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DOI

  • Author: Yin, Jiaoyang

    Aarhus University

  • Author: Vogel, Ulla

    National Research Centre for the Working Environment

  • Author: Gerdes, Lars Ulrik

    Aarhus University

  • Author: Dybdahl, Marianne

    National Research Centre for the Working Environment

  • Author: Bolund, Lars

    Aarhus University

  • Author: Nexø, Bjørn Andersen

    Aarhus University

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The genetic susceptibility to basal cell carcinoma (BCC) among Danish psoriatic patients was investigated in association studies with 12 single nucleotide polymorphisms on chromosome 19q13.2-3. The results show a significant association between BCC and the A-allele of a polymorphism in ERCCI exon4 (Odds ratio 12;95% Confidence Interval 1.17-124; p(X2, two-side) = 0.019) and to a lesser extent with XPD exon6 (p = 0.06). This is in accordance with recent studies of a different group of BCC cases (Rockenbauer et al. (in press) Carcinogenesis; Yin et al. (manuscript submitted for publication). Cancer Epidemiol. Biomarkers Prev), which places two highly influential markers between these two genes. The analysis also confirmed that considerable linkage disequilibrium exists between SNPs both within genes and between genes in this region. The combined studies suggest that genetic variation in nucleotide excision repair is of importance for the development of BCC.

Original languageEnglish
JournalBiochemical Genetics
Volume41
Issue number1-2
Pages (from-to)27-37
Number of pages11
ISSN0006-2928
DOIs
StatePublished - Feb 2003
Externally publishedYes
CitationsWeb of Science® Times Cited: 31

    Keywords

  • Basal cell carcinoma, DNA repair, Epidemiology, Linkage disequilibria, Nucleotide polymorphism, Psoriasis
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