TY - JOUR

T1 - The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens

A1 - Forsberg,Kevin J.

A1 - Reyes,Alejandro

A1 - Wang,Bin

A1 - Selleck,Elizabeth M.

A1 - Sommer,Morten O. A.

A1 - Dantas,Gautam

AU - Forsberg,Kevin J.

AU - Reyes,Alejandro

AU - Wang,Bin

AU - Selleck,Elizabeth M.

AU - Sommer,Morten O. A.

AU - Dantas,Gautam

PB - American Association for the Advancement of Science

PY - 2012

Y1 - 2012

N2 - From Farm to Clinic?Soil organisms have long been assumed to be an important source of antibiotic resistance genes, in part because of antibiotic-treated livestock and in part because of the natural ecology of antibiotic production in the soil. Forsberg et al. (p. 1107) developed a metagenomic protocol to assemble short-read sequence data after antibiotic selection experiments, using 12 different drugs in all antibiotic classes, and compared antibiotic resistance gene sequences between soil bacteria and clinically occurring pathogens. Sixteen sequences, representing seven gene products, were discovered in farmland soil bacteria within long stretches of perfect nucleotide identity with pathogenic proteobacteria.

AB - From Farm to Clinic?Soil organisms have long been assumed to be an important source of antibiotic resistance genes, in part because of antibiotic-treated livestock and in part because of the natural ecology of antibiotic production in the soil. Forsberg et al. (p. 1107) developed a metagenomic protocol to assemble short-read sequence data after antibiotic selection experiments, using 12 different drugs in all antibiotic classes, and compared antibiotic resistance gene sequences between soil bacteria and clinically occurring pathogens. Sixteen sequences, representing seven gene products, were discovered in farmland soil bacteria within long stretches of perfect nucleotide identity with pathogenic proteobacteria.

U2 - 10.1126/science.1220761

DO - 10.1126/science.1220761

JO - Science

JF - Science

SN - 0036-8075

IS - 6098

VL - 337

SP - 1107

EP - 1111

ER -