Tissue-based map of the human proteome

Research output: Research - peer-reviewJournal article – Annual report year: 2015

  • Author: Uhlén, Mathias

    High Throughput Molecular Bioscience, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark

  • Author: Fagerberg, Linn

    KTH - Royal Institute of Technology, Sweden

  • Author: Hallström, Björn M.

    KTH - Royal Institute of Technology, Sweden

  • Author: Lindskog, Cecilia

    Uppsala University, Sweden

  • Author: Oksvold, Per

    KTH - Royal Institute of Technology, Sweden

  • Author: Mardinoglu, Adil

    Chalmers University of Technology, Sweden

  • Author: Sivertsson, Åsa

    KTH - Royal Institute of Technology, Sweden

  • Author: Kampf, Caroline

    Uppsala University, Sweden

  • Author: Sjöstedt, Evelina

  • Author: Asplund, Anna

    Uppsala University, Sweden

  • Author: Olsson, IngMarie

    Uppsala University, Sweden

  • Author: Edlund, Karolina

    Technical University of Dortmund, Germany

  • Author: Lundberg, Emma

    KTH - Royal Institute of Technology, Sweden

  • Author: Navani, Sanjay

    Lab Surgpath, India

  • Author: Szigyarto, Cristina Al-Khalili

    KTH - Royal Institute of Technology, Sweden

  • Author: Odeberg, Jacob

    KTH - Royal Institute of Technology, Sweden

  • Author: Djureinovic, Dijana

    Uppsala University, Sweden

  • Author: Takanen, Jenny Ottosson

    KTH - Royal Institute of Technology, Sweden

  • Author: Hober, Sophia

    KTH - Royal Institute of Technology, Sweden

  • Author: Alm, Tove

    KTH - Royal Institute of Technology, Sweden

  • Author: Edqvist, Per-Henrik

    Uppsala University, Sweden

  • Author: Berling, Holger

    KTH - Royal Institute of Technology, Sweden

  • Author: Tegel, Hanna

    KTH - Royal Institute of Technology, Sweden

  • Author: Mulder, Jan

    Karolinska Institutet, Sweden

  • Author: Rockberg, Johan

    KTH - Royal Institute of Technology, Sweden

  • Author: Nilsson, Peter

    KTH - Royal Institute of Technology, Sweden

  • Author: Schwenk, Jochen M.

    KTH - Royal Institute of Technology, Sweden

  • Author: Hamsten, Marica

    KTH - Royal Institute of Technology, Sweden

  • Author: von Feilitzen, Kalle

    KTH - Royal Institute of Technology, Sweden

  • Author: Forsberg, Mattias

    KTH - Royal Institute of Technology, Sweden

  • Author: Persson, Lukas

    KTH - Royal Institute of Technology, Sweden

  • Author: Johansson, Fredric

    KTH - Royal Institute of Technology, Sweden

  • Author: Zwahlen, Martin

    KTH - Royal Institute of Technology, Sweden

  • Author: Von Heijne, Gunnar

    Stockholm University, Sweden

  • Author: Nielsen, Jens

    Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Pontén, Fredrik

    Uppsala University, Sweden

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Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.
Original languageEnglish
Article number1260419
JournalScience (New York, N.Y.)
Volume347
Issue number6220
Pages (from-to)394-
Number of pages9
ISSN0036-8075
DOIs
StatePublished - 2015
CitationsWeb of Science® Times Cited: 2040
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