Department of Biotechnology and Biomedicine

  • Søltofts Plads, Bygning 221

    DK-2800 Kgs. Lyngby

    Denmark

Research Output 2011 2020

2019
59 Downloads (Pure)

Structural and functional aspects of mannuronic acid-specific PL6 alginate lyase from the human gut microbe Bacteroides cellulosilyticus

Stender, E. G. P., Andersen, C. D., Fredslund, F., Holck, J., Solberg, A., Teze, D., Peters, G. H. J., Christensen, B. E., Aachmann, F. L., Welner, D. H. & Svensson, B., 2019, In : Journal of Biological Chemistry. 294, 47, p. 17915-17930 17 p., jbc.RA119.010206.

Research output: Contribution to journalJournal articleResearchpeer-review

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89 Downloads (Pure)

Substrate preference of an ABC importer corresponds to selective growth on β-(1,6)-galactosides in Bifidobacterium animalis subsp. lactis

Theilmann, M. C., Fredslund, F., Svensson, B., Lo Leggio, L. & Abou Hachem, M., 2019, In : Journal of Biological Chemistry. 294, 31, p. 11701-11711 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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25 Downloads (Pure)

Substrate specificity of novel GH16 endo-β-(1→3)-galactanases acting on linear and branched β-(1→3)-1 galactooligosaccharides

Kalomoiri, P., Holck, J., Coulomb, L., Boos, I., Enemark-Rasmussen, K., Spodsberg, N., Monrad, R. N. & Clausen, M. H., 2019, In : Journal of Biotechnology. 290, p. 44-52

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Surface treatments and functionalization of metal‐ceramic membranes for improved enzyme immobilization performance

Zeuner, B., Ovtar, S., Persson, Å. H., Foghmoes, S. P. V., Berendt, K., Ma, N., Kaiser, A., Della Negra, M. & Pinelo, M., 2019, (Accepted/In press) In : Journal of Chemical Technology and Biotechnology.

Research output: Contribution to journalJournal articleResearchpeer-review

70 Downloads (Pure)

Synthesis of human milk oligosaccharides: Protein engineering strategies for improved enzymatic transglycosylation

Zeuner, B., Teze, D., Muschiol, J. & Meyer, A. S., 2019, In : Molecules. 24, 11, 22 p., 2033.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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Systematically redesigning and optimizing the expression of D-lactate dehydrogenase efficiently produces high-optical-purity D-lactic acid in Saccharomyces cerevisiae

Zhong, W., Yang, M., Mu, T., Wu, F., Hao, X., Chen, R., Sharshar, M. M., Thygesen, A., Wang, Q. & Xing, J., 2019, In : Biochemical Engineering Journal. 144, p. 217-226

Research output: Contribution to journalJournal articleResearchpeer-review

36 Downloads (Pure)

Systematic deletions in the cellobiohydrolase (CBH) Cel7A from the fungus Trichoderma reesei reveal flexible loops critical for CBH activity

Schiano-de-Cola, C., Røjel, N., Jensen, K., Kari, J., Sørensen, T. H., Borch, K. & Westh, P., 2019, In : Journal of Biological Chemistry. 294, 6, p. 1807-1815 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Systematic Evaluation of Site-Specific Recombinant Gene Expression for Programmable Mammalian Cell Engineering

Pristovšek, N., Nallapareddy, S., Grav, L. M., Hefzi, H., Lewis, N. E., Rugbjerg, P., Hansen, H. G., Lee, G. M., Andersen, M. R. & Kildegaard, H. F., 2019, In : ACS Synthetic Biology. 8, 4, p. 758-774 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

Kato, H., Sebe, M., Nagaki, M., Eguchi, K., Kagiyama, I., Hitora, Y., Frisvad, J. C., Williams, R. M. & Tsukamoto, S., 2019, In : Journal of Natural Products. 82, 5, p. 1377-1381 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Taxonomic revision of the biotechnologically important species, Penicillium oxalicum with description of two new species froma cidic and saline soils

Kubátová, A., Hujslová, M., Frisvad, J. C., Chudíčková, M. & Kolařík, M., 2019, In : Mycological Progress. 18, 1-2, p. 215-228 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

225 Downloads (Pure)

Taxonomy of Aspergillus section Flavi and their production of aflatoxins, ochratoxins and other mycotoxins

Frisvad, J. C., Hubka, V., Ezekiel, C. N., Hong, S. B., Nováková, A., Chen, A. J., Arzanlou, M., Larsen, T. O., Sklenář, F., Mahakarnchanakul, W., Samson, R. A. & Houbraken, J., 2019, In : Studies in Mycology. 93, p. 1-63

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Temporal Changes in Effect Sizes of Studies Comparing Individuals with and Without Autism: A Meta-analysis

Rødgaard, E. M., Jensen, K., Vergnes, J. N., Soulières, I. & Mottron, L., 2019, In : JAMA Psychiatry. 76, 11, p. 1124-1132 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

The anatomy of single cell mass cytometry data

Olsen, L. R., Leipold, M. D., Pedersen, C. B. & Maecker, H. T., 2019, In : Cytometry. Part A. 95, 2, p. 156-172 18 p.

Research output: Contribution to journalJournal articleResearchpeer-review

100 Downloads (Pure)

The Distribution of Tryptophan-Dependent Indole-3-Acetic Acid Synthesis Pathways in Bacteria Unraveled by Large-Scale Genomic Analysis

Zhang, P., Jin, T., Kumar Sahu, S., Xu, J., Shi, Q., Liu, H. & Wang, Y., 2019, In : Molecules. 24, 7, 14 p., 1411.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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The Draft Genome of Hariotina reticulata (Sphaeropleales, Chlorophyta) Provides Insight into the Evolution of Scenedesmaceae

Xu, Y., Li, L., Liang, H., Melkonian, B., Lorenz, M., Friedl, T., Petersen, M., Liu, H., Melkonian, M. & Wang, S., 2019, In : Protist. 170, 6, 6 p., 125684.

Research output: Contribution to journalJournal articleResearchpeer-review

The Draft Genome of the Small, Spineless Green Alga Desmodesmus costato-granulatus (Sphaeropleales, Chlorophyta)

Wang, S., Li, L., Xu, Y., Melkonian, B., Lorenz, M., Friedl, T., Petersen, M., Sahu, S. K., Melkonian, M. & Liu, H., 2019, In : Protist. 170, 6, 5 p., 125697.

Research output: Contribution to journalJournal articleResearchpeer-review

65 Downloads (Pure)

The Effect of Inactivated Mycobacterium Paratuberculosis Vaccine on the Response to a Heterologous Bacterial Challenge in Pigs

Jensen, K. J., Hansen, M. S., Heegaard, P. M. H., Benn, C. S. & Jungersen, G., 2019, In : Frontiers in Immunology. 10, 11 p., 1557.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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19 Downloads (Pure)

The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG

Sneideris, T., Sakalauskas, A., Sternke-Hoffmann, R., Peduzzo, A., Ziaunys, M., Büll, A. K. & Smirnovas, V., 2019, In : Biomolecules. 9, 12, 17 p., 855.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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The evolution of TEM-1 extended-spectrum β-lactamases in E. coli by cephalosporins

Clasen, J., Birkegård, A. C., Græsbøll, K. & Folkesson, A., 2019, In : Journal of Global Antimicrobial Resistance. 19, p. 32-39

Research output: Contribution to journalJournal articleResearchpeer-review

The exopolysaccharide properties and structures database: EPS-DB. Application to bacterial exopolysaccharides

Birch, J., Van Calsteren, M-R., Pérez, S. & Svensson, B., 2019, In : Carbohydrate Polymers. 205, p. 565-570

Research output: Contribution to journalJournal articleResearchpeer-review

The first chromosome-level genome for a marine mammal as a resource to study ecology and evolution

Fan, G., Zhang, Y., Liu, X., Wang, J., Sun, Z., Sun, S., Zhang, H., Chen, J., Lv, M., Han, K., Tan, X., Hu, J., Guan, R., Fu, Y., Liu, S., Chen, X., Xu, Q., Qin, Y., Liu, L., Bai, J. & 26 others, Wang, O., Tang, J., Lu, H., Shang, Z., Wang, B., Hu, G., Zhao, X., Zou, Y., Chen, A., Gong, M., Zhang, W., Lee, S. M-Y., Li, S., Liu, J., Li, Z., Lu, Y., Sabir, J. S. M., Sabir, M. J., Khan, M., Hajrah, N. H., Yin, Y., Kristiansen, K., Yang, H., Wang, J., Xu, X. & Liu, X., 2019, In : Molecular Ecology Resources. 19, 4, p. 944-956 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

64 Downloads (Pure)

The growth of amyloid fibrils: rates and mechanisms

Büll, A. K., 2019, In : Biochemical Journal. 476, 19, p. 2677-2703 27 p.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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156 Downloads (Pure)

The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans

La Rosa, S. L., Leth, M. L., Michalak, L., Hansen, M. E., Pudlo, N. A., Glowacki, R., Pereira, G., Workman, C. T., Arntzen, M., Pope, P. B., Martens, E. C., Hachem, M. A. & Westereng, B., 2019, In : Nature Communications. 10, 1, 14 p., 905.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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28 Downloads (Pure)

The Human Milk Microbiota is Modulated by Maternal Diet

Padilha, M., Danneskiold-Samsøe, N. B., Brejnrod, A., Hoffmann, C., Cabral, V. P., Iaucci, J. D. M., Sales, C. H., Fisberg, R. M., Cortez, R. V., Brix, S., Taddei, C. R., Kristiansen, K. & Saad, S. M. I., 2019, In : Microorganisms. 7, 11, 18 p., 502.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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15 Downloads (Pure)

The impact of lifestyle on the development of the gut microbiome in early life in relation to allergies

Myers, P. N., Mie, A., Moll, J. M., Kristiansen, K., Scheynius, A., Alm, J. & Pedersen, S. B., 2019. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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The Kinetics, Thermodynamics and Mechanisms of Short Aromatic Peptide Self-Assembly

Mason, T. O. & Buell, A. K., 2019, Biological and Bio-inspired Nanomaterials. Springer, p. 61-112 52 p. (Advances in Experimental medicine and Biology, Vol. 1174).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

16 Downloads (Pure)

Thermodynamics of amyloid fibril formationfrom chemical depolymerization

Vettore, N. & Büll, A. K., 2019, In : Physical Chemistry Chemical Physics. 21, p. 26184-26194 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

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17 Downloads (Pure)

The role of individual cardiolipin species on stability and activity of Magnesium transporter A (MgtA)

Weikum, J., Subramani, S., Van Dyck, J., Sobott, F. & Morth, J. P., 2019, In : European Biophysics Journal With Biophysics Letters. 48, S1, p. S166-S166 1 p., P-350.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
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205 Downloads (Pure)

The urgent need for microbiology literacy in society

Timmis, K., Cavicchioli, R., Garcia, J. L., Nogales, B., Chavarría, M., Stein, L., McGenity, T. J., Webster, N., Singh, B. K., Handelsman, J., de Lorenzo, V., Pruzzo, C., Timmis, J., Martín, J. L. R., Verstraete, W., Jetten, M., Danchin, A., Huang, W., Gilbert, J., Lal, R. & 12 others, Santos, H., Lee, S. Y., Sessitsch, A., Bonfante, P., Gram, L., Lin, R. T. P., Ron, E., Karahan, Z. C., van der Meer, J. R., Artunkal, S., Jahn, D. & Harper, L., 2019, In : Environmental Microbiology. 21, 5, p. 1513-1528 16 p.

Research output: Contribution to journalEditorialResearchpeer-review

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151 Downloads (Pure)

The Use of a DNA-Intercalating Dye for Quantitative Detection of Viable Arcobacter spp. Cells (v-qPCR) in Shellfish

Salas-Masso, N., Than Linh, Q., Chin, W. H., Wolff, A., Andree, K. B., Dolors Furones, M., Jose Figueras, M. & Bang, D. D., 2019, In : Frontiers in Microbiology. 10, 12 p., 368.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Time-resolved ATP measurements during vesicle respiration

Lin, J., Weixler, D., Daboss, S., Seibold, G. M., Andronescu, C., Schuhmann, W. & Kranz, C., 2019, In : Talanta. 205, 7 p., 120083.

Research output: Contribution to journalJournal articleResearchpeer-review

Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo

Kjelgaard-Petersen, C. F., Sharma, N., Kayed, A., Karsdal, M. A., Mobasheri, A., Hägglund, P., Bay-Jensen, A. C. & Thudium, C. S., 2019, In : Biochemical Pharmacology. 165, p. 91-98 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

169 Downloads (Pure)

Toxin Neutralization Using Alternative Binding Proteins

Jenkins, T. P., Fryer, T., Dehli, R. I., Jürgensen, J. A., Fuglsang-Madsen, A., Føns, S. & Laustsen, A. H., 2019, In : Toxins. 11, 1, 28 p., 53.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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Transfucosylation by and engineering of GH29 α-L-fucosidases for production of human milk oligosaccharides

Zeuner, B., Holck, J., Muschiol, J., Vuillemin, M. & Meyer, A. S., 2019, p. 154-154. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice

Zhu, F., Guo, R., Wang, W., Ju, Y., Wang, Q., Ma, Q., Sun, Q., Fan, Y., Xie, Y., Yang, Z., Jie, Z., Zhao, B., Xiao, L., Yang, L., Zhang, T., Liu, B., Guo, L., He, X., Chen, Y., Chen, C. & 10 others, Gao, C., Xu, X., Yang, H., Wang, J., Dang, Y., Madsen, L., Brix, S., Kristiansen, K., Jia, H. & Ma, X., 2019, In : Molecular Psychiatry.

Research output: Contribution to journalJournal articleResearchpeer-review

Tropodithietic acid induces oxidative stress response, cell envelope biogenesis and iron uptake in Vibrio vulnificus

Dittmann, K. K., Porsby, C. H., Goncalves, P., Mateiu, R. V., Sonnenschein, E. C., Bentzon-Tilia, M., Egan, S. & Gram, L., 2019, In : Environmental Microbiology Reports. 11, 4, p. 581-588

Research output: Contribution to journalJournal articleResearchpeer-review

Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on β-mannan possess distinct manno-oligosaccharide-binding profiles

Ejby, M., Guskov, A., Pichler, M. J., Zanten, G. C., Schoof, E., Saburi, W., Slotboom, D. J. & Abou Hachem, M., 2019, In : Molecular Microbiology. 112, 1, p. 114-130 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

127 Downloads (Pure)

Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes

Nielsen, S. H., Mouton, A. J., DeLeon-Pennell, K. Y., Genovese, F., Karsdal, M. A. & Lindsey, M. L., 2019, In : Matrix Biology. 75-76, p. 43-57 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Unique processes yielding pure azaphilones in Talaromyces atroroseus

Tolborg, G., Ødum, A. S. R., Isbrandt, T., Larsen, T. O. & Workman, M., 2019, In : Applied Microbiology and Biotechnology. 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Utilizing nanoparticles for improving anti-biofilm effects of azithromycin: A head-to-head comparison of modified hyaluronic acid nanogels and coated poly (lactic-co-glycolic acid) nanoparticles

Kłodzińska, S. N., Wan, F., Jumaa, H., Sternberg, C., Rades, T. & Nielsen, H. M., 2019, In : Journal of Colloid and Interface Science. 555, p. 595-606 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

12 Downloads (Pure)

Valuable Fatty Acids in Bryophytes-Production, Biosynthesis, Analysis and Applications

Lu, Y., Eiriksson, F. F., Thorsteinsdóttir, M. & Simonsen, H. T., 2019, In : Nature Plants. 8, 11, 18 p., 524.

Research output: Contribution to journalReviewResearchpeer-review

Open Access
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678 Downloads (Pure)

Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial

Roager, H. M., Vogt, J. K., Kristensen, M., Hansen, L. B. S., Ibrügger, S., Mærkedahl, R. B., Bahl, M. I., Lind, M. V., Nielsen, R. L., Frøkiær, H., Gøbel, R. J., Landberg, R., Ross, A. B., Brix, S., Holck, J., Meyer, A. S., Sparholt, M. H., Christensen, A. F., Carvalho, V., Holst, J. J. & 17 others, Rumessen, J. J., Linneberg, A., Sicheritz-Pontén, T., Dalgaard, M. D., Blennow, A., Frandsen, H. L., Villas-Bôas, S. G., Kristiansen, K., Vestergaard, H., Hansen, T., Ekstrøm, C. T., Ritz, C., Nielsen, H. B., Pedersen, O. B., Gupta, R., Lauritzen, L. & Licht, T. R., 2019, In : Gut. 68, 1, p. 83-93

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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88 Downloads (Pure)

Within-host adaptation mediated by intergenic evolution in Pseudomonas aeruginosa

Khademi, S. M. H., Sazinas, P. & Jelsbak, L., 2019, In : Genome Biology and Evolution. 11, 5, p. 1385-1397 13 p., evz083.

Research output: Contribution to journalJournal articleResearchpeer-review

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17 Downloads (Pure)

Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B

Copmans, D., Kildgaard, S., Rasmussen, S. A., Ślezak, M., Dirkx, N., Partoens, M., Esguerra, C. V., Crawford, A. D., Larsen, T. O. & De Witte, P. A. M., 2019, In : Marine Drugs. 17, 11, 20 p., 607.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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2018

Accelerated collagen turnover in women with angina pectoris without obstructive coronary artery disease: An iPOWER substudy

Nielsen, S. H., Mygind, N. D., Michelsen, M. M., Bechsgaard, D. F., Suhrs, H. E., Genovese, F., Nielsen, H. B., Brix, S., Karsdal, M., Prescott, E. & Kastrup, J., 2018, In : European Journal of Preventive Cardiology. 25, 7, p. 719-727 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

213 Downloads (Pure)

A community-driven reconstruction of the Aspergillus niger metabolic network

Brandl, J., Aguilar-Pontes, M. V., Schäpe, P., Nørregaard, A., Arvas, M., Ram, A. F. J., Meyer, V., Tsang, A., de Vries, R. P. & Andersen, M. R., 2018, In : Fungal Biology and Biotechnology. 5, 16 p., 16.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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800 Downloads (Pure)

A comprehensive and quantitative comparison of text-mining in 15 million full-text articles versus their corresponding abstracts

Westergaard, D., Stærfeldt, H. H., Tønsberg, C., Jensen, L. J. & Brunak, S., 2018, In : P L o S Computational Biology (Online). 14, 2, e1005962.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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390 Downloads (Pure)

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

Frisvad, J. C., 2018, In : World Mycotoxin Journal. 11, 1, p. 73-100

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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206 Downloads (Pure)

A detailed investigation of the porcine skin and nose microbiome using universal and Staphylococcus specific primers

Strube, M. L., Hansen, J. E., Rasmussen, S. & Pedersen, K., 2018, In : Scientific Reports. 8, 9 p., 12751.

Research output: Contribution to journalJournal articleResearchpeer-review

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