Task-specific modulation of effective connectivity during two simple unimanual motor tasks: A 122-channel EEG study

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Standard

Task-specific modulation of effective connectivity during two simple unimanual motor tasks: A 122-channel EEG study. / Herz, Damian M.; Christensen, Mark S.; Reck, Christiane; Florin, Esther; Barbe, Michael T.; Stahlhut, Carsten; Pauls, K. Amande M.; Tittgemeyer, Marc; Siebner, Hartwig R.; Timmermann, Lars.

In: NeuroImage, Vol. 59, No. 4, 2012, p. 3187-3193.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Harvard

Herz, DM, Christensen, MS, Reck, C, Florin, E, Barbe, MT, Stahlhut, C, Pauls, KAM, Tittgemeyer, M, Siebner, HR & Timmermann, L 2012, 'Task-specific modulation of effective connectivity during two simple unimanual motor tasks: A 122-channel EEG study' NeuroImage, vol 59, no. 4, pp. 3187-3193., 10.1016/j.neuroimage.2011.11.042

APA

Herz, D. M., Christensen, M. S., Reck, C., Florin, E., Barbe, M. T., Stahlhut, C., ... Timmermann, L. (2012). Task-specific modulation of effective connectivity during two simple unimanual motor tasks: A 122-channel EEG study. NeuroImage, 59(4), 3187-3193. 10.1016/j.neuroimage.2011.11.042

CBE

Herz DM, Christensen MS, Reck C, Florin E, Barbe MT, Stahlhut C, Pauls KAM, Tittgemeyer M, Siebner HR, Timmermann L. 2012. Task-specific modulation of effective connectivity during two simple unimanual motor tasks: A 122-channel EEG study. NeuroImage. 59(4):3187-3193. Available from: 10.1016/j.neuroimage.2011.11.042

MLA

Vancouver

Author

Herz, Damian M.; Christensen, Mark S.; Reck, Christiane; Florin, Esther; Barbe, Michael T.; Stahlhut, Carsten; Pauls, K. Amande M.; Tittgemeyer, Marc; Siebner, Hartwig R.; Timmermann, Lars / Task-specific modulation of effective connectivity during two simple unimanual motor tasks: A 122-channel EEG study.

In: NeuroImage, Vol. 59, No. 4, 2012, p. 3187-3193.

Publication: Research - peer-reviewJournal article – Annual report year: 2012

Bibtex

@article{65683fbf66a346edaf343a9a757f4b77,
title = "Task-specific modulation of effective connectivity during two simple unimanual motor tasks: A 122-channel EEG study",
keywords = "Sensorimotor system, Effective connectivity, Dynamic causal modeling (DCM), Neural oscillations, Electroencephalography (EEG)",
publisher = "Academic Press",
author = "Herz, {Damian M.} and Christensen, {Mark S.} and Christiane Reck and Esther Florin and Barbe, {Michael T.} and Carsten Stahlhut and Pauls, {K. Amande M.} and Marc Tittgemeyer and Siebner, {Hartwig R.} and Lars Timmermann",
year = "2012",
doi = "10.1016/j.neuroimage.2011.11.042",
volume = "59",
number = "4",
pages = "3187--3193",
journal = "NeuroImage",
issn = "1053-8119",

}

RIS

TY - JOUR

T1 - Task-specific modulation of effective connectivity during two simple unimanual motor tasks: A 122-channel EEG study

A1 - Herz,Damian M.

A1 - Christensen,Mark S.

A1 - Reck,Christiane

A1 - Florin,Esther

A1 - Barbe,Michael T.

A1 - Stahlhut,Carsten

A1 - Pauls,K. Amande M.

A1 - Tittgemeyer,Marc

A1 - Siebner,Hartwig R.

A1 - Timmermann,Lars

AU - Herz,Damian M.

AU - Christensen,Mark S.

AU - Reck,Christiane

AU - Florin,Esther

AU - Barbe,Michael T.

AU - Stahlhut,Carsten

AU - Pauls,K. Amande M.

AU - Tittgemeyer,Marc

AU - Siebner,Hartwig R.

AU - Timmermann,Lars

PB - Academic Press

PY - 2012

Y1 - 2012

N2 - Neural oscillations are thought to underlie coupling of spatially remote neurons and gating of information within the human sensorimotor system. Here we tested the hypothesis that different unimanual motor tasks are specifically associated with distinct patterns of oscillatory coupling in human sensorimotor cortical areas. In 13 healthy, right-handed subjects,we recorded task-induced neural activity with 122-channel electroencephalography (EEG) while subjects performed fast self-paced extension–flexionmovementswith the right index finger and an isometric contraction of the right forearm. Task-related modulations of inter-regional coupling within a core motor network comprising the left primary motor cortex (M1), lateral premotor cortex (lPM) and supplementary motor area (SMA) were then modeled using dynamic causal modeling (DCM). A network model postulating coupling both within and across frequencies best captured observed spectral responses according to Bayesian model selection. DCM revealed dominant coupling within the β-band (13–30 Hz) between M1 and SMA during isometric contraction of the forearm, whereas fast repetitive finger movements were characterized by strong coupling within the γ-band (31–48 Hz) and between the θ- (4–7 Hz) and the γ-band. This coupling pattern was mainly expressed in connections from lPM to SMA and from lPM to M1. We infer that human manual motor control involves task-specific modulation of inter-regional oscillatory coupling both within and across distinct frequency bands. The results highlight the potential of DCM to characterize context-specific changes in coupling within functional brain networks.

AB - Neural oscillations are thought to underlie coupling of spatially remote neurons and gating of information within the human sensorimotor system. Here we tested the hypothesis that different unimanual motor tasks are specifically associated with distinct patterns of oscillatory coupling in human sensorimotor cortical areas. In 13 healthy, right-handed subjects,we recorded task-induced neural activity with 122-channel electroencephalography (EEG) while subjects performed fast self-paced extension–flexionmovementswith the right index finger and an isometric contraction of the right forearm. Task-related modulations of inter-regional coupling within a core motor network comprising the left primary motor cortex (M1), lateral premotor cortex (lPM) and supplementary motor area (SMA) were then modeled using dynamic causal modeling (DCM). A network model postulating coupling both within and across frequencies best captured observed spectral responses according to Bayesian model selection. DCM revealed dominant coupling within the β-band (13–30 Hz) between M1 and SMA during isometric contraction of the forearm, whereas fast repetitive finger movements were characterized by strong coupling within the γ-band (31–48 Hz) and between the θ- (4–7 Hz) and the γ-band. This coupling pattern was mainly expressed in connections from lPM to SMA and from lPM to M1. We infer that human manual motor control involves task-specific modulation of inter-regional oscillatory coupling both within and across distinct frequency bands. The results highlight the potential of DCM to characterize context-specific changes in coupling within functional brain networks.

KW - Sensorimotor system

KW - Effective connectivity

KW - Dynamic causal modeling (DCM)

KW - Neural oscillations

KW - Electroencephalography (EEG)

U2 - 10.1016/j.neuroimage.2011.11.042

DO - 10.1016/j.neuroimage.2011.11.042

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 4

VL - 59

SP - 3187

EP - 3193

ER -