Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A2 activity

Publication: Research - peer-reviewJournal article – Annual report year: 2012

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Tocopheryl succinates (TOSs) are, in contrast to tocopherols, highly cytotoxic against many cancer cells. In this study the enzyme activity of secretory phospholipase A2 towards various succinate-phospholipid conjugates has been investigated. The synthesis of six novel phospholipids is described, including two TOS phospholipids conjugates. The studies revealed that the TOS conjugates are poor substrates for the enzyme whereas the phospholipids with alkyl and phenyl succinate moieties were hydrolyzed by the enzyme to a high extent.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry
Publication date2012
Volume20
Issue13
Pages3972-3978
ISSN0968-0896
DOIs
StatePublished
CitationsWeb of Science® Times Cited: 2

Keywords

  • Drug delivery, Liposomes, Vitamin E, Phospholipase
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