The effect of checkpoint inhibitor therapy on the lymphocyte repertoire composition

Description

In recent years, immunotherapy has become one of the most promising therapies against cancer. In most of the cases, in order to obtain a proper immune response, the inhibition of a few immune regulator molecules is needed. This is achieved by the so-called checkpoint inhibitors. While the effect of checkpoint inhibitors on supporting a cancer-targeted immune response is well known, and it has been observed its role in the expansion of tumour-related lymphocytes, it is unclear if it can also cause the deletion of a part of the lymphocytes that also express on their surface the checkpoint inhibitor targets. In this project we will investigate this question, by using available repertoire sequencing data before and after checkpoint inhibitor therapy, and computational tools to predict the immunogenicity of sequences.

Period	2020 → …
Examinee	Alla Hassan Dahir
Examination held at	Bioinformatics