The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
Publication: Research - peer-review › Journal article – Annual report year: 2010
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The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. / Campa, Daniele; Hüsing, Anika; McKay, James D.; Sinilnikova, Olga; Vogel, Ulla Birgitte; Tjønneland, Anne; Overvad, Kim; Stegger, Jakob; Clavel-Chapelon, Francoise; Chabbert-Buffet, Nathalie; Fagherazzi, Guy; Trichopoulou, Antonia; Zylis, Dimosthenis; Oustoglou, Erifili; Rohrmann, Sabine; Teucher, Birgit; Fisher, Eva; Bouing, Heiner; Masala, Giovanna; Eustoglou, Vittorio; Sacerdote, Carlotta; Panico, Salvatore; Tumino, Rosario; Onland-Moret, Charlotte; H van Gils, Carla; Bueno-de-Mesquita, H Bas; Lund, Eiliv; Dolores Chirlaque, María; Sala, Núria; Ramon Quirós, José; Ardanaz, Eva; Amiano, Pilar; Molina-Montes, Esther; Hallmans, Göran; Lenner, Per; C. Travis, Ruth; Key, Timothy J; Wareham, Nick; Khaw, Kay-Tee; Rinaldi, Sabina; Slimani, Nadia; Chajes, Veronique; Siddiq, Afshan; Riboli, Elio; Kaaks, Rudolf; Canzian, Federico.
In: B M C Cancer, Vol. 10, 2010, p. 563.Publication: Research - peer-review › Journal article – Annual report year: 2010
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TY - JOUR
T1 - The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
A1 - Campa,Daniele
A1 - Hüsing,Anika
A1 - McKay,James D.
A1 - Sinilnikova,Olga
A1 - Vogel,Ulla Birgitte
A1 - Tjønneland,Anne
A1 - Overvad,Kim
A1 - Stegger,Jakob
A1 - Clavel-Chapelon,Francoise
A1 - Chabbert-Buffet,Nathalie
A1 - Fagherazzi,Guy
A1 - Trichopoulou,Antonia
A1 - Zylis,Dimosthenis
A1 - Oustoglou,Erifili
A1 - Rohrmann,Sabine
A1 - Teucher,Birgit
A1 - Fisher,Eva
A1 - Bouing,Heiner
A1 - Masala,Giovanna
A1 - Eustoglou,Vittorio
A1 - Sacerdote,Carlotta
A1 - Panico,Salvatore
A1 - Tumino,Rosario
A1 - Onland-Moret,Charlotte
A1 - H van Gils,Carla
A1 - Bueno-de-Mesquita,H Bas
A1 - Lund,Eiliv
A1 - Dolores Chirlaque,María
A1 - Sala,Núria
A1 - Ramon Quirós,José
A1 - Ardanaz,Eva
A1 - Amiano,Pilar
A1 - Molina-Montes,Esther
A1 - Hallmans,Göran
A1 - Lenner,Per
A1 - C. Travis,Ruth
A1 - Key,Timothy J
A1 - Wareham,Nick
A1 - Khaw,Kay-Tee
A1 - Rinaldi,Sabina
A1 - Slimani,Nadia
A1 - Chajes,Veronique
A1 - Siddiq,Afshan
A1 - Riboli,Elio
A1 - Kaaks,Rudolf
A1 - Canzian,Federico
AU - Campa,Daniele
AU - Hüsing,Anika
AU - McKay,James D.
AU - Sinilnikova,Olga
AU - Vogel,Ulla Birgitte
AU - Tjønneland,Anne
AU - Overvad,Kim
AU - Stegger,Jakob
AU - Clavel-Chapelon,Francoise
AU - Chabbert-Buffet,Nathalie
AU - Fagherazzi,Guy
AU - Trichopoulou,Antonia
AU - Zylis,Dimosthenis
AU - Oustoglou,Erifili
AU - Rohrmann,Sabine
AU - Teucher,Birgit
AU - Fisher,Eva
AU - Bouing,Heiner
AU - Masala,Giovanna
AU - Eustoglou,Vittorio
AU - Sacerdote,Carlotta
AU - Panico,Salvatore
AU - Tumino,Rosario
AU - Onland-Moret,Charlotte
AU - H van Gils,Carla
AU - Bueno-de-Mesquita,H Bas
AU - Lund,Eiliv
AU - Dolores Chirlaque,María
AU - Sala,Núria
AU - Ramon Quirós,José
AU - Ardanaz,Eva
AU - Amiano,Pilar
AU - Molina-Montes,Esther
AU - Hallmans,Göran
AU - Lenner,Per
AU - C. Travis,Ruth
AU - Key,Timothy J
AU - Wareham,Nick
AU - Khaw,Kay-Tee
AU - Rinaldi,Sabina
AU - Slimani,Nadia
AU - Chajes,Veronique
AU - Siddiq,Afshan
AU - Riboli,Elio
AU - Kaaks,Rudolf
AU - Canzian,Federico
PB - BioMed Central Ltd.
PY - 2010
Y1 - 2010
N2 - Background The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC). Methods we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. Results and Conclusions In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.
AB - Background The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC). Methods we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. Results and Conclusions In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.
UR - http://www.biomedcentral.com/1471-2407/10/563
U2 - 10.1186/1471-2407-10-563
DO - 10.1186/1471-2407-10-563
JO - B M C Cancer
JF - B M C Cancer
SN - 1471-2407
VL - 10
SP - 563
ER -