Department of Biotechnology and Biomedicine

  • Søltofts Plads, Bygning 221

    DK-2800 Kgs. Lyngby

    Denmark

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2020

CHRONIC SKIN ULCERS - A STUDY OF THE GLOBAL TISSUE PROTEOME AND PROTEASE CLEAVAGE PRODUCTS

Bundgaard, L., Aagren, M. S., Holstein, P., Sabino, F. & auf dem Keller, U., 2020, In : Wound Repair and Regeneration. 28, 2, p. A18-A19 2 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

2019

A Biomarker of Type VI Collagen Degradation (C6M) Is Associated with Changes in ASDAS MRI Measures of Inflammation in Patients with Axial Spondyloarthritis During TNF Inhibitor Therapy

Nielsen, S. H., Bay-Jensen, A., Østergaard, M., Siebuhr, A., Karsdal, M., Sørensen, I. J., Weber, U., Loft, A. G., Kollerup, G., Thamsborg, G., Madsen, O. R., Møller, J. & Pedersen, S. J., 2019, In : Arthritis and Rheumatology. 71, S10, 3 p., 0583.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Cocktails of human monoclonal IgG antibodies capable of neutralizing dendrotoxin-mediated neurotoxicity of black mamba venom in vivo

Laustsen, A. H., Karatt-Vellatt, A., Masters, E. W., Arias, A. S., Pus, U., Knudsen, C., Oscoz, S., Slavny, P., Griffiths, D. T., Luther, A. M., Leah, R. A., Lindholm, M., Lomonte, B., Mar a Guti rrez, J. & McCafferty, J., 2019, In : Toxicon. 159, Supp. 1, p. S5-S6

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Connecting comorbidities with brain-gut-microbiome-stress axis biology in autism spectrum disorder

Yap, C., Wray, N., Brix, S. & Gratten, J., 2019, In : EUROPEAN NEUROPSYCHOPHARMACOLOGY. 29, p. S227-S228 2 p., T16.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Design of scfab-based chimeric antibodies against Bothrops asper pi-metalloproteinase

Friis, R. U. W., Dam, S. H., Haack, A. M., Hallgren, M. B., Esteban, A. M., Andersen, M. R., Kilstrup, M. & Laustsen, A. H., 2019, In : Toxicon. 158, p. S41-S41

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Discovery and evaluation of monoclonal antibodies for stratification of venoms from brazilian Bothrops, Crotalus, and Lachesis species

Knudsen, C., Dam, S. H., Friis, R. U. W., Haack, A. M., Andersen, J. K. & Laustsen, A. H., 2019, In : Toxicon. 177, p. S38-S38 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Discovery of cross-reactive and recyclable human monoclonal antibodies for new recombinant antivenoms

Ledsgaard, L., Ahmadi, S., Pucca, M. B., Cerni, F. A., Jürgensen, J. A., Knudsen, C., Pus, U., Sørensen, C. V., Føns, S., Janke, R., Knerr, J., Bertelsen, A. B., Dehli, R. I., Esteban, A. M., Karatt-Vellatt, A., McCafferty, J., Lomonte, B., Arantes, E. C. & Laustsen, A. H., 2019, In : Toxicon. 177, p. S38-S38 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Discovery of human antibodies against forest cobra toxins

Jensen, L. L., Øhlenschlæger, M., Karatt-­Vellatt, A., Andersen, M. R., Harrison, R., Casewell, N., McCafferty, J. & Laustsen, A. H., 2019, In : Toxicon. 158, Suppl. 1, p. S51-S52 2 p., 170.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Endotrophin, a fragment of collagen type VI formation (PRO-C6) is associated with progression free survival and mortality in patients with hepatocellular carcinoma

Nielsen, S. H., Uchila, R., Eslam, M., Nielsen, M. J., Leeming, D. J., Vongsuvanh, R., Poorten, D. V. D., Karsdal, M. & George, J., 2019, In : Journal of Hepatology. 70, 1, Supplement, p. e819-e819 1 p., SAT-419.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Factors affecting the intensity of the inflammatory response in experimental porcine bruises

Barington, K., Skovgaard, K., Henriksen, N. L., Johansen, A. S. B. & Jensen, H. E., 2019, In : Journal of Comparative Pathology. 166, p. 117-117 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Guiding antivenom development through linear visualization of venomics data

Dam, S. H., Friis, R. U. W. & Laustsen, A. H., 2019, In : Toxicon. 158, Suppl. 1, p. S44-S44

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Harnessing human monoclonal antibodies for neutralisation of dendrotoxins in a murine model

Knudsen, C., Arias, A. S., Lomonte, B., Mar a Guti rrez, J., Puš, R., Oscoz, S., Masters, E. W., Luther, A. M., Griffiths, D. T., Olesen, M. L., Leah, R. A., Slavny, P., Karatt-Vellatt, A., McCafferty, J. & Laustsen, A. H., 2019, In : Toxicon. 159, Supp. 1, p. S14

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Harnessing monoclonal antibodies for development of a specific treatment against Naja nigricollis envenoming

Jürgensen, J. A., Janke, R., Dehli, R. I., Martos-Esteban, A. & Laustsen, A. H., 2019, In : Toxicon. 177, p. S37-S37 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Harnessing phage display technology for discovery of human IgGs targeting clinically relevant toxins from the venom of the Central American coral snake (Micrurus nigrocinctus)

Méndez, E. B., Fernández, J., Lomonte, B., Gutiérrez, J. M. & Laustsen, A. H., 2019, In : Toxicon. 158, Suppl. 1, p. S45-s45 1 p., 150.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Harnessing phage display technology for generating fully human IgG antibodies that neutralise elapid neurotoxins

Karatt-Vellatt, A., Laustsen, A. H., Masters, E. W., Oscoz, S., Pus, U., Knudsen, C., Slavny, P., Luther, A. M., Leah, R. A., Grifiths, D. T., Olesen, M. L., Lomonte, B., Gutiérrez, J. M. & McCafferty, J., 2019, In : Toxicon. 158, Suppl. 1, p. s18-s18 1 p., 59.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
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High levels of MMP-cleaved mimecan is associated to carotid plaque stability and less future cardiovascular events

Goncalves, I., Tengryd, C., Nielsen, S. H., Genovese, F., Bengtsson, E., Karsdal, M., Leeming, D. J., Nilsson, J. & Edsfeldt, A., 2019, In : European Heart Journal. 40, Suppl. 1, 1 p., 3046.

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Immune Mediator Levels in the Upper Airways Predict Response to Azithromycin for Episodes with Asthma-like Symptoms in Young Children

Carlsson, C. J., Rasmussen, M. A., Brix, S., Wang, N., Stokholm, J., Chawes, B., Bonnelykke, K. & Bisgaard, H. F., 2019, In : Pediatric Pulmonology. 54, S1, p. S75-S76 2 p., A-27.

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Interaction between feruloylated arabinoxylan and nanocellulose: Effect on bulk rheological and material properties

Perzon, A., Muschiol, J., Meyer, A. S., Munk, L., Liu, M., Holland, C., Jørgensen, B. & Ulvskov, P., 2019, In : American Chemical Society. Abstracts of Papers (at the National Meeting). 257, 255.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Interaction of snake venom metalloproteinases with type IV collagen: Role of the different domains in target biding

Apú, N., da Silva, A. R., Kalogeropoulos, K., Herrera, C., Camacho, E., Rucavado, A., Gutiérrez, J. M. & Escalante, T., 2019, In : Toxicon. 177, p. S51-S51 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Monoclonal human IgGs capable of neutralizing elapid neurotoxins in vivo

Pus, U., Laustsen, A. H., Karatt-Vellatt, A., Griffiths, D. T., Oscoz, S., Andersen, M. R., Harrison, R., Casewell, N., Lomonte, B., McCafferty, J. & Gutiérrez, J. M., 2019, In : Toxicon. 158, Suppl. 1, p. S44-S44 1 p., 145.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
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Parasites and plants - bioactive compounds with anti-parasitic effect from Cichorium intybus

Valente, A. H., de Roode, B. M., Williams, A. R., Simonsen, H. T. & Thamsborg, S. M., 2019, In : Planta Medica. 85, 18, 1 p., 1420.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

The role of individual cardiolipin species on stability and activity of Magnesium transporter A (MgtA)

Weikum, J., Subramani, S., Van Dyck, J., Sobott, F. & Morth, J. P., 2019, In : European Biophysics Journal With Biophysics Letters. 48, S1, p. S166-S166 1 p., P-350.

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2018

A marker of collagen type I degradation is associated with cardiovascular events and mortality in patients with known atherosclerosis

Nielsen, S. H., Tengryd, C., Pedersen, S. B., Genovese, F., Bengtsson, E., Karsdal, M., Reese-Petersen, A. L., Leeming, D. J., Edsfeldt, A., Nilsson, J. & Goncalves, I., 2018, In : European Heart Journal. 39, Suppl 1, p. 1040

Research output: Contribution to journalConference abstract in journalResearchpeer-review

A Novel Predictor of Response to Gemtuzumab Ozogamicin Therapy in AML Provides Strategies for Sensitization of Leukemia Stem Cells in Individual Patients

Ng, S. W. K., Erwin, S. E., Mitchell, A., Minden, M. D., Bullinger, L., Doehner, H., Dombret, H., Preudhomme, C., Cheok, M., Dick, J. E. & Wang, J. C. Y., 2018, In : Blood. 132, Suppl. 1, p. 2765-2765 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

A SYSTEM-WIDE STUDY OF THE PROTEOME AND PROTEASE CLEAVAGE PRODUCTS IN CHRONIC SKIN ULCERS

Bundgaard, L. B., Agren, M. S., Holstein, P., Savickas, S., Sabino, F. M. R. & auf dem Keller, U., 2018, In : Wound Repair and Regeneration. 26, 2, p. A19-A19 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Current progress towards the next generation of antivenoms

Laustsen, A. H., 2018, In : Toxicon. 150, p. 319

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Effect of MMP-13 degraded SPARC on type I collagen and its biomarker potential in colorectal cancer

Kehlet, S. N., Harling, H., Jorgensen, L. N., Karsdal, M. A. & Willumsen, N., 2018, In : Journal of Clinical Oncology. 36, 4, 717.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Glucocorticoids Exert a Dual Role in B-Cell Acute Lymphoblastic Leukemia: Apoptosis and Differentiation of Early B-Cell Populations

Sarno, J., Pedersen, C., Jager, A., Burns, T., Gaipa, G., Nolan, G., Bava, A. & Davis, K., 2018, In : Experimental Hematology. Supplement. 64, Supp, p. S100 3157.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Harnessing snake venoms to make T. brucei forever go to sleep

Martos Esteban, A., Carrington, M. & Laustsen, A. H., 2018, In : Toxicon. 150, p. 320-321

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Identification of Gene Regulatory Networks Governing Stemness Properties of Human HSC and LSC

Ng, S. W. K., Xie, S. Z-J., Wagenblast, E., Takayama, N., Jin, L., Mbong, N., Murison, A., Erwin, S. E., Mitchell, A., Van Galen, P., Lupien, M., Minden, M. D., Wang, J. C. Y., Zandstra, P. W. & Dick, J. E., 2018, In : Blood. 132, p. 3832-3832 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Markers of basement membrane remodelling are associated with higher mortality in patients with advanced carotid atherosclerosis

Goncalves, I., Holm Nielsen, S., Tengryd, C., Brix, S., Edsfeldt, A., Genovese, F., Bengtsson, E., Karsdal, M., Julie Leeming, D. & Nilsson, J., 2018, In : European Heart Journal. 39, suppl_1, p. 1039-1040 4982.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Molecular mechanism of the TP901-1 lysogeny switch

Lo Leggio, L., Rasmussen, K. K., Varming, A. K., Frandsen, K. E. H., Thusltrtip, P. W., Kilstrup, M., Hammer, K. & Jensen, M. R., 2018, In : Acta Crystallographica. Section A: Foundations of Crystallography. 74, p. E30-E30 1 p.

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P-192 - Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function

Degendorfer, G., Lorentzen, L. G., Chuang, C. Y., Mariotti, M., Hammer, A., Hoefler, G., Hägglund, P., Malle, E., Wise, S. & Davies, M. J., 2018, In : Free Radical Biology & Medicine. 120, Suppl. 1, p. 102-103

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Recombinant antivenom against the venom of Dendroaspis polylepis

Knudsen, C., Karatt-Vellat, A., Andersen, M. R., Harrison, R., Casewell, N., Kilstrup, M., McCafferty, J. & Laustsen, A. H., 2018, In : Toxicon. 158, Suppl. 1, p. S43-S43 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

2017

Activation of Toll-like Receptor 2 in Human Synovium Explants Increase Tissue Turnover and Secretion of Interleukin-6

Sharma, N., Kayed, A., Kjelgaard-Petersen, C. F., Christiansen, T. G., Karsdal, M., Thudium, C. S. & Bay-Jensen, A-C., 2017, In : Arthritis and Rheumatology. 69, 4 p., 1063.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
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A novel biomarker of laminin turnover is associated with mortality and disease progression in chronic kidney disease

Nielsen, S. H., Guldager Kring Rasmussen, D., Fenton, A., Jesky, M., Ferro, C., Karsdal, M., Genovese, F. & Cockwell, P., 2017, In : Nephrology, Dialysis, Transplantation. 32, Suppl. 3, 1 p.

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A novel urinary biomarker of type VI collagen formation and endotrophin is associated with loss of kidney function in patients with diabetic nephropathy

Genovese, F., Rasmussen, D., Nielsen, S. H., Haas, J., Voelker, J., Karsdal, M. A. & Duffin, K., 2017, In : Nephrology, Dialysis, Transplantation. 32, Suppl. 3, 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
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A serum biomarker reflecting collagen type I degradation (C1M) is an independent risk factor for acute myocardial infarction in postmenopausal women: results from the PERF study

Bertelsen, D. M., Nielsen, S. H., Neergaard, J. S., Karsdal, M. A. & Nielsen, H. B., 2017, In : European Heart Journal. 38, Suppl. 1, p. 722 P3449.

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Establishment of a Human Synovium and Cartilage Co-culture

Kjelgaard-Petersen, C. F., Bay-Jensen, A-C., Christiansen, T., Karsdal, M. A., Hägglund, P., Siebuhr, A. S. & Thudium, C. S., 2017, In : Osteoarthritis and Cartilage. 25, p. 276-277 2 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Ex vivo back-translation of fostamatinib's effect on joint ecm turnover shows significant effect on bone but no effect on the synovium

Kjelgaard-Petersen, C. F., Christensen, T. G., Hagglund, P., Karsdal, M. A., Thudium, C. S. & Bay-Jensen, A-C., 2017, In : Annals of the Rheumatic Diseases. 76, p. 1068-1069 2 p., AB0062.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Identification of citrullination sites specific for peptidylarginine deiminase 2 (PAD2) and PAD4 in fibrinogen from synovial fluid of patients with rheumatoid arthritis

Sharma, M., Damgaard, D., Senolt, L., Svensson, B., Jensen, A. C. B., Nielsen, C. H. & Hagglund, P., 2017, In : Annals of the Rheumatic Diseases. 76, p. 501-501

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Macrophage-derived osteopontin is fragmented by MMP-9 to hinder angiogenesis in the post-myocardial infarction left ventricle

Nielsen, S. H., Flynn, E. R. & Lindsey, M., 2017, In : European Heart Journal. 38, Suppl. 1, p. 331 P1566.

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Open Access
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Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage

Kjelgaard-Petersen, C. F., Sharma, N., Kayed, A., Christensen, B., Karsdal, M., Bay-Jensen, A-C. & Thudium, C. S., 2017, In : Arthritis and Rheumatology. 69, Suppl. 10, 969.

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Open Access
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Non-invasive evaluation of extracellular matrix remodeling in peripheral artery disease

Hernandez Aguilera, A., Nielsen, S. H., Fernandez-Arroyo, S., Martin-Paredero, V., Karsdal, M. A., Genovese, F., Camps, J. & Joven, J., 2017, In : Atherosclerosis. Supplement. 263, p. E68 SAG108.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

PATH-01. Identification of Prognastic Variables Based on Molecular Profiling of Long-Term and Short-Term Surviving Gglioblastoma Patients

Michaelsen, S. R., Urup, T., Olsen, L. R., Gillberg, L., Broholm, H., Grunnet, K., Grønbæk, K., Hamerlik, P., Lassen, U. & Poulsen, H. S., 2017, In : Neuro-Oncology. 19, suppl_6, p. vi170-vi170 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Pre-Treatment of Synovial Fluid Enable Precise and Accurate Measurement of Neo-Epitope Biomarkers

Kjelgaard-Petersen, C. F., Thudium, C. S., Jung, B., Hägglund, P., Simonsen, O., Karsdal, M. A., Mobasheri, A. & Bay-Jensen, A-C., 2017, In : Osteoarthritis and Cartilage. 25, p. 104-105

Research output: Contribution to journalConference abstract in journalResearchpeer-review

2016

Chemotaxonomy of the genus Stemphylium

Olsen, K. J. K. & Andersen, B., 2016, In : Planta Medica. 81, S 01, 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Chondrocyte pro-proliferative compounds may utilize extracellular matrix remodeling processes to regenerate cartilage

Reker, D., Kjelgaard-Petersen, C. F., Gigout, A., Ladel, C., Siebuhr, A., Michealis, M., Karsdal, M. A. & Bay-Jensen, A., 2016, In : Osteoarthritis and Cartilage. 24, Suppl. 1, p. S157 1 p., 261.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Defining carbohydrate binding of glucan phosphatases via Affinity gel electrophoresis

Auger, K., Raththagala, M., Wilkens, C., Svensson, B. & Gentry, M., 2016, In : FASEB Journal. 30, Suppl. 1, 1113.2.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Effects of musculoskeletal related growth factors on cartilage extracellular matrix formation

Kjelgaard-Petersen, C. F., Reker, D., Gudmann, N. S., Gigout, A., Siebuhr, A., Karsdal, M. A., Michealis, M., Ladel, C. & Bay-Jensen, A., 2016, In : Osteoarthritis and Cartilage. 24, Suppl. 1, p. S155 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review