The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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From Farm to Clinic?Soil organisms have long been assumed to be an important source of antibiotic resistance genes, in part because of antibiotic-treated livestock and in part because of the natural ecology of antibiotic production in the soil. Forsberg et al. (p. 1107) developed a metagenomic protocol to assemble short-read sequence data after antibiotic selection experiments, using 12 different drugs in all antibiotic classes, and compared antibiotic resistance gene sequences between soil bacteria and clinically occurring pathogens. Sixteen sequences, representing seven gene products, were discovered in farmland soil bacteria within long stretches of perfect nucleotide identity with pathogenic proteobacteria.
Original languageEnglish
JournalScience
Publication date2012
Volume337
Issue6098
Pages1107-1111
ISSN0036-8075
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 100
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