Synthesis and single crystal X-ray analysis of two griseofulvin metabolites

Publication: Research - peer-reviewJournal article – Annual report year: 2010

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The two phenols, 6-O-desmethyl griseofulvin and 4-O-desmethyl griseofulvin are metabolites of the antifungal drug griseofulvin. Herein, we present an improved synthesis of the 6-phenol derivative, and an unequivocal proof of both structures by single-crystal X-ray analysis.
Original languageEnglish
JournalTetrahedron Letters
Volume51
Issue number45
Pages (from-to)5881-5882
ISSN0040-4039
DOIs
StatePublished - 2010
Peer-reviewedYes
CitationsWeb of Science® Times Cited: 6

Keywords

  • Griseofulvin, Metabolites, Synthesis, X-ray structures
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