Twist Neutrality and the Diameter of the Nucleosome Core Particle

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Twist Neutrality and the Diameter of the Nucleosome Core Particle. / Bohr, Jakob; Olsen, Kasper.

In: Physical Review Letters, Vol. 108, No. 9, 2012, p. 098101-1 - 098101-4.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Bohr, Jakob; Olsen, Kasper / Twist Neutrality and the Diameter of the Nucleosome Core Particle.

In: Physical Review Letters, Vol. 108, No. 9, 2012, p. 098101-1 - 098101-4.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{87da761be8e54325bff9f141188a936c,
title = "Twist Neutrality and the Diameter of the Nucleosome Core Particle",
publisher = "American Physical Society",
author = "Jakob Bohr and Kasper Olsen",
year = "2012",
doi = "10.1103/PhysRevLett.108.098101",
volume = "108",
number = "9",
pages = "098101--1 -- 098101--4",
journal = "Physical Review Letters",
issn = "0031-9007",

}

RIS

TY - JOUR

T1 - Twist Neutrality and the Diameter of the Nucleosome Core Particle

A1 - Bohr,Jakob

A1 - Olsen,Kasper

AU - Bohr,Jakob

AU - Olsen,Kasper

PB - American Physical Society

PY - 2012

Y1 - 2012

N2 - The diameter of the nucleosome core particle is the same for all the eukaryotes. Here we discuss the possibility that this selectiveness is consistent with a propensity for twist neutrality, in particular, for the double helical DNA to stay rotationally neutral when strained. Reorganization of DNA cannot be done without some level of temporal tensile stress, and as a consequence chiral molecules, such as helices, will twist under strain. The requirement that the nucleosome, constituting the nucleosome core particle and linker DNA, has a vanishing strain-twist coupling leads to a requirement for the amount of bending. For the diameter of the coiled DNA we obtain the relatively accurate numerical estimate of 2R=82 Å.

AB - The diameter of the nucleosome core particle is the same for all the eukaryotes. Here we discuss the possibility that this selectiveness is consistent with a propensity for twist neutrality, in particular, for the double helical DNA to stay rotationally neutral when strained. Reorganization of DNA cannot be done without some level of temporal tensile stress, and as a consequence chiral molecules, such as helices, will twist under strain. The requirement that the nucleosome, constituting the nucleosome core particle and linker DNA, has a vanishing strain-twist coupling leads to a requirement for the amount of bending. For the diameter of the coiled DNA we obtain the relatively accurate numerical estimate of 2R=82 Å.

U2 - 10.1103/PhysRevLett.108.098101

DO - 10.1103/PhysRevLett.108.098101

JO - Physical Review Letters

JF - Physical Review Letters

SN - 0031-9007

IS - 9

VL - 108

SP - 098101-1 - 098101-4

ER -