportPh.D. thesisResearch

Open Access
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288 Downloads (Pure)

Exploiting fungal cell factories for pigment production

Tolborg, G., 2018, Kgs. Lyngby: Technical University of Denmark. 193 p.

Research output: Book/ReportPh.D. thesisResearch

Open Access
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279 Downloads (Pure)

Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions

Robertsen, H. L., Musiol-Kroll, E. M., Ding, L., Laiple, K. J., Hofeditz, T., Wohlleben, W., Lee, S. Y., Grond, S. & Weber, T., 2018, In : Scientific Reports. 8, 9 p., 3230.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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285 Downloads (Pure)

Friends and Foes -Comparative Genomics of 23 Aspergillus Flavi Species

Kjærbølling, I., Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Kogle, M. E., Lyhne, E. K., Sato, A., Hainaut, M., Drula, E., Henrissat, B., Kuo, A., Salamov, A., Riley, R., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Friends and foes - comparative genomics of 23 Aspergillus Flavi species

Kjærbølling, I., Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Kogle, M. E., Lyhne, E. K., Kuo, A., Salamov, A., Riley, R., Larsen, T. O., Mortensen, U. H., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 2018. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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158 Downloads (Pure)

Genetic Characterization of Neosartorin Biosynthesis Provides Insight into Heterodimeric Natural Product Generation

Matsuda, Y., Gotfredsen, C. H. & Larsen, T. O., 2018, In : ORGANIC LETTERS. 20, 22, p. 7194-7200 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Genomics driven discovery and engineering of fungal polycyclic polyketides

Subko, K., Wolff, P. B., Theobald, S., Frisvad, J. C., Gotfredsen, C. H., Andersen, M. R., Mortensen, U. H. & Larsen, T. O., 2018, p. 68.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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763 Downloads (Pure)

HldE Is Important for Virulence Phenotypes in Enterotoxigenic Escherichia coli

Maigaard Hermansen, G. M., Boysen, A., Krogh, T. J., Nawrocki, A., Jelsbak, L. & Møller-Jensen, J., 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 253, 13 p., 253.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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185 Downloads (Pure)

Identification of the decumbenone biosynthetic gene cluster in Penicilliuum decumbens and the importance for production of calbistrin

Grijseels, S., Pohl, C., Nielsen, J. C., Wasil, Z., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2018, In : Fungal Biology and Biotechnology. 5, 17 p., 18.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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259 Downloads (Pure)

Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri

Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Larsen, T. O., Nielsen, K. F., Hoof, J. B., Brandl, J., Salamov, A., Riley, R., Gladden, J. M., Phatale, P., Nielsen, M. T., Lyhne, E. K., Kogle, M. E., Strasser, K., McDonnell, E., Barry, K., Clum, A., Chen, C. & 19 others, LaButti, K., Haridas, S., Nolan, M., Sandor, L., Kuo, A., Lipzen, A., Hainaut, M., Drula, E., Tsang, A., Magnuson, J. K., Henrissat, B., Wiebenga, A., Simmons, B. A., Mäkelä, M. R., de Vries, R. P., Grigoriev, I. V., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2018, In : Nature Genetics. 50, p. 1688–1695

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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326 Downloads (Pure)

In vivo engineering of polyketide synthases

Olsen, K. J. K., Larsen, T. O. & Frandsen, R. J. N., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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149 Downloads (Pure)

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kuo, A., Bowyer, P., Matsuda, Y., Mondo, S., Lyhne, E. K., Kogle, M. E., Clum, A., Lipzen, A., Salamov, A., Ngan, C. Y., Daum, C., Chiniquy, J., Barry, K., LaButti, K., Haridas, S. & 7 others, Simmons, B. A., Magnuson, J. K., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 23 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E753-E761

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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158 Downloads (Pure)

Metabolite production by species of Stemphylium

Olsen, K. J. K., Rossman, A. & Andersen, B., 2018, In : Fungal Biology. 122, 2-3, p. 172-181 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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228 Downloads (Pure)

Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation

Matsuda, Y., Bai, T., Phippen, C. B. W., Nødvig, C. S., Kjærbølling, I., Vesth, T. C., Andersen, M. R., Mortensen, U. H., Gotfredsen, C. H., Abe, I. & Larsen, T. O., 2018, In : Nature Communications. 9, 1, 10 p., 2587 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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282 Downloads (Pure)

On the biosynthetic origin of carminic acid

Rasmussen, S. A., Kongstad, K. T., Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F., Gotfredsen, C. H., Stærk, D., Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In : Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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462 Downloads (Pure)

Phylogenetic distribution of roseobacticides in the Roseobacter group and their effect on microalgae

Sonnenschein, E. C., Phippen, C. B. W., Bentzon-Tilia, M., Rasmussen, S. A., Nielsen, K. F. & Gram, L., 2018, In : Environmental Microbiology Reports. 10, 3, p. 383-393

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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53 Downloads (Pure)

Pseudoalteromonas haloplanktis TAC125 produces 4-hydroxybenzoic acid that induces pyroptosis in human A459 lung adenocarcinoma cells

Sannino, F., Sansone, C., Galasso, C., Kildgaard, S., Tedesco, P., Fani, R., Marino, G., de Pascale, D., Ianora, A., Parrilli, E., Larsen, T. O., Romano, G. & Tutino, M. L., 2018, In : Scientific Reports. 8, 1, 10 p., 1190.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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249 Downloads (Pure)

Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei

Frisvad, J. C., Møller, L. L. H., Larsen, T. O., Kumar, R. & Arnau, J., 2018, In : Applied Microbiology and Biotechnology. 102, 22, p. 9481-9515

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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324 Downloads (Pure)

The FlbA-regulated predicted transcription factor Fum21 of Aspergillus niger is involved in fumonisin production

Aerts, D., Hauer, E. E., Ohm, R. A., Arentshorst, M., Teertstra, W. R., Phippen, C., Ram, A. F. J., Frisvad, J. C. & Wösten, H. A. B., 2018, In : Antonie Van Leeuwenhoek. 111, 3, p. 311-322

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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240 Downloads (Pure)

Uncovering secondary metabolite evolution and biosynthesis using gene cluster networks and genetic dereplication

Theobald, S., Vesth, T. C., Rendsvig, J. K., Nielsen, K. F., Riley, R., de Abreu, L. M., Salamov, A., Frisvad, J. C., Larsen, T. O., Andersen, M. R. & Hoof, J. B., 2018, In : Scientific Reports. 8, 12 p., 17957.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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265 Downloads (Pure)
2017

A Dereplication and Bioguided Discovery Approach to Reveal New Compounds from a Marine-Derived Fungus Stilbella fimetaria

Kildgaard, S., Subko, K., Phillips, E., Goidts, V., de la Cruz, M., Díaz, C., Gotfredsen, C. H., Andersen, B., Frisvad, J. C., Nielsen, K. F. & Larsen, T. O., 2017, In : Marine Drugs. 15, 8, 253.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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323 Downloads (Pure)

Bioactive Lipids in Dairy Fat

Hellgren, L. & Nordby, P., 2017, Dairy in Human Health and Disease Across the Lifespan. Elsevier, p. 233-237

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Biosynthesis of acurin A and B in Aspergillus aculeatus

Nielsen, M. L., Wolff, P. P., Petersen, L. M., Andersen, L. N., Petersen, T. I., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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300 Downloads (Pure)

Biosynthesis of acurin A and B in Aspergillus aculeatus

Hoof, J. B., Nielsen, M. L., Wolff, P. P., Petersen, L. M., Andersen, L. N., Petersen, T. I., Holm, D. K., Mortensen, U. H., Nødvig, C. S., Larsen, T. O. & Hoof, J. B., 2017. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
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116 Downloads (Pure)

Biosynthesis of the antimicrobial cyclic lipopeptides nunamycin and nunapeptin by Pseudomonas fluorescens strain In5 is regulated by the LuxR-type transcriptional regulator NunF

Hennessy, R. C., Phippen, C., Nielsen, K. F., Olsson, S. & Stougaard, P., 2017, In : MicrobiologyOpen. 6, 6, 14 p., e00516.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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321 Downloads (Pure)

Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa

Kannangara, R., Siukstaite, L., Borch-Jensen, J., Madsen, B., Kongstad, K. T., Stærk, D., Bennedsen, M., Okkels, F. T., Rasmussen, S. A., Larsen, T. O., Frandsen, R. J. N. & Møller, B. L., 2017, In : Nature Communications. 8, 1, 12 p., 1987 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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351 Downloads (Pure)

Elucidating the biosynthetic pathway of the anticancer secondary metabolite calbistrin in Penicillium decumbens

Grijseels, S., Pohl, C., Wasil, Z., Froslev Nielsen, J. C., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2017. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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178 Downloads (Pure)

Filling The Gaps In The Kirromycin Biosynthetic Gene Cluster In Streptomyces Collinus Tü 365

Robertsen, H. L., Musiol-Kroll, E. M., Ding, L., Lee, S. Y. & Weber, T., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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84 Downloads (Pure)