The geometrical origin of the strain-twist coupling in double helices
Publication: Research - peer-review › Journal article – Annual report year: 2010
A simple geometrical explanation for the counterintuitive phenomenon when twist
leads to extension in double helices is presented. The coupling between strain and
twist is investigated using a tubular description. It is shown that the relation between
strain and rotation is universal and depends only on the pitch angle. For pitch angles
below 39.4◦ strain leads to further winding, while for larger pitch angles strain
leads to unwinding. The zero-twist structure, with a pitch angle of 39.4◦, is at the
unique point between winding and unwinding and independent of the mechanical
properties of the double helix. The existence of zero-twist structures, i.e. structures
that display neither winding, nor unwinding under strain is discussed. Close-packed
double helices are shown to extend rather than shorten when twisted. Numerical
estimates of this elongation upon winding are given for DNA, chromatin, and RNA.
| Original language | English |
|---|---|
| Journal | AIP Advances |
| Publication date | 2010 |
| Volume | 1 |
| DOIs | |
| State | Published |
| Citations | Web of Science® Times Cited: 3 |
|---|
Keywords
- DNA, Proteins, Molecular biophysics, Molecular configurations, Biomechanics
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ID: 5709019