The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

Publication: Research - peer-reviewJournal article – Annual report year: 2010

  • Author: Campa, Daniele

    German Cancer Research Center (DKFZ), Germany

  • Author: Hüsing, Anika

    German Cancer Research Center (DKFZ), Germany

  • Author: McKay, James D.

    International Agency for Research on Cancer, France

  • Author: Sinilnikova, Olga

    Université Claude Bernard, France, Hospices Civils de Lyon/Centre Léon Bérard

  • Author: Vogel, Ulla Birgitte

    Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark

  • Author: Tjønneland, Anne

    Danish Cancer Society, Denmark

  • Author: Overvad, Kim

    Aalborg University Hospital

  • Author: Stegger, Jakob

    Aalborg University Hospital

  • Author: Clavel-Chapelon, Francoise

    Institut Gustave Roussy, France

  • Author: Chabbert-Buffet, Nathalie

    Institut Gustave Roussy, France

  • Author: Fagherazzi, Guy

    Institut Gustave Roussy, France

  • Author: Trichopoulou, Antonia

    University of Athens Medical School, Greece, Department of Hygiene, Epidemiology and Medical Statistics

  • Author: Zylis, Dimosthenis

    University of Athens Medical School, Greece, Department of Hygiene, Epidemiology and Medical Statistics

  • Author: Oustoglou, Erifili

    Hellenic Health Foundation, Greece

  • Author: Rohrmann, Sabine

    German Cancer Research Center (DKFZ), Germany

  • Author: Teucher, Birgit

    German Cancer Research Center (DKFZ), Germany

  • Author: Fisher, Eva

    German Institute of Human Nutrition, Germany

  • Author: Bouing, Heiner

    German Institute of Human Nutrition, Germany

  • Author: Masala, Giovanna

    Cancer Research and Prevention Institute (ISPO), Italy, Molecular and Nutritional Epidemiology Unit

  • Author: Eustoglou, Vittorio

    Istituto Nazionale dei Tumori (IRCCS), Italy

  • Author: Sacerdote, Carlotta

    CPO Piemonte, Italy

  • Author: Panico, Salvatore

    Department of Clinical and Experimental Medicine Federico II University, Italy

  • Author: Tumino, Rosario

    Azienda Ospedaliera "Civile M.P.Arezzo" Ragusa, Italy

  • Author: Onland-Moret, Charlotte

    University Medical Center, The Netherlands, Julius Center

  • Author: H van Gils, Carla

    University Medical Center, The Netherlands, Julius Center

  • Author: Bueno-de-Mesquita, H Bas

    National Institute for Public Health and the Environment, Bilthoven, The NetherlandsNational Institute for Public Health and the Environment, The Netherlands

  • Author: Lund, Eiliv

    University of Tromsø

  • Author: Dolores Chirlaque, María

    Murcia Regional Health Council, Spain

  • Author: Sala, Núria

    Catalan Institute of Oncology, Spain

  • Author: Ramon Quirós, José

    Consejería de Salud y Servicios Sanitarios Principado de Asturias, Spain

  • Author: Ardanaz, Eva

    Public Health Institute of Navarra, Spain

  • Author: Amiano, Pilar

    Public Health Department of Gipuzkoa, Spain

  • Author: Molina-Montes, Esther

    Andalusian School of Public Health, Spain

  • Author: Hallmans, Göran

    Umeå University, Sweden

  • Author: Lenner, Per

    Umeå University, Sweden

  • Author: C. Travis, Ruth

    University of Oxford

  • Author: Key, Timothy J

    University of Oxford

  • Author: Wareham, Nick

    University of Cambridge

  • Author: Khaw, Kay-Tee

    University of Cambridge

  • Author: Rinaldi, Sabina

    International Agency for Research on Cancer, France

  • Author: Slimani, Nadia

    International Agency for Research on Cancer, France

  • Author: Chajes, Veronique

    International Agency for Research on Cancer, France

  • Author: Siddiq, Afshan

    Imperial College London

  • Author: Riboli, Elio

    Imperial College, UK

  • Author: Kaaks, Rudolf

    German Cancer Research Center (DKFZ), Germany

  • Author: Canzian, Federico

    German Cancer Research Center (DKFZ), Germany

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Background The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC). Methods we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. Results and Conclusions In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.
Original languageEnglish
JournalB M C Cancer
Publication date2010
Volume10
Pages563
ISSN1471-2407
DOIs
StatePublished

Bibliographical note

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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