TY - JOUR

T1 - Statistical analysis of DNT detection using chemically functionalized microcantilever arrays

A1 - Bosco,Filippo

A1 - Bache,M.

A1 - Hwu,E.-T.

A1 - Chen,C.H.

A1 - Andersen,S.S.

A1 - Nielsen,K.A.

A1 - Keller,Stephan Sylvest

A1 - Jeppesen,Jakob

A1 - Hwang,I.-S.

A1 - Boisen,Anja

AU - Bosco,Filippo

AU - Bache,M.

AU - Hwu,E.-T.

AU - Chen,C.H.

AU - Andersen,S.S.

AU - Nielsen,K.A.

AU - Keller,Stephan Sylvest

AU - Jeppesen,Jakob

AU - Hwang,I.-S.

AU - Boisen,Anja

PB - Elsevier S.A.

PY - 2012

Y1 - 2012

N2 - The need for miniaturized and sensitive sensors for explosives detection is increasing in areas such as security and demining. Micrometer sized cantilevers are often used for label-free detection, and have previously been reported to be able to detect explosives. However, only a few measurements from 1 to 2 cantilevers have been reported, without any information on repeatability and reliability of the presented data. In explosive detection high reliability is needed and thus a statistical measurement approach needs to be developed and implemented. We have developed a DVD-based read-out system capable of generating large sets of cantilever data for vapor and liquid phase detection of 2,4-dinitrotoluene (DNT). Gold coated cantilevers are initially functionalized with tetraTTF-calix[4]pyrrole molecules, specifically designed to bind nitro-aromatic compounds. The selective binding of DNT molecules on the chemically treated surfaces results in significant bending of the cantilevers and in a decrease of their resonant frequencies. We present averaged measurements obtained from up to 72 cantilevers being simultaneously exposed to the same sample. Compared to integrated reference cantilevers with non-selective coatings the tetraTTF-calix[4]pyrrole functionalized cantilevers reveal a uniform and reproducible behavior.

AB - The need for miniaturized and sensitive sensors for explosives detection is increasing in areas such as security and demining. Micrometer sized cantilevers are often used for label-free detection, and have previously been reported to be able to detect explosives. However, only a few measurements from 1 to 2 cantilevers have been reported, without any information on repeatability and reliability of the presented data. In explosive detection high reliability is needed and thus a statistical measurement approach needs to be developed and implemented. We have developed a DVD-based read-out system capable of generating large sets of cantilever data for vapor and liquid phase detection of 2,4-dinitrotoluene (DNT). Gold coated cantilevers are initially functionalized with tetraTTF-calix[4]pyrrole molecules, specifically designed to bind nitro-aromatic compounds. The selective binding of DNT molecules on the chemically treated surfaces results in significant bending of the cantilevers and in a decrease of their resonant frequencies. We present averaged measurements obtained from up to 72 cantilevers being simultaneously exposed to the same sample. Compared to integrated reference cantilevers with non-selective coatings the tetraTTF-calix[4]pyrrole functionalized cantilevers reveal a uniform and reproducible behavior.

KW - Explosives detection

KW - Cantilever sensor

KW - DVD-ROM

KW - Optical read-out

KW - Calix[4]pyrrole

KW - Tetrathiafulvalene

U2 - 10.1016/j.snb.2012.06.033

DO - 10.1016/j.snb.2012.06.033

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

SN - 0925-4005

VL - 171-172

SP - 1054

EP - 1059

ER -