Department of Biotechnology and Biomedicine

  • Søltofts Plads, Bygning 221

    DK-2800 Kgs. Lyngby

    Denmark

Research Output

2018

Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies

Boyd, M., Thodberg, M., Vitezic, M., Bornholdt, J., Vitting-Seerup, K., Chen, Y., Coskun, M., Li, Y., Lo, B. Z. S., Klausen, P., Jan Schweiger, P., Pedersen, A. G., Rapin, N., Skovgaard, K., Dahlgaard, K., Andersson, R., Terkelsen, T. B., Lilje, B., Troelsen, J. T., Petersen, A. M. & 7 others, Jensen, K. B., Gögenur, I., Thielsen, P., Seidelin, J. B., Nielsen, O. H., Bjerrum, J. T. & Sandelin, A., 2018, In : Nature Communications. 9, 1, 19 p., 1661.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
253 Downloads (Pure)

Chemically controlled interfacial nanoparticle assembly into nanoporous gold films for electrochemical applications

Christiansen, M. U. -B., Seselj, N., Engelbrekt, C., Wagner, M., Stappen, F. N. & Zhang, J., 2018, In : Journal of Materials Chemistry A. 6, 2, p. 556-564

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
71 Downloads (Pure)

Cladosporium species in indoor environments

Bensch, K., Groenewald, J. Z., Meijer, M., Dijksterhuis, J., Jurjevic, Z., Andersen, B., Houbraken, J., Crous, P. W. & Samson, R. A., 2018, In : Studies in Mycology. 89, p. 177-301

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
175 Downloads (Pure)

Collapse of genetic division of labour and evolution of autonomy in pellicle biofilms

Dragoš, A., Martin, M., Garcia, C. F., Kricks, L., Pausch, P., Heimerl, T., Bálint, B., Maróti, G., Bange, G., López, D., Lieleg, O. & Kovács, Á. T., 2018, In : Nature Microbiology. 3, p. 1451-1460

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
102 Downloads (Pure)

Complete Genome Sequence of Shewanella sp. WE21, a Rare Isolate with Multiple Novel Large Genomic Islands

Castillo, D., Gram, L. & Dailey, F. E., 2018, In : Genome Announcements. 6, 16, e00277-18.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
274 Downloads (Pure)

Computational prediction of neoantigens: do we need more data or new approaches?

Eklund, A. C. & Szallasi, Z. I., 2018, In : Annals of Oncology. 29, 4, p. 799-800 2 p.

Research output: Contribution to journalEditorialResearchpeer-review

Correction to: Industrial antifoam agents impair ethanol fermentation and induce stress responses in yeast cells

Nielsen, J. C. F., Senne de Oliveira Lino, F., Rasmussen, T. G., Thykær, J., Workman, C. & Basso, T. O., 2018, In : Applied Microbiology and Biotechnology. 102, 1, p. 513-513 1 p.

Research output: Contribution to journalComment/debateResearchpeer-review

Open Access
File
177 Downloads (Pure)

CRISPR/Cas9-multiplexed editing of Chinese hamster ovary B4Gal-T1, 2, 3 and 4 Tailors N-Glycan Profiles of Therapeutics and Secreted Host Cell Proteins

Amann, T., Hansen, A. H., Kol, S., Min Lee, G., Andersen, M. R. & Kildegaard, H. F., 2018, In : Biotechnology Journal. 13, 10, 9 p., 1800111 .

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
80 Downloads (Pure)

Current progress towards the next generation of antivenoms

Laustsen, A. H., 2018, In : Toxicon. 150, p. 319

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Cyclopiamines C and D: Epoxide Spiroindolinone Alkaloids from Penicillium sp. CML 3020

Kildgaard, S., de Medeiros, L. S., Phillips, E., Gotfredsen, C. H., Frisvad, J. C., Nielsen, K. F., Abreu, L. M. & Larsen, T. O., 2018, In : Journal of Natural Products. 81, 4, p. 785-790 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Design of a new, accurate laccase activity assay method based on "lignin-like" compounds

Perna, V., Agger, J., Holck, J. & Meyer, A. S., 2018, Proceedings of the 255th ACS National Meeting & Exposition. American Chemical Society, Vol. 255. 1 p. 111. (American Chemical Society. Abstracts of Papers (at the National Meeting)).

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Developing a CRISPR/CAS9-assisted recombineering system for natural soil pseudomonads

Hansen, M. L. & Jelsbak, L., 2018, The Danish Microbiological Society Annual Congress 2018 - programme & abstracts. Copenhagen, Denmark: Danish Microbiological Society, p. 34-35

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
151 Downloads (Pure)

Development of a LC-MS/MS method for the quantification of goniodomins A and B and its application to Alexandrium pseudogonyaulax strains and plankton field samples of Danish coastal waters

Krock, B., Tillmann, U., Wen, Y., Hansen, P. J., Larsen, T. O. & Andersen, A. J. C., 2018, In : Toxicon. 155, p. 51-60

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
50 Downloads (Pure)

Developments in support materials for immobilization of oxidoreductases: A comprehensive review

Zdarta, J., Meyer, A. S., Jesionowski, T. & Pinelo, M., 2018, In : Advances in Colloid and Interface Science. 258, p. 1-20

Research output: Contribution to journalJournal articleResearchpeer-review

Dietary Nutrients, Proteomes, and Adhesion of Probiotic Lactobacilli to Mucin and Host Epithelial Cells

Celebioglu, H. U. & Svensson, B., 2018, In : Microorganisms. 6, 3, 17 p., 90.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
128 Downloads (Pure)

Differential bacterial capture and transport preferences facilitate co-growth on dietary xylan in the human gut

Leth, M. L., Ejby, M., Workman, C., Ewald, D. A., Pedersen, S. S., Sternberg, C., Bahl, M. I., Licht, T. R., Aachmann, F. L., Westereng, B. & Abou Hachem, M., 2018, In : Nature Microbiology. 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
463 Downloads (Pure)
Open Access
File
222 Downloads (Pure)

Dissimilar pigment regulation in Serpula lacrymans and Paxillus involutus during inter-kingdom interactions.

Tauber, J. P., Gallegos-Monterrosa, R., Kovács, Á. T., Shelest, E. & Hoffmeister, D., 2018, In : Microbiology. 164, p. 65-77 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
208 Downloads (Pure)

Diversity of Aspergillus section Nigri on the surface of Vitis labrusca and its hybrid grapes

Ferranti, L. D. S., Fungaro, M. H. P., Massi, F. P., Silva, J. J. D., Penha, R. E. S., Frisvad, J. C., Taniwaki, M. H. & Iamanaka, B. T., 2018, In : International Journal of Food Microbiology. 268, p. 53-60

Research output: Contribution to journalJournal articleResearchpeer-review

Division of Labor during Biofilm Matrix Production

Dragos, A., Kiesewalter, H. T., Martin, M., Hsu, C. Y., Hartmann, R., Wechsler, T., Eriksen, C., Brix, S., Drescher, K., Stanley-Wall, N., Kümmerli, R. & Kovács, Á. T., 2018, In : Current Biology. 28, 12, p. 1903-1913

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
68 Downloads (Pure)

Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections

Imamovic, L., Ellabaan, M. M. H., Dantas Machado, A. M., Citterio, L., Wulff, T., Molin, S., Johansen, H. K. & Sommer, M. O. A., 2018, In : CELL. 172, 1-2, p. 121-134

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
167 Downloads (Pure)

Effect of alginate size, mannuronic/guluronic acid content and pH on particle size, thermodynamics and composition of complexes with β-lactoglobulin

Stender, E. G. P., Khan, S., Ipsen, R., Madsen, F., Hägglund, P., Hachem, M. A., Almdal, K., Westh, P. & Svensson, B., 2018, In : Food Hydrocolloids. 75, p. 157-163

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
191 Downloads (Pure)

Effect of MMP-13 degraded SPARC on type I collagen and its biomarker potential in colorectal cancer

Kehlet, S. N., Harling, H., Jorgensen, L. N., Karsdal, M. A. & Willumsen, N., 2018, In : Journal of Clinical Oncology. 36, 4, 717.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Effect of Novel Quercetin Titanium Dioxide-Decorated Multi-Walled Carbon Nanotubes Nanocomposite on Bacillus subtilis Biofilm Development

Raie, D. S., Mhatre, E., El-Desouki, D. S., Labena, A., El-Ghannam, G., Farahat, L. A., Youssef, T., Fritzsche, W. & Kovács, Á. T., 2018, In : Materials. 11, 1, 14 p., 157.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
190 Downloads (Pure)

Effect of TDA-producing Phaeobacter inhibens on the fish pathogen Vibrio anguillarum in non-axenic algae and copepod systems

Rasmussen, B. B., Erner, K. E., Bentzon-Tilia, M. & Gram, L., 2018, In : Microbial Biotechnology. 11, 6, p. 1070-1079

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
142 Downloads (Pure)

Effects of gamma irradiation and comparison of different extraction methods on sesquiterpene lactone yields from the medicinal plant Thapsia garganica L. (Apiaceae)

Mohamed Ibrahim, A. M., Martinez-Swatson, K. A., Benkaci-Ali, F., Cozzi, F., Zoulikha, F. & Simonsen, H. T., 2018, In : Journal of Applied Research on Medicinal and Aromatic Plants. 8, p. 26-32

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
38 Downloads (Pure)

Efficient Oligo nucleotide mediated CRISPR-Cas9 Gene Editing in Aspergilli

Nødvig, C. S., Hoof, J. B., Kogle, M. E., Jarczynska, Z. D., Lehmbeck, J., Klitgaard, D. K. & Mortensen, U. H., 2018, In : Fungal Genetics and Biology. 115, p. 78-89

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
300 Downloads (Pure)

Electrochemically deposited surfaces based on copper and silver with biocidal effect against methicillin resistant S. aureus (MRSA)

Xu, Y., Thomsen, T. R., Gram, L. & Ciacotich, N., 2018, Biofilms 8 Programme and Abstracts. p. 160-160 1 p. P100

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

Open Access
File
231 Downloads (Pure)

Engineering Saccharomyces cerevisiae for co-utilization of D-galacturonic acid and D-glucose from citrus peel waste

Protzko, R. J., Latimer, L. N., Martinho, Z., de Reus, E., Seibert, T., Benz, J. P. & Dueber, J. E., 2018, In : Nature Communications. 9, 10 p., 5059.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
147 Downloads (Pure)

Enhancing Metabolic Models with Genome-Scale Experimental Data

Jensen, K., Gudmundsson, S. & Herrgård, M., 2018, Systems Biology. Rajewsky, N., Jurga, S. & Barciszewski, J. (eds.). 2018 ed. Springer, p. 337-350 (RNA Technologies).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Evaluation of synthetic promoters in Physcomitrella patens

Peramuna, A., Bae, H., Rasmussen, E. K., Dueholm, B., Waibel, T., Critchley, J. H., Brzezek, K., Roberts, M. & Simonsen, H. T., 2018, In : BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 500, 2, p. 418-422

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
47 Downloads (Pure)

Evidence of No Association Between Human Papillomavirus and Breast Cancer

Bønløkke, S., Blaakær, J., Steiniche, T., Høgdall, E., Jensen, S. G., Hammer, A., Balslev, E., Strube, M. L., Knakkergaard, H. & Lenz, S., 2018, In : Frontiers in Oncology. 8, 209.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
142 Downloads (Pure)

Evolution of exploitative interactions during diversification in Bacillus subtilis biofilms

Dragoš, A., Lakshmanan, N., Martin, M., Horváth, B., Maróti, G., García, C. F., Lieleg, O. & Kovács, Á. T., 2018, In : FEMS Microbiology Ecology. 94, 1, 32 p., fix155.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
129 Downloads (Pure)

Exploiting fungal cell factories for pigment production

Tolborg, G., 2018, Kgs. Lyngby: Technical University of Denmark. 193 p.

Research output: Book/ReportPh.D. thesis

Open Access
File
182 Downloads (Pure)

Exploring the Effect of Phage Therapy in Preventing Vibrio anguillarum Infections in Cod and Turbot Larvae

Rørbo, N., Rønneseth, A., Kalatzis, P. G., Rasmussen, B. B., Engell-Sørensen, K., Kleppen, H. P., Wergeland, H. I., Gram, L. & Middelboe, M., 2018, In : Antibiotics. 7, 2, 15 p., 42.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
285 Downloads (Pure)

Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function

Degendorfer, G., Chuang, C. Y-N., Mariotti, M., Hammer, A., Hoefler, G., Hägglund, P., Malle, E., Wise, S. G. & Davies, M. J., 2018, In : Free Radical Biology & Medicine. 115, p. 219-231

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
169 Downloads (Pure)
Open Access
File
152 Downloads (Pure)

Familial co-occurrence of congenital heart defects follows distinct patterns

Ellesøe, S. G., Workman, C. T., Bouvagnet, P., Loffredo, C. A., McBride, K. L., Hinton, R. B., van Engelen, K., Gertsen, E. C., Mulder, B. J. M., Postma, A. V., Anderson, R. H., Hjortdal, V. E., Brunak, S. & Larsen, L. A., 2018, In : European Heart Journal. 39, 12, p. 1015-1022

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
229 Downloads (Pure)

Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions

Robertsen, H. L., Musiol-Kroll, E. M., Ding, L., Laiple, K. J., Hofeditz, T., Wohlleben, W., Lee, S. Y., Grond, S. & Weber, T., 2018, In : Scientific Reports. 8, 9 p., 3230.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
214 Downloads (Pure)

Forensic age determination of human inflicted porcine bruises inflicted within 10 h prior to slaughter by application of gene expression signatures

Barington, K., Jensen, H. E. & Skovgaard, K., 2018, In : Research in Veterinary Science. 120, p. 47-53

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
47 Downloads (Pure)

Friends and Foes -Comparative Genomics of 23 Aspergillus Flavi Species

Kjærbølling, I., Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Kogle, M. E., Lyhne, E. K., Sato, A., Hainaut, M., Drula, E., Henrissat, B., Kuo, A., Salamov, A., Riley, R., Mortensen, U. H., Larsen, T. O., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 2018. 1 p.

Research output: Contribution to conferencePosterResearchpeer-review

Friends and foes - comparative genomics of 23 Aspergillus Flavi species

Kjærbølling, I., Vesth, T. C., Nybo, J. L., Theobald, S., Frisvad, J. C., Kogle, M. E., Lyhne, E. K., Kuo, A., Salamov, A., Riley, R., Larsen, T. O., Mortensen, U. H., Grigoriev, I. V., Baker, S. E. & Andersen, M. R., 2018. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
File
134 Downloads (Pure)

Functional Roles of Starch Binding Domains and Surface Binding Sites in Enzymes Involved in Starch Biosynthesis

Wilkens, C., Svensson, B. & Møller, M. S., 2018, In : Frontiers in Plant Science. 9, 12 p., 1652.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
231 Downloads (Pure)

Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules

Overgaard, N. H., R. Principe, D., M. Schachtschneider, K., Jakobsen, J. T., A. Rund, L., J. Grippo, P., B. Schook, L. & Jungersen, G., 2018, In : Frontiers in Immunology. 9, 13 p., 1301.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
158 Downloads (Pure)

Genetic Characterization of Neosartorin Biosynthesis Provides Insight into Heterodimeric Natural Product Generation

Matsuda, Y., Gotfredsen, C. H. & Larsen, T. O., 2018, In : ORGANIC LETTERS. 20, 22, p. 7194-7200 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic manipulation of structural color in bacterial colonies

Johansen, V. E., Catón, L., Hamidjaja, R., Oosterink, E., Wilts, B. D., Rasmussen, T. S., Sherlock, M. M., Ingham, C. J. & Vignolini, S., 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 11, p. 2652-2657

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
29 Downloads (Pure)

Genome editing: CRISPR-Cas9

Hoof, J. B., Nødvig, C. S. & Mortensen, U. H., 2018, Fungal Genomics: methods and protocols. de Vries, R. P., Tsang, A. & Grigoriev, I. V. (eds.). 2 ed. Humana Press, Vol. 1775. p. 119-132 (Methods in Molecular Biology, Vol. 1775).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Genome Sequences of Shewanella baltica and Shewanella morhuae Strains Isolated from the Gastrointestinal Tract of Freshwater Fish

Castillo, D., Gram, L. & Dailey, F. E., 2018, In : Genome Announcements. 6, 25, 2 p., e00541-18.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
132 Downloads (Pure)

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Waage, J., Standl, M., Curtin, J. A., Jessen, L. E., Thorsen, J., Tian, C., Schoettler, N., Flores, C., Abdellaoui, A., Ahluwalia, T. S., Alves, A. C., Amaral, A. F. S., Antó, J. M., Arnold, A., Barreto-Luis, A., Baurecht, H., van Beijsterveldt, C. E. M., Bleecker, E. R., Bonàs-Guarch, S., Boomsma, D. I. & 32 others, Brix, S., Bunyavanich, S., Burchard, E. G., Chen, Z., Curjuric, I., Custovic, A., Den Dekker, H. T., Dharmage, S. C., Dmitrieva, J., Duijts, L., Ege, M. J., Gauderman, W. J., Georges, M., Gieger, C., Gilliland, F., Granell, R., Gui, H., Hansen, T., Heinrich, J., Henderson, J., Hernandez-Pacheco, N., Holt, P., Imboden, M., Jaddoe, V. W. V., Jarvelin, M. R., Jarvis, D. L., Jensen, K. K., Jónsdóttir, I., Kabesch, M., Kaprio, J., The 23andMe Research Team & AAGC collaborators, 2018, In : Nature Genetics. 50, 8, p. 1072-1080 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
54 Downloads (Pure)

Genomics driven discovery and engineering of fungal polycyclic polyketides

Subko, K., Wolff, P. B., Theobald, S., Frisvad, J. C., Gotfredsen, C. H., Andersen, M. R., Mortensen, U. H. & Larsen, T. O., 2018, p. 68.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
File
540 Downloads (Pure)