Simplified Monolithic Flow Cytometer Chip With Three-Dimensional Hydrodyanmic Focusing And Integrated Fiber-Free Optics

Publication: Research - peer-reviewArticle in proceedings – Annual report year: 2011

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A miniaturized flow cytometry incorporating both fluidic and optical systems has a great possibility for portable
biochemical sensing or point-of-care diagnostics. This paper presents a simple microfluidic flow cytometer combining
reliable 3D hydrodynamic focusing and optical detection without optical fibers in a monolithic architecture fabricated by a
single photolithographic process. The vertical flow focusing is achieved by the optimized inlet geometry in a PDMS lid onto
the substrate with detection channel and integrated optics. The simplified approach indicates the possibility to be applied as a
portable platform of cytometer chip.
Original languageEnglish
Title of host publicationProceedings of 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publication date2011
Pages1888-1890
StatePublished

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
CountryUnited States
CitySeattle, WA
Period02/10/1106/10/11
Internet addresshttp://www.microtas2011.org/

Keywords

  • Flow cytometry, Hydrodynamic focusing, Integrated optics, Particle detection
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