Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A2 activity

Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A₂activity

Publication: Research - peer-review › Journal article – Annual report year: 2012

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Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A₂activity. / Pedersen, Palle Jacob ; Viart, Helene Marie-France ; Melander, Fredrik ; Andresen, Thomas Lars ; Madsen, Robert ; Clausen, Mads Hartvig.

In: Bioorganic & Medicinal Chemistry, Vol. 20, No. 13, 2012, p. 3972-3978.

Publication: Research - peer-review › Journal article – Annual report year: 2012

In: Bioorganic & Medicinal Chemistry, Vol. 20, No. 13, 2012, p. 3972-3978.

Publication: Research - peer-review › Journal article – Annual report year: 2012

Bibtex

@article{9e039b32a0fd48229be36b34a411adc8,

title = "Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A<sub>2 </sub>activity",

publisher = "Pergamon",

author = "Pedersen, {Palle Jacob} and Viart, {Helene Marie-France} and Fredrik Melander and Andresen, {Thomas Lars} and Robert Madsen and Clausen, {Mads Hartvig}",

year = "2012",

volume = "20",

number = "13",

pages = "3972--3978",

journal = "Bioorganic & Medicinal Chemistry",

issn = "0968-0896",

}

RIS

TY - JOUR

T1 - Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A<sub>2 </sub>activity

A1 - Pedersen,Palle Jacob

A1 - Viart,Helene Marie-France

A1 - Melander,Fredrik

A1 - Andresen,Thomas Lars

A1 - Madsen,Robert

A1 - Clausen,Mads Hartvig

AU - Pedersen,Palle Jacob

AU - Viart,Helene Marie-France

AU - Melander,Fredrik

AU - Andresen,Thomas Lars

AU - Madsen,Robert

AU - Clausen,Mads Hartvig

PB - Pergamon

PY - 2012

Y1 - 2012

N2 - Tocopheryl succinates (TOSs) are, in contrast to tocopherols, highly cytotoxic against many cancer cells. In this study the enzyme activity of secretory phospholipase A2 towards various succinate-phospholipid conjugates has been investigated. The synthesis of six novel phospholipids is described, including two TOS phospholipids conjugates. The studies revealed that the TOS conjugates are poor substrates for the enzyme whereas the phospholipids with alkyl and phenyl succinate moieties were hydrolyzed by the enzyme to a high extent.

AB - Tocopheryl succinates (TOSs) are, in contrast to tocopherols, highly cytotoxic against many cancer cells. In this study the enzyme activity of secretory phospholipase A2 towards various succinate-phospholipid conjugates has been investigated. The synthesis of six novel phospholipids is described, including two TOS phospholipids conjugates. The studies revealed that the TOS conjugates are poor substrates for the enzyme whereas the phospholipids with alkyl and phenyl succinate moieties were hydrolyzed by the enzyme to a high extent.

KW - Drug delivery

KW - Liposomes

KW - Vitamin E

KW - Phospholipase

U2 - 10.1016/j.bmc.2012.05.024

DO - 10.1016/j.bmc.2012.05.024

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 13

VL - 20

SP - 3972

EP - 3978

ER -