ThermoFactories: developing novel platform organisms for seaweed biorefining

Elleke Fenna Bosma (Guest lecturer)

Activity: Talks and presentationsConference presentations


Invited presentation about the European project consortium Thermofactories that my porject is a part of, at SeaTech Week 2018 in Brest, France. Abstract:

Brown algae biomass (seaweed) is a promising renewable resource for industrial bioconversions to replace fossil resource-based processes in a green economy. To achieve this, efficient cell factories need to be developed to convert the carbohydrates in the biomass into high-value added products. In the ThermoFactories project, four metabolically different bacteria are engineered for production of a number of industrially important platform and specialty chemicals, including 1,2-propanediol, cadaverine, propanol and lycopene. Whereas model organisms Escherichia coli and Saccharomyces cerevisiae have been engineered to this end, ThermoFactories instead focuses on Thermoanaerobacterium, Rhodothermus marinus, Bacillus methanolicus and Lactobacillus reuteri as novel platform organisms that are inherently better suitable to harsh process conditions such as high salt concentrations and other inhibitors present in the biomass, high temperature and low oxygen. The project implements and integrates systems biology and metabolic engineering, including rounds of model-driven metabolic optimization. Furthermore, feedstock development and process engineering are important parts, to optimize fermentability of the algal hydrolysates and ensure integration with downstream processing and product recovery. A close collaboration between the different European partners in ThermoFactories enables full process integration and development and evaluation of the different novel organisms, aiming at pilot-scale demonstration by the end of the project. In this presentation, I will give a brief overview of the ThermoFactories project, with particular emphasis on the strain development and integration of this with the full process.
Period11 Oct 2018
Event titleInternational Marine Science & Technology Week 2018: Spotlight on Marine Bioresources
Event typeConference
LocationBrest, France
Degree of RecognitionInternational