Small Differences in Attenuation-Corrected Images between Men and Women in Myocardial Perfusion Scintigraphy: A Novel Normal Stress Database
Publication: Research - peer-review › Conference article – Annual report year: 2010
Without internal affiliation
Aim: To develop and compare different normal stress databases for myocardial perfusion scintigraphy (MPS), with regard to men, women, attenuation‐corrected (AC) images and nonattenuation‐ corrected (NC) images. The hypothesis was that AC images show less differences between men and women compared with NC images. Methods: Normal stress perfusion databases were developed for four different groups. A male and a female database were developed, as well as an AC and a NC database. Patients who underwent 99mTc MPS at Malmö University Hospital in 2008 were considered for inclusion. Patients were included in the study group if they had a normal test result (neither fixed nor reversible perfusion defects, normal ejection fraction (≥ 60% for women, ≥ 55% for men) and normal end diastolic volume (≤ 132 ml for women, ≤ 181 ml for men) based on the final report according to clinical routine. The EXINI heart software package was used for interpretation. Patients with diabetes, coronary artery disease, previous myocardial infarction, previous revascularization, ECG signs of myocardial infarction, presence of pre‐excitation, paced rhythms and left bundle branch block were excluded. After this, 131 men and 213 women were included. Bull’s eye plots for these patients were created, and obvious ‘non‐normal’ patients were excluded. Finally, 126 men and 206 women were included. The comparison method consisted both of a pixel‐by‐pixel analysis and a segmental analysis (anterior, septal, inferior, lateral, and apical). The following four comparisons were performed: AC vs. NC for men, AC vs. NC for women, men vs. women for AC and men vs. women for NC. Results: When comparing women within the NC and AC databases, the main finding was that the largest difference in mean counts was found in the inferior segment (lower in the NC group). The same result was found in men. For men and women in the NC group, men showed lower mean counts in the inferior segment. When comparing men and women in the AC group, the largest differences were found in the apical and lateral segments (Table 1). Conclusion: Differences in mean counts when comparing men and women in the AC group were much smaller than when comparing the other groups. The results support the hypothesis that it is possible to use gender‐independent AC stress databases.
|Journal||European Journal of Nuclear Medicine and Molecular Imaging|
|State||Published - 2010|
|Conference||23rd Annual Congress of the European Association of Nuclear Medicine|
|Period||09/10/2010 → 13/10/2010|
|Citations||Web of Science® Times Cited: No match on DOI|
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