Evaluation of Biocompatibility on 3D-printed Inserts using Mouse Intestinal Organoids

Dogan, A. A. (Speaker), Dufva, M. (Other)

Activity: Talks and presentationsConference presentations

Description

Customized 3D-printed inserts are a promising alternative to commercialized air-liquid interphase culture systems [1, 2] to mimic the intestinal tissue for drug absorption/transportation studies [3]. While current models can provide useful information on early biological responses, they have poor predictive capabilities for the physiological features of the intestine [4]. To address these limitations, we aim to provide a customized, cheap, and easy to fabricate/use platform to develop 3D humanized models that are capable of reproducing complex physiological
responses in vitro.

References
[1] Va´radi J, et al., PLoS ONE, 12(1): e0170537 (2017).
[2] Noben, M., et al., United European Gastroenterology Journal, 5(8) (2017).
[3] Jepsen et al., (submitted) Advanced Biosystems, (2020)
[4] Sumigray, K. D., et al., Dev Cell, 45(2):183–197 (2018).
Period2020 → …
Event titleEuropean Organ-on-chip Society Conference 2020: null
Event typeConference