Estimating the burden of disease of congenital toxoplasmosis in Denmark

Stylianos Georgiadis (Guest lecturer), Pires, S. M. (Guest lecturer)

Activity: Talks and presentationsConference presentations

Description

Congenital toxoplasmosis (CT) is a parasitic disease caused by infection with Toxoplasma gondii, which is transmitted from mother to fetus. CT can cause severe fetal and neonatal health problems or even child’s death. The most significant symptoms of CT are included in this study: fetal loss, chorioretinitis, intracranial calcification, hydrocephalus, abnormalities of the central nervous system and neonatal death. Data from comprehensive public health surveillance and other sources were used to estimate i) the morbidity and mortality in Denmark, and ii) the disease burden of CT expressed in disability-adjusted life years (DALYs). Adequate probability distributions were applied to all uncertain parameters in order to provide reliable estimates for the burden of disease. The median disease burden of CT in Denmark in 2017 is calculated to be 155 DALYs with a 95% uncertainty range between 107 and 244 DALYs per year; fetal loss is the leading cause of burden. The disease burden of CT in Denmark is high when compared to other foodborne diseases. This model built on high quality data from comprehensive health registries and can be applied to estimate the disease burden of CT in other countries.
Period3 Dec 2018
Event title2018 Society for Risk Analysis (SRA) Annual Meeting: The Many Faces of Risk
Event typeConference
LocationNew Orleans, United States, Louisiana
Degree of RecognitionInternational

Keywords

  • Congenital toxoplasmosis
  • Burden of disease