Surface-enhanced Raman spectroscopic study of DNA and 6-mercapto-1-hexanol interactions using large area mapping

Publication: Research - peer-reviewJournal article – Annual report year: 2016

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The emergence of 2D SERS substrates with large areas of hot spots has enabled data to be gathered at large scale. This work presents a statistical tool for analysing large amounts of SERS data by utilizing a peak-fitting model in a specific spectral range. By analysing the distributions of Raman intensities and peak positions it is possible to directly inspect the interplay between DNA and 6-mercapto-1-hexanol on gold covered nanopillars. It is demonstrated that optimised functionalization parameters can be extracted from the Raman spectra directly. Using the peak-fitting approach it is possible to avoid miss-interpretation of intensity histograms, where contamination might contribute with an enhanced background and not a peak.
Original languageEnglish
JournalVibrational Spectroscopy
Volume86
Pages (from-to)331-336
ISSN0924-2031
DOIs
StatePublished - 2016
CitationsWeb of Science® Times Cited: 0

Keywords

  • SERS, Area mapping, DNA, 6-mercapto-1-hexanol, Thiol, Gold, Peak-fitting
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