Morphological Lesions in Mouse Liver and Lungs After Lung Exposure to Carbon Nanotubes

Research output: Contribution to journalConference abstract in journal – Annual report year: 2013Researchpeer-review

  • Author: Szarek, J.

    University of Warmia and Mazury in Olsztyn, Poland

  • Author: Mortensen, Alicja

    Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860, Søborg, Denmark

  • Author: Jackson, P.

    National Research Centre for the Working Environment, Denmark

  • Author: Saber, A.T.

    National Research Centre for the Working Environment, Denmark

  • Author: Kyjovska, Z.O.

    National Research Centre for the Working Environment, Denmark

  • Author: Wallin, H.

    National Research Centre for the Working Environment, Denmark

  • Author: Vogel, U.

    National Research Centre for the Working Environment, Denmark

  • Author: Hougaard, K.S.

    National Research Centre for the Working Environment, Denmark

View graph of relations

Introduction: Engineered nanoparticles are smaller than 100 nm in at least one direction and designed to improve or achieve new physicochemical properties. Consequently, toxicological properties may also change. Carbon nanotubes have attracted industrial interest due to their unique properties.

Materials and Methods: One day before mating, 30 mice (C57BL/6BomTac, Taconic Europe, Denmark) were given 67 μg multi-walled carbon nanotubes (NM-400, Nanocyl, Belgium) intratracheally (group A). A further 30 control mice (group B) received vehicle (Millipore water with 2% mouse serum). Lungs and liver were taken from six animals from each group for histopathological examination (haematoxylin and eosin staining) 6 weeks (A1, B1 group) and 4 months (A2, B2) after exposure.

Results: Lungs in A1 mice showed bronchiolar subepithelial oedema and perivascular oedema and sporadic hyperaemia and the presence of macrophages. Oedema was slight in A2 mice, but infiltration of macrophages was more intense. In the liver, microfoci of necrosis, infiltration of inflammatory cells and lesions of Kupffer cells were more intense in A1 than A2 mice.

Conclusions: Intratracheal exposure to multi-walled carbon nanotubes caused inflammatory and degenerative lesions in mouse lungs and liver.
Original languageEnglish
JournalJournal of Comparative Pathology
Volume148
Issue number1
Pages (from-to)93
Number of pages1
ISSN0021-9975
DOIs
Publication statusPublished - 2013
EventESVP/ECVP meeting 2012 - Leon, Spain
Duration: 5 Sep 20128 Sep 2012

Conference

ConferenceESVP/ECVP meeting 2012
CountrySpain
CityLeon
Period05/09/201208/09/2012
CitationsWeb of Science® Times Cited: No match on DOI
Download as:
Download as PDF
Select render style:
APAAuthorCBE/CSEHarvardMLAStandardVancouverShortLong
PDF
Download as HTML
Select render style:
APAAuthorCBE/CSEHarvardMLAStandardVancouverShortLong
HTML
Download as Word
Select render style:
APAAuthorCBE/CSEHarvardMLAStandardVancouverShortLong
Word

ID: 51978284