Tuning in to the Voices: A Multisite fMRI Study of Auditory Hallucinations

Publication: Research - peer-reviewJournal article – Annual report year: 2009

Without internal affiliation

  • Author: Ford, Judith M.

    Yale University

  • Author: Roach, Brian J.

    Yale University

  • Author: Jørgensen, Kasper Winther

    Unknown

  • Author: Turner, Jessica A.

    University of California: Irvine

  • Author: Brown, Gregory G.

    University of California: San Diego

  • Author: Notestine, Randy

    University of California: San Diego

  • Author: Bischoff-Grethe, Amanda

    University of California: San Diego

  • Author: Greve, Douglas

    Massachusetts General Hospital

  • Author: Wible, Cynthia

    Brigham and Women's Hospital

  • Author: Lauriello, John

    University of New Mexico

  • Author: Belger, Aysenil

    University of North Carolina

  • Author: Mueller, Bryon A.

    University of Iowa

  • Author: Calhoun, Vincent

    Yale University

  • Author: Preda, Adrian

    University of California: Irvine

  • Author: Keator, David

    University of California: Irvine

  • Author: O'Leary, Daniel S.

    University of Iowa

  • Author: Lim, Kelvin O.

    University of Minnesota

  • Author: Glover, Gary

    Stanford University

  • Author: Potkin, Steven G.

    University of California: Irvine

  • Author: Mathalon, Daniel H.

    Yale University

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Introduction: Auditory hallucinations or voices are experienced by 75% of people diagnosed with schizophrenia. We presumed that auditory cortex of schizophrenia patients who experience hallucinations is tonically “tuned” to internal auditory channels, at the cost of processing external sounds, both speech and nonspeech. Accordingly, we predicted that patients who hallucinate would show less auditory cortical activation to external acoustic stimuli than patients who did not. Methods: At 9 Functional Imaging Biomedical Informatics Research Network (FBIRN) sites, whole-brain images from 106 patients and 111 healthy comparison subjects were collected while subjects performed an auditory target detection task. Data were processed with the FBIRN processing stream. A region of interest analysis extracted activation values from primary (BA41) and secondary auditory cortex (BA42), auditory association cortex (BA22), and middle temporal gyrus (BA21). Patients were sorted into hallucinators (n = 66) and nonhallucinators (n = 40) based on symptom ratings done during the previous week. Results: Hallucinators had less activation to probe tones in left primary auditory cortex (BA41) than nonhallucinators. This effect was not seen on the right. Discussion: Although “voices” are the anticipated sensory experience, it appears that even primary auditory cortex is “turned on” and “tuned in” to process internal acoustic information at the cost of processing external sounds. Although this study was not designed to probe cortical competition for auditory resources, we were able to take advantage of the data and find significant effects, perhaps because of the power afforded by such a large sample.
Original languageEnglish
JournalSchizophrenia Bulletin
Publication date2009
Volume35
Issue1
Pages58-66
ISSN0586-7614
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 32
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