Description
Parasitic nematodes of humans, livestock, and other animals cause global diseases of major socio-economic importance. They have a significant, long-term impact on human health, causing substantial suffering, and can now be quickly and accurately identified due to advances in DNA sequencing technologies. Third generation-sequencing (TGS) became more accessible and affordable for a wide range of applications, allowing for massive multiplexing of DNA barcode markers resulting in less costly and time-consuming per-sample sequencing. MinION is a promising TGS platform used to generate whole-genomes and characterize genetic profiles potentially associated with loss-of-efficacy by anthelmintic resistance development. One of these examples includes the evaluation of resistance profiles to macrocyclic lactones, widely available anthelmintics that have been known to lose efficacy since 2005. In this sense, nematode whole-genomes and the discovery of molecular markers using this technology can potentially serve as the basis for veterinary monitoring and clinical practice, and for future routine diagnostic tests.| Period | 22 Oct 2022 → 22 Oct 2026 |
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| Degree of Recognition | International |