Targeting Chromosomal Instability and Tumour Heterogeneity in HER2-Positive Breast Cancer

Publication: Research - peer-reviewJournal article – Annual report year: 2010

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Chromosomal instability (CIN) is a common cause of tumour heterogeneity and poor prognosis in solid tumours and describes cell-cell variation in chromosome structure or number across a tumour population. In this article we consider evidence suggesting that CIN may be targeted and may influence response to distinct chemotherapy regimens, using HER2-positive breast cancer as an example. Pre-clinical models have indicated a role for HER2 signalling in initiating CIN and defective cell-cycle control, and evidence suggests that HER2-targeting may attenuate this process. Anthracyclines and platinum agents may target tumours with distinct patterns of karyotypic complexity, whereas taxanes may have preferential activity in tumours with relative chromosomal stability. A greater understanding of karyotypic complexity and identification of methods to directly examine and target CIN may support novel strategies to improve outcome in cancer. J. Cell. Biochem. 111: 782-790, 2010.
Original languageEnglish
JournalJournal of Cellular Biochemistry
Publication date2010
Volume111
Issue4
Pages782-790
ISSN0730-2312
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 15

Keywords

  • HER2, CHROMOSOMAL INSTABILITY, CEP17, BREAST CANCER, DRUG RESISTANCE, MICROTUBULE, TUMOUR HETEROGENEITY
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