In two pig farms with clinical symptoms of PCVD and circulation of PCV2, vaccination was instituted with 2 ml of Porcilis PCV given once at around 4 (3-5) weeks of age. Vaccinations resulted in a uniform serological response. In one farm, where vaccinated pigs were reared separated from non-vaccinated from weaning through to slaughter, the viraemia was prevented. In the other farm viraemia was reduced with at least 2 log(10) units, even though pigs were housed in the same pen as non-vaccinated and viraemic pigs. In this herd a statistically significant (+ 39 g) average daily weight gain was accomplished in vaccinated pigs compared to non-vaccinated during the period 8-16 weeks after weaning. It was concluded that vaccination with Porcilis PCV reduced the virus load in infected pigs, and vaccination had a positive impact on daily weight gain.