Department of Biotechnology and Biomedicine

  • Søltofts Plads, Bygning 221

    DK-2800 Kgs. Lyngby

    Denmark

Research Output 2011 2020

#EUROmicroMOOC: using Twitter to share trends in Microbiology worldwide

López-Goñi, I., Giner-Lamia, J., Álvarez-Ordoñez, A., Benitez-Páez, A., Claessen, D., Cortesao, M., de Toro, M., García-Ruano, D., Granato, E. T., Kovács, ÁT., Romalde, J. L., Sana, T. G., Sánchez-Angulo, M., Sangari, F. J., Smits, W. K., Sturm, T., Thomassin, J. L., Valdehuesa, K. N. G. & Zapotoczna, M., 2019, In : FEMS Microbiology Letters. 366, 11, 4 p., fnz141.

Research output: Contribution to journalJournal articleResearchpeer-review

1H, 13C and 15N backbone and side-chain assignment of a carbohydrate binding module from a xylanase from Roseburia intestinalis

Madland, E., Kitaoku, Y., Sætrom, G. I., Leth, M. L., Ejby, M., Abou Hachem, M. & Aachmann, F. L., 2019, In : Biomolecular N M R Assignments. 13, 1, p. 55-58 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

3.53 Synthetic Biology: An Overview

de Carvalho, Â., Garcia Vanegas, K., Pereira, F., Theobald, S. & Takos, A., 2019, Comprehensive Biotechnology 3rd Edition. Moo-Young, M. (ed.). 3 ed. Pergamon Press, p. 659-670 12 p.

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

3D protein-structure-oriented discovery of clinical relation across chronic lymphocytic leukemia patients

Mochament, K., Agathangelidis, A., Polychronidou, E., Palaskas, C., Kalamaras, E., Moschonas, P., Stamatopoulos, K., Chailyan, A., Overby, N., Marcatili, P., Hadzidimitriou, A. & Tzovaras, D., 2017, In : Lecture Notes in Computer Science. 10209, p. 139-150

Research output: Contribution to journalConference articleResearchpeer-review

235 Downloads (Pure)

A-, B- and C-type prymnesins are clade specific compounds and chemotaxonomic markers in Prymnesium parvum

Binzer, S. B., Svenssen, D. K., Daugbjerg, N., Alves-de-Souza, C., Pinto, E., Hansen, P. J., Larsen, T. O. & Varga, E., 2019, In : Harmful Algae. 81, p. 10-17

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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A biochemical comparison of fungal GH6 cellobiohydrolases

Christensen, S. J., Krogh, K. B. R. M., Spodsberg, N., Borch, K. & Westh, P., 2019, In : Biochemical Journal. 476, 15, p. 2157-2172 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

A biomarker of collagen type I degradation is associated with cardiovascular events and mortality in patients with atherosclerosis

Nielsen, S. H., Tengryd, C., Edsfeldt, A., Brix, S., Genovese, F., Bengtsson, E., Karsdal, M., Leeming, D. J., Nilsson, J. & Goncalves, I., 2019, In : Journal of Internal Medicine. 285, 1, p. 118-123 6 p.

Research output: Contribution to journalJournal articleCommunication

A Biomarker of Type VI Collagen Degradation (C6M) Is Associated with Changes in ASDAS MRI Measures of Inflammation in Patients with Axial Spondyloarthritis During TNF Inhibitor Therapy

Nielsen, S. H., Bay-Jensen, A., Østergaard, M., Siebuhr, A., Karsdal, M., Sørensen, I. J., Weber, U., Loft, A. G., Kollerup, G., Thamsborg, G., Madsen, O. R., Møller, J. & Pedersen, S. J., 2019, In : Arthritis and Rheumatology. 71, S10, 3 p., 0583.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

A biorefinery approach to bioethanol and bioelectricity co-production from tropical seaweeds

Offei, F., Mensah, M., Kemausuor, F. & Thygesen, A., 2019, In : Journal of Applied Phycology. 31, 6, p. 3899-3913 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

102 Downloads (Pure)

A carbohydrate-binding family 48 module enables feruloyl esterase action on polymeric arabinoxylan

Holck, J., Fredslund, F., Møller, M. S., Brask, J., Krogh, K. B. R. M., Lange, L., Welner, D. H., Svensson, B., Meyer, A. S. & Wilkens, C., 2019, In : Journal of Biological Chemistry. 294, 46, p. 17339-17353 16 p., jbc.RA119.009523.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Accelerated collagen turnover in women with angina pectoris without obstructive coronary artery disease: An iPOWER substudy

Nielsen, S. H., Mygind, N. D., Michelsen, M. M., Bechsgaard, D. F., Suhrs, H. E., Genovese, F., Nielsen, H. B., Brix, S., Karsdal, M., Prescott, E. & Kastrup, J., 2018, In : European Journal of Preventive Cardiology. 25, 7, p. 719-727 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

A chemo-enzymatic approach for the synthesis of human milk oligosaccharide backbone structures

Muschiol, J. & Meyer, A. S., 2019, In : Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences. 74, 3-4, p. 85-89 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

213 Downloads (Pure)

A community-driven reconstruction of the Aspergillus niger metabolic network

Brandl, J., Aguilar-Pontes, M. V., Schäpe, P., Nørregaard, A., Arvas, M., Ram, A. F. J., Meyer, V., Tsang, A., de Vries, R. P. & Andersen, M. R., 2018, In : Fungal Biology and Biotechnology. 5, 16 p., 16.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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69 Downloads (Pure)
Open Access
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800 Downloads (Pure)

A comprehensive and quantitative comparison of text-mining in 15 million full-text articles versus their corresponding abstracts

Westergaard, D., Stærfeldt, H. H., Tønsberg, C., Jensen, L. J. & Brunak, S., 2018, In : P L o S Computational Biology (Online). 14, 2, e1005962.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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258 Downloads (Pure)

A CRISPR/Cas9 based toolbox for efficient genome editing of filamentous fungi

Mortensen, U. H., Nødvig, C. S., Jarczynska, Z. D., Nielsen, M. L., Kirchner, F. H. & Hoof, J. B., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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390 Downloads (Pure)

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

Frisvad, J. C., 2018, In : World Mycotoxin Journal. 11, 1, p. 73-100

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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47 Downloads (Pure)

Activation of Toll-like Receptor 2 in Human Synovium Explants Increase Tissue Turnover and Secretion of Interleukin-6

Sharma, N., Kayed, A., Kjelgaard-Petersen, C. F., Christiansen, T. G., Karsdal, M., Thudium, C. S. & Bay-Jensen, A-C., 2017, In : Arthritis and Rheumatology. 69, 4 p., 1063.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
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260 Downloads (Pure)

A Dereplication and Bioguided Discovery Approach to Reveal New Compounds from a Marine-Derived Fungus Stilbella fimetaria

Kildgaard, S., Subko, K., Phillips, E., Goidts, V., de la Cruz, M., Díaz, C., Gotfredsen, C. H., Andersen, B., Frisvad, J. C., Nielsen, K. F. & Larsen, T. O., 2017, In : Marine Drugs. 15, 8, 253.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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206 Downloads (Pure)

A detailed investigation of the porcine skin and nose microbiome using universal and Staphylococcus specific primers

Strube, M. L., Hansen, J. E., Rasmussen, S. & Pedersen, K., 2018, In : Scientific Reports. 8, 9 p., 12751.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Advanced fabrication of porous ceramic multilayers for membrane applications

Kaiser, A., Della Negra, M., Pinelo, M., Zhang, W. A. & Bjørnetun Haugen, A., 2017, Proceedings of ICM 2017. 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearch

60 Downloads (Pure)

A family of microbial lysine transporter polypeptides

Malla, S., Sommer, M. O. A., van der Helm, E., Wieschalka, S. & Förster, J., 26 May 2017, IPC No. C12P 13/ 08 A I, Patent No. WO2017085241, 26 May 2017, Priority date 19 Nov 2015, Priority No. EP20150195401

Research output: Patent

Open Access
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Affinity Electrophoresis for Analysis of Catalytic Module-Carbohydrate Interactions

Cockburn, D., Wilkens, C. & Svensson, B., 2017, Protein-Carbohydrate Interactions: Methods and Protocols. Abbott, D. W. & van Bueren, A. L. (eds.). Springer, Vol. 1588. p. 119-127 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

A fragment of SPARC reflecting increased collagen affinity shows pathological relevance in lung cancer – implications of a new collagen chaperone function of SPARC

Kehlet, S. N., Manon-Jensen, T., Sun, S., Brix, S., Leeming, D. J., Karsdal, M. A. & Willumsen, N., 2018, In : Cancer Biology and Therapy. 19, 10, p. 904-912

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
152 Downloads (Pure)

A fundamental catalytic difference between zinc and manganese dependent enzymes revealed in a bacterial isatin hydrolase

Sommer, T., Bjerregaard-Andersen, K., Uribe, L., Etzerodt, M., Diezemann, G., Gauss, J., Cascella, M. & Morth, J. P., 2018, In : Scientific Reports. 8, 1, 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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159 Downloads (Pure)

Age-related collagen turnover of the interstitial matrix and basement membrane: Implications of age- and sex-dependent remodeling of the extracellular matrix

Kehlet, S. N., Willumsen, N., Armbrecht, G., Dietzel, R., Brix, S., Henriksen, K. & Karsdal, M. A., 2018, In : P L o S One. 13, 3, e0194458.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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74 Downloads (Pure)

Aggrecanase degradation of type III collagen is associated with clinical knee pain

Bay-Jensen, A. C., Kjelgaard-Petersen, C. F., Petersen, K. K., Arendt-Nielsen, L., Quasnichka, H. L., Mobasheri, A., Karsdal, M. A. & Leeming, D. J., 2018, In : Clinical Biochemistry. 58, p. 37-43

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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118 Downloads (Pure)

A highly active endo-levanase BT1760 of a dominant mammalian gut commensal Bacteroides thetaiotaomicron cleaves not only various bacterial levans, but also levan of timothy grass

Mardo, K., Visnapuu, T., Vija, H., Aasamets, A., Viigand, K. & Alamäe, T., 2017, In : PLOS ONE. 12, 1, 25 p., e0169989.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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A human touch to snakebite antivenoms

Laustsen, A. H., 2019, In : Toxicon. 158, Suppl. 1, p. S16-S16 1 p., 52.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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151 Downloads (Pure)

Alginate Trisaccharide Binding Sites on the Surfaceof β-Lactoglobulin Identified by NMR Spectroscopy: Implications for Molecular Network Formation

Stender, E. G. P., Birch, J., Kjeldsen, C., Nielsen, L. D., Duus, J. Ø., Kragelund, B. B. & Svensson, B., 2019, In : ACS Omega. 4, 4, p. 6165-6174 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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171 Downloads (Pure)

Allergic Sensitization at School Age is a Systemic Low-grade Inflammatory Disorder

Chawes, B. L., Stokholm, J., Schoos, A-M. M., Fink, N. R., Pedersen, S. B. & Bisgaard, H., 2017, In : Allergy. 72, 7, p. 1073-1080

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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295 Downloads (Pure)

A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

Hansen, L. B. S., Roager, H. M., Søndertoft, N. B., Gøbel, R. J., Kristensen, M., Vallès-Colomer, M., Vieira-Silva, S., Ibrügger, S., Lind, M. V., Mærkedahl, R. B., Bahl, M. I., Madsen, M. L., Havelund, J., Falony, G., Tetens, I., Nielsen, T., Allin, K. H., Frandsen, H. L., Hartmann, B., Holst, J. J. & 31 others, Sparholt, M. H., Holck, J., Blennow, A., Moll, J. M., Meyer, A. S., Hoppe, C., Poulsen, J. H., Carvalho, V., Sagnelli, D., Dalgaard, M. D., Christensen, A. F., Lydolph, M. C., Ross, A. B., Villas-Bôas, S., Brix, S., Sicheritz-Pontén, T., Buschard, K., Linneberg, A., Rumessen, J. J., Ekstrøm, C. T., Ritz, C., Kristiansen, K., Nielsen, H. B., Vestergaard, H., Færgeman, N. J., Raes, J., Frøkiær, H., Hansen, T., Gupta, R., Licht, T. R. & Pedersen, O., 2018, In : Nature Communications. 9, 1, 13 p., 4630.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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131 Downloads (Pure)

A Major Mycobacterium tuberculosis outbreak caused by one specific genotype in a low-incidence country: Exploring gene profile virulence explanations: Exploring gene profile virulence explanations

Folkvardsen, D. B., Norman, A., Andersen, Å. B., Rasmussen, E. M., Lillebaek, T. & Jelsbak, L., 2018, In : Scientific Reports. 8, 8 p., 11869.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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A marker of collagen type I degradation is associated with cardiovascular events and mortality in patients with known atherosclerosis

Nielsen, S. H., Tengryd, C., Pedersen, S. B., Genovese, F., Bengtsson, E., Karsdal, M., Reese-Petersen, A. L., Leeming, D. J., Edsfeldt, A., Nilsson, J. & Goncalves, I., 2018, In : European Heart Journal. 39, Suppl 1, p. 1040

Research output: Contribution to journalConference abstract in journalResearchpeer-review

169 Downloads (Pure)

A meta-proteomics approach to study the interspecies interactions affecting microbial biofilm development in a model community

Herschend, J., Damholt, Z. B. V., Marquard, A. M., Svensson, B., Sørensen, S. J., Hägglund, P. & Burmølle, M., 2017, In : Scientific Reports. 7, 1, 13 p., 16483.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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91 Downloads (Pure)

A method for improved glycerol utilization in yeast

Strucko, T., Förster, J., Zirngibl, K. & Patil, K. R., 2018, IPC No. C12N1/16; C12N1/18; C12N1/19; C12N9/02; C12N9/10; C12N9/12; C12P1/02; C12P7/06, Patent No. WO2018127572 , 12 Jul 2018, Priority date 5 Jan 2017, Priority No. EP20170150378

Research output: Patent

Open Access
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184 Downloads (Pure)

A modular metabolic engineering approach for the production of 1,2-propanediol from glycerol by Saccharomyces cerevisiae

Islam, Z-U., Klein, M., Aßkamp, M. R., Ødum, A. S. R. & Nevoigt, E., 2017, In : Metabolic Engineering. 44, p. 223-235

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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A Multifunctional Polysaccharide Utilization Gene Cluster in Colwellia echini Encodes Enzymes for the Complete Degradation of κ-Carrageenan, ι-Carrageenan, and Hybrid β/κ-Carrageenan

Christiansen, L., Pathiraja, D., Bech, P. K., Schultz-Johansen, M., Hennessy, R., Teze, D., Choi, I. G. & Stougaard, P., 2020, In : mSphere. 5, 1, 16 p., e00792.

Research output: Contribution to journalJournal articleResearchpeer-review

64 Downloads (Pure)

Analyse af biobaserede materialer

Ottosen, L. M., Bertelsen, I. G. M., Lenau, T., Bonefeld, B., Riisberg, V., Boldrin, A., Astrup, T. & Meyer, A., 2018, 40 p.

Research output: Book/ReportReportCommissioned

Open Access
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176 Downloads (Pure)

Analysis of a gene panel for targeted sequencing of colorectal cancer samples

Jensen, K. H., Izarzugaza, J. M. G., Sierakowska Juncker, A., Borup Hansen, R., Frøstrup Hansen, T., Timshel, P., Blondal, T., Jensen, T. S., Rygaard-Hjalsted, E., Mouritzen, P., Thorsen, M., Wernersson, R., Nielsen, H. B., Jakobsen, A., Brunak, S. & Brandt Sørensen, F., 2018, In : OncoTarget. 9, 10, p. 9043-9060 18 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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74 Downloads (Pure)

Analysis of Pseudomonas putida growth on non-trivial carbon sources using transcriptomics and genome-scale modeling

D'Arrigo, I., Cardoso, J. G. R., Rennig, M., Sonnenschein, N., Herrgård, M. J. & Long, K. S., 2019, In : Environmental Microbiology Reports. 11, 2, p. 87-97 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Ancestral Sequence Reconstruction – eine neue Methode für die Erzeugung thermostabiler Enzyme?

Muschiol, J., 2019, In : BioSpektrum. 25, 1, p. 52-52 1 p.

Research output: Contribution to journalComment/debateResearchpeer-review

An electroplated copper–silver alloy as antibacterial coating on stainless steel

Ciacotich, N., Din, R. U., Sloth, J. J., Møller, P. & Gram, L., 2018, In : Surface and Coatings Technology. 345, p. 96-104

Research output: Contribution to journalJournal articleResearchpeer-review

55 Downloads (Pure)

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

Agerschou, E. D., Flagmeier, P., Saridaki, T., Galvagnion, C., Komnig, D., Heid, L., Prasad, V., Shaykhalishahi, H., Willbold, D., Dobson, C. M., Voigt, A., Falkenburger, B., Hoyer, W. & Buell, A. K., 2019, In : eLife. 8, 31 p., e46112.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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An experimental approach to studying the role of Horizontal Gene Transfer in shaping fungal secondary metabolism

de Reus, P. E., Nielsen, K. F. N. & Frandsen, R. J. N., 2017.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

314 Downloads (Pure)

An extracellular cell-attached pullulanase confers branched α-glucan utilization in human gut Lactobacillus acidophilus

Møller, M. S., Goh, Y. J., Rasmussen, K. B., Cypryk, W., Celebioglu, H. U., Klaenhammer, T. R., Svensson, B. & Abou Hachem, M., 2017, In : Applied and Environmental Microbiology. 83, 10, 35 p., AEM.00402-17.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Animal Models for Influenza A Virus Infection Incorporating the Involvement of Innate Host Defenses: Enhanced Translational Value of the Porcine Model

Starbæk, S. M. R., Brogaard, L., Dawson, H. D., Smith, A. D., Heegaard, P. M. H., Larsen, L. E., Jungersen, G. & Skovgaard, K., 2018, In : I L A R Journal. 59, 3, p. 323-337 15 p., ily009.

Research output: Contribution to journalJournal articleResearchpeer-review

66 Downloads (Pure)

An Integrated Genomics Framework for System-Level Cell Factory Design

Cardinale, S., Ye, L. & Sommer, M. O. A., 2016. 1 p.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Open Access
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An integrated strategy for the effective production of bristle protein hydrolysate by the keratinolytic filamentous bacterium Amycolatopsis keratiniphila D2

Falco, F. C., Espersen, R., Svensson, B., Gernaey, K. V. & Eliasson Lantz, A., 2019, In : Waste Management. 89, p. 94-102

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

An NAD+-dependent sirtuin depropionylase and deacetylase (Sir2La) from the probiotic bacterium Lactobacillus acidophilus NCFM

Olesen, S. V., Rajabi, N., Svensson, B., Olsen, C. A. & Madsen, A. S., 2018, In : Biochemistry. 57, 26, p. 3903-3915

Research output: Contribution to journalJournal articleResearchpeer-review

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