DOI

  • Author: Tung, L.M.

    Tien Giang University, Viet Nam

  • Author: Cong, N.X.

    Hanoi University of Science and Technology, Viet Nam

  • Author: Huy, L.T.

    Hanoi University of Science and Technology, Viet Nam

  • Author: Lan, N.T.

    Hanoi University of Science and Technology, Viet Nam

  • Author: Phan, V.N.

    Hanoi University of Science and Technology, Viet Nam

  • Author: Hoa, N.Q.

    Hanoi University of Science and Technology, Viet Nam

  • Author: Vinh, L.K.

    Vietnamese Academy of Science and Technology, Viet Nam

  • Author: Thinh, N.V.

    Tien Giang University, Viet Nam

  • Author: Tai, L.T.

    Tien Giang University, Viet Nam

  • Author: Ngo, DT

    Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Mølhave, Kristian

    Molecular Windows, Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, 2800, Kgs. Lyngby, Denmark

  • Author: Huy, T.Q.

    National Institute of Hygiene and Epidemiology, Viet Nam

  • Author: Le, A.-T.

    Hanoi University of Science and Technology, Viet Nam

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In recent years, outbreaks of infectious diseases caused by pathogenic micro-organisms pose a serious threat to public health. In this work, Fe3O4-Ag hybrid nanoparticles were synthesized by simple chemistry method and these prepared nanoparticles were used to investigate their antibacterial properties and mechanism against methicilline-resistant Staphylococcus aureus (MRSA) pathogen. The formation of dimer-like nanostructure of Fe3O4-Ag hybrid NPs was confirmed by X-ray diffraction and High-resolution Transmission Electron Microscopy. Our biological analysis revealed that the Fe3O4-Ag hybrid NPs showed more noticeable bactericidal activity than that of plain Fe3O4 NPs and Ag-NPs. We suggest that the enhancement in bactericidal activity of Fe3O4-Ag hybrid NPs might be likely from main factors such as: (i) enhanced surface area property of hybrid nanoparticles; (ii) the high catalytic activity of Ag-NPs with good dispersion and aggregation stability due to the iron oxide magnetic carrier, and (iii) large direct physical contacts between the bacterial cell membrane and the hybrid nanoparticles. The superparamagnetic hybrid nanoparticles of iron oxide magnetic nanoparticles decorated with silver nanoparticles can be a potential candidate to effectively treat infectious MRSA pathogen with recyclable capability, targeted bactericidal delivery and minimum release into environment.
Original languageEnglish
JournalJournal of Nanoscience and Nanotechnology
Volume16
Issue number6
Pages (from-to)5902-5912
Number of pages11
ISSN1533-4880
DOIs
StatePublished - 2016
CitationsWeb of Science® Times Cited: 1

    Keywords

  • Composite Materials, Magnetic Materials, Chemical Synthesis, Electron Microscopy
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