The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

Publication: Research - peer-reviewJournal article – Annual report year: 2010

Standard

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. / Campa, Daniele; Hüsing, Anika; McKay, James D.; Sinilnikova, Olga; Vogel, Ulla Birgitte; Tjønneland, Anne; Overvad, Kim; Stegger, Jakob; Clavel-Chapelon, Francoise; Chabbert-Buffet, Nathalie; Fagherazzi, Guy; Trichopoulou, Antonia; Zylis, Dimosthenis; Oustoglou, Erifili; Rohrmann, Sabine; Teucher, Birgit; Fisher, Eva; Bouing, Heiner; Masala, Giovanna; Eustoglou, Vittorio; Sacerdote, Carlotta; Panico, Salvatore; Tumino, Rosario; Onland-Moret, Charlotte; H van Gils, Carla; Bueno-de-Mesquita, H Bas; Lund, Eiliv; Dolores Chirlaque, María; Sala, Núria; Ramon Quirós, José; Ardanaz, Eva; Amiano, Pilar; Molina-Montes, Esther; Hallmans, Göran; Lenner, Per; C. Travis, Ruth; Key, Timothy J; Wareham, Nick; Khaw, Kay-Tee; Rinaldi, Sabina; Slimani, Nadia; Chajes, Veronique; Siddiq, Afshan; Riboli, Elio; Kaaks, Rudolf; Canzian, Federico.

In: B M C Cancer, Vol. 10, 2010, p. 563.

Publication: Research - peer-reviewJournal article – Annual report year: 2010

Harvard

Campa, D, Hüsing, A, McKay, JD, Sinilnikova, O, Vogel, UB, Tjønneland, A, Overvad, K, Stegger, J, Clavel-Chapelon, F, Chabbert-Buffet, N, Fagherazzi, G, Trichopoulou, A, Zylis, D, Oustoglou, E, Rohrmann, S, Teucher, B, Fisher, E, Bouing, H, Masala, G, Eustoglou, V, Sacerdote, C, Panico, S, Tumino, R, Onland-Moret, C, H van Gils, C, Bueno-de-Mesquita, HB, Lund, E, Dolores Chirlaque, M, Sala, N, Ramon Quirós, J, Ardanaz, E, Amiano, P, Molina-Montes, E, Hallmans, G, Lenner, P, C. Travis, R, Key, TJ, Wareham, N, Khaw, K-T, Rinaldi, S, Slimani, N, Chajes, V, Siddiq, A, Riboli, E, Kaaks, R & Canzian, F 2010, 'The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk' B M C Cancer, vol 10, pp. 563., 10.1186/1471-2407-10-563

APA

Campa, D., Hüsing, A., McKay, J. D., Sinilnikova, O., Vogel, U. B., Tjønneland, A., Overvad, K., Stegger, J., Clavel-Chapelon, F., Chabbert-Buffet, N., Fagherazzi, G., Trichopoulou, A., Zylis, D., Oustoglou, E., Rohrmann, S., Teucher, B., Fisher, E., Bouing, H., Masala, G., Eustoglou, V., Sacerdote, C., Panico, S., Tumino, R., Onland-Moret, C., H van Gils, C., Bueno-de-Mesquita, H. B., Lund, E., Dolores Chirlaque, M., Sala, N., Ramon Quirós, J., Ardanaz, E., Amiano, P., Molina-Montes, E., Hallmans, G., Lenner, P., C. Travis, R., Key, T. J., Wareham, N., Khaw, K-T., Rinaldi, S., Slimani, N., Chajes, V., Siddiq, A., Riboli, E., Kaaks, R., & Canzian, F. (2010). The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. B M C Cancer, 10, 563. 10.1186/1471-2407-10-563

CBE

Campa D, Hüsing A, McKay JD, Sinilnikova O, Vogel UB, Tjønneland A, Overvad K, Stegger J, Clavel-Chapelon F, Chabbert-Buffet N, Fagherazzi G, Trichopoulou A, Zylis D, Oustoglou E, Rohrmann S, Teucher B, Fisher E, Bouing H, Masala G, Eustoglou V, Sacerdote C, Panico S, Tumino R, Onland-Moret C, H van Gils C, Bueno-de-Mesquita HB, Lund E, Dolores Chirlaque M, Sala N, Ramon Quirós J, Ardanaz E, Amiano P, Molina-Montes E, Hallmans G, Lenner P, C. Travis R, Key TJ, Wareham N, Khaw K-T, Rinaldi S, Slimani N, Chajes V, Siddiq A, Riboli E, Kaaks R, Canzian F. 2010. The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. B M C Cancer. 10:563. Available from: 10.1186/1471-2407-10-563

MLA

Vancouver

Campa D, Hüsing A, McKay JD, Sinilnikova O, Vogel UB, Tjønneland A et al. The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. B M C Cancer. 2010;10:563. Available from: 10.1186/1471-2407-10-563

Author

Campa, Daniele; Hüsing, Anika; McKay, James D.; Sinilnikova, Olga; Vogel, Ulla Birgitte; Tjønneland, Anne; Overvad, Kim; Stegger, Jakob; Clavel-Chapelon, Francoise; Chabbert-Buffet, Nathalie; Fagherazzi, Guy; Trichopoulou, Antonia; Zylis, Dimosthenis; Oustoglou, Erifili; Rohrmann, Sabine; Teucher, Birgit; Fisher, Eva; Bouing, Heiner; Masala, Giovanna; Eustoglou, Vittorio; Sacerdote, Carlotta; Panico, Salvatore; Tumino, Rosario; Onland-Moret, Charlotte; H van Gils, Carla; Bueno-de-Mesquita, H Bas; Lund, Eiliv; Dolores Chirlaque, María; Sala, Núria; Ramon Quirós, José; Ardanaz, Eva; Amiano, Pilar; Molina-Montes, Esther; Hallmans, Göran; Lenner, Per; C. Travis, Ruth; Key, Timothy J; Wareham, Nick; Khaw, Kay-Tee; Rinaldi, Sabina; Slimani, Nadia; Chajes, Veronique; Siddiq, Afshan; Riboli, Elio; Kaaks, Rudolf; Canzian, Federico / The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk.

In: B M C Cancer, Vol. 10, 2010, p. 563.

Publication: Research - peer-reviewJournal article – Annual report year: 2010

Bibtex

@article{7fa4613d03d24b84a1cd6ec498bd5fad,
title = "The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk",
publisher = "BioMed Central Ltd.",
author = "Daniele Campa and Anika Hüsing and McKay, {James D.} and Olga Sinilnikova and Vogel, {Ulla Birgitte} and Anne Tjønneland and Kim Overvad and Jakob Stegger and Francoise Clavel-Chapelon and Nathalie Chabbert-Buffet and Guy Fagherazzi and Antonia Trichopoulou and Dimosthenis Zylis and Erifili Oustoglou and Sabine Rohrmann and Birgit Teucher and Eva Fisher and Heiner Bouing and Giovanna Masala and Vittorio Eustoglou and Carlotta Sacerdote and Salvatore Panico and Rosario Tumino and Charlotte Onland-Moret and {H van Gils}, Carla and Bueno-de-Mesquita, {H Bas} and Eiliv Lund and {Dolores Chirlaque}, María and Núria Sala and {Ramon Quirós}, José and Eva Ardanaz and Pilar Amiano and Esther Molina-Montes and Göran Hallmans and Per Lenner and {C. Travis}, Ruth and Key, {Timothy J} and Nick Wareham and Kay-Tee Khaw and Sabina Rinaldi and Nadia Slimani and Veronique Chajes and Afshan Siddiq and Elio Riboli and Rudolf Kaaks and Federico Canzian",
note = "This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",
year = "2010",
doi = "10.1186/1471-2407-10-563",
volume = "10",
pages = "563",
journal = "B M C Cancer",
issn = "1471-2407",

}

RIS

TY - JOUR

T1 - The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

A1 - Campa,Daniele

A1 - Hüsing,Anika

A1 - McKay,James D.

A1 - Sinilnikova,Olga

A1 - Vogel,Ulla Birgitte

A1 - Tjønneland,Anne

A1 - Overvad,Kim

A1 - Stegger,Jakob

A1 - Clavel-Chapelon,Francoise

A1 - Chabbert-Buffet,Nathalie

A1 - Fagherazzi,Guy

A1 - Trichopoulou,Antonia

A1 - Zylis,Dimosthenis

A1 - Oustoglou,Erifili

A1 - Rohrmann,Sabine

A1 - Teucher,Birgit

A1 - Fisher,Eva

A1 - Bouing,Heiner

A1 - Masala,Giovanna

A1 - Eustoglou,Vittorio

A1 - Sacerdote,Carlotta

A1 - Panico,Salvatore

A1 - Tumino,Rosario

A1 - Onland-Moret,Charlotte

A1 - H van Gils,Carla

A1 - Bueno-de-Mesquita,H Bas

A1 - Lund,Eiliv

A1 - Dolores Chirlaque,María

A1 - Sala,Núria

A1 - Ramon Quirós,José

A1 - Ardanaz,Eva

A1 - Amiano,Pilar

A1 - Molina-Montes,Esther

A1 - Hallmans,Göran

A1 - Lenner,Per

A1 - C. Travis,Ruth

A1 - Key,Timothy J

A1 - Wareham,Nick

A1 - Khaw,Kay-Tee

A1 - Rinaldi,Sabina

A1 - Slimani,Nadia

A1 - Chajes,Veronique

A1 - Siddiq,Afshan

A1 - Riboli,Elio

A1 - Kaaks,Rudolf

A1 - Canzian,Federico

AU - Campa,Daniele

AU - Hüsing,Anika

AU - McKay,James D.

AU - Sinilnikova,Olga

AU - Vogel,Ulla Birgitte

AU - Tjønneland,Anne

AU - Overvad,Kim

AU - Stegger,Jakob

AU - Clavel-Chapelon,Francoise

AU - Chabbert-Buffet,Nathalie

AU - Fagherazzi,Guy

AU - Trichopoulou,Antonia

AU - Zylis,Dimosthenis

AU - Oustoglou,Erifili

AU - Rohrmann,Sabine

AU - Teucher,Birgit

AU - Fisher,Eva

AU - Bouing,Heiner

AU - Masala,Giovanna

AU - Eustoglou,Vittorio

AU - Sacerdote,Carlotta

AU - Panico,Salvatore

AU - Tumino,Rosario

AU - Onland-Moret,Charlotte

AU - H van Gils,Carla

AU - Bueno-de-Mesquita,H Bas

AU - Lund,Eiliv

AU - Dolores Chirlaque,María

AU - Sala,Núria

AU - Ramon Quirós,José

AU - Ardanaz,Eva

AU - Amiano,Pilar

AU - Molina-Montes,Esther

AU - Hallmans,Göran

AU - Lenner,Per

AU - C. Travis,Ruth

AU - Key,Timothy J

AU - Wareham,Nick

AU - Khaw,Kay-Tee

AU - Rinaldi,Sabina

AU - Slimani,Nadia

AU - Chajes,Veronique

AU - Siddiq,Afshan

AU - Riboli,Elio

AU - Kaaks,Rudolf

AU - Canzian,Federico

PB - BioMed Central Ltd.

PY - 2010

Y1 - 2010

N2 - Background The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC). Methods we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. Results and Conclusions In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.

AB - Background The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC). Methods we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. Results and Conclusions In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.

UR - http://www.biomedcentral.com/1471-2407/10/563

U2 - 10.1186/1471-2407-10-563

DO - 10.1186/1471-2407-10-563

JO - B M C Cancer

JF - B M C Cancer

SN - 1471-2407

VL - 10

SP - 563

ER -