Department of Biotechnology and Biomedicine

  • Søltofts Plads, Bygning 221

    DK-2800 Kgs. Lyngby

    Denmark

Research Output

2018

Genus-level studies of gene dynamics for the Aspergillus genus

Theobald, S., 2018, Kgs. Lyngby: Technical University of Denmark. 166 p.

Research output: Book/ReportPh.D. thesis

Open Access
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223 Downloads (Pure)

Genus-scale Analysis of Gene Cluster Evolution in Fungi

Kjærbølling, I., 2018, Kgs. Lyngby: Technical University of Denmark. 187 p.

Research output: Book/ReportPh.D. thesisResearch

Open Access
File
193 Downloads (Pure)

Glucocorticoids Exert a Dual Role in B-Cell Acute Lymphoblastic Leukemia: Apoptosis and Differentiation of Early B-Cell Populations

Sarno, J., Pedersen, C., Jager, A., Burns, T., Gaipa, G., Nolan, G., Bava, A. & Davis, K., 2018, In : Experimental Hematology. Supplement. 64, Supp, p. S100 3157.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Glucose-dependent promoters for dynamic regulation of metabolic pathways

Maury, J., Kannan, S., Jensen, N. B., Öberg, F. K., Kildegaard, K. R., Forster, J., Nielsen, J., Workman, C. T. & Borodina, I., 2018, In : Frontiers in Bioengineering and Biotechnology. 6, 63.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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184 Downloads (Pure)

Glycoengineering in CHO cells: Advances in systems biology

Tejwani, V., Andersen, M. R., Nam, J. H. & Sharfstein, S. T., 2018, In : Biotechnology Journal. 13, 3, 16 p., 1700234.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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159 Downloads (Pure)

Guiding recombinant antivenom development by omics technologies

Laustsen, A. H., 2018, In : New Biotechnology. 45, p. 19-27

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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268 Downloads (Pure)

Hampered motility promotes the evolution of wrinkly phenotype in Bacillus subtilis

Richter, A., Hoelscher, T., Pausch, P., Sehrt, T., Brockhaus, F., Bange, G. & Kovács, Á. T., 2018, In : BMC Evolutionary Biology. 18, 1, 11 p., 155.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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134 Downloads (Pure)

Harnessing snake venoms to make T. brucei forever go to sleep

Martos Esteban, A., Carrington, M. & Laustsen, A. H., 2018, In : Toxicon. 150, p. 320-321

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Heterologous production of the widely used natural food colorant carminic acid in Aspergillus nidulans

Frandsen, R. J. N., Khorsand-Jamal, P., Kongstad, K. T., Nafisi, M., Kannangara, R. M., Stærk, D., Okkels, F. T., Binderup, K., Madsen, B., Møller, B. L., Thrane, U. & Mortensen, U. H., 2018, In : Scientific Reports. 8, 1

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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270 Downloads (Pure)

Higher Collagen VI Formation Is Associated With All-Cause Mortality in Patients With Type 2 Diabetes and Microalbuminuria

Rasmussen, D. G. K., Hansen, T. W., von Scholten, B. J., Nielsen, S. H., Reinhard, H., Parving, H. H., Tepel, M., Karsdal, M. A., Jacobsen, P. K., Genovese, F. & Rossing, P., 2018, In : Diabetes Care. 41, 7, p. 1493-1500

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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4 Downloads (Pure)

High-fat feeding induces mobilization of vitamin C in obese prone rats

Tranberg, B., Hellgren, L. I., Lykkesfeldt, J. & Hansen, A. K., 2018, In : Research in Veterinary Science. 119, p. 167-169

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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62 Downloads (Pure)

High-Throughput In Vitro Screening for Inhibitors of Cereal α-Glucosidase

Rugen, M. D., Rejzek, M., Næsted, H., Svensson, B. & Field, R. A., 2018, Plant Chemical Genomics - Methods and Protocols. Fauser, F. & Jonikas, M. (eds.). Springer, p. 101-115 (Methods in Molecular Biology, Vol. 1795).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Histological evaluation of experimental porcine bruises

Barington, K., Skovgaard, K., Henriksen, N. L., Johansen, A. S. B. & Jensen, H. E., 2018, In : Data in Brief. 20, p. 1166-1176

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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139 Downloads (Pure)

HldE Is Important for Virulence Phenotypes in Enterotoxigenic Escherichia coli

Maigaard Hermansen, G. M., Boysen, A., Krogh, T. J., Nawrocki, A., Jelsbak, L. & Møller-Jensen, J., 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 253, 13 p., 253.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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129 Downloads (Pure)
Open Access
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184 Downloads (Pure)

Identification and characterization of biomarkers reflecting extracellular matrix remodeling in cancer

Kehlet, S. N., 2018, Kgs. Lyngby: Technical University of Denmark. 125 p.

Research output: Book/ReportPh.D. thesisResearch

Open Access
File
35 Downloads (Pure)

Identification and characterization of protein cross-links induced by oxidative reactions

Hägglund, P., Mariotti, M. & Davies, M. J., 2018, In : Expert Review of Proteomics. 15, 8, p. 665-681

Research output: Contribution to journalJournal articleResearchpeer-review

Identification of Gene Regulatory Networks Governing Stemness Properties of Human HSC and LSC

Ng, S. W. K., Xie, S. Z-J., Wagenblast, E., Takayama, N., Jin, L., Mbong, N., Murison, A., Erwin, S. E., Mitchell, A., Van Galen, P., Lupien, M., Minden, M. D., Wang, J. C. Y., Zandstra, P. W. & Dick, J. E., 2018, In : Blood. 132, p. 3832-3832 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Identification of the decumbenone biosynthetic gene cluster in Penicilliuum decumbens and the importance for production of calbistrin

Grijseels, S., Pohl, C., Nielsen, J. C., Wasil, Z., Nygård, Y., Nielsen, J., Frisvad, J. C., Nielsen, K. F., Workman, M., Larsen, T. O., Driessen, A. J. M. & Frandsen, R. J. N., 2018, In : Fungal Biology and Biotechnology. 5, 17 p., 18.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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189 Downloads (Pure)

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice

Hagedorn, P. H., Pontoppidan, M., Bisgaard, T. S., Berrera, M., Dieckmann, A., Ebeling, M., Møller, M. R., Hudlebusch, H., Jensen, M. L., Hansen, H. F., Koch, T. & Lindow, M., 2018, In : Nucleic acids research. 46, 11, p. 5366-5380

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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100 Downloads (Pure)

IFN-λ and microRNAs are important modulators of the pulmonary innate immune response against influenza A (H1N2) infection in pigs

Brogaard, L., Larsen, L. E., Heegaard, P. M. H., Anthon, C., Gorodkin, J., Duerrwald, R. & Skovgaard, K., 2018, In : P L o S One. 13, 4, 23 p., e0194765.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
201 Downloads (Pure)

Immense diversity found in secondary metabolite gene clusters in filamentous fungi and bacteria using comparative genomics

Vesth, T., Frisvad, J., Kovács, Á., Jelsbak, L., Weber, T., Baker, S. E. & Andersen, M. R., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Immunologisk respons mod mink astrovirus

Mathiesen, R., Kvisgaard, L. K., Chriél, M., Struve, T. & Heegaard, P. M. H., 2018, Kopenhagen Fur Forskning. Faglig Årsberetning 2018. Aarhus N: Kopenhagen Fur Forskning, p. 113-116 (Faglig Årsberetning).

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Open Access
File
14 Downloads (Pure)

Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

Pereira, S., Kildegaard, H. F. & Andersen, M. R., 2018, In : Biotechnology Journal. 13, 3, 13 p., 1700499 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
884 Downloads (Pure)

Impaired competence in flagellar mutants of Bacillus subtilis is connected to the regulatory network governed by DegU. Running title: Hindered competence by lack of motility

Hölscher, T., Schiklang, T., Dragos, A., Dietel, A-K., Kost, C. & Kovács, Á. T., 2018, In : Environmental Microbiology Reports. 10, 1, p. 23-32

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
240 Downloads (Pure)

Indirect and direct routes to C-glycosylated flavones in Saccharomyces cerevisiae 

Garcia Vanegas, K., Larsen, A. B., Eichenberger, M., Fischer, D., Mortensen, U. H. & Naesby, M., 2018, In : Microbial Cell Factories. 17, 10 p., 107.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
156 Downloads (Pure)

Innovative Immunization Strategies for Antivenom Development

Bermúdez-Méndez, E., Fuglsang-Madsen, A., Føns, S., Lomonte, B., Gutiérrez, J. M. & Laustsen, A. H., 2018, In : Toxins. 10, 11, 452.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
159 Downloads (Pure)

Integrating Engineering, Manufacturing, and Regulatory Considerations in the Development of Novel Antivenoms

Laustsen, A. H. & Dorrestijn, N., 2018, In : Toxins. 10, 8, 8 p., 309.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
139 Downloads (Pure)

Integrative data analysis of genotype, microbiome and metabolomics for prediction of response to diet for improved metabolic health

Nielsen, R. L., Helenius, M., Muktupavela, R., Jensen, C. B., Hansen, L. B. S., Roager, H. M., Søndertoft, N. B., Vestergaard, H., Hansen, T., Bahl, M. I., Brix, S., Kristiansen, K., Licht, T. R., Lauritzen, L., Pedersen, O. & Gupta, R., 2018.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
File
245 Downloads (Pure)

Interaction between structurally different heteroexopolysaccharides and β-lactoglobulin studied by solution scattering and analytical ultracentrifugation

Khan, S., Birch, J., Van Calsteren, M-R., Ipsen, R., Peters, G. H. J., Svensson, B., Harris, P. & Almdal, K., 2018, In : International Journal of Biological Macromolecules. 111, p. 746-754 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
145 Downloads (Pure)

Intergenic evolution during host adaptation increases expression of the metallophore pseudopaline in Pseudomonas aeruginosa

Hermansen, G. M. M., Hansen, M. L., Khademi, S. M. H. & Jelsbak, L., 2018, In : Microbiology. 164, 8, p. 1038-1047

Research output: Contribution to journalJournal articleResearchpeer-review

Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39

Carvalho, S. M., Kloosterman, T. G., Manzoor, I., Caldas, J., Vinga, S., Martinussen, J., Saraiva, L. M., Kuipers, O. P. & Neves, A. P., 2018, In : Frontiers in Microbiology. 9, 15 p., 321.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
141 Downloads (Pure)

Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri

Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Larsen, T. O., Nielsen, K. F., Hoof, J. B., Brandl, J., Salamov, A., Riley, R., Gladden, J. M., Phatale, P., Nielsen, M. T., Lyhne, E. K., Kogle, M. E., Strasser, K., McDonnell, E., Barry, K., Clum, A., Chen, C. & 19 others, LaButti, K., Haridas, S., Nolan, M., Sandor, L., Kuo, A., Lipzen, A., Hainaut, M., Drula, E., Tsang, A., Magnuson, J. K., Henrissat, B., Wiebenga, A., Simmons, B. A., Mäkelä, M. R., de Vries, R. P., Grigoriev, I. V., Mortensen, U. H., Baker, S. E. & Andersen, M. R., 2018, In : Nature Genetics. 50, p. 1688–1695

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
227 Downloads (Pure)

In vivo engineering of polyketide synthases

Olsen, K. J. K., Larsen, T. O. & Frandsen, R. J. N., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Open Access
File
112 Downloads (Pure)

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

Laustsen, A. H., Karatt-Vellatt, A., Masters, E. W., Arias, A. S., Pus, U., Knudsen, C., Oscoz, S., Slavny, P., Griffiths, D. T., Luther, A. M., Leah, R. A., Lindholm, M., Lomonte, B., Gutiérrez, J. M. & McCafferty, J., 2018, In : Nature Communications. 9, 1, 9 p., 3928.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
141 Downloads (Pure)

Isoenergic modification of whey protein structure by denaturation and crosslinking using transglutaminase

Stender, E. G. P., Koutina, G., Almdal, K., Hassenkam, T., Mackie, A., Ipsen, R. & Svensson, B., 2018, In : Food & Function. 9, 2, p. 797-805

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

Keratin2Protein; Valorization of keratinous materials through microbial conversion

Espersen, R., 2018, Kgs. Lyngby: Technical University of Denmark. 272 p.

Research output: Book/ReportPh.D. thesis

Open Access
File
21 Downloads (Pure)

Lav koncentration af immunglobulin G i blodet er associeret med fedtede hvalpe

Mathiesen, R., Chriél, M., Struve, T. & Heegaard, P. M. H., 2018, Kopenhagen Fur Forskning. Faglig Årsberetning 2018. Aarhus N: Kopenhagen Fur Forskning, p. 117-122 (Faglig Årsberetning).

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Open Access
File
26 Downloads (Pure)

Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing

Karathanasi, G., Bojer, M. S., Baldry, M., Johannessen, B. A., Wolff, S., Greco, I., Kilstrup, M., Hansen, P. R. & Ingmer, H., 2018, In : Scientific Reports. 8, 1, 11 p., 3562.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
163 Downloads (Pure)

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species

Kjærbølling, I., Vesth, T. C., Frisvad, J. C., Nybo, J. L., Theobald, S., Kuo, A., Bowyer, P., Matsuda, Y., Mondo, S., Lyhne, E. K., Kogle, M. E., Clum, A., Lipzen, A., Salamov, A., Ngan, C. Y., Daum, C., Chiniquy, J., Barry, K., LaButti, K., Haridas, S. & 7 others, Simmons, B. A., Magnuson, J. K., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 23 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. E753-E761

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
101 Downloads (Pure)

Locked nucleic acid: modality, diversity, and drug discovery

Hagedorn, P. H., Persson, R., Funder, E. D., Albæk, N., Diemer, S. L., Hansen, D. J., Møller, M. R., Papargyri, N., Christiansen, H., Hansen, B. R., Hansen, H. F., Jensen, M. A. & Koch, T., 2018, In : Drug Discovery Today. 23, 1, p. 101-114

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
1059 Downloads (Pure)

Magnetic hydrophobic-charge induction adsorbents for the recovery of immunoglobulins from antiserum feedstocks by high-gradient magnetic fishing

Gomes, C. S. G., Fashina, A., Fernández-Castané, A., Overton, T. W., Hobley, T. J., Theodosiou, E. & Thomas, O. R. T., 2018, In : Journal of Chemical Technology and Biotechnology. 93, 7, p. 1901-1915

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
122 Downloads (Pure)

Markers of Basement Membrane Remodeling Are Associated With Higher Mortality in Patients With Known Atherosclerosis

Nielsen, S. H., Tengryd, C., Edsfeldt, A., Brix, S., Genovese, F., Bengtsson, E., Karsdal, M., Leeming, D. J., Nilsson, J. & Goncalves, I., 2018, In : Journal of the American Heart Association. 7, 21, 10 p., e009193.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
103 Downloads (Pure)

Markers of basement membrane remodelling are associated with higher mortality in patients with advanced carotid atherosclerosis

Goncalves, I., Holm Nielsen, S., Tengryd, C., Brix, S., Edsfeldt, A., Genovese, F., Bengtsson, E., Karsdal, M., Julie Leeming, D. & Nilsson, J., 2018, In : European Heart Journal. 39, suppl_1, p. 1039-1040 4982.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

MARSI: metabolite analogues for rational strain improvement

Cardoso, J. G. R., Zeidan, A. A., Jensen, K., Sonnenschein, N., Neves, A. R. & Herrgård, M. J., 2018, In : Bioinformatics. 34, 13, p. 2319-2321

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
166 Downloads (Pure)

Mass-Spectrometry-Based Identification of Cross-Links in Proteins Exposed to Photo-Oxidation and Peroxyl Radicals Using O-18 Labeling and Optimized Tandem Mass Spectrometry Fragmentation

Mariotti, M., Leinisch, F., Leeming, D. J., Svensson, B., Davies, M. J. & Hägglund, P., 2018, In : Journal of Proteome Research. 17, 6, p. 2017-2027 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women

Bertelsen, D. M., Neergaard, J. S., Bager, C. L., Nielsen, S. H., Secher, N. H., Svendsen, J. H., Bihlet, A. R., Andersen, J. R., Karsdal, M. A., Christiansen, C. & Nielsen, H. B., 2018, In : Scientific Reports. 8, 7 p., 5371.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
118 Downloads (Pure)

Metabolic mechanisms behind the type 2 diabetes susceptible phenotype in low birth weight individuals

Ribel-Madsen, A., 2018, Kgs. Lyngby: Technical University of Denmark. 75 p.

Research output: Book/ReportPh.D. thesisResearch

Open Access
File
217 Downloads (Pure)

Metabolite production by species of Stemphylium

Olsen, K. J. K., Rossman, A. & Andersen, B., 2018, In : Fungal Biology. 122, 2-3, p. 172-181 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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160 Downloads (Pure)

Method for reducing ammonium and lactate production in cho cells

Ley, D., Andersen, M. R. & Kildegaard, H. F., 2018, IPC No. C12N15/52; C12P21/02, Patent No. WO2018033542, 22 Feb 2018, Priority date 15 Aug 2016, Priority No. EP20160184179

Research output: Patent

Open Access
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160 Downloads (Pure)